Infrared and Raman Spectroscopic Imaging E-Book

• Herausgeber: Wiley-VCH
• Kategorie: Wissenschaft und neue Technologien
• Sprache: Englisch

Seitenzahl: 1194

Veröffentlichungsjahr: 2014

Beschreibung

This second edition of the successful ready reference is updated and revised with approximately 30% new content to reflect the numerous instrumental developments and improvements, as well as the significant expansion of this rapidly developing field. For example, the combination of IR imaging with AFM has enhanced the achievable lateral resolution by an order of magnitude down to a few hundred nanometers, thus launching a multiplicity of new applications in material science. Furthermore, Raman and IR spectroscopic imaging have become key technologies for the life sciences and today contribute tremendously to a better and more detailed understanding of numerous biological and medical research topics.
The topical structure of this new edition is now subdivided into four parts. The first treats the fundamentals of the instrumentation for infrared and Raman imaging and mapping and an overview on the chemometric tools for image analysis. The second part describes a wide varie-ty of applications ranging from biomedical via food, agriculture and plants to polymers and pharmaceuticals. This is followed by a description of imaging techniques operating beyond the diffraction limit, while the final part covers special methodical developments and their utility in specific fields.
With its many valuable practical tips, this is a must-have overview for researchers in academic and industrial laboratories wishing to obtain reliable results with this method.

Leseprobe

Table of Contents

Cover

Related Titles

Title Page

Copyright

Preface

List of Contributors

Part I: Basic Methodology

Chapter 1: Infrared and Raman Instrumentation for Mapping and Imaging

1.1 Introduction to Mapping and Imaging

1.2 Mid-Infrared Microspectroscopy and Mapping

1.3 Raman Microspectroscopy and Mapping

1.4 Near-Infrared Hyperspectral Imaging

1.5 Raman Hyperspectral Imaging

1.6 Mid-Infrared Hyperspectral Imaging

1.7 Mapping with Pulsed Terahertz Radiation

1.8 Summary

Acknowledgments

References

Chapter 2: Chemometric Tools for Image Analysis

2.1 Introduction

2.2 Hyperspectral Images: The Measurement

2.3 Image Preprocessing

2.4 Exploratory Image Analysis

2.5 Quantitative Image Information: Multivariate Image Regression (MIR)

2.6 Image Segmentation

2.7 Image Resolution

2.8 Future Trends

References

Part II: Biomedical Applications

Chapter 3: Vibrational Spectroscopic Imaging of Soft Tissue

3.1 Introduction

3.2 Preparation of Soft Tissue for Vibrational Spectroscopic Imaging

3.3 Applications to Soft Tissue

3.4 Conclusions

References

Chapter 4: Vibrational Spectroscopic Analysis of Hard Tissues

4.1 Introduction

4.2 Importance of Tissue Age versus Specimen Age

4.3 FT-IR Spectroscopy

4.4 Raman Spectroscopy

4.5 Clinical Applications of Raman Spectroscopy

References

Chapter 5: Medical Applications of Infrared Spectral Imaging of Individual Cells

5.1 Introduction

5.2 Methods

5.3 Results and Discussion

5.4 Future Potential of SCP/Conclusions

Acknowledgment

References

Part III: Agriculture, Plants, and Food

Chapter 6: Infrared and Raman Spectroscopic Mapping and Imaging of Plant Materials

6.1 Introduction, Background, and Perspective

6.2 Application of Mapping and Imaging to Horticultural Crops

6.3 Application of Mapping and Imaging to Agricultural Crops

6.4 Mapping and Imaging of Wild Plants and Trees

6.5 Application of Mapping and Imaging to Algae

6.6 Interaction Between Plant Tissue and Plant Pathogens

References

Chapter 7: NIR Hyperspectral Imaging for Food and Agricultural Products

7.1 Introduction

7.2 HSI as a “Super” NIR Analyzer

7.3 NIR HS Imager as a “Super” Vision System

7.4 Conclusion

References

Part IV: Polymers and Pharmaceuticals

Chapter 8: FT-IR and NIR Spectroscopic Imaging: Principles, Practical Aspects, and Applications in Material and Pharmaceutical Science

8.1 Introduction

8.2 Instrumentation for NIR and FT-IR Imaging

8.3 Applications of FT-IR and FT-NIR Imaging for Polymer Characterization

8.4 NIR Imaging Spectroscopy for Quality Control of Pharmaceutical Drug Formulations

8.5 FT-IR Spectroscopic Imaging of Inorganic Materials

References

Chapter 9: FT-IR Imaging in ATR and Transmission Modes: Practical Considerations and Emerging Applications

