Bio-Glasses E-Book

• Herausgeber: John Wiley & Sons
• Kategorie: Fachliteratur
• Sprache: Englisch

Seitenzahl: 364

Veröffentlichungsjahr: 2012

Beschreibung

This new work is dedicated to glasses and their variants which can be used as biomaterials to repair diseased and damaged tissues. Bio-glasses are superior to other biomaterials in many applications, such as healing bone by signaling stem cells to become bone cells.

  Key features: 

• First book on biomaterials to focus on bio-glasses
• Edited by a leading authority on bio-glasses trained by one of its inventors, Dr Larry Hench
• Supported by the International Commission on Glass (ICG)
• Authored by members of the ICG Biomedical Glass Committee, with the goal of creating a seamless textbook
• Written in an accessible style to facilitate rapid absorption of information
• Covers all types of glasses, their properties and applications, and demonstrates how glass is an attractive improvement to current procedures
• Of interest to the biomedical as well as the materials science community.

 
The book covers all types of glasses: traditional glasses, bioactive glasses, sol-gel glasses, phosphate glasses, glass-ceramics, composites and hybrids. Alongside discussion on how bio-glasses are made, their properties, and the reasons for their use, the authors also cover their applications in dentistry, bone regeneration and tissue engineering and cancer treatment. Its solid guidance describes the steps needed to take a new material from concept to clinic, covering the essentials of patenting, scale-up, quality assurance and FDA approval.

