Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules E-Book

• Herausgeber: Bentham Science Publishers
• Kategorie: Lebensstil
• Serie: Natural Medicine
• Sprache: Englisch

Seitenzahl: 522

Veröffentlichungsjahr: 2024

Beschreibung

Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules offers a comprehensive exploration of the pharmacological potential of plant-derived compounds. The book provides an in-depth look at the therapeutic applications of phytomolecules in various health conditions. It begins with an analysis of bioactive phloroglucinol compounds and progresses to cover plant-based approaches for managing rheumatoid arthritis, diabetes, cancer, neurological disorders, and antiviral activity. The volume also covers the molecular mechanisms of flavonoids, the preclinical pharmacology of Indian medicinal herbs, and the neuroprotective role of andrographolide in Parkinson’s disease. Designed to inform and inspire, this book is ideal for researchers, clinicians, and students interested in the therapeutic potential of natural products.
Readership:
Undergraduate and graduate students and researchers interested in the therapeutic potential of natural products.

Leseprobe

Table of Contents

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PREFACE

List of Contributors

Pharmacological Potential of Bioactive Phloroglucinol Compounds of the Plant Kingdom

Abstract

INTRODUCTION

OVERVIEW OF PHLOROGLUCINOL COMPOUNDS

Definition

Phloroglucinol as a Scaffold in Biology

Phloroglucinol Derivatives

Monomeric Phloroglucinols

Acyl Phloroglucinols

Phloroglucinol–terpene Adducts

Adducts Involving Chroman Ring Formation

Adducts without Chroman Ring Formation

Phloroglucinol Glycosides

Halogenated Phloroglucinols

Prenylated/geranylated Phloroglucinols

Phloroglucinols Linked to a-pyrone Ring

Cyclic Polyketides

Miscellaneous Monomeric Phloroglucinols

Dimeric Phloroglucinols

Dimers Formed by a Methylene Linkage

Dimers Containing a Chroman Ring

Trimeric Phloroglucinols

Tetrameric and Higher Phloroglucinols

Phlorotannins

PLANT KINGDOM OF PHLOROGLUCINOLS COMPOUNDS AND THEIR USES

Asteraceae

Euphorbiaceae

Hypericaceae

Lamiaceae

Myrtaceae

Rosaceae

PHARMACOLOGICAL ACTIVITIES OF PHLOROGLUCINOL COMPOUNDS

Antibacterial Activity

Antifungal Activity

Anti-inflammatory Activity

Antileishmanial Activity

Antiplasmodial Activity

Antiproliferative Activity

Cytotoxicity Activity

Ferroptosis Inhibitory Activity

α-glucosidase Inhibitory Activity

CONCLUSION

REFERENCES

Raging the War against Rheumatoid Arthritis with Plant-Derived Products: Skepticism to Clinical Development

Abstract

INTRODUCTION

PATHOGENESIS OF RHEUMATOID ARTHRITIS

CONTEMPORARY TREATMENT STRATEGIES AND THEIR LIMITATIONS

HERBAL PRODUCTS: SKEPTICISM

POTENTIAL PLANT-DERIVED PRODUCTS AGAINST RA

Plant-derived Products in Clinical Trials

Plant-based Dietary Interventions

Vegan Diet

Mediterranean Diet

Other Supplement Therapy

Compounds Undergoing Preclinical Development

Luteolin

Quercetin

Genistein

Piperlongumine

Kaempferol

Resveratrol

Ellagic Acid

Gallic acid

Ferulic Acid

Chlorogenic Acid

Oxymatrine

Montanine

Emodin

Chebulanin

CONCLUDING REMARKS

REFERENCES

Recent Updates in Natural Product Research and Novel Approaches to Drug Delivery Using Phytomolecules

Abstract

INTRODUCTION

HERBAL DRUG DELIVERY SYSTEM: SCOPE AND CHALLENGES

NOVEL APPROACHES TO DRUG DELIVERY OF PHYTOMOLECULES FOR THERAPEUTIC BENEFITS

Phytosomes

Methods for Preparation of Phytosomes

Niosomes

Methods for Preparation of Niosomes

Liposomes

Proniosomes

Methods of Preparation of Proniosomes

Ethosomes

Methods of Ethosomes Preparation

Transferosomes

Methods of Preparation of Transferosomes

Microspheres

Advantages of Microspheres

Methods of Preparation of Microspheres

Microemulsions

Advantages of Microemulsions as Drug Carrier

Nanoemulsions

Advantages of Nanoemulsions [75, 76]

