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Beschreibung

This book highlights the applications of deep learning algorithms in implementing big data and IoT enabled smart solutions to treat and care for terminally ill patients. It presents 5 concise chapters showing how these technologies can empower the conventional doctor patient relationship in a more dynamic, transparent, and personalized manner. The key topics covered in this book include:

- The Role of Deep Learning in Healthcare Industry: Limitations

- Generative Adversarial Networks for Deep Learning in Healthcare

- The Role of Blockchain in the Healthcare Sector

- Brain Tumor Detection Based on Different Deep Neural Networks



Key features include a thorough, research-based overview of technologies that can assist deep learning models in the healthcare sector, including architecture and industrial scope. The book also presents a robust image processing model for brain tumor screening.



Through this book, the editors have attempted to combine numerous compelling views, guidelines and frameworks. Healthcare industry professionals will understand how Deep Learning can improve health care service delivery.

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Veröffentlichungsjahr: 2009

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Table of Contents
BENTHAM SCIENCE PUBLISHERS LTD.
End User License Agreement (for non-institutional, personal use)
Usage Rules:
Disclaimer:
Limitation of Liability:
General:
PREFACE
List of Contributors
Role of Deep Learning in Healthcare Industry: Limitations, Challenges and Future Scope
Abstract
INTRODUCTION
A Framework of Deep Learning
LITERATURE REVIEW
E-Health Records by Deep Learning
Medical Images by Deep Learning
Genomics by Deep Learning
Use of Mobiles by Deep Learning
FROM PERCEPTRON TO DEEP LEARNING
Recurrent Neural Network (RNN)
Convolutional Neural Network (CNN)
Boltzmann Machine Technique
Auto-Encoder and Deep Auto-Encoder
Hardware/ Software-Based Implementation
DEEP LEARNING IN HEALTHCARE: FUTURE SCOPE, LIMITATIONS, AND CHALLENGES
CONCLUSION
REFERENCES
Generative Adversarial Networks for Deep Learning in Healthcare: Architecture, Applications and Challenges
Abstract
INTRODUCTION
DEEP LEARNING
The Transition from Machine Learning to DL
Deep Feed-forward Networks
Restricted Boltzmann Machines
Deep Belief Networks
Convolutional Neural Networks
Recurrent Neural Networks
GENERATIVE ADVERSARIAL NETWORKS
GANs Architectures
Deep Convolutional GAN(DCGAN)
InfoGAN
Conditional GANs
Auto Encoder GANs
Cycle GANs
GANs Training Tricks
Objective Function-Based Improvement
Skills Based Techniques
Other Miscellaneous Techniques
STATE-OF-THE-ART APPLICATIONS OF GANS
Image-Based Applications
Sequential Data Based Applications
Other Applications
FUTURE CHALLENGES
CONCLUSION
REFERENCES
Role of Blockchain in Healthcare Sector
Abstract
INTRODUCTION
FEATURES OF BLOCKCHAIN
DATA MANAGEMENT AND ITS SERVICES (TRADITIONAL VS DISTRIBUTED)
DATA DECENTRALIZATION AND ITS DISTRIBUTION
ASSET MANAGEMENT
ANALYTICS
Analytics Process Model
Analytic Model Requirements
IMMUTABILITY FOR BIOMEDICAL APPLIANCES IN BLOCKCHAIN
SECURITY AND PRIVACY
BLOCKCHAIN IN BIOMEDICINE AND ITS APPLICATIONS
Case Study
CONCLUSION AND FUTURE WORK
REFERENCES
Brain Tumor Detection Based on Different Deep Neural Networks - A Comparison Study
Abstract
INTRODUCTION
RELATED WORK
APPROACH
Dataset
Data Pre-Processing
Data Augmentation
Contouring
Transfer Learning
MODELS USED IN THE COMPARISON STUDY
Convolutional Neural Network
Input Layer
Convolution Layer
Activation Layer
Pooling Layer
Fully Connected Layer
Output
VGG 16
ResNet 50
EVALUATION PARAMETERS
RESULTS AND DISCUSSION
Convolutional Neural Network
VGG16 and ResNet50
GUI
CONCLUSION AND FUTURE WORK
NOTES
REFERENCES
A Robust Model for Optimum Medical Image Contrast Enhancement and Tumor Screening
Abstract
INTRODUCTION
LITERATURE REVIEW
PROPOSED MODEL
Dataset
Image Pre-Processing
Features Extraction
Tumor Detection
RESULTS AND DISCUSSION
FUTURE SCOPE
CONCLUSION
REFERENCES
IoT and Big Data Analytics
(Volume 2)
Deep Learning for Healthcare Services
Edited By
Parma Nand
School of Engineering and Technology, Sharda University
Greater Noida, U.P., India
Vishal Jain
Department of Computer Science and Engineering, School of
Engineering and Technology, Sharda University,
Greater Noida, U.P., India
Dac-Nhuong Le
Faculty of Information Technology, Haiphong University, Haiphong, Vietnam
Jyotir Moy Chatterjee
Lord Buddha Education Foundation, Kathmandu, Nepal
Ramani Kannan
Center for Smart Grid Energy Research, Institute of
Autonomous System, Universiti Teknologi PETRONAS
(UTP), Malaysia
&
Abhishek S. Verma
Department of Computer Science & Engineering, School of
Engineering & Technology, Sharda University,
Greater Noida, U.P., India

