Analysis of Single-Cell Data E-Book

Carolin Loos

• Herausgeber: Springer Fachmedien Wiesbaden GmbH
• Kategorie: Wissenschaft und neue Technologien
• Serie: BestMasters
• Sprache: Englisch

Veröffentlichungsjahr: 2016

Beschreibung

Carolin Loos introduces two novel approaches for the analysis of single-cell data. Both approaches can be used to study cellular heterogeneity and therefore advance a holistic understanding of biological processes. The first method, ODE constrained mixture modeling, enables the identification of subpopulation structures and sources of variability in single-cell snapshot data. The second method estimates parameters of single-cell time-lapse data using approximate Bayesian computation and is able to exploit the temporal cross-correlation of the data as well as lineage information.