Nanoparticles

Advantages of Nanoparticles

MARKETED NOVEL DRUG DELIVERY SYSTEM FORMULATIONS BASED ON PLANT EXTRACTS AND ACTIVES

CONCLUSION

References

Molecular Basis of Therapeutic Action of Flavonoids

Abstract

INTRODUCTION

Tannins

Alkaloids

Terpenoids

Saponins

Phenolic Compounds

CLASSIFICATION OF FLAVONOIDS

PHYSIOLOGICAL ROLES OF PLANT FLAVONOIDS

Anti-inflammatory Activity

Anti-cancer Activity

Anti Diabetic Activity

Antithrombogenic Effect

Anti-bacterial Activity

Metabolism of flavonoids

MOLECULAR BASIS OF PHARMACOLOGICAL ACTIONS OF FLAVONOIDS

Flavonols

Kaempferol

Myricetin

Quercetin

Rutin

Isorhamnetin

Fisetin

Flavonone

Eriodictyol

Hesperidin

Naringenin

Flavone

Luteolin

Apigenin

Baicalein

Tangeretin

Anthocyanins

Flavanonols

Chalcone

Isoflavone

Genistein

Formononetin

Biochanin-A

Flavanol

CONCLUSION

REFERENCES

Research Outcomes of Natural Products in Diabetes Mellitus

Abstract

INTRODUCTION

Commonly Used Plants with Proven Anti-Diabetic Activity

Momordica charantia L.

Panax ginseng

Allium cepa L.

Allium sativum L.

Aloe vera L.

Pterocarpus marsupium

Tinospora cordifolia

Tinospora crispa L.

Gymnema sylvestre

Ocimum sanctum L.

Costus igneus

Active Constituents with Reported Anti-diabetic Activity

Anthocyanins

Berberine

Catechins

Curcumin

Ginsenosides

Stevioside

CONCLUSION

REFERENCES

Exploration of Plant Phytomolecules’ Potential for Antiviral Activity

Abstract

INTRODUCTION

VIRAL DISEASES

Respiratory System-related Viral Infection

Gastrointestinal System-related Viral Infection

Exanthematous Viral Disease

Metabolic Viral Diseases

Skin Viral Infections

Hemorrhagic Viral Infections

Viral Diseases Related to the Nervous System

INDIAN TRADITIONAL DRUGS

ROLE OF PRIMARY AND SECONDARY METABOLITES

Bioactive Compounds of Plants and their Pharmacological Activities

CHALLENGES IN PLANT-BASED RESEARCH

FUTURE PROSPECTS OF PLANT-BASED MEDICINE

CONCLUSION

REFERENCES

Preclinical Pharmacology of Some Important Indian Medicinal Herbs in Animal Models and Their Mode of Action

Abstract

INTRODUCTION

PHARMACOLOGICAL ACTIVITY OF MEDICINAL PLANTS

Aloe barbadensis Mill. (Asphodelaceae)

Hepato-protective Activity

Anti-cancer Activity

Hypoglycemic and anti-hyperlipidemic Activities

Anti-inflammatory and Analgesic Activity

Azadirachta indica A. Juss (Meliaceae)

Anti-diabetic Effect

Cardiovascular Effects

Hepato-protective Effect

Analgesic and Anti-inflammatory Activity

Curcuma longa L. (Zingiberaceae)

Anti-inflammatory Activity

Antihyperlipidemic and Antidiabetic Effect

Hepato-protective Activity

Effect on the Gastrointestinal Tract

Cardio-protective Activity

Achyranthes aspera L. (Amaranthaceae)

Anti-inflammatory Activity

Effect on the Nervous System

Antiulcer Activity

Anti-hyperlipidaemic and antihyperglycaemic Effect

Hepato-protective Activity

Emblica officinalis Gaetrn. (Phyllanthaceae)

