Polyphenols E-Book

• Herausgeber: John Wiley & Sons
• Kategorie: Fachliteratur
• Sprache: Englisch

Seitenzahl: 874

Veröffentlichungsjahr: 2023

Beschreibung

Polyphenols Understand polyphenols and their benefits with this comprehensive overview Polyphenols are a group of beneficial compounds--including phenolic acids, flavonoids, anthocyanins, and others--that can be found in a vast range of plants and plant-based foods. Their health benefits and the variety of their applications in functional foods, dietary supplements, and similar areas have made polyphenols a $1 billion market, a figure that is expected to more than double in the next decade. This has placed increased emphasis on areas of cutting-edge research such as the use of bio-based nanodelivery systems to improve the oral bioavailability of polyphenols. Polyphenols constitutes a comprehensive introduction to these compounds, their health benefits, and their potential nutraceutical applications. It incorporates both the biochemical fundamentals of polyphenols and their precise potential to prevent numerous common diseases. The result is an essential reference for a vital, growing area of research and industry. Polyphenols readers will also find: * Detailed coverage of polyphenols' occurrence, bioactivity, and technological applications * In-depth discussion of nano-based delivery systems to increase polyphenols' therapeutic efficacy and oral bioavailability and to reduce required dosages * Guidance for developing treatments for cancers, cardiovascular diseases, inflammatory conditions, and more Polyphenols is ideal for food scientists and manufacturers, medicinal chemists, pharmaceutical scientists, and any biochemical or biomedical researcher or professional working with polyphenols or plant-based foods.

Leseprobe

Polyphenols

Food, Nutraceutical, and Nanotherapeutic Applications

Edited by

Mithun Rudrapal

Department of Pharmaceutical SciencesSchool of Biotechnology and Pharmaceutical SciencesVignan's Foundation for Science, Technology & ResearchGuntur, India

Copyright © 2024 by John Wiley & Sons, Inc. All rights reserved.

Published by John Wiley & Sons, Inc., Hoboken, New Jersey.

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Library of Congress Cataloging-in-Publication Data

Names: Rudrapal, Mithun, editor.

Title: Polyphenols: food, nutraceutical, and nanotherapeutic applications / edited by Mithun Rudrapal, Department of Pharmaceutical Sciences, School of Biotechnology and Pharmaceutical Sciences, Vignan’s Foundation for Science, Technology & Research, Guntur, India.

Description: Hoboken, New Jersey : John Wiley & Sons, [2024] | Includes bibliographical references and index.

Identifiers: LCCN 2023026387 (print) | LCCN 2023026388 (ebook) | ISBN 9781394188833 (hardback) | ISBN 9781394188857 (epdf) | ISBN 9781394188840 (epub) | ISBN 9781394188864 (ebook)

Subjects: LCSH: Polyphenols. | Polyphenols--Physiological effect. | Polyphenols--Therapeutic use. | Functional foods.

Classification: LCC QP671.F52 P658 2024 (print) | LCC QP671.F52 (ebook) | DDC 572/.2--dc23/eng/20230621

LC record available at https://lccn.loc.gov/2023026387

LC ebook record available at https://lccn.loc.gov/2023026388

Cover Image: © altmodern/Getty Images

Cover Design: Wiley

Set in 9.5/12.5pt STIXTwoText by Integra Software Services Pvt. Ltd, Pondicherry, India

