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After a review of the essential concepts of magnetic resonance imaging (MRI), The Challenges of MRI presents the recent techniques and methods of MRI and resulting medical applications. These techniques provide access to information that goes well beyond anatomy, with functional, hemodynamic, structural, biomechanical and biochemical information. MRI allows us to probe living organisms in a multitude of ways, guaranteeing the potential for continuous development involving several disciplines: physics, electronics, life sciences, signal processing and medicine. This collective work is made up of chapters written and designed by experts from the French community. They have endeavored to describe the techniques by recalling the underlying physics and detailing the modeling, methods and strategies for acquiring or extracting information. This book is aimed at master's students and PhD students, as well as lecturers and researchers in medical imaging and radiology.

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Seitenzahl: 640

Veröffentlichungsjahr: 2024

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Image, Field Director – Laure Blanc-Féraud

Imagery in Life Sciences, Subject Head – Françoise Peyrin

The Challenges of MRI

Techniques and Quantitative Methods for Health

Coordinated by

Hélène Ratiney

Olivier Beuf

First published 2024 in Great Britain and the United States by ISTE Ltd and John Wiley & Sons, Inc.

Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the Copyright, Designs and Patents Act 1988, this publication may only be reproduced, stored or transmitted, in any form or by any means, with the prior permission in writing of the publishers, or in the case of reprographic reproduction in accordance with the terms and licenses issued by the CLA. Enquiries concerning reproduction outside these terms should be sent to the publishers at the undermentioned address:

ISTE Ltd27-37 St George’s RoadLondon SW19 4EUUK

www.iste.co.uk

John Wiley & Sons, Inc.111 River StreetHoboken, NJ 07030USA

www.wiley.com

© ISTE Ltd 2024The rights of Hélène Ratiney and Olivier Beuf to be identified as the authors of this work have been asserted by them in accordance with the Copyright, Designs and Patents Act 1988.

Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s), contributor(s) or editor(s) and do not necessarily reflect the views of ISTE Group.

Library of Congress Control Number: 2023943624

British Library Cataloguing-in-Publication DataA CIP record for this book is available from the British LibraryISBN 978-1-78945-113-9

ERC code:LS7 Applied Medical Technologies, Diagnostics, Therapies and Public Health LS7_1 Imaging for medical diagnosis

Introduction

Hélène RATINEY and Olivier BEUF

CREATIS, CNRS, Inserm, INSA Lyon, Université Claude Bernard Lyon 1, France

Since its inception in 1973, magnetic resonance imaging has experienced remarkable technological and methodological advancements. Magnetic resonance imaging (MRI) has reached a certain level of maturity, as well as complexity, where several expertise domains merge: biology, medicine, physical chemistry, physics and computer science. A great number of publications on this topic are aimed at the medical world (radiologists, radiographers), while others describe the physics of MRI and target a wider public, including scientists, from the master level to senior researchers. The present work seeks to cover the techniques and methods considered promising for the future of MRI. These approaches provide data way beyond the anatomical structure, including functional, hemodynamic, structural, biomechanical or even biochemical information. Retrieving each of these kinds of data requires understanding and describing a physical phenomenon and putting this knowledge into practice by drawing upon the areas of engineering and, in particular, signal and image processing.

This work thus strives to describe the practical implementation of a great variety of techniques by recalling the underlying physics and by giving details of the modelization and analysis that enable acquisition strategies and retrieval informations. The authors approached the challenge of providing in each chapter the keys to a general overview of a technique or domain by following summarized formulations and citing bibliographic references considered the most relevant. Indeed, each chapter’s topic could be covered in a separate book in order to completely satisfy the authors’ pedagogic goal. Whether the reader is a master’s or doctoral student, a researcher in medical imaging or a staff member at a university hospital, they will find in this work the information necessary for understanding multiparametric MRI and today’s challenges in the field of MRI.

In the first four chapters, this work covers the fundamental notions and principles, deemed useful in MRI, in a brief but sometimes new way. Chapter 1 describes the basics of an MRI scan and the related instrumentation signal chain while introducing the notion of quantification. A special overview is dedicated to the radiofrequency coils used for the excitation and reception of MRI signals in Chapter 2. In Chapter 3, the main acceleration techniques for fast imaging are described along with citations of the most recent methods. Chapter 4 covers the basics of diffusion MRI. Chapters 5–8 are dedicated to a group of MRI techniques for probing or characterizing tissues and organs in vivo. These include functional imaging (Chapter 5), vascular imaging (Chapter 6), quantitative elastography imaging (Chapter 7), magnetization transfer and ultra-short echo-time imaging (Chapter 8), in vivo nuclear magnetic resonance (NMR) spectroscopy and chemical exchange saturation transfer (CEST) imaging (Chapter 9). Chapter 10 presents some novel methods which provide multiple parameters using a single sequence by combining fast acquisition techniques and advanced data processing. Finally, the last two chapters cover a broader overview by describing the state-of-the-art techniques and challenges in interventional MRI in Chapter 11 and ultra-high-field MRI in Chapter 12.

All the co-authors are members of the French Society for Magnetic Resonance in Biology and Medicine (Société française de résonance magnétique en biologie et médecine – SFRMBM) and this work represents an educational contribution of this community stemming from and disseminating for scientific research.