70,99 €
Which method of contraception best suits your patient's needs? Contraceptive technology has exploded at breakneck speed. The options now available can bewilder patients who need practical advice for family planning. Contraception provides just that practical advice. Divided into three sections covering selection and cost comparison, individual methods of contraception, and risks and benefits for various patient groups, the editor presents a clear pathway to help your patients decide which method is best for them. The book covers all available contraceptive methods with WHO Medical Eligibility Criteria of contraceptives and CDC modifications. It gives sound advice on selecting contraceptive methods for women with bleeding problems, previous ectopic pregnancy, mood and depressive disorders, hirsutism and acne, perimenopausal women, women with HIV and other STIs. Provides an essential guide to all gynecologists, family medicine physicians and health care workers who provide contraceptive advice. Part of the new practical Gynecology in Practice series.
Sie lesen das E-Book in den Legimi-Apps auf:
Seitenzahl: 546
Veröffentlichungsjahr: 2011
Table of Contents
Cover
Table of Contents
Title page
Copyright page
Series Foreword
Preface
Contributors
Section 1: Overview
1 Contraceptive Use: Guidelines and Effectiveness
Introduction
Evidence-based guidelines
Development of WHO evidence-based guidance for contraceptive use
CDC adaptation of WHO evidence-based guidance for contraceptive use
Sources of evidence-based guidelines
Contraceptive effectiveness
Disclaimer
2 Cost and Availability of Contraceptive Methods
Selecting the right contraceptive method
Condoms and other barrier methods
Natural family planning
Contraceptive pills and other hormonal methods
Intrauterine devices/systems
Female and male sterilization
Birth control methods in development
Cost saving of contraceptive methods
Section 2: Individual Contraceptive Methods
3 Combination Oral Contraceptives
Mechanism of action and effectiveness
Good candidates
Poor candidates
Medical eligibility criteria
Advantages of low-dose oral contraceptives
Noncontraceptive health benefits
Risks associated with the use of oral contraceptives
Patient counseling
Selecting the right oral contraceptive: type of formulation
Drug interactions
Supplying the method
New products
Management of problems
4 Progestin-only Oral Contraceptive Pills
Method of action
Effectiveness
Good candidates
Poor candidates
Medical eligibility criteria
Advantages
Metabolic effects
Noncontraceptive benefits
Risks and side effects
Key history and physical elements
Patient counseling
Available options
New products
Supplying the method: counseling points
Management of problems
5 Contraceptive Implants
Introduction
Method of action
Good candidates
Poor candidates
Medical eligibility criteria
Advantages
Noncontraceptive benefits
Risks and side effects
Potential risks
Patient counseling
Available options
New products
Supplying the method
Management of problems
6 Ins and Outs of the Contraceptive Vaginal Ring
Method of action and effectiveness
Good candidates
Poor candidates
Medical eligibility criteria
Advantages
Noncontraceptive benefits
Risks and side effects
Key history and physical elements
Patient counseling
Available options
New products
Supplying the method: counseling points
Management of problems
7 Contraceptive Patch
Introduction
Methods of action and efficacy
Good candidates
Poor candidates
Medical eligibility criteria
Advantages
Noncontraceptive benefits
Risks and side effects
Key history and physical examination
Patient counseling
Other consultation tips
Available options
New products
Managing problems: what ifs …?