Leseprobe

Table of Contents

Title Page

Copyright

List of Contributors

Foreword

Preface

Chapter 1: The Unique Nature of Glass

1.1 What Is Glass?

1.2 Making Glass

1.3 Homogeneity and Phase Separation

1.4 Forming

1.5 Glasses That Are Not “Melted”

1.6 Exotic Glass

1.7 Summary

Further Reading

Chapter 2: Melt-Derived Bioactive Glass

2.1 Bioglass

2.2 Network Connectivity and Bioactivity

2.3 Alternative Bioactive Glass Compositions

2.4 In Vitro Studies

2.5 In Vivo Studies and Commercial Products

References

Chapter 3: Sol-Gel Derived Glasses for Medicine

3.1 Introduction

3.2 Why Use the Sol-Gel Process?

3.3 Sol-Gel Process Principles

3.4 Steps in a Typical Sol-Gel Process

3.5 Evolution of Nanoporosity

3.6 Making Sol-Gel Monoliths

3.7 Making Particles

3.8 Sol-Gel Derived Bioactive Glasses

3.9 Summary

References

Chapter 4: Phosphate Glasses

4.1 Introduction

4.2 Making Phosphate Glasses

4.3 Phosphate Glass Structure

4.4 Temperature Behaviour and Crystallisation

4.5 Phosphate Glass Dissolution

4.6 Cell Compatibility of Glasses

4.7 Phosphate Glass Fibres and Composites

4.8 Applications

4.9 Summary

References

Chapter 5: The Structure of Bioactive Glasses and Their Surfaces

5.1 Structure of Glasses

5.2 Structure of Bioactive Glasses

5.3 Computer Modeling (Theoretical Simulation) of Bioactive Glasses

5.4 Glass Surfaces

5.5 Summary

References

Chapter 6: Bioactive Borate Glasses

6.1 Introduction

6.2 What Differentiates a Bioactive Borate Glass from Other Bioactive Glasses?

6.3 Evaluating Reactive Materials (In Vitro Versus In Vivo Testing)

6.4 Multifunctional Bioactive Borate Glasses

6.5 Applications of Bioactive Borate Glasses in Orthopedics and Dental Regeneration

6.6 Soft Tissue Wound Healing

6.7 Tissue/Vessel Guidance

6.8 Drug Delivery

6.9 Commercial Product Design

6.10 Summary

References

Chapter 7: Glass-Ceramics

7.1 Glass-Ceramics and Their Uses

7.2 Methods Used for the Controlled Crystallization of Glasses

7.3 A Glass-Ceramic That Hardly Expands When Heated

7.4 High-Strength, Moldable Glass-Ceramics for Dental Restoration

7.5 Glass-Ceramics That Are Moldable and Machinable

7.6 Outlook

References

Chapter 8: Bioactive Glass and Glass-Ceramic Coatings

8.1 Introduction

8.2 Enameling

8.3 Glazing

8.4 Plasma Spraying

8.5 Radiofrequency Magnetron Sputtering Deposition

8.6 Pulsed Laser Deposition

8.7 Summary

References

Chapter 9: Composites Containing Bioactive Glass

9.1 Introduction

9.2 Biodegradable Polymers

9.3 Composite Scaffolds Containing Bioactive Glass

9.4 Processing Technologies for Porous Bioactive Composites

9.5 Case Study: the PDLLA-Bioglass Composite Scaffold System

9.6 Final Remarks

References

Chapter 10: Inorganic-Organic Sol-Gel Hybrids

10.1 Introduction

10.2 Hybrids in Medicine and Why They Should Be Silica-Based

10.3 Self-Assembled Hybrid Films and Layers of Grafted Silanes

10.4 Sol-Gel Hybrids

10.5 Ormosils

10.6 Polymer Choice and Property Control in Hybrids

10.7 Maintaining Bioactivity in Sol-Gel Hybrids

10.8 Summary and Outlook

Further Reading

Chapter 11: Dental Applications of Glasses

11.1 Introduction

11.2 Structure of the Human Tooth

11.3 Glass Bioactivity and Teeth

11.4 Bioactive Glass in Dental Bone Regeneration

11.5 Treatment of Hypersensitive Teeth

11.6 Bioactive Glass Coating on Metal Implants

11.7 Antimicrobial Properties of Bioactive Glasses

11.8 Bioactive Glasses in Polymer Composites

11.9 Bioactive Glasses in Glass Ionomer Cements

11.10 Summary

References

Chapter 12: Bioactive Glass as Synthetic Bone Grafts and Scaffolds for Tissue Engineering

12.1 Introduction

12.2 Synthetic Bone Grafts and Regenerative Medicine

12.3 Design Criteria for an Ideal Synthetic Bone Graft

12.4 Bioglass and the Complication of Crystallisation During Sintering

12.5 Making Porous Glasses

12.6 The Future: Porous Hybrids

12.7 Bioactive Glasses and Tissue Engineering

12.8 Regulatory Issues

12.9 Summary

Further Reading

Chapter 13: Glasses for Radiotherapy

13.1 Introduction

13.2 Glass Design and Synthesis

13.3 Non-Degradable or Bio-inert Glasses: Rare Earth Aluminosilicate Glasses

13.4 Biodegradable Glasses: Rare Earth Borate/Borosilicate Glasses

13.5 Design of Radioactive Glass Microspheres for In Vivo Applications

13.6 Treatment of Liver Cancer: Hepatocellular Carcinoma

13.7 Treatment of Kidney Cancer: Renal Cell Carcinoma

13.8 Treatment of Rheumatoid Arthritis: Radiation Synovectomy

13.9 Summary

References

Supplemental Images

Index

This edition first published 2012

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Library of Congress Cataloging-in-Publication Data

Bio-glasses : an introduction / [edited by] Julian Jones and Alexis G. Clare.

p. ; cm.

Includes bibliographical references and index.

ISBN 978-0-470-71161-3 (cloth)

I. Jones, Julian R. II. Clare, Alexis.

[DNLM: 1. Biocompatible Materials. 2. Glass. 3. Drug Delivery Systems. 4. Regeneration. 5. Tissue Scaffolds. QT 37]

610.28–dc23

2012008850

A catalogue record for this book is available from the British Library.

