Chemistry of Bipyrazoles - Kamal M. Dawood - E-Book

Chemistry of Bipyrazoles E-Book

Kamal M. Dawood

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Beschreibung

Chemistry of Bipyrazoles: Synthesis and Applications covers the synthetic pathways for all types of bipyrazoles. 5 chapters cover bipyrazole systems, N,N- and N,C-bipyrazoles, namely 1,1`-bipyrazole, 1,3`-bipyrazole, 1,4`-bipyrazole, 3,3`-bipyrazoles, 3,4`-bipyrazoles and 4,4`-bipyrazoles

The contents explain several types of reactions: 1) condensation reactions of hydrazines with tetracarbonyls, dihydroxydicarbonyl compounds or pyrazole-based difunctional compounds; 2) 1,3-dipolar cycloaddition of pyrazole-based hydrazonoyl halides with activated methylene compounds; 3) metal catalyzed cross-coupling reactions.
The book concludes with a chapter that details the applications of bipyrazole derivatives in different industries. Information about advanced concepts used in chemical engineering such as metal-organic frameworks (MOFs) and corrosion inhibition are highlighted.

The book contents are presented in an easy-to-understand manner suitable for readers in organic chemistry at senior levels of education and industry expertise. Each chapter is supplemented with detailed references.

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Seitenzahl: 170

Veröffentlichungsjahr: 2022

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Table of Contents
BENTHAM SCIENCE PUBLISHERS LTD.
End User License Agreement (for non-institutional, personal use)
Usage Rules:
Disclaimer:
Limitation of Liability:
General:
PREFACE
CONSENT FOR PUBLICATION
CONFLICT OF INTEREST
ACKNOWLEDGEMENT
Chemistry of N,N- and C,N-Linked Bipyrazole Derivatives
Abstract
1. Introduction
2. Synthesis of bipyrazole systems
2.1. Synthesis of 1,1`-Bipyrazoles
2.2. Synthesis of 1,3`-bipyrazoles
2.3. Synthesis of 1,4`-bipyrazoles
Conclusion
References
Chemistry of 3,3`-Bipyrazole Derivatives
Abstract
1. Introduction
2. Synthesis of 3,3`-Bipyrazole Systems
2.1. From 1,3-Dipolar Cycloaddition Reactions
2.2. Via Cyclocondensation Reactions
2.3. From Metal Catalyzed C-H Activation Reactions
3. Reactions of 3,3`-Bipyrazole Derivatives
3.1. Nitration of 3,3`-Bipyrazole Derivatives
3.2. Miscellaneous Reactions
Conclusions
References
Chemistry of 3,4`-Bipyrazoles
Abstract
1. Introduction
2. Synthesis of 3,4`-bipyrazole derivatives
2.1. From 1,3-dipolar Cycloaddition Reactions
2.2. From Cyclocondensation of 4-pyrazolylchalcones
2.3. From Cyclocondensation of 4-pyrazolyl-bifunctional Side-arm with Hydrazines
2.4. From C-C Cross Coupling Between Two Pyrazole Units
Conclusion
References
Chemistry of 4,4`-Bipyrazoles
Abstract
1. Introduction
2. Synthesis of 4,4`-bipyrazole Derivatives
2.1. From Dimerization of Pyrazoles
2.2. From 1,3-dipolar Cycloaddition
2.3. From Functionalized Pyrazoles
Conclusion
References
Applications of Bipyrazole Derivatives
Abstract
1. Introduction
2. Applications of Bipyrazole Derivatives
2.1. Bipyrazoles as Ligands
2.2. Bipyrazoles in Synthesis of Polybipyrazoles
2.3. Bipyrazoles as Energetic Materials
2.4. Bipyrazoles as Corrosion Inhibitors
2.5. Bipyrazoles as Therapeutics
2.6. Bipyrazoles in Metal–organic Frameworks (MOFs)
Conclusion
Chemistry of Bipyrazoles: Synthesis and Applications
Authored by
Kamal M. Dawood &Ashraf A. Abbas
Department of Chemistry, Faculty of Science,
Cairo University
Giza 12613, Egypt

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PREFACE

Kamal M. Dawood,Ashraf A. Abbas
Department of Chemistry
Faculty of Science
Cairo University
Giza 12613, Egypt

Pyrazole is one of the most valuable nitrogen-based heterocycles and is incorporated in the constitution of a wide range of pharmaceuticals and agrochemicals. Direct connection of two pyrazole units produces six different bipyrazole skeletons that can be classified as i) N-N bond connected 1,1`-bipyrazoles; ii) C-N bond connected 1,3`- and 1,4`-bipyrazoles and iii) C-C bond connected 3,3`-, 3,4`- and 4,4`-bipyrazoles.

This book presents the recent achievements in the synthetic platforms toward the directly connected bipyrazole systems and their applications in academic, industrial, and material science fields. The construction of the targeted bipyrazole heterocycles was carried out via a wide-range of synthetic routes that grasp the attention of graduate and postgraduate chemists and pharmacists and material science researchers to make more efforts in this area to reach high impact findings for their applications in our life.

Most of the reported bipyrazoles are highly bioactive heterocycles demonstrating a broad array of significant inhibitory activities against several human diseases and agricultural pesticides and herbicides. They also have considerable applications in the material science area via involvement in the construction of metal-organic frameworks (MOFs) with distinguished industrial applications.

This book is presented in five chapters describing the synthesis of six connected bipyrazole systems and their brilliant and vibrant applications. As a result, we expect that the provided book chapters will be of pronounced support and a valuable source for the scientific community for developing new bipyrazole-based fascinating candidates towards optimization of their pharmacological benefits in the treatment of diseases as well as building up new MOFs for daily life applications that serve the humanity and industry.

We hope that the researchers and readers will find new ideas based on the provided work. Finally, we are very thankful to the Bentham Science Publishers for giving us the chance to publish this book.

CONSENT FOR PUBLICATION

Not applicable.

CONFLICT OF INTEREST

The authors declare that there is no conflict of interest.

ACKNOWLEDGEMENT

Declared none.

Kamal M. Dawood & Ashraf A. Abbas Department of Chemistry, Faculty of Science, Cairo University Giza 12613, Egypt

Chemistry of N,N- and C,N-Linked Bipyrazole Derivatives

Kamal M. Dawood,Ashraf A. Abbas

Abstract

The synthetic routes to three differently connected bipyrazole systems, namely; 1,1`-, 1,3`- and 1,4`-bipyrazoles were reported. The main synthetic platforms were cyclocondensation reactions. Many of the reported bipyrazole derivatives had potent applications in material science as well as in pharmaceutical fields.

Keywords: 1,1`-bipyrazoles, 1,3`-bipyrazoles, 1,4`-bipyrazoles, Cross-coupling, Cyclocondensation, Nitrilimines.