BENTHAM SCIENCE PUBLISHERS LTD.

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PREFACE

This book aims to highlight the different applications of deep learning algorithms in implementing Big Data and IoT-enabled smart solutions to treat and care for terminally ill patients. The book shall also unveil how the combination of big data, IoT, and the cloud can empower the conventional doctor-patient relationship in a more dynamic, transparent, and personalized manner. Incorporation of these smart technologies can also successfully port over powerful analytical methods from the financial services and consumer industries like claims management. This coupled with the availability of data on social determinants of health – such as socioeconomic status, education, living status, and social networks – opens novel opportunities for providers to understand individual patients on a much deeper level, opening the door for precision medicine to become a reality. The real value of such systems stems from their ability to deliver in-the-moment insights to enable personalized care, understand variations in care patterns, risk-stratify patient populations, and power dynamic care journey management and optimization. Successful application of deep learning frameworks to enable meaningful, cost-effective personalized healthcare services is the primary aim of the healthcare industry in the present scenario. However, realizing this goal requires effective understanding, application, and amalgamation of deep learning, IoT, Big Data, and several other computing technologies to deploy such systems effectively. This book shall help clarify understanding of certain key mechanisms and technologies helpful in realizing such systems. Through this book, we attempt to combine numerous compelling views, guidelines, and frameworks on enabling personalized healthcare service options through the successful application of Deep Learning frameworks.

Chapter 1 represents a survey of the role of deep learning in the healthcare industry with its challenges and future scope.

Chapter 2 focuses on recent work done in GAN and implements this technique in the different deep-learning applications for healthcare.

Chapter 3 focuses on the role of blockchain in biomedical engineering applications.

Chapter 4 compares three different architectures of Convolutional Neural Networks (CNN), VGG16, and ResNet50, and visually represents the result to the users using a GUI.

Chapters 5 propose an efficient model for medical image contrast enhancement and correct tumor prediction.

Parma Nand School of Engineering and Technology Sharda University Greater Noida, U.P. IndiaVishal Jain Department of Computer Science and Engineering School of Engineering and Technology Sharda University, Greater Noida U.P., IndiaDac-Nhuong Le Faculty of Information Technology Haiphong University, Haiphong VietnamJyotir Moy Chatterjee Lord Buddha Education Foundation Kathmandu, NepalRamani Kannan Center for Smart Grid Energy Research Institute of Autonomous System Universiti Teknologi PETRONAS (UTP) Malaysia &Abhishek S. Verma Department of Computer Science & Engineering School of Engineering & Technology