Anti-hypercholesterolemic and Anti-hypoglycaemic Activities

Analgesic and antipyretic Activity

Effect on the Central Nervous System

Protective Activity on the Gastrointestinal Tract

Effect on the Reproductive System

DISCUSSION

CONCLUSION

CONSENT FOR PUBLICATON

REFERENCES

Citrus and its Fight against Cancer

Abstract

INTRODUCTION

GEOGRAPHICAL DISTRIBUTION AND TRADITIONAL USES

CITRUS SPECIES AND THEIR ANTICANCER ACTIVITY

Citrus maxima

Citrus aurantium

Citrus bergamia

Citrus reticulata

Citrus sinensis

Citrus hystrix

Citrus limon

CONCLUSION AND FUTURE PERSPECTIVE

REFERENCES

Andrographolide and its Neuroprotective Potential in Ameliorating Parkinson’s Disease

Abstract

INTRODUCTION

PATHOGENESIS OF PARKINSON’S DISEASE

Age, Gender, Race

Genetic Factors

Environmental Risk Factors

Inflammation as a Risk Factor

Role of Andrographolide in Parkinson’s Disease

Andrographolide Inhibits Microglial Cells-induced Parkinson’s Disease

Andrographolide Ameliorates Parkinson’s Disease via Heat Shock Factor 1 Activation

CONCLUSION

REFERENCES

Current Pharmacological Perspectives of Herbal Antidiabetic Drug Formulations

Abstract

INTRODUCTION

MODERN-DAY APPLICATIONS OF ETHNOMEDICINE

SYNTHETIC VERSUS PLANT-BASED MEDICINE

PLANT-BASED MEDICINES' PHARMACOLOGICAL ACTIVITY

IMPACT OF PHYTOCHEMICALS ON DIABETES

THE ROLE OF PLANT-BASED DRUG FORMULATIONS IN DIABETES AVAILABLE ON THE MARKET

THE PROSPECT OF PLANT-BASED ANTI-DIABETIC DRUGS

CONCLUSION

REFERENCES

Natural Medicine

(Volume 3)

Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules

Edited by

Raja Chakraborty

Institute of Pharmacy

Assam Don Bosco University

Tapesia Gardens

Sonapur – 782402

Assam, India

&

Saikat Sen

Faculty of Pharmaceutical Science

Assam down town University

Guwahati 781026, Assam

India

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PREFACE

Plants are a source of a wide variety of natural products with a variety of medicinal characteristics that are always being researched to create new medications. Today, the majority of pharmaceutical drugs are made from these natural ingredients. Plants produce a vast array of chemically diverse secondary metabolites with specific biological activities, but their molecular mechanism, pharmacokinetic profile, and safety have not yet been fully analyzed. Natural product research is experiencing a remarkable resurgence of interest in this age of rapidly advancing science and technology, and the findings are quite intriguing. Current research is gaining renewed attention for its ability to produce novel and intriguing scaffolds with improved physicochemical, pharmacokinetic, and pharmacodynamic properties. However, it is still challenging to analyze the mechanisms of action of herbal medications on a holistic level due to the complexity of substances and their linked various targets of traditional herbal medicine. Additionally, ADME (absorption, distribution, metabolism, and excretion) properties are described as the dynamic alterations in drugs within the body, which are critical in drug discovery and development. The discovery and development of drugs based on natural products are challenging tasks that require a highly integrated interdisciplinary approach. Recent technological innovations, scientific advancements, and research trends all point to the fact that natural products will continue to rank highly as a source of novel medications in the future. Volume 3 (Therapeutic Insights into Herbal Medicine through the Use of Phytomolecules) of Natural Medicine includes different chapters that offer important information about the screening of phytoextracts/phytomolecules for drug discovery.

