Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors E-Book

• Herausgeber: John Wiley & Sons
• Kategorie: Fachliteratur
• Sprache: Englisch

Seitenzahl: 1125

Veröffentlichungsjahr: 2015

Beschreibung

Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors: Diagnosis and Management is a modern, expertly crafted and clinically focused guide to the diagnosis, management and best-practice care of patients suffering from pancreatic cancer, cystic neoplasms and endocrine tumours. Packed with outstanding figures and with reference to the leading society guidelines, its main focus is on the many endoscopic and radiologic diagnostic techniques, medical and surgical management of both full-blown cancer and other tumors, and the risks of each form of treatment. Also covered in detail are issues of tumor recurrence and long-term outcome of treatment. Brought to you by highly skilled national and international leaders in the specialty and an experienced editor team, this is an invaluable guide to practicing gastroenterologists and surgeons in the hospital and clinical environment, as well as oncologists and endocrinologists managing patients with pancreatic tumorous lesions.

Leseprobe

Table of Contents

Title page

Copyright page

Contributors

Preface

Abbreviations

PART I: Ductal Adenocarcinoma of the Pancreas

CHAPTER 1: Histologic Classification and Tumor Staging of Pancreatic Cancer

Histologic Classification of Pancreatic Ductal Neoplasms

Tumor Staging

References

CHAPTER 2: What We Know about Carcinogenesis of Ductal Adenocarcinoma of the Pancreas

Pancreatic Cancer Cell

Pancreatic Cancer Stem Cells

Tumor Stroma Cells

References

CHAPTER 3: Familial Cancer of the Pancreas

Introduction

Definition

Phenotype

Pathology

Genetic Background

Genetic Counselling and Testing

Screening

Conclusion

References

CHAPTER 4: Clinical, Laboratory, and Radiologic Presentation of Pancreatic Cancer

Clinical Presentation

Laboratory Investigations

Radiologic Investigations

References

CHAPTER 5: Standards of Oncologic Pancreatic Surgery

Overview

Preoperative Considerations

Goals of Surgical Treatment

Operative Techniques

Minimally Invasive Pancreatic Resections

Postoperative Course, Complications, and Adjuvant Treatment

Conclusion

References

CHAPTER 6: Extended Resection for Pancreatic Cancer: Risks and Benefits

Introduction

History of Portal Vein Resection

Diagnosis of Cancer Invasion of the Portal Vein

Indications for Portal Vein Resection

Isolated Pancreatoduodenectomy with Portal Vein Resection

Mesenteric Approach

Catheter Bypass of the Portal Vein

Portal Vein Resection and Reconstruction

Postoperative Mortality at Nagoya University Hospital

Long-Term Survival Following Portal Vein resection

References

CHAPTER 7: Risk/Benefit of Total Pancreatectomy for Pancreatic Cancer: Are There Indications?

Historical Notes

Benefits Versus Disadvantages

New Indications

Modified Surgical Techniques

Re-Resection for Recurrent Cancer

Results of Total Pancreatectomy

Conclusion

References

CHAPTER 8: Is there a benefit from additional arterial resection of ductal cancer of the pancreas?

Introduction

Arterial Resection in Pancreatectomy Following Preoperative Chemotherapy or Chemoradiotherapy

Distal Pancreatectomy with Resection of the Celiac Axis

References

CHAPTER 9: Who benefits from ultraradical pancreatic cancer resection?

Introduction

Lymphadenectomy for Pancreatic Head Cancer

Extrapancreatic Nerve Plexus Excision

Vascular Resection

Multivisceral Resection

Randomized Controlled Trials of Standard Versus Extended Lymphadenectomy in Radical Pancreatoduodenectomy

References

CHAPTER 10: Risk and Results of Pancreatic Cancer Resection

The Appropriate Patient and the Appropriate Clinic—Probably the Most Important Presupposition of Successful Pancreatic Surgery

General and Specific Surgical Aspects of Operative and Perioperative Measures to Reduce Complications

Complications and Their Management after Pancreatic Surgical Procedures

References

CHAPTER 11: Pancreatic Cancer: The Role of Bypass Procedures

Obstructive Jaundice

Gastric Outlet Obstruction

Laparoscopic Palliation in Selected Patients

Bypass Versus Palliative REsection

Conclusion

References

CHAPTER 12: Evidence of Adjuvant Chemotherapy of Ductal Pancreatic Cancer

Introduction

Rationale for Adjuvant Chemotherapy

Randomized Controlled Trials of Adjuvant Chemotherapy

Evidence of Adjuvant Chemoradiotherapy

Randomized Controlled Trials of Adjuvant Chemoradiation

Rationale for Adjuvant Combination Therapy

Randomized Controlled Trials of Adjuvant Combination Therapy

Meta-Analyses

Conclusions

Future Directions

References

CHAPTER 13: Neoadjuvant Chemotherapy and Radiochemotherapy: Is There a Survival Advantage for Pancreatic Cancer Patients?