List of Contributors

Aldo R. Boccaccini

Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Erlangen, Germany

Delia S. Brauer

Otto Schott Institute, Friedrich Schiller University Jena, Jena, Germany

Qi-Zhi Chen

Department of Materials Engineering, Monash University, Clayton, Victoria, Australia

Alexis G. Clare

Kazuo Inamori School of Engineering, New York State College of Ceramics, Alfred University, Alfred, USA

Alastair N. Cormack

Kazuo Inamori School of Engineering, New York State College of Ceramics, Alfred University, Alfred, USA

Delbert E. Day

Center for Bone and Tissue Repair, Graduate Center for Materials Research, Materials Science and Engineering Department, Missouri University of Science and Technology, Rolla, Missouri, USA

Satoshi Hayakawa

Department of Bioscience and Biotechnology, Okayama University, Tsushima, Okayama, Japan

Wolfram Höland

Ivoclar Vivadent AG, Schaan, Principality of Liechtenstein

Leena Hupa

Process Chemistry Centre, Åbo Akademi University, Biskopsgatan, Åbo, Finland

Julian R. Jones

Department of Materials, Imperial College London, South Kensington Campus, London, UK

Steven B. Jung

MO-SCI Corporation, HyPoint North, Rolla, Missouri, USA

Matthew D. O'Donnell

Department of Materials, Imperial College London, South Kensington

Campus, London, UK

Akiyoshi Osaka

Department of Bioscience and Biotechnology, Okayama University, Tsushima, Okayama, Japan

Yuki Shirosaki

Department of Bioscience and Biotechnology, Okayama University, Tsushima, Okayama, Japan

Kanji Tsuru

Department of Biomaterials, Kyushu University, Maidashi, Higashi, Fukuoka, Japan

Enrica Verné

Foreword

‘Hamburger. Hot Dog. Ice Cream.’ Five ordinary words, but each had extraordinary significance. It was 1984 when Dr. Gerry Merwin, MD, an Ear, Nose and Throat surgeon at the University of Florida, Gainesville, Florida, whispered the words into the ear of a patient. She was an extraordinary patient—a young mother, expectant with her second child. She was desperate to be able to hear her new-born baby cry. However, the mother was deaf from an infection that had dissolved two of the three bones of her middle ear. Only part of the stapes (stirrup) remained. Under a local anaesthetic, Dr. Merwin had just implanted the world's first Bioglass® device into her middle ear. The implant was designed to conduct sound waves from her eardrum to her inner ear, the cochlea, and thus restore her hearing.

Bioglass was the first man-made material to bond to living tissues. I discovered it in 1969, but the material had to pass 15 years of in vitro (cells growing on it in the laboratory) and in vivo (animal) tests before the first device could be implanted. The University of Florida Shands Hospital Ethics Committee had approved the first human trial after evaluating data from safety tests done on hundreds of mice by Dr. Merwin, his surgical residents and Dr. June Wilson, who interpreted the histology data.

But, the big questions remained: ‘Would this new material work in a human? Would the implant bond to the soft connective tissue of the eardrum? Would it bond to the hard connective tissue (bone) of the stapes? Would it conduct sound? Would normal hearing be restored?’

No one knew the answers to these questions. Ear surgeons had inserted other types of middle ear implants in patients for many years, but they often failed. The materials used were metals and plastics, selected because they were as inert and non-toxic as possible in the body. A thin layer of scar tissue formed around the metal and plastic parts, isolating them from the body, eventually causing the implant to be forced out of position. All of the first-generation biomedical materials used in the body (so-called bio-inert materials) led to the formation of scar tissue. For some clinical needs, the scar tissue poses no problem. For a middle ear implant, scar tissue can be disastrous. Continual vibration and motion of the implant can wear a hole in the eardrum. The implant can come out through the hole, permanently damaging the eardrum.

The Bioglass middle ear implant tested a new concept in repair of the human body, bioactive bonding. The special composition of the glass contained the same compounds as present in bones and tissue fluids: Na2O, P2O5, CaO and SiO2. When a bone is broken, the body uses these compounds to form new bone. The new Bioglass implant released these compounds and the cells in the native bone used them to form a bioactive bond. The collagen of soft connective tissues, such as the tympanic membrane, also bonded to the bioactive hydroxyapatite layer that forms on the bioactive glass surface.

