Fundamentals of Molecular Virology E-Book

• Herausgeber: John Wiley & Sons
• Kategorie: Wissenschaft und neue Technologien
• Sprache: Englisch

Seitenzahl: 1856

Veröffentlichungsjahr: 2025

Beschreibung

Comprehensive coverage of major families of viruses, including human pathogens and viruses of organisms from bacteria to plants, with updated information on antiviral drugs, vaccines, antiviral immunity, and gene therapy

Fundamentals of Molecular Virology is a textbook designed for university students learning about viruses at the undergraduate or graduate levels. Chapters contributed by prominent virologists cover many of the major virus families. Each chapter is designed to tell a story about the viruses covered, including information on discovery, diseases and pathogenesis, virus structure, steps in replication, and interaction with cellular signaling pathways. This approach portrays the "personality" of each virus, helping students to learn the material and build up their knowledge of virology starting with smaller and simpler viruses and proceeding to more complex viruses.

Major importance is given to viruses that infect humans and cause disease, but coverage is broad, including viruses of bacteria, Archaea, algae, invertebrates, and plants. Information boxes highlight applications and research directions of particular significance. Chapters conclude with sections presenting fundamental concepts, review questions, and lists of key terms, which are defined in a glossary at the end of the book.

This 3rd edition of Fundamentals of Molecular Virology includes detailed information on the recent COVID-19 pandemic and mRNA vaccine technology, additional sections on pathogenic herpesviruses, and updates on recent outbreaks of Zika virus, Ebola virus and mpox diseases. New chapters describe hepatitis C virus, rhabdoviruses, viruses of invertebrates, oncolytic viruses, and virus-mediated gene therapy. All chapters, including those on innate and adaptive immune responses to virus infections, virus vaccines, and antiviral agents, were revised and updated.

Leseprobe

Third Edition

Fundamentals of MolecularVIROLOGY

Edited by

CHRISTOPHER D. RICHARDSON

AND

NICHOLAS H. ACHESON

Copyright © 2025 by John Wiley & Sons, Inc. All rights reserved, including rights for text and data mining and training of artificial intelligence technologies or similar technologies.

Published by John Wiley & Sons, Inc., Hoboken, New Jersey.Published simultaneously in Canada.

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Library of Congress Cataloging‐in‐Publication Data Applied for:

Paperback ISBN 9781119885863

Cover Design: WileyCover Images: © Adenosine/Wikimedia Commons, © Thomas Splettstoesser/Wikimedia Commons, © Moonnoon/Shutterstock, © Kateryna Kon/Shutterstock

Nicholas H. Acheson dedicates this book to four mentors whose enthusiasm for virology stimulated his interest when he was a student, and who encouraged him to follow his own path.

Johns Hopkins IIIJames D. WatsonIgor TammPurnell Choppin

Christopher D. Richardson dedicates this textbook to his mentors and friends who helped guide his career in a journey through the world of viruses, starting in Vancouver and progressing to New York, Bethesda, Montreal, Toronto, and culminating in Halifax. Their continuous support and encouragement were genuinely appreciated.

Dennis E. VancePurnell W. ChoppinIgor TammRobert A. LambRobert A. LazzariniDavid Lorne TyrrellPierre TalbotDavid Y. ThomasTak Wah MakFei‐Fei Liu

BRIEF CONTENTS

SECTION I: INTRODUCTION TO VIROLOGY

1. Introduction to Virology

Nicholas H. Acheson, McGill University Christopher D. Richardson, Dalhousie University

2. Virus Structure and Assembly

Stephen C. Harrison, Harvard University

3. Virus Classification: The World of Viruses

Nicholas H. Acheson, McGill University Christopher D. Richardson, Dalhousie University

4. Virus Entry

Ari Helenius, Swiss Federal Institute of Technology, Zurich

SECTION II: VIRUSES OF BACTERIA AND ARCHAEA

5. Single-Stranded RNA Bacteriophages

Jan van Duin, University of Leiden Karthik Chamakura, Armata Pharmaceuticals, Inc., Los Angeles Ryland Young, Texas A&M University