Contents

Cover

Title Page

Copyright Page

List of Contributors

Preface

1 Food Polyphenols: Antioxidant Properties and Health Benefits

2 Plant Polyphenols as Nutraceuticals and Their Antioxidant Potentials

3 Polyphenols: Plant-based Nutraceuticals in Human Health

4 Nanotechnological Approach in Nutraceuticals

5 Polyphenols: Nutraceutical and Nanotherapeutic Approaches

6 Polyphenols in Food Products – Nutraceutical Applications

7 Functionalization of Food Polyphenols for Nanodeliveries

8 Nanodeliveries of Food Polyphenols as Nutraceuticals

9 Polyphenol Rich Extracts from Spices and Nanodelivery Systems

10 Nanodelivery of Polyphenols as Nutraceuticals in Anticancer Interventions

11 Nanodelivery of Polyphenols as Nutraceuticals for CNS Disorders

12 Nanodelivery of Polyphenols as Nutraceuticals for Neurological Disorders

13 Addressing Antimicrobial Resistance by Repurposing Polyphenolic Phytochemicals with Novel Antibacterial Potential

14 Toxicity of Polyphenols Consumed as Food and Nutraceuticals: Remedies through Nanotherapeutic Approaches

15 Nanodelivery of Food Polyphenols for Nutraceutical Applications

16 Polyphenols in Food Products and Nutraceuticals: Bioavailability and Pharmacokinetic Issues

Index

End User License Agreement

List of Tables

CHAPTER 01

Table 1.1 Classes and subclasses...

CHAPTER 02

Table 2.1 Polyphenols for inhibiting...

CHAPTER 03

Table 3.1 Molecular docking analysis...

Table 3.2 Absorption, distribution, metabolism...

CHAPTER 04

Table 4.1 Nanoparticles and their...

CHAPTER 05

Table 5.1 Sources of dietary...

CHAPTER 06

Table 6.1 Main classes of...

Table 6.2 Polyphenols: food sources...

Table 6.3 A summary of...

CHAPTER 07

Table 7.1 Processes involved in...

CHAPTER 08

Table 8.1 Types of polyphenols...

Table 8.2 Chemical structure and...

CHAPTER 09

Table 9.1 Common Indian spices...

CHAPTER 10

Table 10.1 Various anticancer mechanisms...

CHAPTER 11

Table 11.1 Various nanocarrier-loaded...

Table 11.2 Patents of polyphenolic...

Table 11.3 Marketed polyphenols used...

CHAPTER 12

Table 12.1 Polyphenols used in...

Table 12.2 Treatment strategies for...

CHAPTER 13

Table 13.1 Multi-drug resistant...

Table 13.2 Enzymes responsible for...

Table 13.3 Classification of polyphenolic...

Table 13.4 Flavonoids and their...

Table 13.5 Synergistic action of...

CHAPTER 14

Table 14.1 Polyphenols in toxic...

Table 14.2 Effect of polyphenols...

List of Illustrations

CHAPTER 01

Figure 1.1 Classification of dietary...

CHAPTER 02

Figure 2.1 Classification and types...

Figure 2.2 In vitro and...

Figure 2.3 ROS-induced signaling...

CHAPTER 03

Figure 3.1 Polyphenols in disease...

Figure 3.2 3D structure: BACE...

Figure 3.3 2D interaction of...

CHAPTER 04

Figure 4.1 Mode of fluorophore...

Figure 4.2 Uses of nanoencapsulation...

CHAPTER 06

Figure 6.1 Phenolic compound biosynthesis...

Figure 6.2 Mechanisms for the...

CHAPTER 07

Figure 7.1 Use of nanotechnology...

Figure 7.2 Structure of flavonoids...

Figure 7.3 Structure of non...

CHAPTER 08

Figure 8.1 Sources of food...

Figure 8.2 Nanodelivery of food...

CHAPTER 09

Figure 9.1 Spice polyphenols and...

CHAPTER 10

Figure 10.1 Active targeting of...

CHAPTER 11

Figure 11.1 Types of central...

Figure 11.2 Different types of...

Figure 11.3 The bilayer of...

Figure 11.4 Scope of nutraceuticals...

CHAPTER 12

Figure 12.1 Delivery of polyphenols...

CHAPTER 13

Figure 13.1 Mechanisms of developing...

Figure 13.2 Reactive oxygen species...

Figure 13.3 Basic structural skeletons...

Figure 13.4 Structures of plant...

Figure 13.5 Free radical scavenging...