Summary
8 Progestin Injectables
History of DMPA in the United States
Mechanism of action
Efficacy of DMPA
Good candidates
Advantages
Noncontraceptive benefits
Risks and side effects
Patient counseling
Available options
Supplying the method
Management of problems
Conclusions
9 Intrauterine Devices
Introduction
Mechanism of action
Efficacy
Good candidates
Poor candidates
Medical eligibility criteria
Advantages
Noncontraceptive benefits
Risks and adverse effects
Complications related to pregnancy
Patient counseling
Available options
Supplying the method
Managing problems
10 Spermicides
Method of action
Efficacy
Good candidates
Poor candidates
Medical eligibility criteria
Advantages
Disadvantages
Risks and side effects
Key history and physical elements
Patient counseling
Available products
New products
Supplying the method
Management of problems
11 Vaginal Barriers: Diaphragm, Cervical Cap, and Female Condom
Introduction
Method of action
Good candidates
Poor candidates
Medical eligibility criteria
Advantages
Disadvantage
Noncontraceptive benefits
Risks and side effects
Key history and physical elements
Patient counseling
Available options
New products
Supplying the method: counseling points
Management of problems
12 Male Condoms
Method of action and estimates of efficacy
Good candidates
Poor candidates
Medical eligibility criteria
Advantages
Noncontraceptive benefits
Risks and side effects
Key history and physical examination elements
Patient counseling
Available options
New products
Supplying the methods
Management of problems
Conclusions
13 Emergency Contraception
Introduction
Relationship to high-risk sex and pregnancy terminations
Effectiveness
Mechanism of action
Good candidates
Medical eligibility criteria (WHO MEC)
Advantages of emergency contraceptive methods
Risks and side effects
Noncontraceptive benefits
Patient counseling
Available options
New products
Supplying the method
Management of problems
14 Tubal Sterilization
Failure rates
Good candidates
Medical eligibility criteria
Noncontraceptive benefits
Advantages
Risks and side effects
Patient counseling
Available options
Reversal of sterilization
Investigational procedures
Conclusion
Section 3: Guidelines for Use in Selected Populations
15 Postpartum Contraception
Introduction
The postpartum visit
Lactation and contraception
Contraceptive efficacy of lactation: using LAM
Considerations for use of hormonal contraception in lactation
Intrauterine contraception
Postplacental IUD placement
Nonhormonal methods
Sterilization
Postpartum contraception in nonlactating women
Summary
16 Adolescents: Compliance, Ethical Issues, and Sexually Transmitted Infections
Introduction
When to initiate
Barriers to access
Education
Contraceptive counseling
Abstinence
Barrier methods
Combination estrogen/progestin contraceptives
Progestin-only contraception
Intrauterine devices and systems
Emergency contraception
Summary
17 Women 35 Years and Older: Safety Issues
Introduction
Contraceptive choices
Benefits of hormonal contraceptives in older women
Risks
18 Perimenopausal Contraception
The perimenopausal woman
Health issues
Medical eligibility criteria
Actual perimenopausal contraceptive use
Contraceptive options for perimenopausal women
Health concerns/side effects
Barrier contraceptives
Contraception use and compliance
19 Medical Eligibility Requirements
Introduction
Clinical judgment
US Medical Eligibility Criteria for Contraceptive Use
20 Hormonal Contraception and Mood
Introduction
Background
Effect of hormonal contraceptives on mood in women without mood disorders
Effect of hormonal contraceptives on mood in women with mood symptoms or disorders
Conclusions
21 Contraception in Women with Abnormal Uterine Bleeding
Introduction
Need for uniform terminology
Types of abnormal uterine bleeding symptoms
Underlying causes of HMB and HPMB
Investigations prior to starting contraception
Contraceptive choices for women with AUB
Contraceptive options for women with IMB and PCB
Adverse effects of hormonal contraceptives on bleeding patterns
Roles of other nonpreferred methods of contraception in women with HMB or other types of AUB
Acute and severe HMB
Role of surgery for HMB or IMB before contraception
Benefits associated with long-term contraceptive use
Switching contraception in women with persistent HMB or IMB
22 Hirsutism and Acne
Introduction
Causes of hirsutism and acne in women
Patient evaluation
Which conditions should be ruled out before treating hirsutism and acne?
Laboratory studies
Diagnosis
Treatment
Are there other contraceptive methods that work for hirsutism and acne?
Conclusions
23 HIV and Other Sexually Transmitted Infections
Contraception in HIV-infected women
Other sexually transmitted infections
Antibiotics for STIs and other indications
24 Contraception Following Ectopic Pregnancy, and Induced or Spontaneous Abortion
Introduction
Induced abortion
Spontaneous abortion
Ectopic pregnancy
Contraceptive considerations
IUDs and ectopic pregnancy
Conclusion
Index
This edition first published 2011, © 2011 by Blackwell Publishing Ltd
Blackwell Publishing was acquired by John Wiley & Sons in February 2007. Blackwell’s publishing program has been merged with Wiley’s global Scientific, Technical and Medical business to form Wiley-Blackwell.
Registered office: John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK
Editorial offices: 9600 Garsington Road, Oxford, OX4 2DQ, UK
The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK
111 River Street, Hoboken, NJ 07030-5774, USA
For details of our global editorial offices, for customer services and for information about how to apply for permission to reuse the copyright material in this book please see our website at www.wiley.com/wiley-blackwell
The right of the author to be identified as the author of this work has been asserted in accordance with the UK Copyright, Designs and Patents Act 1988.
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher.
Designations used by companies to distinguish their products are often claimed as trademarks. All brand names and product names used in this book are trade names, service marks, trademarks or registered trademarks of their respective owners. The publisher is not associated with any product or vendor mentioned in this book. This publication is designed to provide accurate and authoritative information in regard to the subject matter covered. It is sold on the understanding that the publisher is not engaged in rendering professional services. If professional advice or other expert assistance is required, the services of a competent professional should be sought.
