Biosensor Nanomaterials E-Book

• Herausgeber: Wiley-VCH
• Kategorie: Fachliteratur
• Sprache: Englisch

Seitenzahl: 520

Veröffentlichungsjahr: 2011

Beschreibung

Biosensors are devices that detect the presence of microbials such as bacteria, viruses or a range biomolecules, including proteins, enzymes, DNA and RNA. For example, they are routinely applied for monitoring the glucose concentration in blood, quality analysis of fresh and waste water and for food control. Nanomaterials are ideal candidates for building sensor devces: where in just a few molecules can alter the properties so drastically that these changes may be easily detected by optical, electrical or chemical means. Recent advantages have radically increased the sensitivity of nanomaterial-based biosensors, making it possible to detect one particular molecule against a background of billions of others.
Focusing on the materials suitable for biosensor applications, such as nanoparticles, quantum dots, meso- and nanoporous materials and nanotbues, this text enables the reader to prepare the respective nanomaterials for use in actual devices by appropriate functionalization, surface processing or directed self-assembly. The emphasis throughout is on electrochemical, optical and mechancial detection methods, leading to solutions for today's most challenging tasks.
The result is a reference for researchers and developers, disseminating first-hand information on which nanomaterial is best suited to a particular application - and why.

Leseprobe

Table of Contents

Cover

Table of Contents

Related Titles

Title page

Copyright page

Preface

List of Contributors

1 New Micro- and Nanotechnologies for Electrochemical Biosensor Development

1.1 Introduction

1.2 Carbon Nanotubes

1.3 Conductive Polymer Nanostructures

1.4 Nanoparticles

1.5 Conclusions

2 Advanced Nanoparticles in Medical Biosensors

2.1 Introduction

2.2 Nanoparticles

2.3 Conclusions and Outlook

3 Smart Polymeric Nanofibers Resolving Biorecognition Issues

3.1 Introduction

3.2 Nanofibers

3.3 Electrospinning of Nanofibers

3.4 Biorecognition Devices

3.5 Conclusions

4 Fabrication and Evaluation of Nanoparticle-Based Biosensors

4.1 Introduction

4.2 Nanoparticle-Based Biosensors and their Fabrication

4.3 Evaluation of Nanoparticle-Based Nanosensors

4.4 Applications of Nanoparticle-Based Biosensors

4.5 Conclusions

5 Enzyme-Based Biosensors: Synthesis and Applications

5.1 Introduction

5.2 Synthesis and Characterization of Biosensor Supports

5.3 Application of Enzyme-Based Biosensors

5.4 Conclusions

Acknowledgments

6 Energy Harvesting for Biosensors Using Biofriendly Materials

6.1 Introduction

6.2 Energy Production and Consumption

6.3 Classification of Energy-Harvesting Devices

6.4 Conclusions

7 Carbon Nanotubes: In Vitro and In Vivo Sensing and Imaging

7.1 Introduction

7.2 Carbon Nanotubes: Structure, Physical and Chemical Properties, and Applications

7.3 Near-IR Absorption of Carbon Nanotubes

7.4 Near-IR Photoluminescence of Single-Walled Carbon Nanotubes

7.5 Raman Scattering of Carbon Nanotubes

7.6 Conclusions and Outlook

Acknowledgments

8 Lipid Nanoparticle-Mediated Detection of Proteins

8.1 Introduction to Liposomes

8.2 Saturated Liposomes

8.3 Polymerized Liposomes

8.4 Conclusions

9 Nanomaterials for Optical Imaging

9.1 Introduction

9.2 Doped Nanoparticles

9.3 Conclusions and Outlook

Acknowledgments

10 Semiconductor Quantum Dots for Electrochemical Biosensors

10.1 Introduction

10.2 Attachment of Biomolecules to Quantum Dots

10.3 Quantum Dot-Based Redox Proteins Biosensor

10.4 Quantum Dot-Based Electrochemical Biosensors of Proteins and DNA

10.5 Conclusions

11 Functionalized Graphene for Biosensing Applications

11.1 Introduction

11.2 Preparation of Grapheme

11.3 Functionalized Graphene with Metal Nanoparticles

11.4 Glucose Biosensors Based on Graphene

11.5 Immunosensors Based on Graphene

11.6 Other Electrochemical Biosensors Based on Graphene

11.7 Conclusions

12 Current Frontiers in Electrochemical Biosensors Using Chitosan Nanocomposites

12.1 Introduction

12.2 Chitosan

12.3 Chitosan Nanocomposite-Based Electrochemical Biosensors

