Implantable Bioelectronics E-Book

• Herausgeber: Wiley-VCH
• Kategorie: Wissenschaft und neue Technologien
• Sprache: Englisch

Seitenzahl: 876

Veröffentlichungsjahr: 2014

Beschreibung

Here the renowned editor Evgeny Katz has chosen contributions that cover a wide range of examples and issues in implantable bioelectronics, resulting in an excellent overview of the topic. The various implants covered include biosensoric and prosthetic devices, as well as neural and brain implants, while ethical issues, suitable materials, biocompatibility, and energy-harvesting devices are also discussed.
A must-have for both newcomers and established researchers in this interdisciplinary field that connects scientists from chemistry, material science, biology, medicine, and electrical engineering.

Leseprobe

Table of Contents

Cover

Related Titles

Title Page

Copyright

Preface

List of Contributors

Chapter 1: Implantable Bioelectronics – Editorial Introduction

References

Chapter 2: Magnetically Functionalized Cells: Fabrication, Characterization, and Biomedical Applications

2.1 Introduction

2.2 Magnetic Microbial Cells

2.3 Magnetic Labeling of Mammal (Human) Cells

2.4 Conclusion

Acknowledgment

References

Chapter 3: Untethered Insect Interfaces

3.1 Introduction

3.2 Systems for Tetherless Insect Flight Control

3.3 Implantable Bioelectronics in Insects

3.4 Conclusions

References

Chapter 4: Miniaturized Biomedical Implantable Devices

4.1 Introduction

4.2 Energy Harvesting as a Pathway to Miniaturization

4.3 Implementation of Implantable Devices

4.4 Conclusion

References

Chapter 5: Cross-Hierarchy Design Exploration for Implantable Electronics

5.1 Introduction

5.2 System Overview of a Generic Bioelectronic Implant

5.3 Circuit Design for Low-Power Signal Processing

5.4 Architecture-Level Optimizations for Low-Power Data Processing

5.5 Design of Energy-Efficient Memory

5.6 Wireless Communication Power Delivery

5.7 Conclusion

References

Chapter 6: Neural Interfaces: from Human Nerves to Electronics

6.1 Introduction

6.2 Fusing Robotics with the Human Body: Interfacing with the Peripheral Nervous System

6.3 Listening to the Brain: Interfacing with the Central Nervous System

6.4 Electrical Modulation of the Human Nervous System: Stimulation and Clinical Applications

6.5 Future Directions for Neural Interfacing

References

Chapter 7: Cyborgs – the Neuro-Tech Version

7.1 Introduction

7.2 Biological Brains in a Robot Body

7.3 Deep Brain Stimulation

7.4 General Purpose Brain Implants

7.5 Noninvasive Brain-Computer Interfaces

7.6 Subdermal Magnetic Implants

7.7 RFID Implants

7.8 Conclusions

References

Chapter 8: Interaction with Implanted Devices through Implanted User Interfaces

8.1 Implanted User Interfaces

8.2 Evaluating Basic Implanted User Interfaces

8.3 Qualitative Evaluation

8.4 Medical Considerations

8.5 Discussion and Limitations

8.6 Conclusions

References

Chapter 9: Ultralow Power and Robust On-Chip Digital Signal Processing for Closed-Loop Neuro-Prosthesis

9.1 Introduction

9.2 Algorithm: a Vocabulary-Based Neural Signal

9.3 Hardware Implementation

9.4 Summary

References

Chapter 10: Implantable CMOS Imaging Devices

10.1 Introduction

10.2 Fundamentals of CMOS Imaging Devices

10.3 Artificial Retina

10.4 Brain-Implantable CMOS Imaging Device

10.5 Summary and Future Directions

Acknowledgments

References

Chapter 11: Implanted Wireless Biotelemetry

11.1 Introduction

11.2 Biotelemetry

11.3 Microelectrode Arrays and Interface Electronics

11.4 Conclusion

References

Chapter 12: Nano-Enabled Implantable Device for Glucose Monitoring

12.1 Introduction

12.2 Biomedical Devices for

In Vivo

Analysis

12.3 Conclusions and Final Recommendations

References

Chapter 13: Improving the Biocompatibility of Implantable Bioelectronics Devices

13.1 Introduction

13.2 Implantable Bioelectronic Device Materials

13.3 Surface Composition

13.4 Response to Implantation

13.5 Conclusion

References

Chapter 14: Abiotic (Nonenzymatic) Implantable Biofuel Cells

14.1 Introduction

14.2 Basic Principles

14.3 Abiotic Catalyst Materials and Separator Membranes

14.4 Design Considerations

14.5 State-of-the-Art and Practical Examples

14.6 Conclusion and Outlook

References

Chapter 15: Direct-Electron-Transfer-Based Enzymatic Fuel Cells In Vitro,Ex Vivo, and In Vivo

