Cell-Penetrating Peptides E-Book

• Herausgeber: Wiley-VCH GmbH
• Kategorie: Wissenschaft und neue Technologien
• Sprache: Englisch

Seitenzahl: 712

Veröffentlichungsjahr: 2022

Beschreibung

Cell-Penetrating Peptides

The definitive reference on the rational design of cell-penetrating peptides enables readers to develop tailor-made peptides for their specific needs.

In recent years, cell-penetrating peptides (CPPs) have become valuable tools for the cellular delivery of proteins, nucleic acids, and drugs. These small peptide sequences can be artificially designed and synthesized with custom-made characteristics to mediate the efficient and non-toxic transport of biomolecules, drugs, or nanoparticles into the cell.

Cell-Penetrating Peptides: Design, Development, and Applications provides an up-to-date account of the development and use of CPPs for delivering membrane-impermeable bioactive molecules into cells. Bringing together contributions from leading researchers from around the world, this comprehensive volume describes the characteristics and mechanisms of CPPs as well as their application in both medicine, biotechnology and agriculture.

• Covers rational design and development of cell-penetrating peptides for use in cellular delivery of small molecule drugs, proteins, nucleic acids, and nanoparticles
• Presents the chemical and biological characteristics of CPP action in vitro and in vivo
• Describes the structure and design principles of both synthetic and naturally occurring CPPs
• Discusses key medical applications of CPPs such as oral delivery, intranasal delivery, and clinical trials

Cell-Penetrating Peptides: Design, Development, and Applications is an essential resource for biochemists, medicinal chemists, molecular biologists, biotechnologists, and researchers studying CPPs in both academia and industry.

Leseprobe

Cell-Penetrating Peptides

Design, Development and Applications

Edited by Makoto Oba and Yosuke Demizu

Editors

Prof. Makoto ObaKyoto Prefectural University of Medicine1-5 Shimogamohangi-choSakyo-ku606-0823 KyotoJapan

Dr. Yosuke DemizuNational Institute of Health SciencesDivision of Organic Chemistry3-25-26 Tonomachi210-9501 KawasakiJapan

Cover: © Explode/Shutterstock

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Print ISBN: 978-3-527-35011-7ePDF ISBN: 978-3-527-83601-7ePub ISBN: 978-3-527-83600-0oBook ISBN: 978-3-527-83599-7

Cover Design: FORMGEBER, Mannheim

Preface

The efficient and nontoxic delivery of cell membrane-impermeable bioactive molecules into cells still remains a challenging problem. Cell-penetrating peptides (CPPs) are promising candidates for this purpose. CPPs have been developed for over three decades since the first CPP, transactivator of transcription (Tat) peptide, was found in human immunodeficiency virus type 1 (HIV-1) protein. Since then, many CPP sequences have been discovered in natural peptides and proteins, as well as being artificially designed and synthesized. Their cell-penetrating mechanisms have been investigated in vitro and in vivo. Furthermore, CPPs have been used as delivery tools for drugs, peptides, proteins, nucleic acids, and nanoparticles, and several CPPs are currently under investigation in clinical trials. We wanted to create a book covering such topics.

In the first part of this book, the design of CPPs is described based on the characteristics and typical types of CPPs. In the second part, the mechanisms of CPP action both in vitro and in vivo are introduced from chemical and biological viewpoints. The third part describes CPPs as a delivery tool for drugs, peptides, proteins, nucleic acids, morpholino oligomers, polymer micelles, and lipid-based nanoparticles. The final (fourth) part examines the application of CPPs not only in medical fields but also in agricultural fields. We hope that this book will be of interest to researchers who are studying CPPs, and that it will stimulate their research and aid in the development of the next generation of experts in this field.

We sincerely thank all the contributors to this book; they graciously produced their manuscripts within their busy schedules. The publication of this book would have been impossible without the considerable effort and patience of these contributors and the staff of Wiley-VCH GmbH.

Makoto Oba

Yosuke Demizu

Part IDesign