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Medical Imaging Technologies and Methods for Health Care provides timely, evidence-based information that helps readers understand innovations in medical imaging. These innovations are computer / imaging based technologies which are set to have a bigger i

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Table of Contents
Welcome
Table of Contents
Title
BENTHAM SCIENCE PUBLISHERS LTD.
End User License Agreement (for non-institutional, personal use)
Usage Rules:
Disclaimer:
Limitation of Liability:
General:
PREFACE
Acknowledgements
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
PART I: MEDICAL IMAGING FOR IMAGE MANAGEMENT AND KNOWLEDGE DISCOVERY
Introduction to Recent Advancement in Picture Archiving and Communication System
Abstract
1. INTRODUCTION
2. WEB-BASED THIN CLIENT MODEL
3. USE OF MOBILE AND CLOUD TECHNOLOGY
4. INTELLIGENT PACS
5. CONCLUSION AND REMARKS
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Mobile and Cloud Technology Applications in Picture Archiving and Communication System
Abstract
1. INTRODUCTION
2. APPLICATION OF MOBILE TECHNOLOGY IN PACS
3. APPLICATION OF CLOUD TECHNOLOGY IN COMPUTER-AIDED DETECTION
4. DISCUSSION AND CONCLUSION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Data Mining and Big Data in Medical Imaging
Abstract
1. DATA MINING AND BIG DATA
2. MEDICAL IMAGING AND DATA MINING
3. CLINICAL ENVIRONMENT OF RADIOGRAPHY
4. DICOM EXTRACTION
5. DATA PROCESSING SOFTWARE: R AND RATTLE
6. RANDOM FOREST
7. VARIABLE IMPORTANCE MEASURES
8. USE OF DATA MINING IN DOSE MONITORING
9. DISCUSSION AND CONCLUSION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
PART II: MEDICAL IMAGING FOR BETTER HEALTH AND DISEASE DETECTION
Computer Aided Detection in Medical Imaging
Abstract
1. INTRODUCTION
2. CAD METHOD IN THE DETECTION OF STROKE
3. RESULTS
4. CONCLUDING REMARKS
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Use of Biomechanical Engineering Method in Image Registration of Breast
Abstract
1. INTRODUCTION
2. METHODOLOGY
3. RESULTS
4. DISCUSSION
5. CONCLUSION
ETHICS APPROVAL
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Advanced Imaging Analytic Tools for Risk Stratification of Alzheimer’s Disease
Abstract
1. BACKGROUND
2. SEGMENTATION AND QUANTITATIVE DETECTION OF WMH
3. BRAIN VOLUME ANALYTIC TOOL
4. LIMITATION OF THE PRESENT STUDY
5. CONCLUSION
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Imaging Beyond Bone Mineral Density
Abstract
1. Imaging Beyond Bone Mineral Density
2. SUMMARY
CONFLICT OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
Computer-Aided Diagnosis Model for Skin Cancer Detection
Abstract
1. INTRODUCTION
2. MATERIALS AND METHODS
3. RESULTS
4. DISCUSSION
FURTHER CONSIDERATIONS
CONCLUSION
REFERENCES
Recent Advances in Imaging
(Volume 1)
Medical Imaging Technologies and Methods
for Health Care
Authored by
Fuk-hay Tang
School of Dentistry and Health Science, Charles Sturt University, Bathurst,
New South Wales,Australia

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PREFACE

The fast-moving advancement in medical imaging technology has revolutionized health care science. When information technology integrates with imaging technology, it is taking health care to new horizons. On the other hand, there is an increase in the number of health care workers to meet the need of growing population and requirement of quality health services. This accelerates the demand for applied and basic research on top of professional practices.

The potential and promising ideas in imaging technology are knowledge discovery and data mining in large image database, use of smart mobile devices in facilitating handy health care services, applications of biomechanical engineering methods and analytic methods for medical imaging. These thoughts are realized in the content of this book where it is divided into two parts. Part I deals with image management and knowledge discovery. It starts with an overview of recent advancement in Picture Archiving and Communication Systems. Then, the emerging mobile and cloud technology are discussed in Chapter 2. In Chapter 3, the applications of data mining and big data are explored.

In Part II, the medical imaging methods are extended for better health and disease detection. In Chapter 4, it high-lights the computer-aided method, while the recent study on the finite element analysis for breast image registration is elaborated in Chapter 5. Chapter 6 is a comprehensive risk analysis of Alzheimer diseases using image analysis while Chapter 7 examines bone mineral density evaluation methods by imaging. Lastly, Chapter 8 introduces how artificial neural networks work on skin lesions detection.

To meet the striking needs of this emerging discipline of health care science, the intended readers of this book are graduate students or researchers who are interested in research topics related to imaging technology. Also, this book will be of interest to health care community. It provides information for health care science and inspires new ideas for research.