6. Microviruses

Bentley A. Fane, University of Arizona Aaron P. Roznowski, University of Arizona

7. Bacteriophage T7

William C. Summers, Yale University Ian J. Molineux, University of Texas, Austin

8. Bacteriophage T4

Deborah M. Hinton, National Institutes of Health, Bethesda Eric S. Miller, North Carolina State University

9. Bacteriophage Lambda

Michael Feiss, University of Iowa

10. Viruses of Archaea

David Prangishvili, Institut Pasteur, Paris Mart Krupovic, Institut Pasteur, Paris

SECTION III: POSITIVE-STRAND RNA ANIMAL VIRUSES

11. Picornaviruses

Bert L. Semler, University of California, Irvine

12. Flaviviruses

Richard Kuhn, Purdue University Shelton Bradrick, Trudeau Institute, New York

13. Hepaciviruses

John Lok Man Law, Memorial University of Newfoundland Michael Houghton, University of Alberta

14. Togaviruses and Rubella Virus

Anil Kumar, University of Saskatchewan Milton Schlesinger, Washington University, St. Louis Sondra Schlesinger, Washington University, St. Louis Tom C. Hobman, University of Alberta

15. Coronaviruses

Marc Desforges, Ste. Justine Hospital, Université de Montréal Pierre Talbot, Institut Armand-Frappier Mark Denison, Vanderbilt University

SECTION IV: NEGATIVE-STRAND AND DOUBLE-STRANDED RNA ANIMAL VIRUSES

16. Paramyxoviruses and Pneumoviruses

Nicholas H. Acheson, McGill University Daniel Kolakofsky, University of Geneva Laurent Roux, University of Geneva Christopher D. Richardson, Dalhousie University

17. Rhabdoviruses

Valery Grdzelishvili, University of North Carolina, Charlotte Cassandra A. Catacalos, University of North Carolina, Charlotte

18. Filoviruses

Heinz Feldmann, Rocky Mountain Laboratories, Montana Hans-Dieter Klenk, University of Marburg Nicholas H. Acheson, McGill University Angela Rasmussen, University of Saskatchewan

19. Bunyaviruses

Richard M. Elliott, University of Glasgow Lev Levanov, University of Helsinki Alexander Plyusnin, University of Helsinki

20. Influenza Viruses

Dalius J. Briedis, McGill University Alyson Kelvin, University of Calgary

21. Reoviruses

Kristen M. Ogden, Vanderbilt University Terence S. Dermody, University of Pittsburgh School of Medicine

SECTION V: SMALL DNA ANIMAL VIRUSES

22. Parvoviruses

Peter Beard, École Polytechnique Fédérale de Lausanne Sarah Wootton, University of Guelph

23. Polyomaviruses

Nicholas H. Acheson, McGill University James A. DeCaprio, Dana-Farber Cancer Institute, Harvard University

24. Papillomaviruses

Greg Matlashewski, McGill University Lawrence Banks, International Centre for Genetic Engineering and Biotechnology, Trieste Miranda Thomas, International Centre for Genetic Engineering and Biotechnology, Trieste

SECTION VI: LARGE DNA ANIMAL VIRUSES

25. Adenoviruses

Philip Branton, McGill University Richard C. Marcellus, McGill University Luca D. Bertzbach, Leibniz Institute of Virology, Hamburg Thomas Dobner, Leibniz Institute of Virology, Hamburg

26. Herpesviruses

Bernard Roizman, University of Chicago Gabriella Campadelli-Fiume, University of Bologna Richard Longnecker, Northwestern University Bruce Banfield, Queens University Craig McCormick, Dalhousie University

27. Poxviruses

Richard Condit, University of Florida Matthew D. Gresseth, Medical University of South Carolina Paula Traktman, Medical University of South Carolina

SECTION VII: VIRUSES WITH A REVERSE TRANSCRIPTASE

28. Retroviruses

Alan Cochrane, University of Toronto

29. Human Immunodeficiency Virus

Alan Cochrane, University of Toronto

30. Hepadnaviruses

Christopher D. Richardson, Dalhousie University William Addison, University of Alberta D. Lorne Tyrrell, University of Alberta