The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting a specific method, diagnosis, or treatment by physicians for any particular patient. The publisher and the author make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of fitness for a particular purpose. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. Readers should consult with a specialist where appropriate. The fact that an organization or Website is referred to in this work as a citation and/or a potential source of further information does not mean that the author or the publisher endorses the information the organization or Website may provide or recommendations it may make. Further, readers should be aware that Internet Websites listed in this work may have changed or disappeared between when this work was written and when it is read. No warranty may be created or extended by any promotional statements for this work. Neither the publisher nor the author shall be liable for any damages arising herefrom.
Library of Congress Cataloging-in-Publication Data
Contraception / edited by Donna Shoupe, Division of Reproductive
Endocrinology, Keck School of Medicine, University of Southern California.
p. ; cm.—(Gynecology in practice)
Includes bibliographical references and index.
ISBN 978-1-4443-3351-0 (pbk. : alk. paper)
ISBN 978-1-4443-4263-5 (ebk)
1. Contraception. I. Shoupe, Donna, editor. II. Series: Gynecology in practice.
[DNLM: 1. Contraception–methods. 2. Contraceptive Agents. 3. Contraceptive Devices. 4. Fertilization–drug effects. WP 630]
RG136.C557 2011
613.9′43–dc22
2010047407
A catalogue record for this book is available from the British Library.
Series Foreword
In recent decades, massive advances in medical science and technology have caused an explosion of information available to the practitioner. In the modern information age, it is not unusual for physicians to have a computer in their offices with the capability of accessing medical databases and literature searches. On the other hand, however, there is always a need for concise, readable, and highly practicable written resources. The purpose of this series is to fulfill this need in the field of gynecology.
The Gynecology in Practice series aims to present practical clinical guidance on effective patient care for the busy gynecologist. The goal of each volume is to provide an evidence-based approach for specific gynecologic problems. “Evidence at a glance” features in the text provide summaries of key trials or landmark papers that guide practice, and a selected bibliography at the end of each chapter provides a springboard for deeper reading. Even with a practical approach, it is important to review the crucial basic science necessary for effective diagnosis and management. This is reinforced by “Science revisited” boxes that remind readers of crucial anatomic, physiologic or pharmacologic principles for practice.
Each volume is edited by outstanding international experts who have brought together truly gifted clinicians to address many relevant clinical questions in their chapters. The first volumes in the series are on Chronic Pelvic Pain, one of the most challenging problems in gynecology, Disorders of Menstruation, Infertility, and Contraception. These will be followed by volumes on Sexually Transmitted Diseases, Menopause, Urinary Incontinence, Endoscopic Surgeries, and Fibroids, to name a few. I would like to express my gratitude to all the editors and authors, who, despite their other responsibilities, have contributed their time, effort, and expertise to this series.
Finally, I greatly appreciate the support of the staff at Wiley-Blackwell for their outstanding editorial competence. My special thanks go to Martin Sugden, PhD; without his vision and perseverance, this series would not have come to life. My sincere hope is that this novel and exciting series will serve women and their physicians well, and will be part of the diagnostic and therapeutic armamentarium of practicing gynecologists.
Aydin Arici, MD
Professor
Department of Obstetrics, Gynecology, and Reproductive Sciences
Yale University School of Medicine
New Haven, USA
Preface
When scanning for topics related to world population it is not surprising that family planning is the first entry. This entry, however, is followed by overpopulation, overconsumption, water crisis, sustainable development, food security, green revolution, world energy resources and consumption. An article entitled “The Day of Six Billion” reviews the world population that reached 1 billion in 1804, 2 billion in 1927, 3 billion in 1960, 4 billion in 1974, 5 billion in 1987, and 6 billion in 1999. Some estimates project that the world will reach 7 billion in 2011–12, 8 billion in 2025, 9 billion in 2040, and 10 billion in 2061. These enormous growths in population would place tremendous strains on world energy and food supplies and incite economical and political conflict.
There is evidence, however, that efforts to curb the population explosion have been effective and that another scenario may instead unfold. The global population growth rate, which reached a peak in 1963 (2.2%), has since been steadily slowing and by 2008 was cut by half. While growth rates remain high in Latin America, the Middle East and Sub-Saharan Africa, some countries, especially in central and eastern Europe, have a negative population growth. Within the next 10 years, Japan and some countries in western Europe are expected to have a negative population growth. If these trends continue, the world growth rate may diminish to zero. Addressing these very different possible scenarios, the United Nation’s projections for world population in 2050 ranged from 8 billion to 10.5 billion.