9.1 FT-IR Imaging: Introduction

9.2 FT-IR Imaging: Technical Considerations

9.3 Practical Applications

9.4 Conclusion and Outlook

Acknowledgment

References

Chapter 10: Terahertz Imaging of Drug Products

10.1 Introduction

10.2 Low Wavenumber Region in the Infrared Spectrum

10.3 THz-TDS Technology and Applications

10.4 THz Imaging in the Pharmaceutical Industry

10.5 Going Forward

10.6 Competition versus Cost: A Challenge for the Future

10.7 Conclusion

Acknowledgments

References

Part V: Imaging Beyond the Diffraction Limit

Chapter 11: Spectroscopic Imaging of Biological Samples Using Near-Field Methods

11.1 Tip-Enhanced Raman Scattering (TERS)

11.2 Detection of Biomolecules

11.3 Biopolymers

11.4 Membranes, Viruses, and Bacteria

11.5 Conclusion

References

Chapter 12: Infrared Mapping below the Diffraction Limit

12.1 Introduction and Description of Early Work

12.2 Near-Field Microscopy by Elastic Scattering from a Tip

12.3 Combination of AFM and Photothermal FT-IR Spectroscopy

References

Part VI: Developments in Methodology

Chapter 13: Subsurface Raman Spectroscopy in Turbid Media

13.1 Introduction

13.2 Techniques for Deep Noninvasive Raman Spectroscopy

13.3 Examples of Application Areas

13.4 Conclusions

References

Chapter 14: Nonlinear Vibrational Spectroscopic Microscopy of Cells and Tissue

14.1 Introduction

14.2 Principles of Nonlinear Optical Imaging

14.3 Instrumentation for Multimodal Nonlinear Microscopy

14.4 Applications

References

Chapter 15: Widefield FT-IR 2D and 3D Imaging at the Microscale Using Synchrotron Radiation