15.1 Introduction

15.2 Oxidoreductases for Direct-Electron-Transfer-Based Biodevices

15.3 Design of Enzyme-Based Biodevices

15.4 Examples of Direct Electron Transfer Enzymatic Fuel Cells

15.5 Outlook

References

Chapter 16: Enzymatic Fuel Cells: From Design to Implantation in Mammals

16.1 Introduction

16.2 Design of Implantable Bioelectrodes of Glucose Biofuel Cells

16.3 Packaging of Implanted Biofuel Cells

16.4 Surgery

16.5 Implanted Biofuel Cell Performances

References

Chapter 17: Implanted Biofuel Cells Operating In Vivo

17.1 Implanted Biofuel Cells

Acknowledgment

References

Chapter 18: Biomedical Implantable Systems – History, Design, and Trends

18.1 Introduction

18.2 History: Review of Implant Systems

18.3 Design of Implant Systems

18.4 Present Challenges

18.5 Future Trends

Acknowledgments

References

Chapter 19: Brain–Computer Interfaces: Ethical and Policy Considerations

19.1 Introduction

19.2 Neuroethics

19.3 Brain–Computer Interfaces

19.4 Noninvasive Interfaces

19.5 Partially Invasive Interfaces

19.6 Invasive Interfaces

19.7 Development of Brain–Computer Interfaces

19.8 Therapy/Enhancement

19.9 Ethical Issues

19.10 Brain Chips and Cloning

19.11 Regulatory Procedures

19.12 Principles and Standards for Adoption

References

Chapter 20: Conclusions and Perspectives

References

Index

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Guide

Cover

Table of Contents

Preface

Chapter 1: Implantable Bioelectronics – Editorial Introduction

List of Illustrations

Figure 1.1

Figure 1.2

Figure 1.3

Figure 1.4

Figure 1.5

Figure 2.1

Figure 2.2

Figure 2.3

Figure 2.4

Figure 2.5

Figure 2.6

Figure 2.7

Figure 2.8

Figure 3.1

Figure 3.2

Figure 3.3

Figure 3.4

Figure 3.5

Figure 4.1

Figure 4.2

Figure 4.5

Figure 4.3

Figure 4.4

Figure 4.6

Figure 4.7

Figure 5.1

Figure 5.2

Figure 5.3

Figure 5.4

Figure 5.5

Figure 5.6

Figure 5.7

Figure 5.8

Figure 5.9

Figure 5.10

Figure 5.11

Figure 5.12

Figure 5.13

Figure 6.1

Figure 6.2

Figure 6.3

Figure 6.4

Figure 6.5

Figure 6.6

Figure 7.1

Figure 7.2

Figure 7.3

Figure 7.4

Figure 8.1

Figure 8.16

Figure 8.2

Figure 8.3

Figure 8.4

Figure 8.5

Figure 8.6

Figure 8.7

Figure 8.8

Figure 8.9

Figure 8.10

Figure 8.11

Figure 8.12

Figure 8.13

Figure 8.14

Figure 8.15

Figure 8.17

Figure 9.1

Figure 9.2

Figure 9.3

Figure 9.4

Figure 9.5

Figure 9.6

Figure 9.7

Figure 9.8

Figure 9.9

Figure 9.10

Figure 9.11

Figure 9.12

Figure 9.13

Figure 9.14

Figure 9.15

Figure 9.16

Figure 9.17

Figure 9.18

Figure 9.19

Figure 9.20

Figure 9.21

Figure 9.22

Figure 9.23

Figure 9.24

Figure 9.25

Figure 9.26

Figure 10.1

Figure 10.2

Figure 10.3

Figure 10.4

Figure 10.5

Figure 10.6

Figure 10.7

Figure 10.8

Figure 10.9

Figure 10.10

Figure 10.11

Figure 10.12

Figure 10.13

Figure 10.14

Figure 10.15

Figure 10.16

Figure 10.17

Figure 10.18

Figure 10.19

Figure 10.20

Figure 10.22

Figure 10.21

Figure 10.23

Figure 10.24

Figure 10.25