12.4 Conclusions and Future Aspects

13 Nanomaterials as Promising DNA Biosensors

13.1 Introduction

13.2 Nanomaterials as Signal Amplifiers for Hybridization

13.3 Conclusions

14 Nanocomposites and their Biosensor Applications

14.1 Introduction

14.2 Nanocomposites

14.3 Biosensors

14.4 Types of Biosensors

14.5 Biosensors Applications

14.6 Nanocomposites for Biosensor Applications

14.7 Conclusions

Index

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The Editors

Prof. Songjun Li

Key Lab. Pesticide & Chem. Bio

Ministry of Education

Ctrl. China Normal University

Wuhan 430079

China

Prof. Dr. Jagdish Singh

North Dakota State University

Dept. Pharmac. Sciences

Fargo, ND 58108-6050

USA

Prof. Dr. He Li

University of Jinan

School of Medical and Life Sciences

No 106 Jiwei Road

Jinan, Shandong 250022

China

Prof. Dr. Ipsita A. Banerjee

Fordham University

Dept. of Chemistry

Bronx, NY 10458

USA

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ISBN: 978-3-527-32841-3

ISBN: 978-3-527-63517-7 (Epub)

ISBN: 978-3-527-63519-1 (Mobi)

Preface

There is a tremendous interest in reliable sensors and detection systems. Growing concerns about public exposure to harmful agents have fueled the essential requirement of developing and designing new sensing and detection systems. An immense knowledge base on biosensor materials is already assessable, but most of the available biosensor materials are limited to detecting both biological and chemical reagents under a relatively simple and undisturbed background. These available sensors have only limited ability for rapid sensing and discrimination of small amounts of harmful agents embedded in large amounts of a chemically inert but complex background. Scientists in this field are working under pressure to meet these challenges. Nanomaterials, because of the excellent electronic, magnetic, acoustic, and light properties, as well as their unique nanosize effects, have provided a key solution to these impending challenges.

Impressive progress has been made over the past few years because of the timely use of nanomaterials in the field of biosensors. Nanomaterials with the most promising outlook enable us to alter the texture in sensing and controlled modes by their unique electronic, magnetic, acoustic, and light properties or through external stress, electric and magnetic fields, temperature, moisture and pH, and so on. Nanotechnology, coupled with the recent advances in molecular device materials, biomimetic polymers, hybridized composites, supramolecular systems, information- and energy-transfer materials, environmentally friendly materials, and so on, has led to a profound revolution in the field of biosensors. This book summarizes the main applications of nanotechnology in the field of biosensors. The emphasis is to highlight the latest and most significant progress made in this field. Other aspects such as the biosensing principle, mechanism, design, and methods are also described. When providing a relatively comprehensive description on the current knowledge and technologies, we hope to provide an insight into some new directions in this field. As such, this book can be used not only as a textbook for advanced undergraduate and graduate students, but also as a reference book for researchers in biotechnology, nanotechnology, biomaterials, medicine, bioengineering, and other related disciplines.

Several books, each composed of many chapters, are probably not enough to cover all details in the field of biosensor nanomaterials. Thus, it is difficult to live up to the ideal of an absolute and comprehensive summary. Fortunately, because of their expert backgrounds, all of the contributors have done their best when describing their chapters. Owing to the multidisciplinary nature of this subject, a large number of experts with different backgrounds have been invited to contribute their research. Without doubt, if it was not for the participation of such a diverse group of experts, we would not have been able to accomplish our goal of developing a systematic book in the field of biosensor nanomaterials.

