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In recent years, we have witnessed significant advances in obstetric anesthesia, providing greater safety for the mother and the fetus, as well as an improvement in pain management procedures during labor.

This volume presents updates in obstetrics and gynecology that are reflective of the changes in the demographics and associated clinical presentations of gynecological pathologies. It compiles state of the art information on the subject in 20 chapters contributed by more than 50 experts in obstetric anesthesia. The main objective of this volume is to inform and update readers about the different aspects essential to the practice of anesthesia and analgesia during pregnancy, labor, cesarean section and puerperium. The contents also include information about the management of pregnant women with different pathologies and high-risk pregnancies.

The authors believe that it is essential for all anesthesiologists to be aware of the latest advances and well-contrasted scientific evidence that will allow them to carry out their usual clinical activity.
The volume approaches the subject in a clear and didactic way for the benefit of all professionals involved in this field, including anesthesiologists, gynecologists, obstetricians, surgeons, clinicians and allied healthcare service providers.

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Veröffentlichungsjahr: 2003

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Table of Contents
BENTHAM SCIENCE PUBLISHERS LTD.
End User License Agreement (for non-institutional, personal use)
Usage Rules:
Disclaimer:
Limitation of Liability:
General:
PREFACE
List of Contributors
Fetomaternal Physiology: Physiological Changes during Pregnancy
Abstract
INTRODUCTION
Respiratory System
Cardiovascular Changes
Hematological and Fluid Status Changes
Renal Changes
Gastrointestinal and Hepatobiliary Changes
Neurological Changes
Metabolic and Endocrine Changes
Immunological Changes
Other Changes
PLACENTAL PHYSIOLOGY
Blood Supply
Transfer Across the Placenta
Oxygen and Carbon Dioxide
Drug Transfer
Fetal Circulation
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Safety in the Obstetric Patient: Simulation Training for Anesthesiologists in the Obstetrics Field
Abstract
INTRODUCTION
Safety and Quality in Obstetrics
Strategies to Improve Quality in Obstetrics
How About Safety in the Obstetric Field?
Strategies to Improve Safety in Obstetrics
The Role of Anesthesiologist in the Safety of the Obstetric Patient
SIMULATION TRAINING FOR ANESTHESIOLOGISTS IN THE OBSTETRICS FIELD
Competency-Based Curriculum in Anesthesia
Improvement Technical Skills
Improvement Non-Technical Skills
Improvement Individual Clinical Competence
Improvement Safety of the Clinical Environment
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Airway Management in Pregnancy
Abstract
INTRODUCTION
SPECIFIC CONSIDERATIONS OF THE OBSTETRIC AIRWAY
SAFE GENERAL ANAESTHESIA IN THE OBSTETRIC PATIENT
Pre-Operative Evaluation
POINT-OF-CARE ULTRASOUND (PoCUS) IN PREGNANCY
Gastric Contents
Difficult Airway
Fasting and Antacid Prophylaxis
Planning and Preparation
Preoxygenation
Cricoid Pressure
Face Mask Ventilation during Apnoea
First Intubation Attempt
Second Intubation Attempt
FAILED TRACHEAL INTUBATION
CAN´T INTUBATE, CAN´T OXYGENATE
AWAKEN PATIENT VS CONTINUE SURGERY
EXTUBATION
UNANTICIPATED DIFFICULT AIRWAY IN OBSTETRIC PATIENTS
ANTICIPATED DIFFICULT AIRWAY DURING OBSTETRIC GENERAL ANAESTHESIA
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Anesthesia for Fetal Surgery
Abstract
INTRODUCTION
PHYSIOLOGY
GENERAL MANAGEMENT IN ALL INSTANCES OF FETAL SURGERY
TYPES OF FETAL INTERVENTIONS
Minimally Invasive Interventions
Anesthetic Management
Open Midgestation Fetal Surgery
Anesthetic Management
Ex Utero Intrapartum Therapy (EXIT) and Procedure Requiring Second Team in the Operating Room (PRESTO) Procedures
Anesthetic Management
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Regional and Parenteral Analgesia in Labour
Abstract
INTRODUCTION
REGIONAL ANALGESIA
Neuraxial Analgesia
Neuraxial Techniques
Maintenance and Dosing of Epidural Analgesia
Effects of Neuraxial Analgesia on Labour and Newborn
Regional Blocks for Labour Analgesia
Pudendal Nerve Block
Paracervical Block
PARENTERAL ANALGESIA
Opioids
Opioids Used in Labour Analgesia
Ketamine
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Comparison Between Different Parenteral Medications
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Local Anesthetics and Adjuvants for Labor: Local Anesthetic Systemic Toxicity
Abstract
INTRODUCTION
MECHANISM OF ACTION OF LOCAL ANESTHETICS
Properties and Implications of Local Anesthetics
DIFFERENCES BETWEEN LOCAL ANESTHETICS AND THEIR EFFECTS
Lidocaine
Mepivacaine
Bupivacaine
Levobupivacaine
Ropivacaine
LOCAL ANESTHETICS ADJUVANTS
Opioids
Fentanyl
Morphine
Meperidine (Pethidine)
Adrenaline
Bicarbonate
Other Local Anesthetics Additives
POSSIBLE DOSES OF ADMINISTRATION
Epidural Catheter for Labor
Combined Epidural-Spinal Technique
Patient-Controlled/Continuous/Intermittent Perfusion
Caesarean Section
LOCAL ANESTHETIC SYSTEMIC TOXICITY (LAST)
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Anesthesia for Cesarean Section
Abstract
INTRODUCTION
REGIONAL ANESTHESIA FOR CESAREAN SECTION
Complications of Regional Anesthesia
Cardiovascular Effects
Nausea and Vomiting
Post-Dural Puncture Headache
Central Nervous System Infections
Accidental Puncture of a Blood Vessel
GENERAL ANESTHESIA FOR CESAREAN SECTION
Induction of General Anesthesia
Bronchoaspiration
Maintenance of Anesthesia
Antibiotic Prophylaxis
Deep Vein Thrombosis
ACUTE POSTOPERATIVE PAIN
ANESTHETIC MANAGEMENT FOR CESAREAN SECTION IN COVID-19 PATIENT
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Locoregional Anesthesia Comments in the Obstetric Patient and Eventual Complications
Abstract
INTRODUCTION
PAIN AND LABOR ANALGESIA
MECHANISM OF PAIN
CONSEQUENCES OF PAIN
LABOR ANALGESIA
Neuraxial Obstetric Analgesia
Indications [11, 28, 29, 31, 33]
Contraindications [11, 28, 29, 31, 33]
Epidural
LOCAL ANESTHETICS AND ADJUVANTS
MAINTENANCE OF ANALGESIA
Spinal (Intrathecal)
Combined Spinal-Epidural Technique
COMMETS ON EPIDURAL OBSTETRIC ANALGESIA
Other Therapies
Paracervical Block
Pudendal Block
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Uterotonic Agents
Abstract
INTRODUCTION
UTEROTONIC AGENTS
Oxytocin
Clinical considerations
Carbetocin
Ergot Alkaloids
Prostaglandins and Analogues
Prostaglandin E2 (Dinoprostone)
Prostaglandin F2α (Carboprost)
Prostaglandin E1 (Misoprostol)
USE OF UTEROTONIC AGENTS
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Anesthesia for Non-Obstetric Surgery in Pregnancy
Abstract
INTRODUCTION
ANESTHETIC IMPLICATIONS OF PHYSIOLOGICAL CHANGES IN THE PREGNANT WOMAN
Impact of Respiratory Changes
Impact of Changes on the Airway
Impact of Cardiovascular Changes
Impact of Neuroaxial Changes
Impact of Digestive Changes
Impact of Hepato-Renal Changes
Impact of Hematological Changes
IMPACT OF ANESTHESIA ON THE FETUS
Anesthesia, Embryogenesis and Fetal Outcome
Teratogenicity of Anesthetic Agents
Induction Agents
Inhalation Anesthesia
Neuromuscular Blocking Agents
Neuromuscular Block Reversers