Figure 10.26

Figure 10.27

Figure 11.1

Figure 11.2

Figure 11.3

Figure 11.4

Figure 11.5

Figure 11.6

Figure 11.7

Figure 11.8

Figure 11.9

Figure 11.10

Figure 11.11

Figure 11.12

Figure 11.13

Figure 11.14

Figure 11.15

Figure 12.1

Figure 12.2

Figure 12.3

Figure 12.4

Figure 12.5

Figure 13.1

Figure 13.2

Figure 13.3

Figure 13.4

Figure 13.5

Figure 14.1

Figure 14.2

Figure 14.3

Figure 14.4

Figure 14.5

Figure 14.7

Figure 14.6

Figure 14.8

Figure 14.9

Figure 14.10

Figure 15.1

Figure 15.2

Figure 15.3

Figure 15.4

Figure 15.5

Figure 15.6

Figure 15.7

Figure 15.8

Figure 15.9

Figure 15.10

Figure 16.1

Figure 16.2

Figure 16.3

Figure 16.4

Figure 16.5

Figure 16.6

Figure 16.7

Figure 17.1

Figure 17.2

Figure 17.3

Figure 17.4

Figure 17.5

Figure 17.6

Figure 17.7

Figure 17.8

Figure 17.9

Figure 18.1

Figure 18.2

Figure 18.3

Figure 18.4

Figure 18.5

Figure 18.6

Figure 18.7

Figure 18.8

Figure 18.9

Figure 18.10

Figure 18.11

Figure 18.12

Figure 18.13

Figure 18.14

Figure 18.15

Figure 18.17

Figure 18.16

Figure 18.18

Figure 18.19

Figure 18.20

Figure 18.21

List of Tables

Table 3.1

Table 4.1

Table 9.1

Table 9.2

Table 11.1

Table 11.2

Table 11.3

Table 13.1

Table 13.2

Table 13.3

Table 13.4

Table 14.1

Table 14.2

Table 14.3

Table 15.1

Table 15.2

Table 16.1

Table 16.2

Table 18.1

Related Titles

Katz, E. (ed.)

Biomolecular Information Processing

From Logic Systems to Smart Sensors and Actuators

2012

ISBN: 978-3-527-33228-1

Katz, E. (ed.)

Molecular and Supramolecular Information Processing

From Molecular Switches to Logic Systems

2012

ISBN: 978-3-527-33195-6

Katz, E. (ed.)

Information Processing Set

2 Volumes (consisting of "Biomolecular Information Processing" and "Molecular and Supramolecular Information Processing")

2012

ISBN: 978-3-527-33245-8

Wallace, G.G., Moulton, S., Kapsa, R.M.I., Higgins, M.

Organic Bionics

2012

ISBN: 978-3-527-32882-6

Cosnier, S., Karyakin, A. (Eds.)

Electropolymerization

Concepts, Materials and Applications

2010

ISBN: 978-3-527-32414-9

Alkire, R.C., Kolb, D.M., Lipkowski, J. (Eds.)

Bioelectrochemistry

Fundamentals, Applications and Recent Developments

2012

ISBN: 978-3-527-32885-7

Kumar, C.S. (ed.)

Nanotechnologies for the Life Sciences

10 Volume Set

2011

Print ISBN: 978-3-527-33114-7

Waser, R. (ed.)

Nanoelectronics and Information Technology

Advanced Electronic Materials and Novel Devices

Third, Completely Revised and Enlarged Edition

2012

Print ISBN: 978-3-527-40927-3

Implantable Bioelectronics

Edited by

Evgeny Katz

The Editor

Prof. Evgeny Katz

Clarkson University

Department of Chemistry

Clarkson Avenue 8

USA

All books published by Wiley-VCH are carefully produced. Nevertheless, authors, editors, and publisher do not warrant the information contained in these books, including this book, to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details or other items may inadvertently be inaccurate.