Songjun Li, PhD (Email: [email protected])

Jagdish Singh, PhD (Email: [email protected])

He Li, PhD (Email: [email protected])

Ipsita A. Banerjee, PhD (Email: [email protected])

Editors

About the Editors

Dr. Songjun Li, the leading editor of Biosensors Nanomaterials, is a Professor of Chemistry. He received his PhD degree in 2005 from the Chinese Academy of Sciences. Subsequently, he was appointed by Central China Normal University (CCNU) as an Associate Professor with a research interest in molecular recognition. He doubles also as an Invited Professor at the University of Jinan (China) and an Adjunct Professor at Jiangsu University (China). From 2005 to 2008, he worked as Deputy Director of the Chemical Experimental Center of CCNU. He was a postdoctoral fellow in the University of Wisconsin-Milwaukee (USA) during the period from August 2008 to August 2009. Currently, he is working in Cranfield Health (one of the most successful biosensor R & D centers around the world) of Cranfield University (UK) as the Marie Curie Fellow of Europe. During the past 10 years, Dr. Li, as the principal investigator and first author (excluding non-principal investigator and coauthor), has published about 40 papers in international peer-reviewed journals. He was also the leading editor for three other books: Smart Polymer Materials for Biomedical Application (Nova Science, USA, 2010), Smart Nanomaterials for Sensor Applications (Bentham Science, USA, 2010), and Current Focus on Colloids and Surfaces (Transworld Research Network, India, 2009). In March 2010, he cofounded the international principal journal Advanced Materials Letters and has been the Editor-in-Chief since then. He also serves as an editorial member or on the editorial boards of American Journal of Environmental Sciences, Journal of Public Health and Epidemiology, Open Electrochemistry Journal, and Journal of Computational Biology and Bioinformatics Research. He has been invited over 100 times to be a reviewer for various grants and international journals. His recent interest is focused on designing and developing novel, highly substrate-selective molecular recognition systems with molecular imprinting.

Dr. Jagdish Singh is Professor and Chair of the Department of Pharmaceutical Sciences at North Dakota State University (NDSU) College of Pharmacy, North Dakota, and a Fellow of the American Association of Pharmaceutical Scientists and a Fellow of Pharmacy and Biotechnology. Dr. Singh’s research efforts focus on mechanistic studies for developing and testing novel delivery technologies to deliver biotechnologically derived molecules (e.g., peptides, proteins, and genes). His research has been funded by the US Department of Defense, National Institutes of Health, PhRMA Foundation, and American Foundation for Pharmaceutical Education. Recently, he has been successful in establishing an Economic Development Center of Excellence in Vaccinology, called the Center of Biopharmaceutical Research and Production. He has published over 138 peer-reviewed papers and 250 abstracts. Dr. Singh has twice received the NDSU College of Pharmacy Researcher of the Year award, and was recognized with the Fred Waldron Research Award in 2002 in recognition of his outstanding contribution in research and creative activities at NDSU. Dr. Singh has supervised 30 graduate students and postdoctoral fellows, and over two dozen undergraduate and professional (PharmD) research students. He is a member and actively participates in several national and international professional and scientific societies (e.g., American Association of Advancement of Science, American Association of Pharmaceutical Scientists, American Association of Colleges of Pharmacy, and Controlled Release Society, Inc.). He is also a member of the US Pharmacopeia (1995–current), and serves as reviewer of grants and manuscripts for numerous pharmaceutical and biomedical journals.