Local Anesthetics
Analgesics
Opioids
Sedatives
Maternal Anesthesia and Neurocognitive Outcomes
ANESTHETIC MANAGEMENT
Practical Considerations
Preoperative Assessment
Intraoperative Assessment
Fetal Monitoring
Postoperative Analgesia
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Anesthetic Management of the Pregnant Patient with Comorbidities
Abstract
INTRODUCTION
Multiple Sclerosis
Spinal Cord Injury
Myasthenia Gravis
Epilepsy
Muscular and Myotonic Dystrophy
Neurocutaneous Syndromes
Brain Tumors
Cerebrovascular Accidents
PREGNANT PATIENT WITH CARDIOVASCULAR DISORDERS
PREGNANT PATIENT WITH RESPIRATORY DISORDERS
PREGNANT PATIENT WITH INFECTIOUS DISORDERS
VHS
VIH
Conclusion
PREGNANT PATIENT WITH ENDOCRINE DISORDERS
Diabetes Mellitus
Hyperthyroidism
Obesity
PREGNANT PATIENT WITH AUTOIMMUNE DISORDERS
PREGNANT PATIENT WITH COAGULATION DISORDERS
PREGNANT PATIENT WITH RENAL DISEASE
PREGNANT PATIENT WITH HEPATIC DISEASE
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Anesthetic Management of Pregnant Patients with Infectious Disease
Abstract
INTRODUCTION
ETIOLOGY OF MATERNAL FEVER
Infectious Causes
Intraamniotic Infection (Chorioamnionitis)
Urologic Infections
Respiratory Tract Infection
Genital Herpes Infection
Postpartum Infection
Non-Infectious Causes
Neuraxial Analgesia
ANESTHETIC MANAGEMENT FOR THE FEBRILE OR INFECTED PARTURIENT
Neuraxial Anesthesia
General Anesthesia
ANESTHETIC CONSIDERATIONS OF THE MOST COMMON INFECTIONS DURING PREGNANCY [13, 32]
Herpes Simplex Virus (HSV)
Hepatitis
Human Inmunodeficiency Virus (HIV)
Urinary Tract Infections
Chorioamnionitis
Pneumonia
Septic Shock
COVID-19 & PREGNANCY
Anesthetic Management
Labor Analgesia
Caesarean Section
General Anesthesia
Postoperative/Postpartum Care
SPECIAL SITUATIONS
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Obstetric Hemorrhage
Abstract
INTRODUCTION
CAUSES OF POSTPARTUM HEMORRHAGE
Risk Factors
MANIFESTATIONS AND DIAGNOSIS
Amount of Bleeding
Clinical Changes
Laboratory Evaluation
POSTPARTUM HEMORRHAGE PREVENTION
MANAGEMENT OF POSTPARTUM HEMORRHAGE
Objectives
Specific Measures
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Hypertensive Disorders in Pregnancy
Abstract
INTRODUCTION
PATHOPHYSIOLOGY OF PREECLAMPSIA
Uterine Artery Remodelling
Immunological Factors
Genetic Factors
DIAGNOSIS OF HYPERTENSIVE DISORDERS OF PREGNANCY
Classification of Hypertensive Disorders of Pregnancy
RISK FACTORS FOR DEVELOPING PREECLAMPSIA
OBSTETRIC MANAGEMENT OF PREECLAMPSIA
Management of Antihypertensive Drugs
MANAGEMENT OF ECLAMPSIA
RECOMMENDATIONS FOR DELIVERY
ANAESTHETIC MANAGEMENT OF PREECLAMPSIA
Severe Preeclampsia, Preeclampsia without Criteria for Severity, and HELLP Syndrome
Airway Assessment
Assessment of Hemodynamic Disturbances
Coagulation
Hemodynamic Monitoring
Transthoracic Echocardiography
Blood Pressure Goals
Intravenous Fluid Management
Obstetric Analgesia
ANAESTHETIC CONSIDERATIONS
Prevention of Post-Partum Hemorrhage
General Anaesthesia
Anaesthetic Management of Preeclampsia
Use of Magnesium Sulphate
Treatment of Hypertensive Crisis
Post-Operative Pain Management
Role of Ultrasound and Echocardiography in Treatment
Immediate and Long-Term Morbidity
INTENSIVE CARE MANAGEMENT
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Air and Amniotic Fluid Embolism
Abstract
INTRODUCTION
INCIDENCE AND MORTALITY
AMNIOTIC FLUID CHARACTERISTICS
RISK FACTORS
PATHOGENESIS
CLINICAL MANIFESTATIONS
DIAGNOSIS
Diagnostic tests
DIFFERENTIAL DIAGNOSIS
PREVENTION
TREATMENT
Patient Monitoring and Management [4]
Disseminated Intravascular Coagulopathy Treatment
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Postoperative Management of Postnatal Complications
Abstract
INTRODUCTION
Uterine Atony
Uterotonic Treatment
Oxytocin
Carbetocin
Methylergonovine and Carboprost
Misoprostol
Non-Pharmacological Management
Uterine Compression Sutures
Balloon Tamponade
Surgical Interventions
Retained Products of Conception
Genital Trauma
PULMONAR EMBOLISM IN POST PARTUM
Pulmonary Thromboembolism
Clinical Suspicion
Treatment
Amniotic Fluid Embolism
Diagnosis Approach
Management
General Management
Pharmacological Management
PRE-ECLAMPSIA / ECLAMPSIA
Anesthetic Management
Pain Management
POSTANESTHETIC COMPLICATIONS
Postpartum Headache
Backache
Postpartum Neuropathy
Severe Infection
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Analgesia after Labor and Cesarean Section: Chronic Pain after Pregnancy
Abstract
INTRODUCTION
POSTPARTUM CHRONIC PAIN RELATED TO DELIVERY METHOD
Chronic Pain After Cesarean Section
Chronic Pain After Vaginal Delivery
Influencing Factors on Postpartum Chronic Pain
Interventions for Decreasing the Risk of Postpartum Chronic Pain
CHRONIC PAIN AFTER CHILDBIRTH UNRELATED TO DELIVERY METHOD
Low Back Pain
Pelvic Girdle Pain
Other Pain Conditions
CHRONIC PAIN TREATMENT AFTER DELIVERY
The Relevance of Pain Drugs' Transfer into Breast Milk.
Treatment of Chronic Pain After Cesarean Section and Instrumentalized Vaginal Delivery
Treatment for Other Types of Chronic Pain After Delivery
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Anesthesia for Assisted Reproduction
Abstract
INTRODUCTION
BACKGROUND
Ovarian Hyperstimulation
Follicular Puncture
Fertilization Techniques
In Vitro Fertilization
Intracytoplasmic Sperm Injection
Embryo Culture and Embryo Transfer
ANESTHETIC CONSIDERATIONS
ACUPUNCTURE AND ASSISTED REPRODUCTION
OVARIAN HYPERSTIMULATION SYNDROME
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Anesthetic Management for External Cephalic Version
Abstract
BACKGROUND
EXTERNAL CEPHALIC VERSION
Factors that Predict a Successful ECV
Contraindications
UPDATED RECOMMENDATIONS ACCORDING TO SCIENTIFIC SOCIETIES
Recommendation with a High Level of Evidence (Level A)
Recommendation with Limited Scientific Evidence Level (Level B)
Evidence Level C Recommendations
ANESTHESIA IN THE EXTERNAL CEPHALIC VERSION
NEURAXIAL ANESTHESIA
REMIFENTANIL
INHALATIONAL ANESTHESIA
OTHER ANALGESIC OPTIONS
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Mindfulness-Based Interventions during Pregnancy and Labour
Abstract
INTRODUCTION
MENTAL DISSORDES EXPERIENCED BY PREGNANT AND POSTPARTUM WOMEN
PHYSIOLOGY OF MATERNAL DISTRESS DURING PREGNANCY
POSSIBLE PHYSIOLOGICAL MEDIATORS OF THE EFFECTS OF MATERNAL PSYCHOLOGICAL DISTRESS ON BIRTH AND HEALTH OUTCOMES
PERINATAL DEPRESSION AND POSTPARTUM DEPRESSION
Perinatal Depression
Postpartum Depression
TREATMENT OF DEPRESSION DURING PREGNANCY
Pharmacotherapy
Risks of not Treating Maternal Depression during Pregnancy
SLEEP PROBLEMS DURING PREGNANCY
MATERNAL MENTAL HEALTH MANAGEMENT
MINDFULNESS-BASED INTERVENTIONS IN PREGNANCY
Mindfulness Interventions to Reduce Maternal Prenatal Stress
Efficacy of Mindfulness and Yoga Interventions
MINDFULNESS-BASED PROGRAMS
EXAMPLE OF A MINDFULNESS-BASED PROGRAMME
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
REFERENCES
Recent Advances in Anesthesiology
Volume 4
Obstetric Anesthesia: Clinical Updates
Edited by
Eugenio Daniel Martinez-Hurtado
Department of Anesthesiology and Intensive Care
University Hospital Infanta Leonor
Madrid, Spain
Monica Sanjuan-Alvarez
&
 Marta Chacon-Castillo
Department of Anesthesiology and Intensive Care,
University Hospital Severo Ochoa,
Madrid, Spain

