Novel Drug Delivery Systems (Part 2) E-Book
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- Herausgeber: Bentham Science Publishers
- Kategorie: Fachliteratur
- Sprache: Englisch
Novel Drug Delivery Systems (Part 2) covers the advanced techniques and innovations transforming pharmaceutical sciences, with a focus on enhancing drug efficacy and patient outcomes. This comprehensive guide explores a wide array of delivery methods, including nasopulmonary, transdermal, ocular, nanotechnology-based, implantable, and controlled-release injectables. Each chapter provides an in-depth analysis of these unique delivery routes, presenting both foundational knowledge and the latest technological advancements in the field.
Designed for students, researchers, and professionals in pharmaceuticals and medicine, this book bridges basic concepts with cutting-edge practices, emphasizing the science and impact of controlled drug delivery.
Key Features:
- Detailed exploration of nasopulmonary, transdermal, ocular, and implantable delivery systems
- Insight into nanotechnology's role in drug delivery
- Comprehensive coverage of controlled-release injectables
Readership:
Ideal for students, researchers, and industry professionals seeking to deepen their understanding of advanced drug delivery methods
Das E-Book können Sie in Legimi-Apps oder einer beliebigen App lesen, die das folgende Format unterstützen:
Seitenzahl: 429
Veröffentlichungsjahr: 2024
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FOREWORD
The field of pharmaceutical sciences is ever-evolving, driven by the pursuit of more efficient, targeted, and patient-friendly therapeutic solutions. At the forefront of this transformation are Novel Drug Delivery Systems (NDDS), which hold the potential to revolutionize drug administration and efficacy paradigms. This book provides a comprehensive exploration of NDDS, meticulously crafted for postgraduate students and researchers ready to lead this exciting frontier.
The authors delve into the principles and advantages of NDDS, emphasising their potential to enhance drug bioavailability, reduce side effects, and improve patient compliance. It sets the stage for subsequent discussions on how NDDS can address these challenges by providing more effective and targeted therapeutic options. This book introduces various NDDS platforms and their applications in managing chronic diseases. As you navigate through these chapters, you will encounter a blend of rigorous scientific analysis and practical insights. The discussions are enriched with illustrative figures, tables, and real-world examples that elucidate complex concepts and foster a deeper understanding. This book is more than just a compilation of knowledge; it is a call to action for the next generation of pharmacy professionals and researchers. The advancements in NDDS hold the promise of revolutionising healthcare, and it is through your dedication and innovation that this promise will be realised.
I am confident that this book will serve as a valuable guide and reference in your journey towards mastering NDDS. May it empower you to make significant contributions to the field of pharmacy and to the betterment of patient care worldwide.
PREFACE
We are excited to present the second volume of our comprehensive book on novel drug delivery systems. Following the foundation laid in Volume 1, this volume delves deeper into specialized and emerging technologies that are reshaping drug delivery, broadening the scope of controlled release systems in diverse therapeutic areas.
This volume begins with Chapter 1, "Nasopulmonary Drug Delivery Systems", which explores the promising potential of nasal and pulmonary routes for drug administration. The chapter discusses the intricate dynamics of drug delivery to these regions, emphasizing their relevance in targeting respiratory diseases and systemic drug administration.
In Chapter 2, "Transdermal Route of Drug Delivery", the focus shifts to the innovative methods for delivering drugs through the skin. This chapter offers a detailed look at transdermal systems, their design, applications, and the advances that are transforming this route into a powerful tool for controlled drug delivery.
Ocular drug delivery presents unique challenges due to the sensitivity and complexity of the eye. Chapter 3, "Ocular Drug Delivery Systems", provides valuable insights into the technological advances that are improving the administration of therapeutics to the eye, ensuring precise and effective treatment for ocular conditions.
Chapter 4, "Nanotechnology and its Concepts", opens up the fascinating world of nanotechnology, a field that holds immense promise for revolutionizing drug delivery. This chapter delves into nanoscale materials and their applications in achieving targeted, controlled, and efficient delivery of therapeutics at the cellular and molecular levels.
Continuing the exploration of innovative approaches, Chapter 5, "Implantable Drug Delivery Systems", examines how implantable devices can provide long-term, controlled release of drugs, particularly in chronic conditions. This chapter offers a comprehensive look at the development, design, and applications of these devices in clinical practice.
The volume concludes with Chapter 6, "Controlled Release Injectables", which offers a thorough overview of the advancements in injectable formulations designed for sustained and controlled drug release. This chapter highlights the critical role injectables play in modern medicine, providing an in-depth understanding of the latest innovations in this area.
As with the first volume, our goal was to equip readers—whether students, researchers, or professionals—with a deeper understanding of the latest developments in controlled drug delivery systems. The content in this volume reflects the expanding horizons of drug delivery and presents cutting-edge research that is driving the future of pharmaceutical sciences.
We extend our deepest appreciation to the expert authors who have contributed to this volume. Their commitment to advancing knowledge in novel drug delivery has made this collection a valuable resource for readers worldwide. We hope that this volume, like the one before it, will inspire continued innovation and progress in the field of pharmaceutical sciences.
DEDICATION
I would like to dedicate this book To My Late Grandfather, Whose love and Teachings have been guiding light throughout my life To My family Members
I would like to dedicate this book To
List of Contributors
Nasopulmonary Route of Drug Delivery
Bhushan R. Rane1,*,Akash J. Amkar1,Ashish S. Jain1Abstract
Nasopulmonary drug delivery has gained a lot of interest as a convenient, reliable, and promising technique for systemic drug administration. It is especially used for molecules that can only be delivered intravenously and are inefficient when taken orally. This is due to the high vascularization seen above the upper nasal cavity and alveolar region of the pulmonary system, wide surface area, avoidance of first-pass metabolism, gut wall metabolism, and/or destruction in the gastrointestinal tract. Numerous therapeutic compounds may be supplied intranasally for topical or systemic administration. Presently, the nose-to-brain administration route offers targeted delivery. Several further advantages are expected to emerge via the pulmonary route to achieve systemic effects and treat lung disorders. Barriers that prevent absorption through the nasal and pulmonary pathways must be overcome to achieve these therapeutic benefits. Numerous drug delivery devices are being researched for nasal and pulmonary administration of liquid, semisolid, and solid formulations to deliver the medications quickly and/or efficiently to the target area. They are especially suitable for the administration of biotechnological products like proteins, peptides, hormones, and vaccines, as well as poorly soluble drugs, to improve bioavailability. Pulmonary drug delivery has triggered intense scientific and biomedical interest in recent years, and it has made significant progress in the context of local treatment for lung disorders, owing to improved local targeting and fewer systemic adverse effects with the administration of minute therapeutic levels. The chapter attempts to provide some information regarding the nasopulmonary drug delivery system, including the anatomy of the nasal cavity and respiratory tract, the mechanism of drug absorption, characteristics that are considered during the selection of drugs for the nasopulmonary system, factors that affect nasal and pulmonary drug absorption, techniques to improve absorption, dose calculation specifically for intranasal delivery, formulation of dosage forms according to requirement, novel drug formulations, recent improvements of the nasal and pulmonary delivery systems, and some of the patents and commercially also available formulations. The impact of COVID-19 and intranasal vaccine development is discussed in this chapter.