15.1 Introduction

15.2 Optical Evaluation

15.3 Mathematical Evaluation of Hyperspectral Cubes

15.4 Widefield versus Raster Scanning Geometries

15.5 Examples

15.6 Conclusions

References

Index

End User License Agreement

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Guide

Cover

Table of Contents

Preface

Part I: Basic Methodology

Chapter 1: Infrared and Raman Instrumentation for Mapping and Imaging

List of Illustrations

Figure 1.1

Figure 1.2

Figure 1.3

Figure 1.4

Figure 1.5

Figure 1.6

Figure 1.7

Figure 1.8

Figure 1.9

Figure 1.10

Figure 1.11

Figure 1.12

Figure 1.13

Figure 1.14

Figure 1.15

Figure 1.16

Figure 1.17

Figure 1.18

Figure 1.19

Figure 1.20

Figure 1.21

Figure 1.22

Figure 1.23

Figure 2.1

Figure 2.2

Figure 2.3

Figure 2.4

Figure 2.5

Figure 2.6

Figure 2.7

Figure 2.8

Figure 2.9

Figure 2.10

Figure 2.11

Figure 2.12

Figure 2.13

Figure 2.14

Figure 2.15

Figure 2.16

Figure 2.17

Figure 2.18

Figure 3.1

Figure 3.2

Figure 3.3

Figure 3.4

Figure 3.5

Figure 3.6

Figure 3.7

Figure 3.8

Figure 3.9

Figure 3.10

Figure 3.11

Figure 3.12

Figure 3.13

Figure 3.14

Figure 4.1

Figure 4.2

Figure 4.3

Figure 4.4

Figure 4.5

Figure 5.1

Figure 5.2

Figure 5.3

Figure 5.7

Figure 5.4

Figure 5.5

Figure 5.6

Figure 5.8

Figure 5.9

Figure 5.10

Figure 5.11

Figure 5.12

Figure 5.13

Figure 5.14

Figure 5.15

Figure 5.16

Figure 5.17

Figure 5.18

Figure 6.1

Figure 6.2

Figure 6.3

Figure 6.4

Figure 6.5

Figure 6.6

Figure 6.7

Figure 6.8

Figure 6.9

Figure 6.10

Figure 6.11

Figure 6.12

Figure 6.13

Figure 6.14

Figure 6.15

Figure 6.16

Figure 6.17

Figure 6.18

Figure 6.19

Figure 6.20

Figure 6.21

Figure 6.22

Figure 6.23

Figure 6.24

Figure 6.25

Figure 6.26

Figure 6.27

Figure 6.28

Figure 6.29

Figure 6.30

Figure 6.31

Figure 6.32

Figure 6.33

Figure 6.34

Figure 7.1

Figure 7.2

Figure 7.3

Figure 7.4

Figure 7.5

Figure 7.6

Figure 7.7

Figure 7.8

Figure 7.9

Figure 7.10

Figure 7.11

Figure 8.1

Figure 8.2

Figure 8.3

Figure 8.4

Figure 8.5

Figure 8.6

Figure 8.7

Figure 8.8

Figure 8.9

Figure 8.10

Figure 8.11

Figure 8.12

Figure 8.13

Figure 8.14

Figure 8.15

Figure 8.16

Figure 8.17

Figure 8.18

Figure 8.19

Figure 8.20

Figure 8.21

Figure 8.22

Figure 8.23

Figure 8.24

Figure 8.25

Figure 8.26

Figure 8.27

Figure 8.28

Figure 8.29

Figure 8.30

Figure 8.31

Figure 8.32

Figure 8.33

Figure 8.34

Figure 8.35

Figure 8.36

Figure 8.37

Figure 8.38

Figure 8.39

Figure 8.40

Figure 8.41

Figure 8.42

Figure 8.43

Figure 8.44

Figure 9.1

Figure 9.2

Figure 9.3

Figure 9.4

Figure 9.5

Figure 9.6

Figure 9.7

Figure 9.8

Figure 9.9

Figure 9.10

Figure 9.11

Figure 9.12

Figure 9.13

Figure 9.14

Figure 9.15

Figure 9.16

Figure 9.17

Figure 9.18

Figure 9.19

Figure 9.20

Figure 9.21

Figure 9.22

Figure 9.23

Figure 9.24

Figure 9.25

Figure 9.26

Figure 9.27

Figure 9.28

Figure 9.29

Figure 9.30

Figure 10.1

Figure 10.2

Figure 10.3

Figure 10.4

Figure 10.5

Figure 10.6

Figure 10.7

Figure 10.8

Figure 10.9

Figure 10.10

Figure 10.11

Figure 10.12

Figure 10.13

Figure 10.14

Figure 10.15

Figure 10.16

Figure 10.17

Figure 10.18

Figure 10.19

Figure 10.20

Figure 10.21

Figure 10.22

Figure 10.23

Figure 10.24

Figure 11.1

Figure 11.2

Figure 11.3

Figure 11.4

Figure 11.5

Figure 11.6

Figure 11.7

Figure 11.8

Figure 11.9

Figure 11.10

Figure 11.11

Figure 11.12

Figure 11.13

Figure 12.1

Figure 12.2

Figure 12.3

Figure 12.4

Figure 12.5

Figure 12.6

Figure 12.7

Figure 12.8

Figure 12.9

Figure 12.10

Figure 12.11

Figure 12.12

Figure 12.13

Figure 12.14

Figure 12.15

Figure 12.16

Figure 12.17

Figure 12.18

Figure 12.19

Figure 12.20

Figure 12.21

Figure 12.22

Figure 12.23

Figure 12.24

Figure 12.25

Figure 13.1

Figure 13.2

Figure 13.3

Figure 13.4

Figure 13.5

Figure 13.6

Figure 13.7

Figure 13.8

Figure 13.9

Figure 13.10

Figure 13.11

Figure 13.12

Figure 14.1

Figure 14.2

Figure 14.3

Figure 14.4

Figure 14.5

Figure 14.6

Figure 14.7

Figure 14.8

Figure 15.1

Figure 15.2

Figure 15.3

Figure 15.4

Figure 15.5

Figure 15.6

Figure 15.7

Figure 15.8

Figure 15.9

Figure 15.10

Figure 15.11

Figure 15.12

Figure 15.13

Figure 15.14

Figure 15.15

Figure 15.16

Figure 15.17

List of Tables

Table 1.1

Table 5.1

Table 5.2

Table 8.1

Table 8.2

Table 8.3

Table 8.4

Table 8.5

Table 9.1

Table 11.1

Table 15.1

Table 15.2

Related Titles

Gauglitz, G., Moore, D. S. (eds.)

Handbook of Spectroscopy

Second, Completely Revised and Enlarged Edition

2014

ISBN: 978-3-527-32150-6

Leahy, M. J. (ed.)

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2012

ISBN: 978-3-527-32894-9

Schlücker, S. (ed.)