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PREFACE

Obstetric anesthesia encompasses the anesthetic and analgesic procedures performed during all the stages of labor for vaginal delivery as well as cesarean section. Anesthesiologists have cared for the security of pregnant women since 1847 when James Young Simpson performed the first analgesia for labor. Since then, and even more in the last decades, obstetric anesthesia has become an important aspect of routine anesthetic practice, as women demand to be able to enjoy painless childbirth.

Obstetric anesthesia is a challenge for all of us, because it involves two patients in the same procedure, with different physiologic characteristics, and with different needs. For this reason, our primary target should be to promote a painless and safe delivery, without disturbing uterine contractions or fetoplacental circulation.

Obstetric anesthesia requires a comprehensive approach, not only limiting us to pain relief during labor, but also including the appropriate management of cesarean section and of any potential complications derived of both labor and surgery, while avoiding any fetal compromise.

The Editors of this handbook consider it essential that anesthesiologists understand the importance of obstetric anesthesia in our daily practice. In this handbook, we intend to compile all updated, didactic, and exhaustive information, and we deem every professional should know to face the act of anesthetizing a pregnant patient.

Finally, we would like to thank the co-authors’ collaboration for the achievement of this handbook. As we are all professionals from different institutions, we are able to compare different scenarios and ways to conduct anesthesia, which enriches the text content. Lastly, we would like to acknowledge the readers of this handbook, who are responsible for modern, high-quality and safe anesthesia. These last words are dedicated to the new generation of anesthesiologists; we hope that with this handbook they acquire new knowledge and benefit from our experience.

Eugenio Daniel Martínez Hurtado Department of Anesthesiology and Intensive Care University Hospital Infanta Leonor Madrid, SpainMonica San Juan Álvarez Department of Anesthesiology and Intensive Care University Hospital Severo Ochoa Madrid, SpainMarta Chacón Castillo Department of Anesthesiology and Intensive Care

List of Contributors

Adriana Carolina Orozco VinascoDepartment of Anesthesiology and Critical Care, University Hospital Severo Ochoa, Leganes, Madrid, SpainAleix Clusella MoyaDepartment of Anesthesiology, Hospital Sant Joan de Déu Esplugues, Barcelona, SpainAlicia Ruiz EscobarDepartment of Anaesthesiology and Intensive Care, Hospital Universitario Infanta Leonor, Madrid, SpainAna Plaza MoralHospital Clinic, University of Barcelona, Barcelona, SpainAndrea Alejandra Rodriguez EsteveDepartment of Anaesthesiology, Hospital Universitario Fundacion Alcorcon, Madrid, SpainAndrea Alejandra Rodriguez EsteveDepartment of Anaesthesiology, Hospital Universitario Fundacion Alcorcon, Madrid, SpainAniza S. González LumbrerasHospital Angeles Lomas, 52763 Méx., MexicoAnna Conesa MariegesHospital Universitario Vall d’Hebron, Barcelona, SpainAntonio López HernándezHospital Clinic, University of Barcelona, Barcelona, SpainBlanca Gómez del Pulgar VázquezDepartment of Anesthesiology and Critical Care, University Hospital Severo Ochoa, Leganes, Madrid, SpainCarlos Hugo Salazar ZamoranoDepartment of Anesthesiology and Critical Care, Hospital Universitario 12 de Octubre, Madrid, SpainCarmen Gomar SanchoUniversity of Barcelona and University Vic-Central de Catalonia, Barcelona, SpainCarreño Anna PascualDepartment of Anesthesiology, Hospital Sant Joan de Déu, Esplugues, Barcelona, SpainCarolina Forero CortésMaternal and Child Anesthesiology. Sant Joan de Dèu Hospital, Barcelona, SpainClara Hernández CeraMaternal and Child Anesthesiology. Sant Joan de Dèu Hospital, Barcelona, SpainClara Isabel Fernandez SánchezDepartment of Anesthesiology and Critical Care, University Hospital Severo Ochoa, Leganes, Madrid, SpainDaniel Vieyra CortésGenesis Reproductive Medicine, Hospital Ángeles del Pedregal, 10700 Ciudad de México, CDMX, México Universidad Nacional Autónoma de México, 04510 Ciudad de México, CDMX, MéxicoDavid Orozco VinascoDepartment of Anesthesiology and Critical Care, Clínica Calle 100, Bogotá, ColombiaElena Sánchez RoyoHospital Universitario Vall d’Hebron, Barcelona, SpainElena Suárez EdoHospital Universitario Vall d’Hebron, Barcelona, SpainEnrique Alonso RodríguezDepartment of Anesthesiology and Critical Care, University Hospital Severo Ochoa, Leganes, Madrid, SpainEsperanza Martin MateosDepartment of Anesthesiology, Hospital Sant Joan de Déu, Esplugues Barcelona, SpainEugenio D. Martinez HurtadoDepartment of Anaesthesiology and Intensive Care, Hospital Universitario Infanta Leonor, Madrid, SpainEva Maria Blazquez GomezDepartment of Anesthesiology, Hospital Sant Joan de Déu, Esplugues, Barcelona, SpainInés Almagro VidalDepartment of Anesthesiology and Intensive Care, Hospital Central de la Defensa - Gómez Ulla, Madrid, SpainIrene González del PozoDepartment of Anesthesiology and Intensive Care, Hospital Central de la Defensa - Gómez Ulla, Madrid, SpainIrene León CarsíHospital Clinic, University of Barcelona, Barcelona, SpainIrene Riquelme OsadoDepartment of Anesthesia, Acute Pain and Chronic Pain, Hospital Sanitas La Moraleja, Madrid, SpainJavier Alcázar EsterasDepartment of Anesthesia, Acute Pain and Chronic Pain, Hospital Universitario de Torrejón de Ardoz, Madrid, SpainJuan José Correa BarreraDepartment of Anesthesiology and Critical Care, University Hospital Severo Ochoa, Leganes, Madrid, SpainLaura Fernandez TellezDepartment of Anaesthesiology, Hospital Universitario Fundacion Alcorcon, Madrid, SpainLaura Reviriego AgudoDepartment of Anesthesiology and Intensive Care, Hospital Clínico Universitario, Valencia, SpainLigia María Pérez CubíasMaternal and Child Anesthesiology, Sant Joan de Dèu Hospital, Barcelona, SpainLuis Humberto García LorantHospital Angeles Lomas, 52763 Méx., MexicoMaría de la Flor RobledoDepartment of Anesthesiology and Critical Care, University Hospital Severo Ochoa, Leganes, Madrid, SpainMaría Gómez RojoDepartment of Anesthesiology and Intensive Care, Hospital Ramon y Cajal, Madrid, SpainMaria Luz Serrano RodriguezDepartment of Anaesthesiology, Hospital Universitario Fundacion Alcorcon, Madrid, SpainMaría Mercedes García DomínguezDepartment of Anesthesiology and Critical Care Hospital, Universitario Infanta Leonor, Madrid, SpainMarina Vendrell JordàHospital Clinic, University of Barcelona, Barcelona, SpainMarta Chacón CastilloDepartment of Anesthesiology and Critical Care, University Hospital Severo Ochoa, Leganes, Madrid, SpainMarta López DoueilDepartment of Anesthesiology, Hospital Virtual Valdecilla, Santander, SpainMarta María Galnares GómezMidwifery Unit, Hospital Virtual Valdecilla, Santander, SpainMiguel Ángel Fernández VaqueroDepartment of Anesthesiology and Critical Care, Clínica Universidad de Navarra, Madrid, SpainMireia Pozo AlbiolDepartment of Anesthesiology, Hospital Sant Joan de Déu, Esplugues, Barcelona, SpainMiriam Sánchez MerchanteDepartment of Anesthesiology and Critical Care, Hospital Universitario Fundación Alcorcón, Madrid, SpainMónica San Juan ÁlvarezDepartment of Anesthesiology and Critical Care, University Hospital Severo Ochoa, Leganes, Madrid, SpainMonir Kabiri SacramentoDepartment of Anesthesiology and Critical Care, Grupo Hospitalario Universitario, Hospital Universitario HM, Madrid, SpainMontserrat Franco CabreraHospital Angeles Lomas, 52763 Méx., México Hospital Ángeles Pedregal, 05370 Ciudad de México, CDMX, México Hospital Español de México, 11520 Ciudad de México, CDMX, México The American British Cowdray Medical Center (ABC), 05370 Ciudad de México, CDMX, MéxicoNatalia Martos GisbertDepartment of Anesthesiology and Critical Care, University Hospital Severo Ochoa, Leganés, Madrid, SpainPablo Solís MuñozDepartment of Anesthesiology and Critical Care, University Hospital Severo Ochoa Leganes, Madrid, SpainPatricia Alfaro de la TorreDepartment of Anesthesia, Acute Pain and Chronic Pain, Hospital Joan XXIII, Tarragona, SpainPaula Agostina VulloDepartment of Anesthesiology and Intensive Care, Hospital Central de la Defensa - Gómez Ulla, Madrid, SpainPedro Charco MoraDepartment of Anesthesiology and Intensive Care, Hospital Universitario y Politécnico La Fe, Valencia, SpainPilar Hernández PintoDepartment of Anesthesiology, Hospital Virtual Valdecilla, Santander, SpainRodrigo Sancho CarranchoDepartment of Anesthesiology, Hospital Virtual Valdecilla, Santander, SpainRosa Fernández GarcíaDepartment of Anesthesia Acute Pain and Chronic Pain, Hospital Universitario Príncipe de Asturias, Madrid, SpainSara Hervilla EzquerraDepartment of Anaesthesiology, Hospital Universitario Fundacion Alcorcon, Madrid, SpainSerafín Alonso VilaHospital Universitario Vall d’Hebron, Barcelona, SpainSergi Boada PieDepartment of Anesthesia, Acute Pain and Chronic Pain, Hospital Joan XXIII, Tarragonay, SpainSusana Manrique MuñozHospital Universitario Vall d’Hebron, Barcelona, SpainYobanys Rodríguez TéllezMaternal and Child Anesthesiology, Sant Joan de Dèu Hospital, Barcelona, Spain