Library of Congress Card No.: applied for

British Library Cataloguing-in-Publication Data

A catalogue record for this book is available from the British Library.

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The Deutsche Nationalbibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data are available on the Internet at <http://dnb.d-nb.de>.

© 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Boschstr. 12, 69469 Weinheim, Germany

All rights reserved (including those of translation into other languages). No part of this book may be reproduced in any form – by photoprinting, microfilm, or any other means – nor transmitted or translated into a machine language without written permission from the publishers. Registered names, trademarks, etc. used in this book, even when not specifically marked as such, are not to be considered unprotected by law.

Print ISBN: 978-3-527-33525-1

ePDF ISBN: 978-3-527-67317-9

ePub ISBN: 978-3-527-67316-2

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oBook ISBN: 978-3-527-67314-8

Preface

Scientific research and engineering in the area of implantable bioelectronic devices have been progressing rapidly in the last two decades, greatly contributing to medical and technological advances, thus resulting in numerous applications. In addition, this research absorbs novel achievements and discoveries in microelectronics, computing, biotechnology, materials science, micromachinery, and many other science and technology areas. The present book overviews the multidisciplinary field of implantable bioelectronics, highlighting its key aspects and future perspectives. The chapters written by the leading experts cover different subareas of the science and technology related to implantable bioelectronics – together covering the multifaceted area and its applications. The different topics addressed in this book will be of high interest to the interdisciplinary community active in the area of implantable bioelectronics. It is hoped that the collection of the different chapters will be important and beneficial for researchers and students working in various areas related to bioelectronics, including microelectronics, biotechnology, materials science, computer science, medicine, and so on. Furthermore, the book is aimed at attracting young scientists and introducing them to the field, while providing newcomers with an enormous collection of literature references. I, indeed, hope that the book will spark the imagination of scientists to further develop the topic.

It should be noted that the field of implantable bioelectronics relates to some extent to the fascinating area of unconventional computing, the consideration of which is outside the scope of the present book. This complementary area of molecular/biomolecular computing was covered in two other recent books from Wiley-VCH: Molecular and Supramolecular Information Processing: From Molecular Switches to Logic Systems, E. Katz (Ed.), Wiley-VCH, Weinheim, Germany, 2012 and Biomolecular Information Processing – From Logic Systems to Smart Sensors and Actuators, E. Katz (Ed.), Wiley-VCH, Weinheim, Germany, 2012.

Finally, the editor (E. Katz) and publisher (Wiley-VCH) express their gratitude to all authors of the chapters, whose dedication and hard work made this book possible, hoping that the book will be interesting and beneficial to researchers and students working in various areas related to bioelectronics. I would like to conclude this preface by thanking my wife Nina for her support in every respect in the past 40 years. Without her help, it would not have been possible to complete this work.

August 2013

Evgeny KatzPotsdam, NY, USA

List of Contributors

Anne Agur

University of Toronto

Department of Surgery

Faculty of Medicine

Toronto, Medical Sciences Building

Canada

Abhishek Basak

Case Western Reserve University

Department of Electrical Engineering and Computer Science

Nanoscape Research Laboratory

Euclid Avenue

Cleveland, OH 44106

USA

Ravi V. Bellamkonda

WH Coulter Professor and

School Chair

GRA Distinguished Scholar

Georgia Institute of Technology and Emory University School of Medicine

Wallace H. Coulter Department of Biomedical Engineering

Ferst Dr

Atlanta, GA 30332-0535

USA

Swarup Bhunia

Case Western Reserve University

Department of Electrical Engineering & Computer Science

Glennan Building

Cleveland, OH 44106

USA

Joav Birjiniuk

Georgia Institute of Technology and Emory University School of Medicine

Wallace H. Coulter Department of Biomedical Engineering

Ferst Dr

Atlanta, GA 30332

USA

Zoltan Blum

Malmö University

Biomedical Sciences

Health and Society

Jan Waldenströms gata 25

SE-20506 Malmö

Sweden

Jordi Colomer-Farrarons

University of Barcelona

Department of Electronics

Bioelectronics and Nanobioengineering Research Group (SIC-BIO)

Martí i Franquès 1

Planta 2

Barcelona

Spain

Serge Cosnier

CNRS-Université Joseph Fourier