Raja Chakraborty Institute of Pharmacy Assam Don Bosco University Tapesia Gardens Sonapur – 782402 Assam, India &Saikat Sen Faculty of Pharmaceutical Science Assam down town University Guwahati 781026, Assam India

List of Contributors

Alakesh BharaliDepartment of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science (Girijananda Chowdhury University), Azara, Guwahati-781017, Assam, IndiaAniya TeliFaculty of Pharmaceutical Sciences, Assam down town University, Panikhaiti, Guwahati 781026, Assam, IndiaArnab SarkarDepartment of Pharmaceutical Technology, Jadavpur University, West Bengal, Kolkata 700032, India Bioequivalence Study Centre, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, IndiaAbhik PaulDepartment of Pharmaceutical Technology, Jadavpur University, West Bengal, Kolkata 700032, IndiaAvik MajiDepartment of Pharmaceutical Technology, Jadavpur University, West Bengal, Kolkata 700032, IndiaBhanu P. SahuDepartment of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science (Girijananda Chowdhury University), Azara, Guwahati-781017, Assam, IndiaBiswajit DashAmity Institute of Pharmacy, Amity University, Kolkata- 700135, West Bengal, IndiaBimal DebbarmaInstitute of Pharmacy, Assam Don Bosco University, Tapesia, Kamarkuchi, Assam-782402, IndiaChayanika BordoloiDepartment of Pharmaceutics, NEF College of Pharmacy, Saukuchi, Guwahati-781040, Assam, IndiaDamiki LalooDepartment of Pharmacognosy, Girijananda Chowdhury Institute of Pharmaceutical Science (Girijananda Chowdhury University), Azara, Guwahati-781017, Assam, IndiaGanesh Prasad MishraKSCP, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, IndiaGunjan KalyaniColumbia Institute of Pharmacy, Tekari, Raipur, Chhattisgarh, IndiaInnocent SutngaInstitute of Pharmacy, Assam Don Bosco University, Tapesia, Kamarkuchi, Assam-782402, IndiaJunmoni NathDepartment of Pharmaceutics, NEF College of Pharmacy, Saukuchi, Guwahati-781040, Assam, IndiaKavimani S.College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry-605006, IndiaKhaji Firdous BanuRaghavendra Institute of Pharmaceutical Education and Research (Autonomous), Anantapuramu, Andhra Pradesh-515721, IndiaLubhan SinghKSCP, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, IndiaLoushambam Samananda SinghInstitute of Pharmacy, Assam Don Bosco University, Tapesia, Kamarkuchi, Assam-782402, IndiaMayuren CandasamyDepartment of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur 57000, MalaysiaManish PathakKSCP, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, IndiaManajit BoraCentral Ayurveda Research Institute, Borsojai, Beltola, Guwahati-781028, Assam, IndiaManish Kumar GautamFaculty of Pharmaceutical Sciences, Assam down town University, Panikhaiti, Guwahati 781026, Assam, IndiaNiranjan DasDepartment of Chemistry, Iswar Chandra Vidyasagar College, Belonia-799155, Tripura, IndiaNilip Kanti DebBengal College of Pharmaceutical Technology, Dubrajpur, Birbhum- 731123, West Bengal, IndiaNagaladinne NizamuddinSt John’s College of Pharmaceutical, Yerrakota, Yemmiganur, Kurnool, Andhra Pradesh-518360, IndiaPobitra BorahSchool of Pharmacy, Graphic Era Hill University, Dehradun-248002, Uttarakhand, IndiaPran Kishore DebDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman 19392, JordanPriyanka PandeySwami Vivekanand College of Pharmacy, Indore, Madhya Pradesh, IndiaPuspita RoyDepartment of Pharmaceutical Technology, Jadavpur University, West Bengal, Kolkata 700032, IndiaPeter De Roux SumeInstitute of Pharmacy, Assam Don Bosco University, Tapesia, Kamarkuchi, Assam-782402, IndiaPhaibiang LapasamInstitute of Pharmacy, Assam Don Bosco University, Tapesia, Kamarkuchi, Assam-782402, IndiaRupesh Kumar PandeyKSCP, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, IndiaRavindra Kumar PandeyColumbia Institute of Pharmacy, Tekari, Raipur, Chhattisgarh, IndiaRaja ChakrabortyInstitute of Pharmacy, Assam Don Bosco University, Tepesia, Guwahati, Assam- 782402, IndiaRage RekhaRaghavendra Institute of Pharmaceutical Education and Research (Autonomous), Anantapuramu, Andhra Pradesh-515721, IndiaRavishankar Ram ManiFaculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, MalaysiaSubhash C. MandalPharmacognosy and Phytotherapy Research Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata -700032, IndiaSimeon Fogue KouamDepartment of Chemistry, Higher Teacher Training College, University of Yaounde, Yaounde, CameroonSangeeta HazarikaDepartment of Pharmaceutical Engineering & Technology, , , , Indian Institute of Technology (BHU), Varanasi-221005, Uttar Pradesh, IndiaSittarthan V.College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry-605006, IndiaSubrat Kumar Bhattamisra1Department of Pharmacy, School of Health Sciences, Central University of South Bihar, Gaya, Bihar-824236, IndiaSokindra KumarKSCP, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, IndiaShiv Shankar ShuklaColumbia Institute of Pharmacy, Tekari, Raipur, Chhattisgarh, IndiaSejuti Ray ChowdhuryDepartment of Pharmaceutical Technology, School of Medical Science, Adamas University, Kolkata- 700126, West Bengal, IndiaSharad D. PawarCentral Ayurveda Research Institute, 4-CN Block, Sector – V, Bidhannagar, Kolkata- 700 091, West Bengal, IndiaSandip MondalAmity Institute of Pharmacy, Amity University, Kolkata- 700135, West Bengal, IndiaShrabanti SarkarDepartment of Pharmaceutical Technology, Jadavpur University, West Bengal, Kolkata 700032, IndiaSasikala ChinnappanFaculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, MalaysiaSwarnalatha GundlapalliMahathi College of Pharmacy, CTM Rd, Madanapalle, Andhra Pradesh-517319, IndiaSrilakshmi Bada Venkatappa GariFaculty of Pharmaceutical Sciences, Jawaharlal Nehru Technological University Anantapur (JNTUA), Anantapur, Andhrapradesh-515002, IndiaTanmoy BanerjeeDepartment of Pharmaceutical Technology, Adamas University, West Bengal, Barasat-700126, IndiaTanmoy GuriaDepartment of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi - 835 215, (Jharkhand), IndiaTriveni SingirisettyRaghavendra Institute of Pharmaceutical Education and Research (Autonomous), Anantapuramu, Andhra Pradesh-515721, IndiaVimalavathini R.College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry-605006, IndiaVinod Kumar BangarapuMahathi College of Pharmacy, CTM Rd, Madanapalle, Andhra Pradesh-517319, IndiaVinod Kumar NelsonRaghavendra Institute of Pharmaceutical Education and Research (Autonomous), Anantapuramu, Andhra Pradesh-515721, IndiaYvan Anderson Tchangoue NgandjuiDepartment of Chemistry, Higher Teacher Training College, University of Yaounde, Yaounde, Cameroon