Fetomaternal Physiology: Physiological Changes during Pregnancy

Adriana Carolina Orozco Vinasco1,*,Mónica San Juan Álvarez2,David Orozco Vinasco2
1 Department of Anesthesiology and Critical Care, University Hospital Severo Ochoa, Leganes, Madrid, Spain
2 Department of Anesthesiology and Critical Care, Clínica Calle 100, Bogotá, Colombia

Abstract

Anesthesia during pregnancy is challenging due to the extreme physiological and anatomical changes that occur. Deep knowledge of these changes and how they influence anesthesia is critical in order to offer safe anesthetic care to both, mother and the child. In this chapter, we will review the main features that occur in the respiratory, cardiovascular, central nervous, renal, and gastrointestinal systems, among others, and how it affects pharmacodynamics, pharmacokinetics, airway management and conduct of anesthesia. Fetomaternal circulation and fetal physiology focused on anesthesia will also be discussed.

Keywords: Anesthesia, Fetoplacental circulation, Fetal-maternal exchange, Placenta, Pregnancy.
*Corresponding author Adriana Carolina Orozco Vinasco: Department of Anesthesiology and Critical Care, University Hospital Severo Ochoa, Leganes, Madrid, Spain; E-mail: [email protected]

INTRODUCTION

Changes during pregnancy are meant to serve a double objective: providing fetal well being, guaranteeing oxygen, nutrients supply, carbon dioxide and waste products removal, and preparing the maternal body for labor, delivery and lactation.

These changes can persist weeks after delivery and some may be long lasting [1, 2]. Maternal changes during pregnancy changes are summarized in Table 1.

Respiratory System

Changes begin in the first trimester. Higher basal metabolism causes oxygen consumption to augment by about 60%; subsequently, a larger amount of carbon

dioxide is produced. Greater minute ventilation is required to cope with this demand. Progesterone has stimulating effects on respiration, by raising sensitivity to carbon dioxide in the central nervous system (CNS). The net result is an increase of 50% in minute ventilation due, mostly, to higher tidal volume, causing physiological hypocapnia of around 30 mmHg. Renal compensation occurs so pH remains near 7.44. Despite this the hemoglobin dissociation curve shifts to the right due to an increase in 2,3-bisphosphoglycerate raising maternal P50 (partial pressure at which hemoglobin is 50% saturated), easing the offload of oxygen across the placenta [1-3]. Residual volume (RV) and residual functional capacity (RFC) are diminished (15% and 20%, respectively), the latter sometimes exceeded by closing capacity (CC). Owing to raised oxygen consumption and changes in RV and RFC, pregnant women desaturate more rapidly than their non-pregnant counterparts [3-5]. Inhalational anesthetics are up taken and eliminated more rapidly due to the greater minute ventilation and cardiac output [5, 6].

Table 1Main physiological and anatomical changes during pregnancy.Respiratory ChangesOxygen consumption+ 60%Minute ventilation+ 50%PCO2Decrease to 30 mmHgResidual volume- 15%Functional residual capacity- 20%Airway capillariesEngorgementDiaphragmDisplaced cephaladRibsFlaringCardiovascularLeft ventricle mass+ 50%Cardiac output+ 40-50%Heart rate+ 25%Stroke volume+ 25%Systemic/Pulmonary vascular resistance- 20%/-34%Systolic blood pressure- 6-8%Diastolic blood pressure- 20-25%Hematological and Fluid ChangesRed blood cells mass+ 25%Hemoglobin and hematocrit-15%White blood cells during laborRaise 9-11 x 109/L Up to 15 x109/LTotal plasma protein- 18%Plasmatic cholinesterase- 20-25%Colloid osmotic pressure-18%Plasma volume+ 50%Extravascular volume If edema+ 1.7 L + 5 LPlatelets=/-10%Prothrombin time/Activated partial thromboplastin time- 20%Antithrombin III- 10%Protein SDecreaseProtein CNo changeFibrinolysisRaiseI, VII, IX, VIII factors+ 100- 150%X, XII factors+ 30%XI, XIII factors- 40-50%Renal ChangesRenal blood flow, Glomerular filtration rate+ 50%Na+, H2O and Cl- reabsorption+ 50%Creatinine clearanceRaiseSerum creatinineDecrease (~0.5-0.6 mg/dL)Glucose, amino acids and uric acid reabsorptionDecreaseUrinary tract smooth muscleRelaxationHCO3- excretionRaiseGastrointestinal and Hepatobiliary ChangesEsophagusDisplaced cephaladLower esophageal sphincter pressureDecreaseBarrier pressure- 45-50%Alkaline phosphataseRaise up to 4 timesBilirubin, lactic deshydrogenase and transaminasesNo change or raiseCholecystokininDecreaseNeurological ChangesMinimum alveolar concentration- 40%Pain thresholdRaiseEpidural space sizeDecreaseLocal anesthetic requirements- 40%Cerebral spinal fluid volumeDecreaseSympathetic toneRaiseMetabolic and Endocrine ChangesMetabolic basal rate+ 15%Cortisol level and half lifeIncreaseInsulinResistanceImmunological ChangesT-cell activityDecreaseCell immunityDecreaseImmunoglobulin GDecreaseImmunoglobulin ERaiseNeutrophilsRaiseNeutrophil chemotaxis and adherenceDecrease

Regarding anatomical changes, capillaries in the upper airway are engorged, causing edema and friability. Facemask ventilation and intubation may be hindered. Thoracic cage diameter is increased by 5-7 cm due to flaring of the ribs, and thus restricting movement. Changes in the subcostal angle persist after delivery. The diaphragm is displaced cephalad by the growing uterus [2, 4, 5].