Introduction

Surgery First Followed by Adjuvant Therapy: Overview of Clinical Trials, Lack of Progress, and Reasons Why

Surgery after Induction therapy: pros and Cons of the Neoadjuvant Approach

Importance of Accurate Pretreatment Staging: Eligibility for Clinical Trials Must Be Standardized

Neoadjuvant Therapy for Resectable Pancreatic Cancer: Evidence in Support of a Survival Advantage

Neoadjuvant Treatment Schemas for Resectable Disease: Current Recommendations from the Medical College of Wisconsin

Neoadjuvant Therapy for Borderline Resectable Pancreatic Cancer: Consensus Has Developed in Support of this Approach

Neoadjuvant Treatment Schemas for Borderline Resectable Disease: Current Recommendations from the Medical College of Wisconsin

Pretreatment Molecular Diagnostics as a Guide to Neoadjuvant Therapy: Is the Future Now?

Conclusions

References

CHAPTER 14: Standards of Palliative Chemotherapy and Chemoradiotherapy of Local Advanced Pancreatic Cancer, Side Effects, and Survival Benefits

Introduction

Locally Advanced PC: Palliative Chemoradiotherapy

Locally Advanced PC: Palliative Chemotherapy

References

CHAPTER 15: Management of Local and Distant Recurrence after Pancreatic Cancer Resection

Introduction

Rate and Site of Recurrence after Pancreatic Resection

Management of Local Recurrence

Management of Distant Recurrence

Conclusion

References

CHAPTER 16: Survival 3, 5, and 10 years after adjuvant regional and neoadjuvant chemotherapy in resectable pancreatic cancer patients: an institutional experience

Introduction

Actual 3- and 5-Year Survival after Pancreatic Cancer Resection

Patients Who Survived More Than 5 Years postoperatively

Comment

References

CHAPTER 17: Nonductal Primary Malignancies of the Pancreas: Acinus Cell Carcinoma

Introduction

Clinical Presentation

Diagnostic Investigations

Treatment

Conclusion

References

CHAPTER 18: Nonductal Primary Malignancies of the Pancreas: Metastatic Malignancies

Overview

Burden of Disease

Diagnosis and Evaluation

Patient Selection for Metastasectomy

Operative Approach

Primary Neoplasms Metastatic to the Pancreas

Safety and Efficacy of Metastasectomy

References

PART II: Periampullary Cancers

CHAPTER 19: Histopathology of Tumors of the Ampulla of Vater

Adenoma

Invasive Carcinoma of the Ampullary Region

Neuroendocrine Neoplasm of the Ampulla of Vater

Mesenchymal Tumors of the Ampullary Region

Secondary Tumors

References

CHAPTER 20: Clinical Approach to Periampullary Cancer

Clinical Presentation: Most-Frequent and Rare Clinical Symptoms

Diagnostic Protocol, Fast Track, and Regular Diagnostic Procedures

Laboratory Investigation

Standard Radiologic Procedures for Diagnosis and Staging

References

CHAPTER 21: Adenoma of the Papilla of Vater and Endoscopic Management

Introduction

Clinical Presentations

Diagnosis by Imaging Modalities

Laboratory Measurements

Strategy for Endoscopic Management

Endoscopic Resection

Conclusion

References

CHAPTER 22: Controversies about Local or Regional Treatment of Adenoma of the Papilla of Vater: the Japanese Experience

Introduction

Standard Operative Procedures for Adenoma of the Papilla of Vater

Surgical Outcome in Our Institution

Overall Discussion

References

CHAPTER 23: Cancer of the Papilla: Surgical Management

Introduction

Treatment Principles for Adenoma of the Papilla and Ampullary Cancer

References

CHAPTER 24: Evidence of Surgical Management of Distal Common Bile Duct Cancer

Goals of Surgical Treatment

Indication for Standard Surgical Procedures and Specific Limited Surgical Techniques

Bile Duct Resection

Duodenum-Preserving Total Pancreatic Head Resection

Lymphadenectomy for DCBDC

References

CHAPTER 25: Evidence of Surgical Management of Duodenal Cancer

References

CHAPTER 26: Survival and Chance of Cure after Surgery, Adjuvant Chemotherapy, and Palliative Chemotherapy of Periampullary Cancers

Introductions

Ampullary Carcinoma

Duodenal Carcinoma

Distal Cholangiocarcinoma

Pathologic Factors

Adjuvant Therapy

References

PART III: Cystic Neoplastic Lesions of the Pancreas

CHAPTER 27: Histologic Classification and Staging of Cystic Neoplastic Lesions of the Pancreas

Serous Cystic Neoplasm

Intraductal Papillary Mucinous Neoplasm (IPMN)

Mucinous Cystic Neoplasm

Solid Pseudopapillary Neoplasm

References

CHAPTER 28: Clinical Presentation of Cystic Neoplastic Lesions of the Pancreas

Intraductal Papillary Mucinous Neoplasm

Mucinous Cystic Neoplasm

Serous Cystic Neoplasm

Solid Pseudopapillary Neoplasm

References

CHAPTER 29: Endoscopic Ultrasonography and Cystic Fluid Analysis of the Pancreas: Evidence of Diagnostic Measures

Introduction

Pancreatic Cystic Fluid Aspiration

Components of Pancreatic Cystic Fluid Analysis

EUS-FNA of Pancreatic Cystic Lesions: When to Do and What to Test

Summary

References

CHAPTER 30: Natural History of IPMN: Adenoma–Carcinoma Sequence in IPMN

Introduction

Age of Patients with Benign IPMN and with Malignant IPMN

Nonoperative Follow-Up of IPMN

Nonoperative Follow-Up of Main-Duct IPMN

Follow-Up after Surgery for IPMN

Conclusion