Dr. He Li is a Professor of Chemistry. He is currently the Associate Editor for the international principal journal Advanced Materials Letters. He received his PhD degree in 2004 from the Chinese Academy of Sciences. Subsequently, he joined the University of Jinan (China), and became an Associate Professor with research interests in nanomaterials and their biomedical applications. He doubled also as Chair of the Pharmaceutical Engineering Department during the period from 2007 to 2009. At present, he is working in the University of Wisconsin (USA) as a Senior Visiting Scientist. In his personal database, he has published over 30 papers in international peer-reviewed journals. He has also been an invited reviewer for various grants and journals (over 40 times). His recent works are focused on designing and developing advanced functional materials for nanomedicine and biosensor applications. Specifically, he is designing and synthesizing multifunctional nanocarriers for cancer therapy and diagnosis, and fabricating biosensors (especially electrochemical biosensors) made of nanomaterials to detect various biomolecules in the field of clinical diagnosis, bioaffinity assays, and environmental monitoring.

Dr. Ipsita Banerjee received her PhD Degree in Chemistry from the University of Connecticut (USA) in 2001, following which she worked as a Postdoctoral Research Associate at the University of Notre Dame, Indiana (2001–2002), at the Chemical and Biomolecular Engineering Department and at Hunter College, New York (2002–2004), Department of Chemistry and Biochemistry in the field of Bio­nanotechnology. She then joined the Chemistry Department at Fordham University, New York in fall 2004 as a Faculty Member. Her current research focuses on the area of molecular self-assembly and supramolecular nanostructures in order to understand the important fundamental aspects of the surface chemistry associated with the growth and development of functional nanobiomaterials. She also works on the development of nanomaterials with tailored properties wherein the shape, size, and porosity can be controlled via new bioengineering routes. Specifically, her research interests are geared toward the design and synthesis of nanomaterials for potential biomedical applications and molecular therapeutics for tissue regeneration, drug delivery, examining the mechanisms of peptide folding (both natural and artificial), catalysis and green synthetic methods for the preparation of nanoparticles for preparation of new improved materials for catalysis and applications as antibacterials, and device fabrication for optoelectronics and biosensors. Over the past 9 years, Dr. Banerjee has authored/coauthored over 45 articles in journals and various proceedings, and has presented at many conferences leading to over 70 presentations. She serves as a reviewer for multiple international journals and is also an Editorial Board Member of the journal Advanced Materials Letters.

List of Contributors

Francesca Berti

Cranfield University

Cranfield Health

Vincent Building

College Road

Cranfield MK43 0AL

UK

Università degli Studi di Firenze

Dipartimento di Chimica “Ugo Schiff”