List of Contributors

Abhishek S. VermaDepartment of Computer Science & Engineering, School of Engineering & Technology, Sharda University, Greater Noida, U.P., IndiaAnupam SharmaHMR Institute of Technology & Management, Delhi, IndiaArif AnsariData Sciences and Operations, Marshall School of Business, University of Southern California, Los Angeles, California, United StatesChitrapadi GururajDepartment of Electronics and Telecommunication Engineering, BMS College of Engineering, Bengaluru, Visvesvaraya Technological University, Belagavi, IndiaDac-Nhuong LeFaculty of Information Technology, Haiphong University, Haiphong, VietnamGeeta RaniComputer and Communication Engineering, Manipal University, Jaipur, IndiaInduja Kanchisamudram SeshagiribabuDepartment of Computer Science (Artificial Intelligence), Andrew and Erna Viterbi School of Engineering, University of Southern California, Los Angeles, California, United StatesJyotir Moy ChatterjeeLord Buddha Education Foundation, Kathmandu, NepalKarthikeyan JothikumarDepartment of Computer Science Engineering, National Engineering College, Tamil Nadu, IndiaMonika AgarwalDayanand Sagar University, Bangalore, IndiaMandeep SinghRaj Kumar Goel Institute of Technology, Ghaziabad, IndiaMegha GuptaIMS Engineering College, Ghaziabad, IndiaNitesh PradhanComputer Science Engineering, Manipal University, Jaipur, IndiaParita JainKIET Group of Institutes, Ghaziabad, IndiaParma NandSchool of Engineering and Technology, Sharda University Greater Noida, U.P., IndiaPuneet Kumar AggarwalABES Engineering College, Ghaziabad, IndiaPradeep SinghDepartment of Computer Science & Engineering, National Institute of Technology, Raipur, Chhattisgarh, IndiaRamani KannanCenter for Smart Grid Energy Research, Institute of Autonomous System, Universiti Teknologi PETRONAS (UTP), MalaysiaShankey GargDepartment of Computer Science & Engineering, National Institute of Technology, Raipur, Chhattisgarh, IndiaSheik Abdullah AbbasSchool of Computer Science Engineering, Vellore Institute of Technology, Chennai, Tamil Nadu, IndiaShrividhiya GaikwadDepartment of Electronics and Telecommunication Engineering, BMS College of Engineering, Bengaluru, Visvesvaraya Technological University, Belagavi, IndiaSukruta Nagraj KashyapDepartment of Electronics and Telecommunication Engineering, BMS College of Engineering, Bengaluru, Visvesvaraya Technological University, Belagavi, IndiaSrujana Kanchisamudram SeshagiribabuDepartment of Electronics and Telecommunication Engineering, BMS College of Engineering, Bengaluru, Visvesvaraya Technological University, Belagavi, IndiaVishal JainDepartment of Computer Science and Engineering, School of Engineering and Technology, Sharda University, Greater Noida, U.P., IndiaVijaypal Singh DhakaComputer and Communication Engineering, Manipal University, Jaipur, India

Role of Deep Learning in Healthcare Industry: Limitations, Challenges and Future Scope

Mandeep Singh1,*,Megha Gupta2,Anupam Sharma3,Parita Jain4,Puneet Kumar Aggarwal5
1 Raj Kumar Goel Institute of Technology, Ghaziabad, India
2 IMS Engineering College, Ghaziabad, India
3 HMR Institute of Technology & Management, Delhi, India
4 KIET Group of Institutes, Ghaziabad, India
5 ABES Engineering College, Ghaziabad, India

Abstract

Nowadays, the acquisition of different deep learning (DL) algorithms is becoming an advantage in the healthcare sector. Algorithms like CNN (Convolution Neural Network) are used to detect diseases and classify the images of various disease abnormalities. It has been proven that CNN shows high performance in the classification of diseases, so deep learning can remove doubts that occur in the healthcare sector. DL is also used in the reconstruction of various medical diagnoses images like Computed Tomography and Magnetic Resonance Imaging. CNN is used to map input image data to reference image data, and this process is known as the registration of images using deep learning. DL is used to extract secrets in the healthcare sector. CNN has many hidden layers in the network so that prediction and analysis can be made accurately. Deep learning has many applications in the healthcare system, like the detection of cancer, gene selection, tumor detection, recognition of human activities, the outbreak of infectious diseases, etc. DL has become famous in the field of healthcare due to its open data source. In the case of the small dataset, CNN becomes an advantage as it does not provide an excellent way to statistical importance. Deep Learning is a technique that includes the basis of ANN (Artificial neural networks), appears as a robust tool for machine learning, and encourages recasting artificial intelligence. Deep learning architecture has more than two hidden layers, as in ANN; it is only one or two. Therefore, this chapter represents a survey of the role of deep learning in the healthcare industry with its challenges and future scope.

