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Beschreibung

In recent years, there has been a growing awareness of the multiple interrelationships between depression and various physical diseases. The WPA is providing an update of currently available evidence on these interrelationships by the publication of three books, dealing with the comorbidity of depression with diabetes, heart disease and cancer. Depression is a frequent and serious comorbid condition in diabetes, which adversely affects quality of life and the long-term prognosis. Co-occurrent depression presents peculiar clinical challenges, making both conditions harder to manage. Depression and Diabetes is the first book devoted to the interaction between these common disorders. World leaders in diabetes, depression and public health synthesize current evidence, including some previously unpublished data, in a concise, easy-to-read format. They provide an overview of the epidemiology, pathogenesis, medical costs, management, and public health and cultural implications of the comorbidity between depression and diabetes. The book describes how the negative consequences of depression in diabetes could be avoided, given that effective depression treatments for diabetic patients are available. Its practical approach makes the book ideal for all those involved in the management of these patients: psychiatrists, psychologists, diabetologists, general practitioners, diabetes specialist nurses and mental health nurses.

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Seitenzahl: 272

Veröffentlichungsjahr: 2011

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Contents

Series Page

Copytright

List of Contributors

Preface

CHAPTER 1 The Epidemiology of Depression and Diabetes

RATES OF DEPRESSION IN PEOPLE WITH DIABETES

INTERNATIONAL VARIATIONS IN RATES OF DEPRESSION IN PEOPLE WITH DIABETES

RISK FACTORS FOR DEPRESSION IN PEOPLE WITH DIABETES

DEPRESSION AS A RISK FACTOR FOR DIABETES

DEPRESSIVE SYMPTOMATOLOGY AND GLYCAEMIC CONTROL

MILD DEPRESSION AND OTHER PSYCHOLOGICAL COMORBIDITIES IN PEOPLE WITH DIABETES

LONGER-TERM OUTCOMES AND THE IMPACT OF DEPRESSION IN DIABETES

CONCLUSIONS

ACKNOWLEDGEMENTS

REFERENCES

CHAPTER 2 Unraveling the Pathogenesis of the Depression–Diabetes Link

LIMITATIONS OF THE PSYCHOLOGICAL MODEL

DEPRESSION AND INSULIN RESISTANCE

DEPRESSION AND ACTIVITY OF THE HYPOTHALAMIC–PITUITARY–ADRENAL (HPA) AXIS

THE DIABETES-DEPRESSION LINK AND THE AUTONOMIC NERVOUS SYSTEM

THE DIABETES–DEPRESSION LINK AND THE INNATE INFLAMMATORY RESPONSE

GENETICS OF THE DIABETES–DEPRESSION LINK

THE DIABETES–DEPRESSION LINK AND BIRTH WEIGHT

THE DIABETES–DEPRESSION LINK AND EARLY CHILDHOOD ADVERSITY

THE ROLE OF ANTIDEPRESSANTS

CONCLUSIONS

REFERENCES

CHAPTER 3 Medical Costs of Depression and Diabetes

MEDICAL COSTS OF DIABETES AND OF DEPRESSION

IMPACT OF COEXISTING DEPRESSION AND DIABETES ON DISABILITY, PRODUCTIVITY AND QUALITY OF LIFE

MEDICAL COSTS OF COEXISTING DIABETES AND DEPRESSION

COSTS OF TREATMENT OF COEXISTING DIABETES AND DEPRESSION

AREAS FOR FUTURE RESEARCH

REFERENCES

CHAPTER 4 Treatment of Depression in Patients with Diabetes: Efficacy, Effectiveness and Maintenance Trials, and New Service Models

EFFICACY STUDIES

EFFECTIVENESS TRIALS: COLLABORATIVE DEPRESSION CARE

MAINTENANCE TRIALS

NEW TREATMENT MODELS

IMPROVING DEPRESSION CARE IN INDIVIDUAL PATIENTS WITH DIABETES

CHANGES IN PRIMARY CARE SYSTEMS NECESSARY TO IMPROVE OUTCOMES OF PATIENTS WITH DEPRESSION AND DIABETES

CONCLUSIONS

REFERENCES

CHAPTER 5 Diabetes and Depression: Management in Ordinary Clinical Conditions

THE IMPACT OF SETTINGS ON THERAPY

THE CLINICAL INTERPLAY BETWEEN DEPRESSION, COGNITIVE DYSFUNCTION, DIABETIC COMPLICATIONS AND GLYCAEMIC CONTROL

COORDINATION OF CARE AND USE OF TREATMENTS FOR DEPRESSION

OPTIMIZING THE PROVIDER-PATIENT RELATIONSHIP

HEALTH CARE USE

CONCLUSIONS

REFERENCES

CHAPTER 6 Depression and Diabetes: Sociodemographic and Cultural Aspects and Public Health Implications

WOMEN, DEPRESSION AND DIABETES

DEPRESSION AND DIABETES IN LATE LIFE

SOCIOECONOMIC STATUS, DEPRESSION AND DIABETES

MIGRATION, DIABETES AND DEPRESSION

IMPACT OF ETHNICITY-RELATED CULTURE

MEASURES TO REDUCE HEALTH DISPARITIES AMONG PEOPLE FROM DIFFERENT CULTURAL BACKGROUNDS

INTERVENTION STRATEGIES AND RESEARCH DIRECTIONS FORTRANSCULTURAL HEALTH NEEDS

CONCLUSIONS

REFERENCES

Acknowledgement

Index

World Psychiatric Association titles on Depression

In recent years, there has been a growing awareness of the multiple interrelationships between depression and various physical diseases. This series of volumes dealing with the comorbidity of depression with diabetes, heart disease and cancer provides an update of currently available evidence on these interrelationships.

