Advanced Techniques of Analytical Chemistry: Volume 1 E-Book
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- Herausgeber: Bentham Science Publishers
- Kategorie: Wissenschaft und neue Technologien
- Serie: Advanced Techniques of Analytical Chemistry
- Sprache: Englisch
Advanced Techniques of Analytical Chemistry explains analytical chemistry in an accessible manner for students. The book provides basic and practical knowledge that helps the learner to understand the methods used in conducting experiments. Readers will understand the key concepts of qualitative and quantitative analysis through easy-to-read chapters written for chemistry students.Volume 1 covers the topic of volumetric analysis in detail. Topic-wise chapters introduce the reader to volumetric titrations and then explain the range of titration techniques which include aqueous acid-base titration, non-aqueous titration, redox titration, complexometric titration and some miscellaneous methods like diazotisation titration, Kjeldahl’s method and the oxygen flask combustion method.The combination of basic and advanced methods makes this an ideal textbook for chemistry students at graduate and undergraduate levels as well as an ideal handbook for the laboratory instructor.
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Seitenzahl: 187
Veröffentlichungsjahr: 2022
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FOREWORD
Dr. Prabhakar Kumar VermaThe classical analytical techniques include gravimetric, volumetric, and titrimetric methods; on the other hand, instrumental techniques involve ultraviolet-visible (UV-Vis), infrared (IR), and near-infrared (NIR) spectrophotometry fluorimetry, atomic spectroscopy (absorption/emission), electroanalytical chromatography.
The current volume of a book titled “Advance Techniques of Analytical Chemistry-Volume-1” is about techniques depending on the nature of reactions such as Acid-Base titrations which involve the reaction of an acid and a base. Redox titrations include redox reaction between analyte and titrant as the key reaction, Non-aqueous titrations, Complexometric titration which involves the formation of a colored complex compound, and some miscellaneous methods like Diazotisation Titrations, Kjeldahl Method and Oxygen flask combustion method, etc.
Advance Techniques of Analytical Chemistry-Volume-1 covers a number of important analytical chemistry topics. It does not, however, cover spectroscopic such as mass spectroscopy, IR or NMR as well as chromatographical techniques such as TLC, HPLC, HPTLC and other advanced techniques because these qualitative applications will be covered adequately incoming volumes i.e. Volume-II and Volume-III.
We are happy to recommend this book to students and researchers as there is more material than anyone can cover in one semester; I hope that the diversity of topics will meet the needs of different instructors.
Preface
Dr. Anju GoyalMr. Harish KumarThe main purpose of this book is to cover the basic concept of volumetric titrations. Modern Advance Techniques of Analytical Chemistry essentially involves, as a necessary integral component, even greater horizons than the actual prevalent critical analysis of not only the active pharmaceutical substances but also the secondary pharmaceutical product(s) i.e., the dosage forms having the either single or multi-component formulated product. The fundamental reasons for this sudden legitimate surge in the newer evolving methodologies in the ‘analysis of drug substances’ are perhaps due to the tremendous growth in the progress of ‘medicinal chemistry’ towards achieving one ultimate objective which is to obtain ‘better drugs for a better world’. With the advent of computer-aided-drug modeling (CADM) the critical, scientific, and faster approach to newer drug entities based on the biologically active prototypes, combinatorial chemistry, chiral chemistry, and biotechnology has paved the way towards more specific, potent, and above all, less toxic ‘drugs’ to improve the ultimate quality of life in humans.
Keeping in view the above astronomical growth in the design of complicated, specific, and highly active drug molecules, equally viable, rigorous, accurate, and precise analytical methods have been evolved with the time which has now occupied pivotal and vital positions in most of the Official Compendia viz., USP, BP, Int.P., Eur. P, IP, etc., for the analysis of such compounds both in pure and dosage forms.
The present book on ‘Advance Techniques of Analytical Chemistry’ caters for the much-needed handbook and reference book, which is current about the esteemed philosophy of analytical chemistry, obvious solid support towards drug discovery, development, stability studies, bioavailability, and pharmacokinetic studies, and above all the quality assurance of pure drugs together with their respective dosage forms.
The textbook on ‘Advance Techniques of Analytical Chemistry’ would enormously serve the undergraduates, postgraduates, researchers, analytical chemists working in the Quality Assurance Laboratories, new drug development, production and control, teaching, or regulatory authorities.
List of Contributors
Introduction to Analytical Chemistry
Sapna Kumari1,*,Anju Goyal1,Madhukar Garg1,Harish Verma2Abstract
Analytical chemistry, a branch of chemistry, deals with the analysis of substances. Identification of the constituents from the mixture or substance is called qualitative analysis while Quantitative Analysis deals with determining the purity of the constituents present in the mixture. This is also known as assay method. Various methods like volumetric analysis, gravimetric analysis, polarimetry, refractometry, photometry, fluorimetry, electrochemical methods, chromatographic methods and biological methods comes under the category of quantitative analysis. Volumetric titrations are the elementary procedures applied in the life sciences, pharmaceutics, industrial analysis, water pollution and clinical chemistry and are used to determine the amount of analyte with the standard solution. Main advantages of these methods are cost-effective, rapid and simple, while disadvantages include pH, temperature, and humidity sensitivity, indicator requirement, occurrence of human error, etc.