Figure 13.6 Mechanisms of the...

CHAPTER 15

Figure 15.1 Health benefits of...

Figure 15.2 Classification of nutraceuticals...

Figure 15.3 Classification of food...

Figure 15.4 Antimicrobial action of...

Figure 15.5 Factors affecting bioavailability...

Figure 15.6 Nanoparticles for polyphenol...

Figure 15.7 Common bio-based...

Figure 15.8 Process of extraction...

Guide

Cover

Title Page

Copyright Page

Table of Contents

List of Contributors

Preface

Begin Reading

Index

End User License Agreement

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List of Contributors

Raghu Ram AcharDivision of Biochemistry, School of Life SciencesJSS Academy of Higher Education and ResearchMysuruKarnatakaIndia

Kamoru A. AdedokunRoswell Park Comprehensive Cancer CenterUniversity at BuffaloBuffaloNYUSA

Mujidat T. Adeyemo-ImodoyeDepartment of Medical Laboratory ScienceSomolu General HospitalLagos Health Service CommissionLagos StateNigeria

Jyotirmoi AichSchool of Biotechnology and BioinformaticsD Y Patil Deemed to be UniversityNavi MumbaiMaharashtraIndia

Tanisha AmbawatSchool of Biotechnology and BioinformaticsD Y Patil Deemed to be UniversityNavi MumbaiMaharashtra, India

Anuthilakesh T.Division of Biochemistry, School of Life SciencesJSS Academy of Higher Education and ResearchMysuruKarnatakaIndia

Anyanwu O. GabrielDepartment of BiochemistryBingham UniversityKaruNasarawaNigeria

Apoorva M.R.Division of Biochemistry, School of Life SciencesJSS Academy of Higher Education and ResearchMysuruKarnatakaIndia

Merin BabuSynthite Industries Pvt. Ltd.Synthite ValleyKadayiruppuKeralaIndia

Ibrahim O. BelloDepartment of Biological SciencesSouthern Illinois University EdwardsvilleEdwardsvilleILUSA

Atul R. BendaleMahavir Institute of PharmacyNashikMaharashtraIndia

Bhargavi K.Division of Biochemistry, School of Life SciencesJSS Academy of Higher Education, and ResearchMysuruKarnatakaIndia

Mustansir BhoriSchool of Biotechnology and BioinformaticsD Y Patil Deemed to be UniversityNavi MumbaiMaharashtraIndia

Baby Kumaranthara ChackoC.V.J. Creative CentreBio Ingredients, Synthite Industries Pvt. Ltd.Synthite ValleyKadayiruppuKeralaIndia

Shreya DasSchool of Biotechnology and BioinformaticsD Y Patil Deemed to be UniversityNavi MumbaiMaharashtraIndia

Sweta DasB. K. Birla CollegeBirla College Campus RdKalyanMaharashtraIndia

Ameyota DeSchool of Biotechnology and BioinformaticsD Y Patil Deemed to be UniversityNavi MumbaiMaharashtraIndia

Prashanta Kumar DebDepartment of Pharmaceutical Sciences and TechnologyBirla Institute of TechnologyRanchiJharkhandIndia

Shine DevarajanSchool of Biotechnology and BioinformaticsD Y Patil Deemed to be UniversityBelapurNavi MumbaiMaharashtraIndia

Sneha DokhaleB. K. Birla CollegeBirla College Campus RdKalyanMaharashtraIndia

Priaunsh DuttSchool of Biotechnology and BioinformaticsD Y Patil Deemed to be UniversityNavi MumbaiMaharashtraIndia

Samiksha GarseSchool of Biotechnology and BioinformaticsD Y Patil Deemed to be UniversityNavi MumbaiMaharashtra, India

Sachin GoelDepartment of Biological Sciences and EngineeringNetaji Subhas University of TechnologyNew DelhiIndia