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Analytical, Biophysical and Life Science Applications

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ISBN: 978-3-527-32567-2

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Applied NMR Spectroscopy for Chemists and Life Scientists

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ISBN (Hardcover): 978-3-527-32775-1

ISBN (Softcover): 978-3-527-32774-4

Edited by Reiner Salzer and HeinzW. Siesler

Infrared and Raman Spectroscopic Imaging

Second, Completely Revised and Updated Edition

The Editors

Prof. Reiner Salzer

Bioanalytische Chemie

Technische Universität Dresden

Helmholtzstr 10

01062 Dresden

Germany

Prof. Heinz W. Siesler

Universität Duisburg-Essen

Inst. f. Physikalische Chemie

Schützenbahn 70

45117 Essen

Germany

All books published by Wiley-VCH are carefully produced. Nevertheless, authors, editors, and publisher do not warrant the information contained in these books, including this book, to be free of errors. Readers are advised to keep in mind that statements, data, illustrations, procedural details or other items may inadvertently be inaccurate.

Library of Congress Card No.: applied for

British Library Cataloguing-in-Publication Data

A catalogue record for this book is available from the British Library.

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The Deutsche Nationalbibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data are available on the Internet at <http://dnb.d-nb.de>.

© 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Boschstr. 12, 69469 Weinheim, Germany

All rights reserved (including those of translation into other languages). No part of this book may be reproduced in any form – by photoprinting, microfilm, or any other means – nor transmitted or translated into a machine language without written permission from the publishers. Registered names, trademarks, etc. used in this book, even when not specifically marked as such, are not to be considered unprotected by law.

Print ISBN: 978-3-527-33652-4

ePDF ISBN: 978-3-527-67816-7

ePub ISBN: 978-3-527-67815-0

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Preface

Five years after the completion of the first edition of this book, Wiley-VCH approached us with the request to prepare a second edition. On the one hand, this was certainly a consequence of the successful marketing of this book but, on the other hand, we accepted this challenge because since the publication of the first edition numerous new instrumental developments and improvements as well as a significant expansion of the imaging technique have taken place. Thus, for example, the combination of IR imaging with atomic force microscopy (AFM) enhanced the achievable lateral resolution by an order of magnitude down to a few hundred nanometers and thereby launched a multiplicity of new applications in material science. Furthermore, Raman and IR spectroscopic imaging studies have become key technologies for the life sciences and today contribute tremendously to a better and more detailed understanding of numerous biological and medical research topics.

In order to cover these novel developments, the chapters of the previous edition have not only been updated but new chapters have been added. For this purpose, the topical structure of the new edition had to be extended and is now subdivided into four parts. In Part 1, the fundamentals of the instrumentation for infrared and Raman imaging and mapping and an overview on the chemometric tools for image analysis are treated in two introductory chapters. Part 2 comprises Chapters 3 4 5 6 7 8 9 10 and describes a wide variety of applications ranging from biomedical via food, agriculture, and plants to polymers and pharmaceuticals. In Part 3, Chapters 11 and 12 describe imaging techniques operating beyond the diffraction limit, and finally Part 4 (Chapters 13 14 15) covers special methodical developments and their utility in specific fields.

We would like to thank the authors of the previous edition for the willingness to contribute again the latest achievements in their field of research and gratefully acknowledge the spontaneous agreement of the new authors to add their expertise to the new edition. We are fully aware that without the effort, commitments, and sacrifices of these authors, the timely publication of this volume would not have been possible. We would also like to acknowledge the superb job and professional support by Wiley-VCH in the final composition and edition of the book. Last but not least, our greatest debt of gratitude goes to our families for their patience and understanding.

Dresden and Essen

January 2014

Reiner Salzer and

Heinz W. Siesler

List of Contributors

Ebrahim Aboualizadeh

University of Wisconsin-Milwaukee

Department of Physics

Milwaukee, WI 53211

USA

Zahrasadat Alavi

University of Wisconsin-Milwaukee

Department of Physics

Milwaukee, WI 53211

USA

Max Almond

Gloucestershire Hospitals NHS Foundation Trust

Department of Esophagogastric Surgery

Great Western Road

Gloucester, GL13NN

UK

Véronique Bellon-Maurel

IRSTEA – Montpellier Supagro

UMR ITAP, Information – Technologies – Environmental Analysis – Agricultural Processes

BP 50 95, Montpellier Cedex 1, 34033

France

Benjamin Bird

Northeastern University

Laboratory for Spectral Diagnosis (LSpD)