Compared to pre-gestation values, during labor, minute ventilation may reach as high as 200% and oxygen consumption rises up to 75%. FRC returns to the pre-pregnancy values after two weeks. After birth, minute ventilation, PCO2 and oxygen consumption gradually return to pre-gestational values during the next 6 to 8 weeks [2].

Cardiovascular Changes

The gravid uterus causes the heart to move anteriorly and to the left, so a left axis can be seen in ECG. Other electrocardiographic changes include T flattening and ST depression. Left ventricular hypertrophy is also common. A raise in cardiac output (CO) of 40-50% is seen at term due to greater heart rate (+25%) and stroke volume (+25%) [2-4]. The increase in cardiac output may cause a reduction in the latency of drugs acting peripherally [6]. Blood flow is diverted to the uterus, but is also increased in the kidneys and skin, when compared to non-pregnant women. A supplementary CO increase occurs during labor (40-60%, depending on contractions) and immediately after labor, where it can meet 80-100% when compared to values before labor. This occurs because of placental transfusion and aortocaval decompression [1, 2, 4]. Systemic vascular resistance (SVR) decreases by 20% due to both, vasodilatory mediators (estrogens, prostacyclin, progesterone) and low resistance bed (uteroplacental). Diastolic pressure is more affected than systolic (decrease of 25% and 8%, respectively). Pulmonary vascular resistance declines by 34%. Hypotension can occur in the supine position due to the compression of the inferior vena cava and aorta, which leads to a drop in CO. This effect is more pronounced when sympathetic activity, one of the compensatory mechanisms, is attenuated (e.g. spinal anesthesia). The aortocaval compression causes right heart filling pressures to diminish and lower limbs venous hypertension. Lateral positioning may partially relieve hypotension [2-4]. After delivery, CO returns to pregnancy levels after 24 hours, and to pre-pregnancy values after up to 24 weeks; the heart rate becomes normal after two weeks [2, 3].

Hematological and Fluid Status Changes

At term, despite a 25% raise in red blood cell mass, physiological anemia (hemoglobin and hematocrit decrease by 15%) takes place on a dilutional basis, due to a 50% increase in plasma volume. The latter is the consequence of changes in the release of renin and aldosterone, as well as other hormones. These mechanisms compensate the blood loss during delivery. After which, placental autotransfusion should outweigh the physiological blood loss. Extravascular volume is as well increased by 1.7 L in the absence of edema; in case it is present, the raise may be as much as 5L [3, 4]. Plasma protein concentration is reduced and consequently is colloid osmotic pressure. Plasma cholinesterase is reduced up to 25% and thus the effects of succinylcholine may be longer lasting, but not clinically relevant. Infection unrelated leukocytosis develops throughout gestation, reaching 15 x 109/L during labor. Nevertheless, polymorphonuclear cells function is diminished accounting for reduced neutrophil chemotaxis and adherence [2, 3].

During pregnancy, the concentration of most coagulation factors is augmented, noticeably of factors I, VII, VII and IX; and mildly of X and XII. Factors II and V hover pre-pregnancy values, whereas factors XI and XII are decreased. Regarding anticoagulation factors, protein C remains unchanged and antithrombin III and protein S are diminished. Blood viscosity is augmented. All these changes result in hypercoagulability. There is increased platelet consumption and turnover that, along with dilution, may lead to a decrease of up to 10% [1, 3]. Fibrinolysis is enhanced leading to a 100% rise in fibrin degradation products [3]. Coagulation and anticoagulation factors return to basal values after two weeks. The rest of the hematological and fluid changes reverse after 8 weeks [2].

Renal Changes

Renal blood flow and glomerular filtration rate increase by 50% because of vasodilation, and thus is creatinine clearance. Therefore, a decrease in serum creatinine is observed. Sodium, water and chloride reabsorption are enhanced up to 50% as a result of hormones with a mineralocorticoid effect such as cortisol, renin, aldosterone and progesterone. However, glucose, amino acids, and uric acid reabsorption decline, hence, proteinuria is considered above 300 mg per day. Bicarbonate excretion is raised to counteract the increase in minute ventilation [2, 3]. Renal changes cause unaltered drug elimination to increase, e.g. cephalosporins [6].

Progesterone has a potassium-sparing effect and can also lead to urinary stasis due to smooth muscle relaxation in the urinary tract. Hydronephrosis incidence is 80% in the second trimester. Therefore, during pregnancy, there might be more urinary tract infections [3].

Gastrointestinal and Hepatobiliary Changes

Bioavailability after oral absorption remains unchanged [6]. From mid-pregnancy onwards, women are at higher risk of regurgitation and aspiration, so they should be considered full stomach [4, 5]. The gravid uterus raises intrabdominal pressure and displaces the esophagus cephalad, lowering the inferior esophageal sphincter pressure. Estrogens and progesterone further reduce this pressure owing to muscle-relaxing effects. Gastrin production by the placenta may increase gastric acid production [3]. These factors contribute to the development of gastroesophageal reflux. Gastric emptying is not delayed, except for labor and delivery, followed by return to the basal status within 18 hours after delivery [2, 5].

Hepatic blood flow remains at pre-pregnancy values, but minor increases in hepatic markers, such as bilirubin, lactic dehydrogenase and transaminases, may occur [2-4]. However, the activity of most P450 cytochrome enzymes is increased, affecting the metabolism of phenytoin, midazolam and morphine [2].

There is a supplementary production of alkaline phosphatase by the placenta; hence its value is raised up to four times. Cholecystokinin release is diminished and thus is gallbladder contraction. Therefore, pregnant patients are prone to gallstone formation [2, 4].

Neurological Changes

By eight to twelve weeks of gestation, a 40% reduction in the minimum alveolar concentration (MAC) for inhaled anesthetic agents takes place. The underlying mechanism is unclear, but is probably a consequence of the rise in progesterone, β- endorphin and other endocrine factors [2-5]. There is also a rise in pain threshold, due, apparently, to the actions of estrogens and progesterone in spinal opioid receptors and in descending noradrenergic pathways [2].

During pregnancy, epidural venous plexus is engorged, thus conditioning a decrease in the size of the epidural space and in the cerebral spinal fluid (CSF) volume in the subarachnoid space [3]. There may be an increase in epidural fat, further shrinking the epidural space. At term, local anesthetic requirements in neuroaxial techniques are diminished by 40% approximately. Nevertheless, these changes begin in the first trimester (before aortocaval compression and the other changes occur), suggesting other mechanisms [2-4, 6].

An increase in the sympathetic tone takes place to neutralize the effects of aortocaval compression. As said before, the sympathetic block can result in profound hypotension [3].

Metabolic and Endocrine Changes

Several factors contribute to a 15% augmentation in metabolic basal rate, especially after mid pregnancy [1, 3, 5]. Thyroid gland size and function are increased, but free plasma thyroid hormones do not change due to a two-fold increase in Thyroid-binding globulin level. Cortisol plasma level is increased, and the half life is lengthened. Pituitary gland increases in size thus becoming vulnerable to ischemia and hemorrhage as its perfusion occurs at venous pressure [3].

