Cell Biology E-Book

Stephen R. Bolsover

• Herausgeber: John Wiley & Sons
• Kategorie: Wissenschaft und neue Technologien
• Serie: Short Course
• Sprache: Englisch

Seitenzahl: 745

Veröffentlichungsjahr: 2022

Beschreibung

An accessible and straightforward intro to cell biology

In the newly revised Fourth Edition of Cell Biology: A Short Course, a distinguished team of researchers delivers a concise and accessible introduction to modern cell biology, integrating knowledge from genetics, molecular biology, biochemistry, physiology, and microscopy. The book places a strong emphasis on drawing connections between basic science and medicine.

Telling the story of cells as the units of life in a colorful and student-friendly manner, Cell Biology: A Short Course takes an “essentials only” approach. It conveys critical points without overburdening the reader with extraneous or secondary information. Clear diagrams and examples from current research accompany special boxed sections that focus on the importance of cell biology in medicine and industry. A new feature, “BrainBoxes” describes some of the key people who created the current understanding of Cell Biology.

The book has been thoroughly revised and updated since the last edition and includes:

• Thorough introduction to cells and tissues, membranes, organelles, and the structure of DNA and genetic code
• Explorations of DNA as a data storage medium, transcription and the control of gene expression, and recombinant DNA and genetic engineering
• Discussion of the manufacture of proteins, protein structure, and intracellular protein trafficking
• Description of ions and voltages, intracellular and extracellular signaling
• Introduction to the cytoskeleton and cell movement
• Discussion of cell division and apoptosis

Perfect for undergraduate students seeking an accessible, one-stop reference on cell biology, Cell Biology: A Short Course is also an ideal reference for pre-med students.

Leseprobe

CELL BIOLOGY

A Short Course

FOURTH EDITION

Stephen BolsoverAndrea Townsend‐NicholsonGreg FitzHarrisElizabeth ShephardJeremy HyamsSandip Patel

This fourth edition first published 2022© 2022 John Wiley & Sons Ltd

Edition HistoryJohn Wiley & Sons, Inc. (From Genes to Cells, 1e, 1997) (2e, 2004) (3e, 2011)

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

The right of Stephen Bolsover, Andrea Townsend‐Nicholson, Greg FitzHarris, Elizabeth Shephard, Jeremy Hyams, and Sandip Patel to be identified as the authors of this work has been asserted in accordance with law.

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Library of Congress Cataloging‐in‐Publication Data applied for

Names: Bolsover, Stephen, 1954‐ author.Title: Cell biology: a short course / Stephen Bolsover, Andrea Townsend‐Nicholson, Greg FitzHarris, Elizabeth Shephard, Jeremy Hyams, Sandip Patel.Description: Fourth edition. | Hoboken, NJ: Wiley‐Blackwell, 2022. | Includes bibliographical references and index.Identifiers: LCCN 2021049318 (print) | LCCN 2021049319 (ebook) | ISBN 9781119757764 (hardback) | ISBN 9781119757771 (adobe pdf) | ISBN 9781119757788 (epub)Subjects: LCSH: Cytology.Classification: LCC QH581.2 .B65 2022 (print) | LCC QH581.2 (ebook) | DDC 571.6–dc23/eng/20211007LC record available at https://lccn.loc.gov/2021049318LC ebook record available at https://lccn.loc.gov/2021049319

Cover Design: WileyCover Image: © Hybrid Medical Animation/Science Source

PREFACE

Our aim in previous editions of Cell Biology, A Short Course was to cover a wide area of cell biology in a form especially suitable for first‐year undergraduates, keeping the book to a manageable size so that neither the content, the cost, nor the weight was too daunting for the student. For the fourth edition we have thoroughly revised the content to concentrate on the core of cell biology: the structure of the cell, how it is made, and how cells and the parts of cells interact and move.

We begin (Section 1, Chapters 1 and 2) by describing the components of the cell as seen in the microscope. We then (Section 2, Chapters 3–8) turn to the central dogma of molecular biology and describe how DNA is used to make RNA which in turn is used to make protein. We end this section with chapters on protein structure and on recombinant DNA technology and genetic engineering. Section 3 (Chapters 9–11) describes how cells use electricity, ion concentrations, and chemical messengers to interact with and respond to external cues. Section 4 (Chapters 12–14) describes the physically moving cell: intracellular trafficking, the cytoskeleton and molecular motors, and cell division and death. Finally, in Section 5 (Chapter 15) we use cystic fibrosis as a case study that illustrates how all the areas of knowledge covered in this book contribute to an understanding of this disease and have allowed the development of novel clinical treatments.

Boxed material throughout the book is divided into EXAMPLES that illustrate the topics covered in the main text, explanations of the MEDICAL RELEVANCE of the material, and IN-DEPTH sections that extend the coverage beyond the content of the main text. We include BRAINBOXES highlighting a number of the scientists who have made significant contributions to cell biology, either by making critical discoveries, or by creating the tools that made those discoveries possible. REVIEW QUESTIONS in extended matching‐set format at the end of each chapter help the reader assess how well they have assimilated and understood the material, while each chapter also poses a “THOUGHT QUESTION” that tests concepts rather than facts.

A comprehensive website accompanies the book at www.wiley.com/go/bolsover/cellbiology4. This includes additional examples, in‐depth explanations, and medical discussions for which there was no room in the printed book. Students who would like to test their understanding of the subject will find additional review questions, while teachers can find suggestions of essay titles. The website gives links to other internet resources together with references to primary research publications to allow readers to trace the origin of statements in the text. Lastly, the website allows download of all the figures from the book as slides for use by teachers.

ACKNOWLEDGMENTS

We are very grateful to Professors Jean‐Claude Labbé (IRIC, Université de Montréal) and Stephanie Schorge (University College London) for critical reading of the manuscript.

ABOUT THE COMPANION WEBSITE

This book is accompanied by a companion website.

www.wiley.com/go/bolsover/cellbiology4

This website includes:

Figures from the book in PowerPoint

Additional examples and revision resources

SECTION 1THE STRUCTURE OF THE CELL

The cell is the fundamental unit of life. A cell comprises a complex and ordered mass of protein, nucleic acid, and many biochemical species separated from the world outside by a limiting membrane. Cells expend energy to maintain a highly ordered state, and this expenditure of energy and the ability to repair themselves distinguishes living cells from lifeless packets of biological material such as viruses. In the first two chapters we will describe the basic structure of cells and how they can be observed with a microscope. We will describe how, in animals, cells containing the same DNA database assume very different shapes and functions and organize themselves into tissues.

Chapter 1

: A Look at Cells and Tissues

Chapter 2

: Membranes and Organelles