Department of Chemistry and Chemical Biology

Huntington Ave

Boston, MA 02115

USA

K. L. Andrew Chan

Department of Chemical Engineering

Imperial College London

London, SW7 2AZ

United Kingdom

Volker Deckert

Institute of Physical Chemistry and Abbe Center of Photonics

University of Jena

Helmholtzweg 4

Jena

Germany

and

Leibniz Institute of Photonic Technology – IPHT

Albert-Einstein-Str 9

Jena

Germany

Tanja Deckert-Gaudig

Leibniz Institute of Photonic Technology – IPHT

Nanoscopy department

Albert-Einstein-Str 9

Jena

Germany

Max Diem

Northeastern University

Laboratory for Spectral Diagnosis (LSpD)

Department of Chemistry and Chemical Biology

Huntington Ave

Boston, MA 02115

USA

Jennifer A. Dougan

Department of Chemical Engineering

Imperial College London

London, SW7 2AZ

United Kingdom

Ludovic Duponchel

Université Lille 1. Sciences et Technologies de Lille (USTL)

Laboratoire de Spectrochimie Infrarouge et Raman (LASIR CNRS UMR 8516)

Bâtiment C5

Villeneuve d'Ascq, 59655

France

Jennifer Fore

Northeastern University

Laboratory for Spectral Diagnosis (LSpD)

Department of Chemistry and Chemical Biology

Huntington Ave

Boston, MA 02115

USA

Roberta Galli

Dresden University of Technology

Carl Gustav Carus Faculty of Medicine

Clinical Sensoring and Monitoring

Fetscher Str. 74

Dresden

Germany

Sonja Gamsjaeger

Hanusch Hospital

1st Medical Department, Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling

Heinrich Collin Str. 30

A-1140, Vienna

Austria

Nathalie Gorretta

IRSTEA – Montpellier Supagro

UMR ITAP

Information – Technologies – Environmental Analysis – Agricultural Processes

BP 50 95, Montpellier Cedex 1 34033

France

Peter R. Griffiths

Griffiths Consulting LLC

Edgehill Drive

Ogden, UT 84403

USA

Elke Grotheer

Beiersdorf AG

Research & Development

Unnastraße 48

20253 Hamburg

Germany

Gennadi Gudi

Julius Kühn-Institute

Federal Research Centre for Cultivated Plants

Institute for Ecological Chemistry

Plant Analysis and Stored Product Protection

Königin-Luise-Strasse 19

Berlin

Germany

Thomas Hancewicz

Unilever Research & Development

Trumbull 40 Merrit Blvd.

Trumbull, CT 06611

USA

Carol J. Hirschmugl

University of Wisconsin-Milwaukee

Department of Physics

Milwaukee, WI 53211

USA

and

US Forest Service

Forest Products Laboratory

One Gifford Pinchot Drive

adison, WI 53726

USA

Uwe Hoffmann

NIR-Tools

Katernberger Straße 107

45327 Essen

Germany

Anna de Juan

Universitat de Barcelona

Department of Analytical Chemistry

Chemometrics group

Diagonal 645

Barcelona, 08028

Spain

Sergei G. Kazarian

Department of Chemical Engineering

Imperial College London

London SW7 2AZ

United Kingdom

Klaus Klaushofer

Hanusch Hospital

1st Medical Department, Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling

Heinrich Collin Str. 30

Vienna, A-1140

Austria

Olga Kolomiets

MS S.P.R.L.,

206/9 Avenue van Overbeke

BE 1083 Ganshoren

Belgium

Christoph Krafft

Institute of Photonic Technology

Jena

Germany

Andrea Krähmer

Julius Kühn-Institute

Federal Research Centre for Cultivated Plants

Institute for Ecological Chemistry

Plant Analysis and Stored Product Protection

Königin-Luise-Strasse 19

Berlin

Germany

Lucas Langelüddecke

Institute of Physical Chemistry and Abbe Center of Photonics

Nanospectroscopy department

University of Jena

Helmholtzweg 4

Jena

Germany

Nora Laver

Tufts Medical Center

Department of Pathology

Boston, MA

USA

Kathleen Lenau

Northeastern University

Department of Chemistry and Chemical Biology

Laboratory for Spectral Diagnosis (LSpD)