Despite a rise in the number of ß cells in the pancreas and of the insulin receptor sites, a resistance to insulin occurs. This is probably the result of cortisol, prolactin, human placental lactogen and other hormones. Pregnant women are prone to hyperglycemia and ketosis; reversion of this phenomenon occurs 24 hours after delivery [2, 3].

Melanocyte stimulating hormone is increased, and causes hyperpigmentation [3].

Immunological Changes

The maternal immunological system is modified to offer “tolerance” to the fetus, as it expresses foreign (paternal) antigens. The main changes are summarized in Table 1.

Other Changes

Fetus, placenta, amniotic fluid and increase in maternal water and fat, cause pregnant women to gain 10-12 kg (17%) in average. This conditions a greater distribution volume of both, lipo- and hydrophilic drugs. Nevertheless, the reduction in plasma proteins causes an increase in plasma-free drug, due to reduced binding, and toxicity is more likely [3, 4, 6].

Breasts are enlarged and may interfere with ventilation and intubation [2-4]. Blood flow to mucosa and skin is increased; if drugs are administered to these areas, absorption may be enhanced [6].

The placenta produces relaxin, which causes generalized relaxation in ligaments. Lumbar lordosis is increased and it may alter neuroaxial distribution of anesthetics [2, 3].

PLACENTAL PHYSIOLOGY

The placenta is a large area of exchange between the mother and the fetus; it supplies blood and nutrients, and removes waste products. The placenta contains maternal tissue (intervillous space) and fetal tissues (chorionic villi). Its greatest growth occurs in the third trimester, when it usually reaches a weight of about 500 g [3, 4]. The placenta has also endocrine and immunological functions and is metabolically active by producing enzymes involved in biotransformation [2] (Table 2).

Table 2Other functions of the placenta.- Endocrine - Human placental lactogen - Human chorionic gonadotrophin - Relaxin - Estrogens and/or Progesterone - Thyroid- stimulating hormone - Prostaglandins - Immunological - Barrier to some infections

Blood Supply

The uterine arteries provide blood to the placenta through the spiral arteries, which penetrate the intervillous space, where the exchange takes place. In the nongravid uterus, blood flow is about 100 ml/min, but it may be as high as 800 ml/min (500-800 ml/min) by term. Only 20% blood flow is distributed in the myometrium. Placental blood flow is dependent on maternal CO, as it lacks autoregulation. So if hypotension occurs (e.g. hypovolemia, sympathetic block, aortocaval compression) uterine blood flow can be severely impaired. Normally, uterine arteries remain dilated due to several humoral factors such as estrogens, prostacyclin and nitric oxide. Nevertheless, endogenous and exogenous vasoconstrictors, as well as preeclampsia/eclampsia, can alter vascular resistance thus decreasing uterine blood flow. Another situation, where uterine blood flow can decrease, is when there is a raise in venous pressure, for example during contractions, aortocaval compression and during the second stage of labor. Normal placental circulation is a low resistance system [3, 4].

Transfer Across the Placenta

Oxygen and Carbon Dioxide

Oxygen and carbon dioxide cross the placenta by simple diffusion. The placenta is about 20 times more permeable to carbon dioxide than oxygen; only dissolved carbon dioxide crosses.

The main determinant of oxygen transfer is the gradient between maternal and fetal PO2, but fetal hemoglobin concentration is also important. Maternal hemoglobin dissociation curve is shifted to the right so it has less affinity for oxygen, and conversely fetal hemoglobin is left shifted, so its affinity for oxygen is higher. Furthermore, fetal pH increases during exchange (increasing affinity for oxygen by further shifting the dissociation curve to the left), because CO2 is transferred to the mother, whose blood pH in turn decreases thus enhancing oxygen offload. This phenomenon is known as the double Bohr effect and 2-8% of oxygen is transferred by this mechanism [1, 2].

A similar effect, the double Haldane effect occurs, regarding carbon dioxide transport. As maternal blood becomes more deoxygenated, its affinity for carbon dioxide increases, while as fetal blood becomes more oxygenated, carbon dioxide offload is enhanced. This phenomenon is responsible for up to 46% of carbon dioxide transport across the placenta. There is also a favorable carbon dioxide concentration gradient between the fetus and the mother [1, 2].

Nutrients (summarized in Table 3).

Table 3Placental transfer mechanism of nutrients.NutrientTransport Mechanism- Sodium - Water - Potassium - Fatty acids- Simple diffusion- Glucose- Facilitated diffusion- Calcium - Iron - Iodine - Phosphate- Active transport- Amino acids- Secondary active transport (linked to sodium)- Proteins (immunoglobulin G)- PinocytosisAdapted from: Mushambi, M. Physiology of pregnancy. In: Lin, T, et al., Eds. Fundamentals of anaesthesia. 4th ed. Cambridge: Cambridge University Press, 2016; pp. 512-30.

Drug Transfer

Most drugs, except for muscle relaxants, cross the placenta. Several factors are involved in drug transfer degrees.

High Lipid Solubility: Volatile and intravenous induction drugs are highly lipophilic and cross the placenta, for example, halothane, nitrous oxide, sodium thiopental, ketamine, and propofol. The latter is greatly protein bound, so its transfer is increased when maternal proteins are lowered (e.g. preeclampsia). There is a hazard of diffusion hypoxia in the newborn, in case nitrous oxide is used. Benzodiazepines also cross, as they are lipophilic and non-ionized.Molecular weight: Substances weighing <500-600 daltons, such as most drugs, cross the placenta readily. Succinylcholine has a low molecular weight, but is highly ionizated, so crossing is hindered [2, 3].Ionization: Only non-ionized fraction of the drug crosses the placenta. Most drugs used in the anesthetic field have high non-ionized fraction. Muscle relaxants are an exception; they do not cross the placenta as they are poorly ionizated and are not very lipophilic [3, 4].pH: It can alter ionization, especially if the pKa of the drug is near physiological pH, whereas even small pH changes can cause great changes in ionization. Furthermore, fetal pH is always lower, so once some un-ionized drugs cross the placenta, they became ionized in fetal blood, hindering a reverse diffusion. This can cause accumulation and happens with weak bases such as opioids and local anesthetics. This phenomenon is known as “ion trapping” and occurs especially when the fetal pH decreases, e.g. fetal distress [2-4].Protein binding: During pregnancy, proteins decline globally and it can result in a major free drug fraction that diffuses across the placenta. Situations where binding is further decreased include acidosis and preeclampsia [3, 4].Fetomaternal gradient: when the underlying transfer mechanism is simple diffusion [3].Uterine blood flow: It affects drugs that readily cross the placenta. At a higher blood flow, a greater transfer occurs [3].

Fetal Circulation

At term, the fetus will have a blood volume between 120-160 ml/kg [4]. Before birth, the lungs and the liver are poorly functional, so only a small blood fraction will cross these organs. Blood enters the fetus via one umbilical vein, then it flow diverts, with the majority passing trough the ductus venosus directly to the inferior vena cava (IVC) and thus bypassing the liver. Most of the well-oxygenated blood entering the right atrium passes across the foramen ovale to the left atrium, then to the left atrium and aorta, from where it is distributed among arteries to the head and limbs. Deoxygenated blood entering the right atrium trough the superior vena cava (SVC) passes though the tricuspid valve to the rigth ventricle and then to the pulmonary artery. Most of this blood crosses the ductus arteriosus to the descending aorta, only a small fraction reaches the lungs. The blood returns to the placenta by two umbilical arteries (Fig. 1) [1, 4, 7].

CONCLUSION

Changes during pregnancy are meant to serve a double objective: providing fetal well being and preparing the maternal body for labor, delivery and lactation.

Owing raised oxygen consumption and changes in RV and RFC, pregnant women desaturate more rapidly, than their non-pregnant counterparts.