Acknowledgements

I am greatly indebted to the co-authors who contributed to the chapters of this book:

Mr Edward Wong (Faculty Director - Medical Imaging Informatics, Hong Kong College of Radiographers and Radiation Therapists) helped me about the architecture and applications of the data mining program in Chapter 3.

Dr Janice Xue, my former PhD student and current research associate at the Chinese University of Hong Kong, wrote a detailed principle and application of biomechanical engineering method for breast imaging in Chapter 5.

Dr Christopher Lai of the Hong Kong Polytechnic University appraised the advanced imaging analytic tools for risk stratification of Alzheimer’s disease in Chapter 6.

Dr Yau Ming (Patrick) Lai of the Hong Kong Polytechnic University and Professor Ling Qin of the Chinese University of Hong Kong reviewed the technique of bone mineral density detection using imaging and various methods in Chapter 7.

Last but not the least, Mr TT Wong, my former undergraduate student, and current practicing radiographer, carried out the experimental part of computer-aided detection for skin cancer detection and helped to prepare the manuscript in Chapter 8.

I thank all the above researchers by spending countless days and nights to the success completion of this book.

CONSENT FOR PUBLICATION

Not applicable.

CONFLICT OF INTEREST

The author declares no conflict of interest, financial or otherwise.

Professor Fuk Hay Tang School of Dentistry and Health Science Charles Sturt University, Bathurst New South Wales Australia Email: [email protected] Tel: +61 2 693 32980

PART I: MEDICAL IMAGING FOR IMAGE MANAGEMENT AND KNOWLEDGE DISCOVERY

Introduction to Recent Advancement in Picture Archiving and Communication System

Fuk-hay Tang

Abstract

The recent developments of information technology have enhanced the Picture Archiving and Communication System. There are developments in mobile devices, cloud computing technology and intelligence method in the PACS. This chapter elaborates the advancement that has been made and explores their impacts.

Keywords: Advancement, Cloud Computing, Intelligent PACS, Thin Client, Picture Archiving and Communication System, PACS.

1. INTRODUCTION

With the advent of fast speed network and smart mobile devices, the speedy delivery of data and information has reshaped the healthcare services. Recent developments of Picture Archiving and Communication System (PACS) and cloud computing are renovating the practice of patient management. Undoubtedly the explosion of smart mobile devices applications (the ‘apps’) and Gigabit Ethernet and 4G wireless mobile telecommunication technology are the drivers for the advances.

2. WEB-BASED THIN CLIENT MODEL

The models of PACS architectures can be categorized into stand-alone model, client-server model, and web-based model.

For stand-alone model, the PACS workstations have large computing capability and are able to provide local storage (SCU storage service) and run image processing and 3D reconstruction locally without relying on network connection. The workstations usually required an UPS to sustain the stability of the system.

For thin client model, the clients reply on services provided by a centralized server through network connections. The clients usually have limited computing power and local storage. Most web-based computers or smartphones, handheld tablet PCs can access to the PACS to perform similar tasks as standalone PACS workstations. The thin clients usually do not need local installation of PACS

application software to designated computers. There is no AE title or port number requirement for the PACS workstation. Instead, the software or PACS client program is accessible through the web. This offers a ready-on-line solution for user of PACS where the PACS can be accessible for registered users nearly anywhere in the institution.

3. USE OF MOBILE AND CLOUD TECHNOLOGY

“Cloud computing is a model for enabling ubiquitous, convenient, on-demand network access to a shared pool of configurable resource that can be rapidly provisioned and released with minimal effort or service provider interaction.” (National Institute of Standards and Technology, [1]). It is comprised of 5 essential characteristics: on-demand self-service, broad network access, resource pooling, rapid elasticity and measured service.

The service model may include “Software as a service (SaaS), Platform as a service (PaaS) and Infrastructure as a Service (IaaS).

The deployment models are: private cloud, community cloud, public cloud and hybrid cloud.

Traditionally, IT supports are very important for PACS deployment. Maintenance of database and everyday QA for image transfer are daily work for PACS manager. With cloud computing, on-site IT infrastructure is minimal. Patient database becomes centralized and there is sharing of data across the hospitals and imaging centres. By using cloud technology, essentially there is no need to install the PACS client, or they just install the on-demand active x components.

4. INTELLIGENT PACS

As PACS has become an essential technology to manage digital images for the past 20 years, it offers a vast resource for knowledge discovery through image data that present in the digital images. On the other hand, computer-aided detection and diagnosis (CAD) exploits computing methods to extract quantitative information to enhance clinical management including diagnosis in a more efficient way. It must be clear that CAD is used as a tool to assist a doctor who takes the computer output as a second opinion. The final decision is still lying on the doctor who manages a patient.

