Computational Pharmaceutics E-Book

• Herausgeber: John Wiley & Sons
• Kategorie: Wissenschaft und neue Technologien
• Serie: Advances in Pharmaceutical Technology
• Sprache: Englisch

Seitenzahl: 703

Veröffentlichungsjahr: 2015

Beschreibung

Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques  are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems.

The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems.

Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field.

This book is included in the Advances in Pharmaceutical Technology book series.

Leseprobe

Advances in Pharmaceutical TechnologyA Wiley Book Series

Series Editors:

Dennis Douroumis, University of Greenwich, UKAlfred Fahr, Friedrich–Schiller University of Jena, GermanyJűrgen Siepmann, University of Lille, FranceMartin Snowden, University of Greenwich, UKVladimir Torchilin, Northeastern University, USA

Titles in the Series:

Hot-Melt Extrusion: Pharmaceutical ApplicationsEdited by Dionysios Douroumis

Drug Delivery Strategies for Poorly Water-Soluble DrugsEdited by Dionysios Douroumis and Alfred Fahr

Forthcoming titles:

Novel Delivery Systems for Transdermal and Intradermal Drug DeliveryEdited by Ryan F. Donnelly and Thakur Raghu Raj Singh

Pulmonary Drug Delivery: Advances and Challenges by Ali Nokhodhi and Gary P. Martin

Computational Pharmaceutics

Application of Molecular Modeling in Drug Delivery

Edited by

DEFANG OUYANG AND SEAN C. SMITH

This edition first published 2015© 2015 John Wiley & Sons, Ltd.

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Library of Congress Cataloging-in-Publication Data

Computational pharmaceutics : application of molecular modeling in drug delivery / edited by Defang Ouyang and Sean C. Smith.      p. ; cm. – (Advances in pharmaceutical technology)   Includes bibliographical references and index.

   ISBN 978-1-118-57399-0 (cloth)I. Ouyang, Defang, editor.   II. Smith, Sean C., editor.   III. Series: Advances in pharmaceutical technology.[DNLM:   1. Drug Delivery Systems–methods.   2. Computational Biology–methods.   3. Drug Design.   4. Models, Molecular.   QV 785]   RM301.25   615.1′9–dc23

            2014050194

A catalogue record for this book is available from the British Library.

List of Contributors

Amanda S. Barnard,CSIRO Virtual Nanoscience Laboratory, Australia

Alex Bunker,Centre for Drug Research, Faculty of Pharmacy, University of Helsinki, Finland

Robin Curtis,School of Chemical Engineering and Analytical Sciences, Manchester Institute of Biotechnology, University of Manchester, UK

Dennis E. Discher,Department of Chemical and Biomolecular Engineering, University of Pennsylvania, USA

Zhiwei Feng,Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, China

Yong Gan,Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China

Jingkai Gu,Research Center for Drug Metabolism, Jilin University, China

Zhen Guo,Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China; and Institute of Pharmaceutical Innovation, University of Bradford, UK

You He,Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, China

Tingjun Hou,Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, China

Myungshim Kang,Department of Chemistry, College of Staten Island, City University of New York, USA

Peng Ke,Merck & Co, Inc., UK

Lin Lai,CSIRO Virtual Nanoscience Laboratory, Australia

Dennis Lam,Department of Chemistry, College of Staten Island, City University of New York, USA

Youyong Li,Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, China

Sharon M. Loverde,Department of Chemistry, College of Staten Island, City University of New York, USA

Vinuthaa Murthy,School of Psychological and Clinical Sciences, Charles Darwin University, Australia

Sang Young Noh,Department of Chemistry and Centre for Scientific Computing, University of Warwick, UK; and Molecular Organization and Assembly in Cells Doctoral Training Centre, University of Warwick, UK

Rebecca Notman,Department of Chemistry and Centre for Scientific Computing, University of Warwick, UK

David William O’Neill,Department of Chemistry and Centre for Scientific Computing, University of Warwick, UK

Defang Ouyang,Institute of Chinese Medical Sciences, University of Macau, Macau

Harendra S. Parekh,School of Pharmacy, The University of Queensland, Australia

Sarah L. Price,Department of Chemistry, University College London, UK

Sheng Qi,School of Pharmacy, University of East Anglia, UK

Xiaohong Ren,Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China; and Research Center for Drug Metabolism, Jilin University, China

Dorota Roberts,School of Chemical Engineering and Analytical Sciences, Manchester Institute of Biotechnology, University of Manchester, UK

Gabriele Sadowski,Department of Biochemical and Chemical Engineering, TU Dortmund University, Germany

Carl H. Schwable,School of Life and Health Sciences, Aston University, UK

Qun Shao,Institute of Pharmaceutical Innovation, University of Bradford, UK

Raj K. Singh Badhan,Medicines Research Unit, School of Life and Health Sciences, Aston University, UK

Sean C. Smith,School of Chemical Engineering, University of New South Wales, Australia

Xiaotian Sun,Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, China

Sachin S. Thakur,School of Pharmacy, The University of Queensland, Australia

Jim Warwicker,Faculty of Life Sciences, Manchester Institute of Biotechnology, University of Manchester, UK

Li Wu,Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China; and Research Center for Drug Metabolism, Jilin University, China

Tiqiao Xiao,Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, China

Zhi Ping Xu,Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Australia

Xianzhen Yin,Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China; and Institute of Pharmaceutical Innovation, University of Bradford, UK

Peter York,Institute of Pharmaceutical Innovation, University of Bradford, UK

Jiwen Zhang,Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China; and Research Center for Drug Metabolism, Jilin University, China

Series Preface

The series Advances in Pharmaceutical Technology covers the principles, methods, and technologies that the pharmaceutical industry use to turn a candidate molecule or new chemical entity into a final drug form and hence a new medicine. The series will explore means of optimizing the therapeutic performance of a drug molecule by designing and manufacturing the best and most innovative of new formulations. The processes associated with the testing of new drugs, the key steps involved in the clinical trials process, and the most recent approaches utilized in the manufacture of new medicinal products will all be reported. The focus of the series will very much be on new and emerging technologies and the latest methods used in the drug development process.