Via della Lastruccia 3

50019 Sesto Fiorentino, Firenze

Italy

Shunsheng Cao

Jiangsu University

School of Materials Science and Engineering

Xuefu Road 301

Zhenjiang 212013

China

Juanrong Chen

Jiansu University

School of Environment

Xuefu Road 301

Zhenjiang 212013

China

William Cheung

Rutgers University

Chemistry Department

73 Warren Street

Newark, NJ 07102

USA

Christian Cimorra

Cranfield University

Cranfield Health

Vincent Building

College Road

Cranfield MK43 0AL

UK

Bin Du

University of Jinan

School of Chemistry and Chemical Engineering

No 106 Jiwei Road

Jinan 250022

China

Dan Fei

De Montfort University

School of Pharmacy

Gateway Street

Leicester LE1 9BH

UK

Yi Ge

Cranfield University

Cranfield Health

Vincent Building

College Road

Cranfield MK43 0AL

UK

Huixin He

Rutgers University

Chemistry Department

73 Warren Street

Newark, NJ 07102

USA

Ryne C. Hendrickson

North Dakota State University

Department of Pharmaceutical Sciences

1401 Albrecht Boulevard

Fargo, ND 58102

USA

Xin Jin

Jiangsu University

School of Materials Science and Engineering

Xuefu Road 301

Zhenjiang 212013

China

Bernard Knudsen

University of Wisconsin-Milwaukee

Department of Mechanical Engineering

3400 North Maryland Avenue

Milwaukee, WI 53211

USA

Premlata Kumari

Sardar Vallabhbhai National Institute of Technology

Applied Chemistry Department

Ichchhanath

Surat, Gujarat 395007

India

Benedict Law

North Dakota State University

Department of Pharmaceutical Sciences

1401 Albrecht Boulevard

Fargo, ND 58105-6050

USA

Buddhadev Layek

North Dakota State University

Department of Pharmaceutical Sciences

1401 Albrecht Boulevard

Fargo, ND 58102

USA

He Li

University of Jinan

School of Medical and Life Sciences

No 106 Jiwei Road

Jinan 250022

China

Songjun Li

Central China Normal University

College of Chemistry

Key Laboratory of Pesticide & Chemical Biology of Ministry of Education

152 Luoyu Road

Wuhan, 430 079

China

Ruchi Malik

North Dakota State University

Department of Pharmaceutical Sciences

1401 Albrecht Boulevard

Fargo, ND 58105-6050

USA

Sanku Mallik

North Dakota State University

Department of Pharmaceutical Sciences

1401 Albrecht Boulevard

Fargo, ND 58102

USA

Rhishikesh Mandke

North Dakota State University

Department of Pharmaceutical Sciences

1401 Albrecht Boulevard

Fargo, ND 58102

USA

Ajay K. Mishra

University of Johannesburg

Department of Chemical Technology

PO Box 17011

Doornfontien, 2028 Johannesburg

Republic of South Africa

Rajeev Mishra

Nihon University

School of Medicine

Department of Cancer Genetics

Tokyo 1738 610

Japan

Shivani B. Mishra

University of Johannesburg

Department of Chemical Technology

PO Box 17011

Doornfontien, 2028 Johannesburg

Republic of South Africa

Erin K. Nyren-Erickson

North Dakota State University

Department of Pharmaceutical Sciences

1401 Albrecht Boulevard

Fargo, ND 58102

USA

Zhiyong Qian

Sichuan University

West China Medical School

West China Hospital

State Key Lab of Biotherapy

No 1 Branch Park Four of Gaopeng Road

Chengdu 610041

China

Radheshyam Rai

Universidade de Aveiro

Departmento de Engenharia Cerâmica e do Vidro and CICECO

Campus Universitário de Santiago

3810-193 Aveiro

Portugal

Gitanjali Sharma

North Dakota State University

Department of Pharmaceutical Sciences

1401 Albrecht Boulevard

Fargo, ND 58102

USA

Jagdish Singh

North Dakota State University

Department of Pharmaceutical Sciences

1401 Albrecht Boulevard

Fargo, ND 58102

USA

Ashutosh Tiwari

Jiangsu University

Science and Engineering

Zhenjiang 212013

China

National Institute for Materials Science

Sengen 1-2-1

Tsukuba 305 0047

Japan

Anthony P. F. Turner

Cranfield University

Cranfield Health

Vincent Building

College Road

Cranfield MK43 0AL

UK

Anil V. Wagh

North Dakota State University

Department of Pharmaceutical Sciences

1401 Albrecht Boulevard

Fargo, ND 58105-6050

USA

Chunyan Wang

University of Wisconsin-Milwaukee

Department of Mechanical Engineering

12901 Bruce B. Downs Blvd.

Tampa, FL, 33613

USA

Qin Wei

University of Jinan

School of Chemistry and Chemical Engineering

Street No 106 Jiwei Road

Jinan 250022

China

Weiwei Wu

Jiangsu University

School of Materials Science and Engineering

Street Xuefu Road 301

Zhenjiang 212013

China

Minghui Yang

University of Jinan

School of Chemistry and Chemical Engineering

No 106 Jiwei Road

Jinan 250022

China

Xueji Zhang

University of South Florida

Department of Chemistry

4202 East Fowler Avenue

Tampa, FL 33620-5250

USA

University of Science & Technology

Institute of Biomedicine and Bioengineering

No. 30 Xueyuan Rd.

Beijing 100083

China

Zhiyuan Zhao

Jiangsu University

School of Materials Science and Engineering

Xuefu Road 301

Zhenjiang 212013

China