Supine Hypotension can occur due to the compression of inferior vena cava and aorta, which leads to a drop in CO, being more pronounced when sympathetic activity is attenuated. Dilutional anemia and hypercoagulability are typical during pregancy.

At term, the requirements of both local anesthetics in neuroaxial tecniques and MAC, lessen by 40%. Most drugs, except for muscle relaxants, cross the placenta.

Deep knowledge of the physiological and anatomical changes during pregnancy and how they influence anesthesia is critical in order to offer a safe anesthetic care to both, mother and child.

Fig. (1)) Fetal circulation.

CONSENT FOR PUBLICATION

Not applicable.

CONFLICT OF INTEREST

The authors declare no conflict of interest, financial or otherwise.

ACKNOWLEDGEMENT

Declared none.

REFERENCES

[1]Hall JE. HME Guyton and Hall Textbook of Medical Physiology (International Edition.) International Edition.20201045-59.[2]Kacmar RMGR. Physiologic Changes of Pregnancy. In: Chestnut DH, eds. Chestnut’s obstetric anesthesia: principles and practice (6th ed.) 6th ed.Chestnut DH. 201913-37.[3]Lin T. M. M. Physiology of pregnancy. Fundamentals of anaesthesia (4th ed.) 4th ed.2016512-30.[4]Flood PR. Anestesia en Obstetricia. In: Miller RD, eds. Anestesia (8th ed.) 8th ed.Miller RD. 20152328-58.[5]Braveman F, Scavone BM, Blessing ML. Obstetric Anesthesia. In: Barash PG, eds. Clinical Anesthesia (8th ed.) 8th ed.Barash PG. 20172841-925.[6]Chestnut DH. T. G. Pharmacology during pregnancy and lactation. Chestnut’s obstetric anesthesia: principles and practice (6th ed.) 6th ed.2019313-35.[7]Lin T. A. W. Fetal and newborn physiology. Fundamentals of anaesthesia 4th ed 2016531-6.

Safety in the Obstetric Patient: Simulation Training for Anesthesiologists in the Obstetrics Field

Pilar Hernández Pinto1,*,Marta López Doueil1,Rodrigo Sancho Carrancho1,Marta María Galnares Gómez2
1 Department of Anesthesiology, Hospital Virtual Valdecilla, Santander, Spain
2 Midwifery Unit, Hospital Virtual Valdecilla, Santander, Spain

Abstract

The principal goal of health systems is to provide safe and quality healthcare for the patient. Deficiencies in the environment in which obstetric care is provided, inadequate teamwork and communication, and poor individual performance during emergencies have been identified as preventable causes of harm to obstetric patients. There is growing evidence about training in Emergency Obstetric Care (EmOC) that reduces the risk of maternal and newborn mortality and morbidity. The Institute of Medicine identifies team-based training and simulation as methods to improve patients’ safety, especially in the obstetrics field, these may add value to it. Recent research works review the effectiveness of training in EmOC and the use of simulation in improved health outcomes. It remains unclear whether this translates into improved patient outcomes.

Keywords: Communication, Competency-Based Medical Education, Emergency Obstetric Care, Maternal Mortality, Multidisciplinary Care, Nontechnical and Technical Skills, Obstetric Anaesthesia, Patient Safety, Simulation, Teamwork, Team Training.
*Corresponding author Pilar Hernández Pinto: Department of Anesthesiology, Hospital Virtual Valdecilla, Santander, Spain; E-mail: [email protected]

INTRODUCTION

Safety and Quality in Obstetrics

The Institute of Medicine (IOM) recognizes patient safety as indistinguishable from the provision of quality healthcare. Safety and quality are closely intertwined. Safety methodologies try to avoid preventable adverse events (pAEs) while quality projects aspire to achieve the best possible results as health outcomes, patient satisfaction, access, and equity [1, 2].

Patient safety and quality improvement in obstetrics is an important issue having three factors: obstetric admissions are one of the main reasons for hospitalization; secondly, family's expectations for a healthy and happy outcome, and lastly the increase in medical litigation claims and trials with costs associated [3]. At a global level, the goal is to achieve safe and quality care in obstetrics and labor settings with a reduction of maternal and neonatal morbidity and mortality.

Maternal survival has significantly enhanced since the incorporation of the United Nations Millennium Development Goal (MDGs), the maternal mortality ratio (MMR) has decreased in 43.9% of the countries from 1990 to 2015 [4]. However, MMR remains high in many parts of the world, especially in low-income and middle-income countries (LMICs). Nearly 50% of these direct maternal deaths are caused by hemorrhage and hypertensive disorders of pregnancy. In high-income countries (HICs), indirect maternal deaths (underlying cardiac and embolic diseases and associated conditions like obesity, multiple gestations, and assisted reproductive technologies) outnumber direct deaths. The United Nations Sustainable Development Goal (SDG) aspires to reduce the global MMR to less than 70 per 100.000 live births by the year 2030. Evidence suggests that the majority of these and other potentially life-threatening complications such as sepsis, complications from delivery, and unsafe abortion could be prevented by timely and effective emergency obstetric care [5, 6]. However, it has been shown that more than half of all women with obstetric complications lack access to this life-saving intervention [7].

Strategies to Improve Quality in Obstetrics

The minimum care package required during pregnancy and childbirth addresses the main causes of maternal death, stillbirth and early neonatal death referred to as emergency obstetric care (EmOC) [8]. The basic components include antibiotics, oxytocic drugs, anticonvulsants, manual removal of placenta, removal of retained products of conception, assisted vaginal delivery and resuscitation of the newborn baby using a bag and mask. It has been argued that a more comprehensive set of signal functions includes caesarean section, blood transfusion and care for small and sick newborns [9]. In many cases, the required infrastructure (as equipment and consumables) is available, but staff may lack the competency to provide all EmOC signal functions. EmOC relies on the presence of suitably trained and competent healthcare providers. Short competency-based training in EmOC results in significant improvements in healthcare provider knowledge/skills and change in clinical practice [9]. Regular training is recommended and, in some cases, mandatory, to ensure the continued accreditation of healthcare providers. In the early 1990s, EmOC training courses such as the Advanced Life Support in obstetrics (ALSO) and Managing Obstetric Emergencies and Trauma (MOET) were developed to meet this need in high-income settings. However, in the era of the SDGs, competition for limited resources is high, and the cost-effectiveness of training packages is important to aid decision-makers in the most efficient use of resources and assess value-for-money. Very little is published about the costs and cost-effectiveness of training [10]. The wider health, social and economic benefits resulting from relatively small investments in training can be substantial, suggesting that these investments are likely to be of good value for money [11].

Guidelines and protocols endorsed by maternal safety organizations have been developed. They emphasize early and aggressive management of obstetric hemorrhage starting with risk factor identification, rapid diagnosis, timely management and multidisciplinary review. Systems to accelerate the initial response include an obstetric emergency response team, a postpartum hemorrhage cart (“PPH cart”) and emergency hemorrhage medication packs.

Guidelines and protocols for acute management of hypertension focus on early diagnosis, prompt antihypertensive therapy, and seizure prophylaxis with magnesium sulfate [12].

How About Safety in the Obstetric Field?

The combination of gradually more complex systems controlled by “imperfect” humans is the basis of the patient safety problem in current medicine.

The World Health Organization (WHO) defines patient safety as the “absence of preventable harm to a patient during the process of health care and reduction of risk of unnecessary harm associated with health care to an acceptable minimum”.

The Institute of Medicine observed that the root cause of 70% of errors in general and up to 80% of obstetric sentinel events can be traced to the process of team skills [13]. As many as 9% of pregnant patients will experience an adverse event during their delivery and up to 87% of adverse events in the obstetric population are deemed preventable [14]. In 2004, Joint Commission Sentinel Event Alert studied 47 perinatal deaths and identified non-medical factors topped the list of identified root causes, particularly communication and organizational culture, which contributed significantly to deficient perinatal outcomes [15]. This sentinel event alert was essential for clarifying obstetric safety threats and for risk reduction strategies that any unit starting a patient safety program should focus on.

