Micro- and Nanomanipulation Tools E-Book

• Herausgeber: Wiley-VCH
• Kategorie: Fachliteratur
• Serie: Advanced Micro and Nanosystems
• Sprache: Englisch

Seitenzahl: 1153

Veröffentlichungsjahr: 2015

Beschreibung

Combining robotics with nanotechnology, this ready reference summarizes the fundamentals and emerging applications in this fascinating research field. This is the first book to introduce tools specifically designed and made for manipulating micro- and nanometer-sized objects, and presents such examples as semiconductor packaging and clinical diagnostics as well as surgery.
The first part discusses various topics of on-chip and device-based micro- and nanomanipulation, including the use of acoustic, magnetic, optical or dielectrophoretic fields, while surface-driven and high-speed microfluidic manipulation for biophysical applications are also covered. In the second part of the book, the main focus is on microrobotic tools. Alongside magnetic micromanipulators, bacteria and untethered, chapters also discuss silicon nano- and integrated optical tweezers. The book closes with a number of chapters on nanomanipulation using AFM and nanocoils under optical and electron microscopes. Exciting images from the tiniest robotic systems at the nano-level are used to illustrate the examples throughout the work.
A must-have book for readers with a background ranging from engineering to nanotechnology.

Leseprobe

Table of Contents

Cover

Related Titles

Title Page

Copyright

About the Editors

Series Editors Preface

Preface

List of Contributors

Chapter 1: High-Speed Microfluidic Manipulation of Cells

1.1 Introduction

1.2 Direct Cell Manipulation

1.3 Indirect Cell Manipulation

1.4 Summary

Acknowledgments

References

Chapter 2: Micro and Nano Manipulation and Assembly by Optically Induced Electrokinetics

2.1 Introduction

2.2 Optically Induced Electrokinetic (OEK) Forces

2.3 OEK-Based Manipulation and Assembly

2.4 Summary

References

Chapter 3: Manipulation of DNA by Complex Confinement Using Nanofluidic Slits

3.1 Introduction

3.2 Slitlike Confinement of DNA

3.3 Differential Slitlike Confinement of DNA

3.4 Experimental Studies

3.5 Design of Complex Slitlike Devices

3.6 Fabrication of Complex Slitlike Devices

3.7 Experimental Conditions

3.8 Conclusion

Disclaimer

References

Chapter 4: Microfluidic Approaches for Manipulation and Assemblyof One-Dimensional Nanomaterials

4.1 Introduction

4.2 Microfluidic Assembly

4.3 Summary

References

Chapter 5: Optically Assisted and Dielectrophoretical Manipulation of Cells and Molecules on Microfluidic Platforms

5.1 Introduction

5.2 Operating Principle and Fundamental Physics of the ODEP Platform

5.3 Applications of the ODEP Platform

5.4 Conclusion

References

Chapter 6: On-Chip Microrobot Driven by Permanent Magnetsfor Biomedical Applications

6.1 On-Chip Microrobot

6.2 Characteristics of Microrobot Actuated by Permanent Magnet

6.3 Friction Reduction for On-Chip Robot

6.4 Fluid Friction Reduction for On-Chip Robot

6.5 Applications of On-Chip Robot to Cell Manipulations

6.6 Summary

References

Chapter 7: Silicon Nanotweezers for Molecules and Cells Manipulation and Characterization

7.1 Introduction

7.2 SNT Operation and Design

7.3 SNT Process

7.4 DNA Trapping and Enzymatic Reaction Monitoring

7.5 Cell Trapping and Characterization

7.6 General Concluding Remarks and Perspectives

Acknowledgments

References

Chapter 8: Miniaturized Untethered Tools for Surgery

8.1 Introduction

8.2 Macroscale Untethered Surgical Tools

8.3 Microscale Untethered Surgical Tools

8.4 Nanoscale Untethered Surgical Tools

8.5 Conclusion

Acknowledgments

References

Chapter 9: Single-Chip Scanning Probe Microscopes

9.1 Scanning Probe Microscopy

9.2 The Role of MEMS in SPM

9.3 CMOS–MEMS Manufacturing Processes Applied to sc-SPMs

9.4 Modeling and Design of sc-SPMs

9.5 Imaging Results

9.6 Conclusion

References

Chapter 10: Untethered Magnetic Micromanipulation

10.1 Physics of Micromanipulation

10.2 Sliding Friction and Surface Adhesion

10.3 Fluid Dynamics Effects

10.4 Magnetic Microrobot Actuation

10.5 Locomotion Techniques

10.6 Manipulation Techniques

10.7 Conclusions and Prospects

References

Chapter 11: Microrobotic Tools for Plant Biology

11.1 Why Do We Need a Mechanical Understanding of the Plant Growth Mechanism?

11.2 Microrobotic Platforms for Plant Mechanics

11.3 Biomechanical and Morphological Characterization of Living Cells

11.4 Conclusions

References

Chapter 12: Magnetotactic Bacteria for the Manipulation and Transport of Micro- and Nanometer-Sized Objects