Developed countries have traditionally had much lower fertility rates than developing countries, due to a combination of factors relating to greater wealth, education, and urbanization. Although mortality rates are generally lower in developed countries, birth control options are well known and accessible. Many reproductive-aged women in these countries are motivated to use contraceptive methods as they pursue education or job goals or wish to control spacing and number of children. A variety of private and public sector programs help defray the costs of contraceptives for those with limited financial means, and a barrage of mass media advertisements help educate the general public on contraceptive options.
Advances in contraceptive technology, worldwide availability, and effective dissemination of information regarding contraceptive options will continue to play a vital role in the world’s economic and political wellbeing. This book is dedicated to those individuals and organizations that have tirelessly advanced these goals around the world. Over the next decade, the impact of their hard work and dedication will continue to show impact and will help to determine which of the scenarios presented above will unfold.
This book is also dedicated to the authors who were willing to take the time to share their expertise. The authors were asked to write a clinically pertinent chapter and include a list of references at the end of the chapter that could be used by interested readers to further expand their knowledge on particular topics. These authors represent a variety of titles, practices, academic backgrounds, and areas of expertise.
The book is divided into three sections. The first section includes chapters on appropriate selection of contraceptive options and cost comparison of contraceptives. Chapter 1 introduces the new Centers for Disease Control and Prevention medical eligibility criteria adaptation for the United States (the US MEC). Chapter 2 presents a comparison of the 1-, 5-, and 10-year present values of the contraceptives available in the United States. These values include the cost of the method, the medical costs of obtaining the method, and the cost of pregnancy as a result of method failure.
The second section of the book includes chapters on the contraceptive options currently available in the United States, with sections on method of action, good candidates, poor candidates, medical eligibility criteria, advantages, noncontraceptive benefits, risks and side effects, patient counseling, available options, new products, supplying the method, and management of problems. Each of the following methods is addressed separately:
oral contraceptivesprogestin only contraceptivescontraceptive implantscontraceptive vaginal ringcontraceptive patchprogestin injectablesintrauterine devicesspermicidesvaginal barriers: diaphragm, cervical cap, and female condommale condomsemergency contraceptiontubal sterilizationThe third section of the book includes chapters on various medical conditions and the risks and benefits associated with various contraceptive options:
postpartumadolescents: compliance, ethical and STD issueswomen 35 years and older: safety issuesperimenopausal contraception—staging of reproductive aging in womenmedical eligibility criteria—WHO MEC and US MEChormonal contraception and mood—depressive disorders, PMDD and PMS, major depressive disorders, postpartum depression, schizophrenia, bipolar, anxiety and panic disorderabnormal uterine bleeding—uniform terminology, structural and nonstructural etiologieshirsuitism and acne—causes and patient evaluation, diagnosis and treatmentHIV and other sexually transmitted infections—antiretroviral interactions with hormonal contraceptives, reducing transmission to partners and fetuscontraception following ectopic pregnancy or spontaneous or induced abortion.This book is designed to highlight the important issues surrounding contraceptive technology including safety, lifestyle, costs of method, costs of method failure, noncontraceptive benefits, interaction with various medical conditions, and managing side effects. There is an important emphasis on the WHO MEC and CDC modifications as these are the guidelines important to clinicians.
A final tribute is given to those who excel in contraceptive technology and in all areas of human endeavors.