SECTION VIII: VIROIDS AND PRIONS

31. Viroids and Hepatitis Delta Virus

Jean-Pierre Perreault, Université de Sherbrooke Martin Pelchat, University of Ottawa Charith Raj Adkar-Purushothama, Université de Sherbrooke

32. Prions

Dalius J. Briedis, McGill University David Westaway, University of California, San Francisco

SECTION IX: VIRUSES OF PLANTS, ALGAE, AND INVERTEBRATES

33. Cucumber Mosaic Virus

Marilyn J. Roossinck, Pennsylvania State College of Agricultural Sciences

34. Viruses of Algae and Mimivirus, a Giant Virus

Michael J. Allen, University of Exeter William H. Wilson, Marine Biological Association, Plymouth John A. Duffy, University of Exeter

35. Baculoviruses

Eric Carstens, Queens University Robert L. Harrison, U.S. Department of Agriculture, Beltsville, Maryland

36. Viruses of Invertebrates

Peter Krell, University of Guelph

SECTION X: HOST DEFENSES AGAINST VIRUS INFECTION

37. Innate Immune Responses Against Virus Infection

Karen Mossman, McMaster University John Hiscott, Istituto Pasteur-Fondazione Cenci Bolognetti, Rome Alessandra Zevini, Istituto Pasteur-Fondazione Cenci Bolognetti, Rome

38. Adaptive Immune Responses to Virus Infection

Malcolm G. Baines, McGill University Karen Mossman, McMaster University Naglaa Shoukry, University of Montreal

SECTION XI: MEDICAL APPLICATIONS OF VIROLOGY

39. Antiviral Vaccines

Brian Ward, McGill University Hilary E. Hendin, McGill University

40. Antiviral Chemotherapy

Donald M. Coen, Harvard Medical School

41. Oncolytic Viruses

Vishnupriyan Kumar, Dalhousie University Liang-Tzung Lin, Taipei Medical University Shashi Gujar, Dalhousie University

42. Virus-Mediated Gene Therapy

Richard Peluso, Renovacor, Philadelphia Christopher D. Richardson, Dalhousie University

PREFACE

This book is written for students who are learning about viruses for the first time in a university course at the undergraduate or graduate level. As the title implies, it concentrates on the molecular mechanisms of virus replication and on the interactions between viruses and the cells in which they replicate. The book approaches learning about virology by presenting chapters, many of which cover a specific virus family, using one or two well‐studied viruses as examples. Several other chapters discuss a variety of the many viruses that infect Archaea, algae, or invertebrates. These chapters are each designed to tell a story about the viruses being considered and to portray their “personality”, with the idea that this will help students learn about and remember each virus group.

This organizational scheme has been used in a number of successful virology textbooks, including Salvador Luria’s classic 1953 book, General Virology. Luria was one of the founding members of the “phage group,” a coalition of physicists, biologists, and chemists who, during the 1940s, chose to study bacteriophages in order to understand the molecular basis of life and, in doing so, invented the field of molecular biology. Their approach was to study how the proteins and nucleic acids of viruses interact with cellular molecules and organelles, transforming the cell into a factory that can produce many new progeny virus particles. Their underlying hope, which was largely achieved, was to use viruses as a tool to help understand how cells work.

The amount of knowledge that has accumulated about viruses has expanded enormously in recent years, as in many other areas of biomedical sciences. Fields Virology has become the classic reference book for knowledge about human and animal viruses during the past 40 years; that book is also organized in chapters that cover specific virus families. Our own teaching experience and conversations with numerous colleagues have convinced us that there is a real need for a concise, up‐to‐date textbook organized around the concept of virus families and designed specifically for teaching university students.

The problem was to make such a book accessible to beginning students without oversimplifying the material. Our approach was to ask a number of prominent virology researchers and teachers to write chapters on viruses that they knew well, using a set of criteria that we provided. We then edited and sometimes rewrote these chapters into a common style, and, in many cases, we created or redesigned the illustrations.

No individual could possibly write knowledgeably about the large spectrum of viruses that a virology course should cover, so a collaborative approach was necessary. However, a textbook that is an effective learning tool must have a coherent organization and a clear, consistent style of writing and illustration. Our job has been to craft the original chapters that we received into what we hope are readable and easily understood units.