Keywords: Artificial neural networks (ANN), Auto-encoders (AEs), Bioinformatics, Biological neural networks, Boltzmann machine, Convolution neural networks (CNN), Deep autoencoders, Deep belief networks (DBNs), Deep learning (DL), Deep neural nets (DNNs), Deep structures, Electronic health records (EHRs), Genomics, Machine learning (ML), Medical images, Medical informatics, Pervasive sensing, Restricted boltzmann machines (RBMs), Recurrent neural nets (RNNs), State-of-the-art ML, Unified medical language system (UMLS).
*Corresponding author Mandeep Singh: Raj Kumar Goel Institute of Technology, Ghaziabad, India; E-mail: [email protected]

INTRODUCTION

Deep learning has emerged as an interesting new technique in machine learning in recent years. Deep learning, in contrast to more standard Neural Networks (NNs), makes use of numerous hidden layers. A large number of neurons provides a broadcast level of coverage of the initial stage data; the non-linear permutations of the results are in a lower-dimensional projection, and it is a feature of the space. So that every higher-perceptual level is correlated to a lower-dimensional projection. A fine result is given as an effective abstraction at a high level for the raw data or images if the network is suitably weighted. This high level of abstraction allows for the creation of an automatic feature set that would otherwise require hand-crafted or customized features [1]. The development of an autonomous feature set without human interaction has significant advantages in sectors such as health informatics. In medical imaging, for example, it might be more complex and difficult to describe the features by using descriptive methods. Implicit traits could be used to identify fibroids and polyps, as well as anomalies in tissue morphology like tumors. Such traits may also be used to determine nucleotide sequences in translational bioinformatics so that they potentially bind strongly [2]. Several architectures stand out among the numerous methodological versions of deep learning. Since 2010, the number of papers using the deep learning method has increased. It has an interleaved sequence of feedforward layers that employ convolutional filters, followed by reduction, rectification, or pooling layers. Each network layer generates a high-level abstract characteristic [3]. The mechanism allows visual information in the form of related fields and is similar to this physiologically inspired architecture. Deep Belief Networks (DBNs), stacked Auto-encoders acting as deep Auto-encoders, extending artificial NNs with many layers as Deep Neural Nets (DNNs), and extending artificial NNs with directed cycles as Recurrent Neural Nets are all possible architectures for deep learning (RNNs). The latest developments in graphics processing units (GPUs) have also had a substantial impact on deep learning's practical adoption and acceleration. Many of the theoretical notions that underlie deep learning were already proposed before the advent of GPUs, albeit they have only recently gained traction [4].

A new era in healthcare is entering in which vast biomedical data is becoming increasingly crucial. The abundance of biomedical data presents both opportunities and obstacles for healthcare research. Exploring the relationships between all of the many bits of information in these data sets, in particular, is a major difficulty in developing a credible medical tool that is based on machine learning and data-driven approaches. Previous research has attempted to achieve this goal by linking numerous data to create different information that is used in finding data from data clusters. An analytical tool is required based on machine learning techniques that are not popular in the medical field, even though existing models show significant promise. Indeed, due to their sparsity, variability, temporal interdependence, and irregularity, it makes a fine important issue in biomedical data. New challenges are introduced by different medical ontologies, which are used in the data [5]. In biomedical research, expert selection having the composition to employ based on ad hoc is a frequent technique. The supervised specification of the feature space, on the other hand, scales poorly and misses out on new pattern discovery chances. On the other hand, depict learning methodologies allow for the product adaptation of the depictions needed for the prognosis from data sets. Expert systems are a reflection of an algorithm with several presentation levels. They are made up of basic but complex sections that successively change a representation at the beginning level with given input data into and at the end level, a slightly more abstract representation. In computer vision, audio recognition, and natural language processing applications, deep learning models performed well and showed considerable promise. Deep learning standards present the intriguing potential for information related to biomedical, given their established efficacy in several areas and the quick growth of methodological advancements. DL approaches are already being used or are being considered for use in health care [4]. On the other hand, deep learning technologies have not been evaluated for medical issues that are well enough for their accomplishment. Deep learning contains various elements, such as its improved performance, end-to-end learning scheme with integrated feature learning, and ability to handle complicated and multi-modality data, which could be beneficial in health care. The deep learning researchers accelerate these efforts, which must clarify several problems associated with the features of patient records, but there is a need for enhanced models and strategies which also allow transfer learning to hook up with clinical information via frameworks and judgment call support in the clinic [5]. This article stresses the essential components that will have a significant effect on healthcare, a full background in technological aspects, or broad, deep learning applications. Conversely, biomedical data is concentrated solely by us, including that derived from the image of clinical background, EHRs, genomics, and different medically used equipment. Other data sources are useful for patient health monitoring, and deep learning has yet to be widely applied in these areas. As a result, we will quickly present the basics of deep learning and the medical applications to examine the problems, prospects, and uses of these methods in medicine and next-generation health care [6].