This comprehensive book includes topics on:
All of the currently available contraceptive methods in the US including those recently introducedWHO Medical Eligibility Criteria for contraceptives and CDC modificationsSelecting contraceptive methods for women with bleeding problems, previous ectopic pregnancy, mood and depressive disorders, hirsutism and acne, perimenopausal women, women with HIV and other STIs.An important and useful reference for:
Contraceptive Healthcare ProvidersGynecologistsFamily Medicine PhysiciansNurse practitionersInternistsPhysician AssistantsDonna Shoupe
Los Angeles
Contributors
Susan A. Ballagh, MD Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance, CA, USA
Paula H. Bednarek, MD, MPH Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA
Nerys Benfield, MD Department of Obstetrics Gynecology and Reproductive Sciences, University of California, San Francisco and San Francisco General Hospital, San Francisco, CA, USA
Timothy Campbell, PhD Economics and Finance, Marshall School of Business, University of Southern California, USA
Catherine Cansino, MD, MPH Department of Obstetrics and Gynecology, The Ohio State University, Colombus, OH, USA
Mitchell Creinin, MD Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine and Magee Research Institute Hospital, Pittsburgh, PA, USA
Kathryn M. Curtis, PhD Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
Philip D. Darney, MD, MSC Department of Obstetrics Gynecology and Reproductive Sciences, University of California, San Francisco and San Francisco General Hospital, San Francisco, CA, USA
Alison B. Edelman, MD, MPH Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA
Ian S. Fraser, AO, MD Department of Obstetrics, Gynaecology and Neonatology, Queen Elizabeth II Research Institute for Mothers and Infants, University of Sydney, NSW, Australia
Jeffrey T. Jensen, MD, MPH Department of Obstetrics and Gynecology and Department of Public Health and Preventive Medicine, Oregon Health and Science University, Portland, OR, USA
Ronna Jurow, MD, MS Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, USA
Andrew M. Kaunitz, MD Department of Obstetrics and Gynecology, University of Florida College of Medicine, Jacksonville, FL, USA
Charles M. March, MD Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, USA
Polly A. Marchbanks, PhD Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
Susanna Meredith, MD Department of Obstetrics and Gynecology, University of Florida College of Medicine, Jacksonville, FL, USA
Daniel R. Mishell Jr, MD Division of Reproductive Endocrinology and Infertility, Keck School of Medicine, University of Southern California, USA
Anita L. Nelson, MD Department of Obstetrics and Gynecology, David Geffen School of Medicine at ULCA and Harbor-UCLA Medical Center, Torrance, CA, USA
Melanie Ochalski, MD Department of Obstetrics and Gynecology and Reproductive Sciences, Center for Fertility and Reproductive Endocrinology, University of Pittsburgh Physicians, Magee-Womens Hospital, Pittsburgh, PA, USA
Andrea Rapkin, MD Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Matthew F. Reeves, MD, MPH Medical Affairs, WomanCare Global, Chapel Hill, NC, USA
Regina-Maria Renner, MD, MPH Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA
Frans J.M.E. Roumen, MD, PhD Department of Obstetrics and Gynaecology, Atrium Medical Centre Parkstad, Heerlen, The Netherlands
Jennefer A. Russo, MD Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh Medical Center, Magee-Womens Hospital, Pittsburgh, PA, USA
Joseph S. Sanfilippo, MD, MBA Department of Obstetrics and Gynecology and Reproductive Sciences, Center for Fertility and Reproductive Endocrinology, University of Pittsburgh Physicians, Magee-Womens Hospital, Pittsburgh, PA, USA
Jill L. Schwartz, MD, MPH Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Arlington, VA, USA
Donna Shoupe, MD Division of Reproductive Endocrinology and Infertility, Keck School of Medicine, University of Southern California, CA, USA
Sarita Sonalkar, MD Department of Obstetrics and Gynecology, Boston University School of Medicine, Boston, MA, USA
Stephanie B. Teal, MD, MPH Department of Obstetrics and Gynecology, University of Colorado Denver School of Medicine, Aurora, CO, USA
Naomi K. Tepper, MD, MPH Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
Alice Stek, MD Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
DeShawn L. Taylor, MD, MSc Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Section 1: Overview
1
Contraceptive Use: Guidelines and Effectiveness
Kathryn M. Curtis, Naomi K. Tepper, and Polly A. Marchbanks
Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, USA
Introduction
Clinicians are now able to rely on evidence-based guidelines to efficiently incorporate scientific evidence into clinical practice regarding appropriate selection and use of specific contraceptive methods.
Contraceptive effectiveness is also an important factor in contraceptive choice; tools are available to assist providers in communicating contraceptive effectiveness to family planning patients.
Evidence-Based Guidelines
As the volume of scientific literature rapidly expands, it has become increasingly difficult for individual clinicians to keep up with finding, reading, and interpreting new evidence to put into practice. A PubMed search using the terms “contraception” and “family planning” yielded an average of 130 new articles per month in 2010. Many clinicians rely on evidence-based guidelines to efficiently use the best scientific evidence when making decisions about patient care.
EVIDENCE AT A GLANCE
The World Health Organization’s evidence-based guidance on contraceptive use (WHO Medical Eligibility Criteria for Contraceptive Use (MEC)) is used around the world and has been adapted by several countries, including the United States.The Centers for Disease Control and Prevention (CDC) has recently adapted the WHO MEC for use in the United States (US MEC). While the vast majority of the CDC recommendations are identical to the WHO recommendations, some adaptations were made to more accurately focus on methods currently available in the USA, and to better reflect the surgical and medical practices of the USALesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