12.1 Introduction

12.2 Magnetotactic Bacteria

12.3 Component Sizes and Related Manipulation Approaches

12.4 Conclusions and Discussion

References

Chapter 13: Stiffness and Kinematic Analysis of a Novel Compliant Parallel Micromanipulator for Biomedical Manipulation

13.1 Introduction

13.2 Design of the Micromanipulator

13.3 Stiffness Modeling of the Micromanipulator

13.4 Kinematics Modeling of the Micromanipulator

13.5 Conclusion

References

Chapter 14: Robotic Micromanipulation of Cells and Small Organisms

14.1 Introduction

14.2 Robotic Microinjection of Cells and Small Organisms

14.3 Robotic Transfer of Biosamples

14.4 Robot-Assisted Mechanical Characterization of Cells

14.5 Conclusion

References

Chapter 15: Industrial Tools for Micromanipulation

5.1 Introduction

5.2 Microrobotics for Scientific Instrumentation

5.3 Microrobotics for Microassembly

5.4 Future Challenges

References

Chapter 16: Robot-Aided Micromanipulation of Biological Cells with Integrated Optical Tweezers and Microfluidic Chip

16.1 Introduction

16.2 Cell Micromanipulation System with Optical Tweezers and Microfluidic Chip

16.3 Enhanced Cell Sorting Strategy

16.4 Novel Cell Manipulation Tool

16.5 Conclusion

References

Chapter 17: Investigating the Molecular Specific Interactions on Cell Surface Using Atomic Force Microscopy

17.1 Background

17.2 Single-Molecule Force Spectroscopy

17.3 Force Spectroscopy of Molecular Interactions on Tumor Cells from Patients

17.4 Mapping the Distribution of Membrane Proteins on Tumor Cells

17.5 Summary

Acknowledgments

References

Chapter 18: Flexible Robotic AFM-Based System for Manipulation and Characterization of Micro- and Nano-Objects

18.1 AFM-Based Flexible Robotic System for Micro- or Nanomanipulation

18.2 In situ Peeling of 1D Nanostructures Using a Dual-Probe Nanotweezer

18.3 In situ Quantification of Living Cell Adhesion Forces: Single-Cell Force Spectroscopy with a Nanotweezer

18.4 Conclusion and Future Directions

References

Chapter 19: Nanorobotic Manipulation of Helical Nanostructures

19.1 Introduction

19.2 Nanorobotic Manipulation Tools and Processes

19.3 Characterization of Helical Nanobelts

19.4 Applications

19.5 Summary

References

Chapter 20: Automated Micro- and Nanohandling Inside the Scanning Electron Microscope

20.1 Introduction and Motivation

20.2 State of the Art

20.3 Automation Environment

20.4 Case Studies

20.5 Outlook

Acknowledgments

References

Chapter 21: Manipulation of Biological Cells under ESEM and Microfluidic Systems

21.1 Introduction

21.2 ESEM-Nanomanipulation System

21.3 ESEM Observation of Single Cells

21.4 Manipulation of Biological Cells under ESEM

21.5 Manipulation of Biological Cells under Microfluidics

21.6 Conclusion

References

Index

End User License Agreement

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Guide

Cover

Table of Contents

Preface

Begin Reading

List of Illustrations

Chapter 1: High-Speed Microfluidic Manipulation of Cells

Figure 1.1 Two major examples of cell manipulation approaches in microfluidic channels, namely (a) direct cell [5] and (b) indirect cell manipulation [21].

Figure 1.2 Direct cell manipulation techniques. Cell morphology can be manipulated (a,b) mechanically and electrically [53, 54], (c) mechanically and optically [55], (d) through cell and wall interactions [56], or (e,f) by pure hydrodynamic forces [57, 58].