Taking into account the five root causes of adverse perinatal events from the Joint Commission Sentinel Event Alert, possible safety interventions would focus on

communication, organizational culture, staff competence, orientation, and training, and fetal monitoring.

Communication: Staff resource management is a method to improve communication and coordination between members of a healthcare team. Topics covered in staff resources management programs such as Team STEPPS (Team Strategies and Tools to Enhance Performance and Patient Safety) and Med Teams address four main skills: leadership, situation monitoring, mutual support and communication. Team STEPPS identified communication tools such as check-back (or closed loop communication) to ensure the recipient has understood the sender´s information correctly, SBAR (an acronym standing for situation, background, assessment and recommendation) which can be used when requesting help in emergency situations, call-out, which is used to convey critical information to a larger group of people efficiently and checklist for handovers, have improved both teamwork and relevant outcomes [16].Organizational Culture: It integrates safety thinking and practices into clinical activities, changing from the traditional culture of hierarchy and blames a just culture for uncovering the systems that lead to risky activities or adverse outcomes. Safety Attitudes Questionnaire is the only safety climate survey that demonstrated a relationship between improvements in safety culture and patient outcomes, both in general medicine and obstetrics.Staff Competence: Competence is the ability to do something successfully and competently. One way to achieve this is by developing protocols, guidelines and checklists from a multidisciplinary process. This allows for the application of evidence-based standards and the creation of a shared mental model of how care should be provided in certain conditions and situations.Orientation and Training: To improve practical and communication skills and to train for unusual events.Fetal Monitoring: There is very little evidence of the effect of accreditation in fetal monitoring on outcomes.

Strategies to Improve Safety in Obstetrics

Most safety strategies need multidimensional solutions, including health provider education and training, work to improve team coordination and communication, and organization of administrative and structural processes. The growing effort of healthcare institutions to implementing training programs to address these issues has raised new questions about how to best train for effective performance in such systems.

Simulation in obstetrics has been rapidly expanding and the amount of published research in this area has increased in recent years. In 2011, Riley et al. [17] showed that establishing multidisciplinary training programs and simulation exercises improved perinatal outcomes. The introduction of shoulder dystocia training for all maternity staff was associated with improved management and neonatal outcomes of births complicated by shoulder dystocia [18]. Simulation has been tested as an educational tool and as an intervention to improve outcomes in specific drills scenarios such as surgical delivery, eclampsia, postpartum hemorrhage and shoulder dystocia. Clinical topics in which simulation training is associated with improved clinical outcomes are: shoulder dystocia management, forceps delivery, emergency unplanned Cesarean delivery, postpartum hemorrhage, and neonatal resuscitation [19].

The management of obstetric emergencies, not only requires technical ability but also requires a range of non-technical skills such as communication, leadership and situational awareness. Simulation has been used to train technical and nontechnical skills, to review the environmental design of an existing or new obstetric unit, and is effective in assisting in the implementation of new technology or in the optimization of a plan [20].

Obstetric emergencies and team-based drills are common in obstetric simulation curricula. Simulation-Based Team Training (SBTT) and Multidisciplinar Simulation-Based Team Training (MD-SBTT) programmes have been developed and implemented across the globe [21]. The most popular are MOSES (Multidisciplinary obstetric simulated emergency scenarios), ESMOE (essential steps in managing obstetric emergencies), PROMPT (Practical Obstetric Multi-professional training), ASLO (Advanced Life Support in Obstetrics) or the MOET (Managing Obstetrics Emergencies and Trauma) where obstetrics, midwives and anesthesiologists can train together in emergency obstetric and newborn care. Simulation-based communication-training programs have been aimed to help obstetrics and gynecology trainees to develop communication skills [22].

Lately, there is a need for a robust evaluation of the effectiveness of training to improve training programmes and to provide information on how these can be developed and delivered to have the desired effect [23]. Data on the retention of knowledge and skills over time are useful to determine how frequently healthcare providers should be “re-trained” to maintain competency in EmOC. There is limited data to suggest the optimum length of a training EmOC. Longer training programmes were associated with greater improvement in skills compared with shorter programmes. Ameh et al. [9] conducted a systematic review of studies that evaluated the effectiveness of training in EmOC assessing four levels: participant reaction, knowledge, and skills, change in behaviour and clinical practice and availability of EmOC and health outcomes. They found strong evidence for improved clinical practice (adherence to protocols, resuscitation technique, communication and teamwork) and improved neonatal outcomes reduced trauma after shoulder dystocia, reduced the number of babies with hypothermia and hypoxia). Less strong evidence was found for the reduction in the number of cases of postpartum haemorrhage, case fatality rates, stillbirths and institutional maternal mortality. Knowledge and skills can be retained for up to 1-year post training and healthcare providers report being confident to provide EmOC for up to 1-year post-training. Skills decline at a faster pace than knowledge. No studies assessing knowledge and skills retention > 12 months because there will be several confounding factors to account for. Some obstetric complications are not common and to retain the ability to correctly manage such complications, health care workers should have the opportunity to have “booster” training at regular intervals [24].

Furthermore, means of assessing the communication, behavioral and nontechnical skills (NTS) of a team are necessary because these are important factors in team interactions. Recently, Onwochei et al. [25] reviewed the tools available to assess team effectiveness in obstetric emergencies. They found the most reliable tools identified were the Clinical Teamwork Scale, The Global Assessment of Obstetric Team Performance and the Global Rating Scale of performance. However, they were still lacking in terms of quality and validity. Further studies are required to assess how outcomes, such as performance and patient safety are influenced when using teamwork assessment tools.

In the obstetrics area, patients and families should play a central role in their own safety. Communication with expectant mothers/patients and their partners, close relatives or friends providing social support should be improved to ensure patient safety, including the avoidance of pAEs. Thus, applications (app) are even being developed to offer an effective and inexpensive way to promote effective communication between staff, patients, and their social support providers. Improving communication is expected to reduce pAEs and increase both work and patient satisfaction [26].

Not all women benefit from robust support. Race, ethnicity, primary spoken language, poverty, social capital, literacy, numeracy, and racism at the interpersonal and system level all contribute to a woman´s capacity to safely navigate the healthcare system. Women from vulnerable backgrounds are least able to engage in effective partnerships with their clinical care teams, and the resulting disconnects can increase the risk for serious patient harm. A culture of equity can support and advance a culture of safety by converging both clinical attention and system innovations on those individuals and groups who are most likely to benefit [12].

At hospitals, the risks associated with patient care can never be completely eliminated. Incident reporting systems make it possible to report incidents related to health care and obtain useful information on the sequence of events that led to their production, facilitating learning opportunities to avoid their repetition. Incident reporting systems are explicitly recommended by the WHO and by the Council of the European Union. They are a useful learning tool that favors the dissemination of the culture of patient safety, as long as professionals are adequately and promptly informed about the problems identified and improvement measures taken.

The Role of Anesthesiologist in the Safety of the Obstetric Patient

The role of anesthesiologists in obstetrics units and labor suites, considered high-risk areas in the hospital setting, is crucial. The anesthesiologist is a member of the delivery unit team which involves many different clinicians, patients and their relatives. The Anesthesia Patient Safety Foundation articulated the vision that “no patient shall be harmed by anesthesia”, leading the movement toward a safer future [27]. A reduction in maternal morbidity and mortality should be the number one concern for obstetric anesthesiologists who have the role of a perioperative/peripartum physician.

Anesthesia-related maternal deaths are extremely rare. Airway disasters account for most deaths from general anesthesia. Technological advances, including pulse oximetry, capnography, airway management aids, along with improvements in drugs markedly reduced the risk associated with general anesthesia. Neuraxial anesthesia is considered a safe technique. The most frequent causes of serious complications (1:3000 obstetric anesthetics) of neuraxial anesthesia are high neuraxial block (1:4.336), peripartum respiratory arrest (1:10.042) and unrecognized spinal catheter (1:15.435) [12]. Sobhy et al. [28