Pharmacological Potential of Bioactive Phloroglucinol Compounds of the Plant Kingdom

Yvan Anderson Tchangoue Ngandjui1,*,Niranjan Das2,Subhash C. Mandal3,Simeon Fogue Kouam1

1 Department of Chemistry, Higher Teacher Training College, University of Yaounde, Yaounde, Cameroon

2 Department of Chemistry, Iswar Chandra Vidyasagar College, Belonia-799155, Tripura, India

3 Pharmacognosy and Phytotherapy Research Laboratory, Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata -700032, India

Abstract

Historically, natural products, which are substances generated by living organisms found in nature, have made an important contribution to pharmacotherapy, especially those from plant sources. Phloroglucinols are significant bioactive polyphenolic compounds that are found in plants, marine and microbial sources. Their chemical structures include an aromatic phenyl ring with three hydroxyl groups and are usually made of two or more rings linked together through methylene bridges. They exist widely in several plant families and are known for their significant biological potentials, such as antibacterial, antifungal, anti-inflammatory, antileishmanial, antiplasmodial, antiproliferative and cytotoxicity activities. This book chapter provides an overview of phloroglucinol compounds in the world, their location in the plant, and their pharmacological applications.

Keywords: Biological activity, Medicinal plants, Natural products, Phloroglucinols, Phytomedicine.

*Corresponding author Yvan Anderson Tchangoue Ngandjui: Department of Chemistry, Higher Teacher Training College, University of Yaounde, Yaounde, Cameroon; E-mail: [email protected]

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