Huntington Ave

Boston, MA 02115

USA

Marcel Maeder

The University of Newcastle

Department of Chemistry

Callaghan NSW, 2308

Australia

Ellen Marcsisin

Northeastern University

Department of Chemistry and Chemical Biology

Laboratory for Spectral Diagnosis (LSpD)

Huntington Ave

Boston, MA 02115

USA

Eric C. Mattson

University of Wisconsin-Milwaukee

Department of Physics

Milwaukee, WI 53211

USA

Pavel Matousek

STFC Rutherford Appleton Laboratory

Central Laser Facility

Research Complex at Harwell

Harwell Oxford, OX11 0QX

UK

Antonella I. Mazur

Northeastern University

Department of Chemistry and Chemical Biology

Laboratory for Spectral Diagnosis (LSpD)

Huntington Ave

Boston, MA 02115

USA

Miloš Miljković

Northeastern University

Department of Chemistry and Chemical Biology

Laboratory for Spectral Diagnosis (LSpD)

Huntington Ave

Boston, MA 02115

USA

Ellen V. Miseo

Analytical Answers, Inc.

Arrow Drive, Woburn

MA 01801

USA

Richard Mendelsohn

Rutgers University

Department of Chemistry

Newark College

New Jersey, 07102 Newark

USA

Annette Naumann

Julius Kühn-Institute

Federal Research Centre for Cultivated Plants

Institute for Ecological Chemistry

Plant Analysis and Stored Product Protection

Königin-Luise-Strasse 19

Berlin

Germany

Michael Nasse

University of Wisconsin-Milwaukee

Department of Physics

Milwaukee, WI 53211

USA

and

Laboratory for Applications of Synchrotron Radiation

Karlsruhe Institute of Technology

Karlsruhe

Germany

Kostas Papamarkakis

Northeastern University

Department of Chemistry and Chemical Biology

Laboratory for Spectral Diagnosis (LSpD)

Huntington Ave

Boston, MA 02115

USA

Eleftherios P. Paschalis

Hanusch Hospital

1st Medical Department, Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling

Heinrich Collin Str. 30

A-1140 Vienna

Austria

Sara Piqueras

Universitat de Barcelona

Department of Analytical Chemistry,

Chemometrics group, Diagonal 645

Barcelona, 08028

Spain

and

IDAEA-CSIC

Jordi Girona 18

Barcelona, 08034

Spain

Jürgen Popp

Institute of Physical Chemistry and Abbe Center of Photonics

University Jena

Helmholtzweg 4 Jena, 07743

Germany

and

University Jena

Institute of Physical Chemistry and Abbe Center of Photonics

Jena

Germany

Jennifer Schubert

Northeastern University

Department of Chemistry and Chemical Biology

Laboratory for Spectral Diagnosis (LSpD)

Huntington Ave

Boston, MA 02115

USA

Hartwig Schulz

Julius Kühn-Institute

Federal Research Centre for Cultivated Plants

Institute for Ecological Chemistry

Plant Analysis and Stored Product Protection

Königin-Luise-Strasse 19

Berlin

Germany

and

Julius Kühn-Institute

Federal Research Centre for Cultivated Plants

Institute for Ecological Chemistry

Plant Analysis and Stored Product Protection

Erwin-Baur-Strasse 27

Quedlinburg

Germany

Julia Sedlmair

US Forest Service

Forest Products Laboratory

One Gifford Pinchot Drive

Madison, WI 53726

USA

Heinz W. Siesler

University of Duisburg-Essen

Department of Physical Chemistry

Schuetzenbahn 70

45117 Essen

Germany

Gerald Steiner

Dresden University of Technology

Carl Gustav Carus Faculty of Medicine

Clinical Sensoring and Monitoring

Fetscher Str. 74

Dresden

Germany

Romá Tauler

IDAEA-CSIC

Jordi Girona 18

Barcelona, 08034

Spain

Douglas Townsend

Northeastern University

Department of Chemistry and Chemical Biology

Laboratory for Spectral Diagnosis (LSpD)

Huntington Ave

Boston, MA 02115

USA

Michel Ulmschneider

Pharmaceutical Quality Control

Hoffmann - La Roche AG

Basel

Switzerland

Miriam Unger

CETICS Healthcare Technologies GmbH

Schelztorstraße 54-56

Esslingen am Neckar

Germany

Christian Vogel

BAM Federal Institute for Materials Research and Testing

Unter den Eichen 87

12205 Berlin

Germany

Part IBasic Methodology

1Infrared and Raman Instrumentation for Mapping and Imaging

Peter R. Griffiths and Ellen V. Miseo