The theory underlying a second generation of biomedical materials, based upon bioactive bonding, was ready for its final test.

Dr. Merwin whispered the five words. A big smile appeared on the face of the patient and she repeated: ‘Hamburger. Hot Dog. Ice Cream!’ The Bioglass middle ear implant worked.

Ten years later in a follow-up study, the implant was still working, and the mother could hear her 10-year-old child laughing and singing. In the years since, thousands of patients have had their hearing restored with bioactive middle ear implants. The field of medicine and the nature of biomaterials had been changed forever.

It is now nearly 30 years since this first, epochal human trial. The speciality field of bioactive materials has expanded exponentially in those years. Millions of patients have undergone various types of repair and reconstructive surgery using formulations of bioactive materials, such as Bioglass, synthetic hydroxyapatite, Si-substituted hydroxyapatite (Actifuse®), tricalcium phosphates (e.g. Vitoss®), bioactive glass–ceramics (A/W glass–ceramic, Cerabone®), and so on. However, the grandfather material, 45S5 Bioglass, is still the material with the highest level of bioactivity and the fastest rate of bioactive bonding, and for some applications is the so-called ‘gold standard’. Bioglass is now used as a synthetic bone graft (e.g. NovaBone®) and it can now be found as the active ingredient (NovaMin®) in a market leading brand of toothpaste for sensitive teeth. The soluble glass dissolves and seals the tubules in exposed dentine, preventing exposure of nerve endings to hot and cold food and drinks.

Thus, understanding the science, technology and applications of bioactive glasses is a very important educational need for the healthcare and glass community. Many new developments have occurred during the past 30 years that are not discussed in standard materials science textbooks. Many subjects, such as sol–gel processing of bioactive gel–glasses, genetic stimulation of osteogenesis by ionic dissolution products of bioactive glasses, stimulation of angiogenesis, bioactive composites, hybrid bioactive materials, phosphate glasses, bioactive materials with hierarchical porosity, molecular modelling of glass structures and bioactivity mechanisms, tissue engineering and regenerative medicine, are now important topics in the field that did not even exist as concepts in 1984. Also, other important biomedical glass and glass–ceramic systems for therapeutic treatment of tumours and repair of diseased and damaged teeth are in widespread use and enhancing the quality of life for millions of patients throughout the world.

This important new book provides a basic level of understanding of all of the above topics. Of special importance is the fact that this book assumes that the reader is just getting started in the field. It is a primer. It provides the necessary foundation of science and technology at a beginning level in order for the reader to explore later the multitude of papers being published annually in this new field. Without a basic understanding, such as provided by this book, a person is easily confused. The reason is that the interface generated over time between a bioactive glass and the body is controlled by an integrated synthesis of inorganic chemistry, physical chemistry and biochemistry. The man-made material and the living material become as one at a molecular level. This type of ‘living interface’ mimics that between hard and soft connective tissues in the body that has evolved over billions of years. This unique character of bioactive bonding requires a unique textbook in order to comprehend and explore these materials and their clinical use. This unique book provides the fundamental level of comprehension needed. I hope it encourages the bright young creative minds of the future to enter the field and take bioactive glasses and related materials forward to the next generation of medical devices and continue to improve the quality of life of patients. For the experienced researcher, the book provides a comprehensive overview of the important current topics in the field written by world-class authors. Unlike many conference proceedings, this volume has been written by carefully selected contributors who have created much of the subject matter they discuss in their chapters, and as a consequence the contents are authoritative.

To all readers, beginner or experienced: read, enjoy and marvel at this wonderful material!