Usually CAD is resided in a stand-alone workstation. In order to facilitate efficient detection of abnormality, the CAD server can be integrated with the PACS [2].

Undoubtedly, the integration of CAD in PACS workflow would streamline direct viewing of CAD outputs and utilizes the PACS database and enhances a more accurate and efficient diagnostic process. Huang [3] described three scenarios about the CAD-PACS integration using different editions of CAD-PACS toolkit. Also, the results of CAD were combined with the radiologist reports using DICOM structure report (SR) object.

A further extension of intelligent PACS is that the PACS –CAD can be deployed in the cloud environment. This enables a speedy and handy access to CAD service through the deployment of smart mobile devices. In the below section, we described the use of mobile devices (ipad, iphone, android smart phone and tablet) for PACS.

The following is a design of a cloud-based mobile intelligent system integrated with PACS. The whole computer-aided detection system is deployed in the internet (the “Cloud”) and it provides computer-aided computation service and web services.

The cloud-based mobile intelligent system consists of three major components: 1. CAD component. 2. The Interface Service component, and 3. Web Service component. This is further discussed in Chapter 2.

The unique feature of PACS is that images are stored in DICOM (Digital Imaging and Communications in Medicine) format. A DICOM data file consists of image header, including imaging modality, patient details, space for report and reasons for the test; and the the image pixel data (Fig. 1). Extraction of information in the DICOM header provides a resource for data mining. On the other hand, the deployment of PACS in a hospital provides a source of large volume of image data. This facilitate knowledge discoveries in PACS. The use of data mining in medical imaging will be discussed in the chapter that follows.

5. CONCLUSION AND REMARKS

The establishment of PACS has been revolutionized from high performance unix server with standalone workstation to web technology with thin clients and smart mobile devices. PACS is no longer confined to a single workplace but becomes available nearly everywhere. However, this raises the concern for security and patient privacy.

On the other hand, PACS is not just an image distribution management system but a means that can generate knowledge and facilitate clinical judgment.

Fig. (1)) DICOM header information.

CONFLICT OF INTEREST

The author(s) confirm that this chapter contents have no conflict of interest.

ACKNOWLEDGEMENTS

Declared none.

REFERENCES

[1]Mell P, Grance T. The NIST Definition of Cloud Technology. The National Institute Standard of Standard and Technology 2011. Special Edition 800-145. p. 2.[2]Dubey RB, Hanmandlu M. Integration of CAD into PACS. 2nd International Conference on Power, Control and Embedded Systems (ICPCES).[3]Huang HK, PACS and Imaging Informatics: Basic Principles and Applications, 2nd Edition. John Wiley and Sons, 2010, pp. 807-859.

Mobile and Cloud Technology Applications in Picture Archiving and Communication System

Fuk-hay Tang

Abstract

In this chapter, a model of secured mobile system is described for image distribution in hospitals. In this system, it consists of mobile application server and mobile application client. The mobile application server communicates with hospital PACS and the client is embedded in the end-user’s smart phone. The IMEI code of the mobile phone is sent by SMS to designated user to ensure security. The system can manage DICOM images with image processing capability with reasonable image quality. The mobile PACS demonstrates a model of using smart phone to improve the efficiency of health care services by speedy delivery of image information.

Keywords: Filmless, Health Care, Medical Images, Mobile Phone, PACS, Smart Phone.

1. INTRODUCTION

Digital technology has been widely used in medical field in the recent years with the advent of fast speed wireless networks and the deployment of cloud computing technology. The use of mobile phone for management of medical image distribution and the cloud computing environment in medical application with the integration to hospital Picture Archiving and Communication System (PACS) have been reported [1, 2]. On the other hand, cloud computing is a model for Internet-based computing which allows users to access service or applications from the Internet (the ‘cloud’) without the need to know or control the technology behind. The advantage of using cloud computing technology is that resources such as servers, software application, and data can be shared on demand [3].

In health care and medical areas, there are problems of resource allocation when implementing digital and filmless environment. In addition, maintenance of the computer system exerts another loading on health managers. It follows that cloud computing model offers a potential solution for health-care industry as it can alleviate the burden of resource-demanding computer facilities and infrastructure while it can keep health-care data updated. Applications of the Cloud computing concept can be found in health care and medical areas such as ultrasound [4],

content retrieval [5] and genomics [6].

With the development of speedy wireless data network, mobile and cloud technologies offer promising solutions for efficient delivery of health care services. In the following discussion, we attempt to elaborate on two application models of mobile technology and cloud technology in medical imaging.

2. APPLICATION OF MOBILE TECHNOLOGY IN PACS

There were initiatives for handy access to medical images by personal digital assistant (PDA), window mobile or iPhone [7, 8] or iPad [9] or other mobile device [6