Madhusmita GogoiDepartment of Pharmaceutical SciencesFaculty of Science and EngineeringDibrugarh UniversityDibrugarhAssamIndia

Sikiru O. ImodoyeHuntsman Cancer InstituteUniversity of UtahSalt Lake CityUTUSA

Viju JacobNutraceuticals Division, Bio IngredientsSynthite Industries Pvt. Ltd.Synthite ValleyKadayiruppuErnakulamKeralaIndia

C.V.J. Creative CentreBio Ingredients, Synthite Industries Pvt. Ltd.Synthite ValleyKadayiruppuKeralaIndia

Gourav JainDepartment of PharmacyShri Govindram Seksariya Institute of Technology & Science (SGSITS)IndoreMadhya PradeshIndia

Aayushi KadamDepartment of Food and Human Nutritional SciencesUniversity of ManitobaCanada

Ramut T. KamorudeenDepartment of Public HealthUniversity of SouthWales, PontypriddUK

Koyel KarDepartment of Pharmaceutical ChemistryBCDA College of Pharmacy & TechnologyHridaypurWest BengalIndia

Monalisa KeshAmity Institute of BiotechnologyAmity University Uttar PradeshNoidaIndia

Swapnil Devidas KhamborkarSynthite Industries Pvt. Ltd.Synthite ValleyKadayiruppuKeralaIndia

Manohar M.V.Centre of excellence in Molecular Biology & Regenerative MedicineDepartment of BiochemistryJSS Medical College, JSS-AHERMysuruKarnataka, India

Akhil NagarDepartment of Pharmaceutical ChemistryR. C. Patel Institute of Pharmaceutical Education and ResearchShirpurMaharashtraIndia

Neelesh Kumar NemaNutraceuticals DivisionBio Ingredients, Synthite Industries Pvt. Ltd.Synthite ValleyKadayiruppuErnakulamKeralaIndia

Nithish G.S.Indian Institute of Science Education and Research TirupatiC/O Sree Rama Engineering College (Transit Campus Mangalam)TirupatiAndhra PradeshIndia

Ogah F. ChinenyeDepartment of BiochemistryBingham UniversityKaruNigeria

André M. OliveiraFederal Centre of Technological Education of Minas Gerais (CEFET-MG)Alameda das PerdizesContagemMGBrazil

Ifeoluwa T. OyeyemiDepartment of Biosciences and BiotechnologyUniversity of Medical SciencesOndoNigeriaDepartment of Chemistry and BiochemistryOld Dominion UniversityHampton BoulevardNorfolkVAUSA

Amogha G PaladhiDepartment of BotanyCHRIST (Deemed to be) UniversityBengaluruKarnatakaIndia

Santwana PalaiDepartment of Veterinary Pharmacology & ToxicologyCollege of Veterinary Science and Animal HusbandryOdisha University of Agriculture & TechnologyBhubaneswarOdishaIndia

Sharad P. PandeyDepartment of PharmacyShri Govindram Seksariya Institute of Technology & Science (SGSITS)IndoreMadhya PradeshIndia

Arpita PaulDepartment of Pharmaceutical SciencesFaculty of Science and EngineeringDibrugarh UniversityDibrugarhAssamIndia

Aneena PeterSynthite Industries Pvt. Ltd.Synthite ValleyKadayiruppuKeralaIndia

Pruthvi G.R.Division of BiochemistrySchool of Life SciencesJSS Academy of Higher Education and ResearchMysuruKarnatakaIndia

Nayana RajanSynthite Industries Pvt. Ltd.Synthite ValleyKadayiruppuKeralaIndia

Mithun RudrapalDepartment of Pharmaceutical SciencesSchool of Biotechnology andPharmaceutical Sciences, Vignan’s Foundation for Science, Technology & ResearchGunturIndia

Sachithra SabuSynthite Industries Pvt. Ltd.Synthite ValleyKadayiruppuKeralaIndia

Rakesh SagarDepartment of PharmacyShri Govindram Seksariya Institute of Technology & Science (SGSITS)IndoreMadhya PradeshIndia