A Framework of Deep Learning

An artificial intelligence technology can discover associations between data without requiring it to be defined beforehand. The capacity to build predictive models, a strong assumption required about the underlying mechanisms, which are often unclear or inadequately characterized, is the main attraction. Because they are made up of typically linear, a single modification of the traditional techniques, which is the ability to access required data from its raw data form. DL differs from traditional machine learning in terms of getting required data from the raw data [7]. DL, in reality, permits computational models made up of many intermediate layers to form neural networks to learn several degrees of abstraction for information representations [8].

Traditional ANNs, on the other hand, typically have three layers to provide training and supervision solely for the task at hand, and are rarely generalizable. Alternatively, each layer in the system of deep learning optimizes a local unsupervised criterion to build an observation pattern of data to get as inputs from the layer below. Deep neural networks examine a layer-by-layer irregular method to initialize the endpoints in subsequent hidden layers to learn generalizable “deep structures” and their representations. Those types of representations are sent into a supervised layer to use as a backpropagation method; the entire network is in a fine network that is very good to optimum in the specific final goal [9].

The unsupervised pre-training breakthrough, new ways to avoid overfitting, the use of general-purpose graphics processing units to speed up calculations, and the development of unsupervised pre-training breakthrough made it possible to develop high-level components to quickly assemble neural networks to find a solution for different tasks by establishing state-of-the-art [10]. In reality, DL is proven to be effective at uncovering subtle structures and is responsible for considerable, achieving outstanding results in image object detection, envisioned, and natural language translation and generation. Healthcare flooring could be achieved by relevant clinical-ready successes in the way of the new generation of deep learning-based smart solutions for genuine medical care [11].

LITERATURE REVIEW

Deep learning's application used in medicines is new and has not been properly investigated. In this chapter reviewed some of the most important recent literature on deep model applications. Publications are cited in this literature review for lighting the types of communication networks and medical data that were taken into account (Table 1).

To our knowledge, no research has used deep learning in all of these data sets, or a subset of them is joint for medical data examination and prediction representation. Many exploratory studies assessed the combined use of genomes and EHRs, but they did not use deep learning; therefore, they were not included in this review. The most common deep learning architectures are used in the healthcare industry. These models explain the basic concepts that underpin their construction (Table 2).

E-Health Records by Deep Learning

Deep learning (DL) has lately been used to handle aggregated data. Structured (e.g., diagnoses, prescriptions) data and unstructured data are both included in EHRs. The majority of this literature used a deep architecture to the process of a health care system for a specific clinical task. A frequent technique is to demonstrate that deep learning outperforms traditional machine learning models in terms of metrics. While most articles show end-to-end supervised networks in this situation, unsupervised models are also provided in multiple papers [12]. Deep learning was utilized in many research to predict disease-based conditions. Liu et al. [13] reported that four layers outperformed baselines in predicting serious heart failure and serious chronic diseases. Short attention of RNNs with sharing and sentiment classification was utilized in a deep dynamic end-to-end network that affects current disease conditions and the medical future is projected. The authors also advocated using a decay effect to control the LSTM unit to manage irregular events, which are difficult to handle in longitudinal EHRs. DeepCare was tested on diabetes and mental health patient cohorts for disease progression modeling, intervention recommendation, and future risk prediction. It utilized RNNs with gated recurrent units (GRU) to create an ending model that is based on patient history to encounter with future diagnoses and treatments.

Deep learning has also been used for the continuous-time model of information, such as laboratory findings, to identify specific phenotypes automatically. RNNs and LSTM were utilized by Lipton et al. [14