Larry Hench

Inventor of Bioglass®

20 September 2011

Preface

I found out about ‘Bioglass’ by accident. I was giving a presentation in a lecture competition in London, while I was an undergraduate at Oxford. After my talk—the subject of which (spray forming of aluminium alloys) is incidental—I began chatting to one of my fellow contestants about his biomaterials presentation. As I expressed interest in the work, Larry Hench overheard and began telling me about his own work. I was captivated and decided I should do all I could to do a PhD in Larry's group. It was a while later (a few weeks actually, due to Larry's humble nature) that I realised that he invented Bioglass and was a founder of the field of ‘bioactive ceramics’. Even though I was studying materials science in a top university, I had not heard of Bioglass or the many variants that had been developed since its invention. It should not be left to chance events for young people to come across these important and exciting materials.

So, one aim for us in writing this book is to make more people aware of bio-glasses and their variants, their application in medicine and their great potential for future clinical procedures. The book covers a wide range of material, from what a glass is, through the origins of bioactivity and how bioactive glasses can regenerate bone and heal wounds, to glasses used in cancer treatment and new-generation materials for dental reconstruction and tissue engineering. Other books available, at the time of writing, either seemed to try to cover too broad an area—such as all bioceramics—or were a collection of articles collated at conferences on the very latest developments in the field, which were perhaps not accessible to the non-expert.

We set out to produce a book that was accessible to those curious about materials in medicine, whether their background was scientific, engineering or medical. We hope that undergraduate students will find the book interesting, and decide that this is an area about which they would like to discover more or in which perhaps they would like to follow a career. The international profile of bio-glasses is increasing all the time, so more and more healthcare professionals will be exposed to bio-glass-related treatments and devices. Owing to its introductory and accessible nature, this book will be a useful tool for healthcare professionals to quickly learn about bio-glasses and their potential. Anyone brushing their teeth with the latest generation of toothpastes (containing fine Bioglass particles) may also be curious to discover how the active ingredient works in treating sensitive teeth.

I would like to take this opportunity to thank a few people. First, my co-editor, Alexis Clare—who came up with the concept for this book—as it would not have been possible without her. Alexis and I are both very pleased that Larry was so willing to write the Foreword to this book in his ‘retirement’, while he works on new projects developing materials for soaking up and recycling oil slicks, materials for supercapacitors and, of course, writing his Boing Boing, the Bionic Cat children's stories that introduce science concepts to children. We would also like to thank the other members of Technical Committee 4 (TC04) of the International Commission of Glass (ICG) for their contributions, many of them writing chapters for this book, and of course the ICG itself.

Julian R. Jones

Senior Lecturer, Department of Materials, Imperial College London

and Visiting Professor at Nagoya Institute of Technology, Japan

Chair of Technical Committee 4 (TC04)

of the International Commission of Glass (ICG)

March, 2012

Chapter 1

The Unique Nature of Glass

Alexis G. Clare

Kazuo Inamori School of Engineering, New York State College of Ceramics, Alfred University, Alfred, USA

1.1 What Is Glass?

We tend to think of glass as a single material from which we manufacture many useful articles, such as windows, drinking vessels, and storage containers that can contain quite corrosive liquids, including aggressive laboratory chemicals. Therefore, the glass has to be quite corrosion-resistant and inert, including being able to maintain its optical properties while being in aggressive environments such as a dishwasher or extreme weather. For a material that we generally view as “delicate,” in terms of attack from chemicals, it can be quite resistant. Another extreme environment is the human body. An implanted medical device is subjected to a warm and wet environment with continual fluid flow and complex mechanical loads, but perhaps more importantly there are many cells, some at work to reject foreign inert materials. They do this by encapsulating the materials with fibrous (scar) tissue. Hip replacements generally last 15 years or so, and in 2009 there was the story of a man who cut himself shaving and out of his chin fell a piece of glass. He had a lump under his chin, but he thought it was an abscess. In fact, 20 years earlier he was involved in a car accident and a piece of the windscreen embedded in his chin, unbeknown to him. The inert glass would have been sealed off from the body by fibrous tissue and over the years it was pushed out through the soft tissue to the skin.