Abhishek K. SahDepartment of PharmacyShri Govindram Seksariya Institute of Technology & Science (SGSITS)IndoreMadhya PradeshIndia

Linson Cheruveettil SajanSynthite Industries Pvt. Ltd.Synthite ValleyKadayiruppuKeralaIndia

Puneet K. SamaiyaDepartment of PharmacyShri Govindram Seksariya Institute of Technology & Science (SGSITS)IndoreMadhya PradeshIndia

Malik A. SanusiDepartment of Biochemistry and Molecular BiologyObafemi Awolowo UniversityIle-IfeOsun StateNigeria

Biswatrish SarkarDepartment of Pharmaceutical Sciences and TechnologyBirla Institute of TechnologyRanchiJharkhandIndia

Smitha SarojamSynthite Industries Pvt. Ltd.Synthite ValleyKadayiruppuKeralaIndia

Yashika ShadijaSchool of Biotechnology and BioinformaticsD Y Patil Deemed to be UniversityNavi MumbaiMaharashtraIndia

Kanchanlata TungareSchool of Biotechnology and BioinformaticsD Y Patil Deemed to be UniversityNavi MumbaiMaharashtraIndia

Sugumari VallinayagamDepartment of BiotechnologyVel Tech Rangarajan Dr. Sagunthala R and D Institute of Science and TechnologyChennaiTamil Nadu

Zwanden S. YahayaDepartment of Pharmaceutics and Industrial PharmacyFaculty of Pharmaceutical SciencesKaduna State University,KadunaNigeria

Aamena YusufSchool of Biotechnology and BioinformaticsD Y Patil Deemed to be UniversityNavi MumbaiMaharashtraIndia

Kamaruz ZamanDepartment of Pharmaceutical SciencesFaculty of Science and EngineeringDibrugarh UniversityDibrugarhAssamIndia

Preface

The book titled “Polyphenols: Food, Nutraceutical, and Nanotherapeutic Applications” provides us with detailed information on the potential health benefits of food polyphenols against human diseases and their therapeutic interventions as nutraceuticals and nanoformulations. Plant-based foods, including nutraceuticals, functional foods, and dietary supplements, have gradually become an area of increasing interest because of the potential health implications of polyphenol-based food products available in the global market. Long-term consumption of foods rich in polyphenols has been reported to improve conditions in diabetes, osteoporosis, cancer, neurological disorders, and cardiovascular diseases. The market demand for polyphenol-based food products and nutraceutical preparations is increasing rapidly with social and economic developments and the improvement in people’s health awareness. The beneficial effects of polyphenol-based nutraceuticals and their nanoformulations attract more consumers. However, many polyphenols have low oral bioavailability, which limits the application of polyphenols as nutraceuticals and in the form of nanomedicine. This book would be a useful resource for researchers working in the areas of dietary polyphenols, nanodelivery, and nutraceutical applications. The book chapters provide up-to-date information relating to the ongoing research on food polyphenols along with their health and therapeutic implications as antioxidants. The chapters are described in a lucid and consistent manner in order to aid flow, continuity, and technical presentation. In this book, the health benefits of plant polyphenols in the prevention of various major diseases, such as cancer, neurological disorders, central nervous system disorders, cardiovascular diseases, bacterial infections, and inflammatory disorders, are summarized. This book particularly delineates food polyphenols and their antioxidant potentials with special emphasis on their nutraceutical applications and nanodeliveries. The bioavailability and pharmacokinetic issues and toxicity are also demonstrated. This book will be useful to drug discovery scientists (R&D), pharmaceutical scientists, biomedical scientists, food scientists, healthcare professionals, phytochemists, biochemists, clinicians, pharmacologists, dietician, nutritionists, research students, professors, and other researchers working in the field of polyphenols, nutraceuticals, and nanomedicine research.

Mithun Rudrapal

June, 2023