Depression and Diabetes

Edited by Wayne Katon, Mario Maj and Norman Sartorius

ISBN: 9780470688380

Depression and Heart Disease

Edited by Alexander Glassman, Mario Maj and Norman Sartorius

ISBN: 9780470710579

Depression and Cancer

Edited by David W. Kissane, Mario Maj and Norman Sartorius

ISBN: 9780470689660

Related WPA title on depression:

Depressive Disorders, 3e

Edited by Helen Herrman, Mario Maj and Norman Sartorius

ISBN: 9780470987209

For all other WPA titles published by John Wiley & Sons Ltd, please visit the following website pages:

http://eu.wiley.com/WileyCDA/Section/id-305609.html

http://eu.wiley.com/WileyCDA/Section/id-303180.html

This edition first published 2010 2010, John Wiley & Sons, Ltd.

Wiley-Blackwell is an imprint of John Wiley & Sons, formed by the merger of Wiley’s global Scientific, Technical and Medical business with Blackwell Publishing.

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Library of Congress Cataloguing-in-Publication Data

Depression and diabetes/editors, Wayne Katon, Mario Maj, Norman Sartorius.

p.; cm.

Includes bibliographical references and index.

Summary: ‘‘Depression and Diabetes is the first book devoted to the interaction between these common disorders. World leaders in diabetes, depression, and public health synthesize current evidence, including some previously unpublished data, in a concise, easy-to-read format. They provide an overview of the epidemiology, pathogenesis, medical costs, management, and public health and cultural implications of the comorbidity between depression and diabetes. The book describes how the negative consequences of depression in diabetes could be avoided, given that effective depression treatments for diabetic patients are available.’’–Provided by publisher.

ISBN 978-0-470-68838-0 (paper)

1. Diabetes–Treatment. 2. Diabetes–Psychological aspects. 3. Depression, Mental–Treatment. I. Katon, Wayne. II. Maj, Mario, 1953- III. Sartorius, N.

[DNLM: 1. Depressive Disorder. 2. Diabetes Complications. WM 171 D42238 2010]

RC660.D43 2010

616.4’6206-dc22

2010016178

ISBN: 9780470688380

A catalogue record for this book is available from the British Library.

List of Contributors

Juliana Chan Hong Kong Institute of Diabetes and Obesity; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China

Paul Ciechanowski Department of Psychiatric and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA

Leonard E. Egede Department of Medicine, Center for Health Disparities Research, Medical University of South Carolina; and Center for Disease Prevention and Health Interventions for Diverse Populations, Ralph H. Johnson VA Medical Center, Charleston, SC, USA

Christina van der Feltz-Cornelis Department of Clinical and Developmental Psychology, University of Tilburg; Centre of Top Clinical Care for Somatoform Disorder, GGZ Breburg, Breda; Trimbos Institute, Utrecht, The Netherlands

Richard Hellman Department of Medicine, University of Missouri, Kansas City, MO, USA

Norbert Hermanns Research Institute, Mergentheim, Germany

Khalida Ismail Department of Psychological Medicine, Institute of Psychiatry, King’s College London, London, UK

Wayne Katon Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA

Cathy E. Lloyd Faculty of Health and Social Care, The Open University, Milton Keynes, UK

Hairong Nan Hong Kong Institute of Diabetes and Obesity, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China

Arie Nouwen School of Psychology, University of Birmingham, Birmingham, UK

Frans Pouwer Centre for Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Tilburg, The Netherlands

Rose Ting Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China

Leigh Underwood Greater Western Area Health Service/Centre for Rural and Remote Mental Health, New South Wales, Australia

Kirsty Winkley Diabetes and Mental Health Unit, King’s College London, and Institute of Psychiatry, London, UK

Preface

The association between depression and diabetes was first described in the seventeenth century by Thomas Willis, an English physician and anatomist, who stated, ‘Diabetes is caused by sadness or long sorrow’. Indeed, in modern times, a systematic review found that depression earlier in life increased the risk of development of type 2 diabetes by up to 37%.

Evidence of a bidirectional relationship between depression and diabetes has also been recently documented in large prospective studies. Comorbid depression is associated with an increased risk of poor glycemic control, diabetes complications and mortality. Incident diabetes complications have also been found to be risk factors for subsequent development of depressive episodes.

In this book, authors on the cutting edge of research in patients with comorbid depression and diabetes describe the most up-to-date findings. The importance of the research on depression and diabetes has been emphasized in recent years because of the modern-day epidemic of obesity and diabetes that is emerging in both high and low income countries. The direct medical and indirect personal and familial costs of this epidemic are starting to get international attention. In the United States, the cost of diabetes already is estimated to represent about 10% of all medical costs and is expected to increase by 50-100% over the next decade. The public health importance and the scientific issues related to the comorbidity of depression and diabetes have led to an international scientific collaboration, the Diabetes and Depression Initiative, which is bringing together a number of organizations and experts, several of whom have participated in the production of this volume.

In this exciting new text, Cathy Lloyd and colleagues describe the epidemiology of depression and diabetes, including the prevalence and course of depression in patients with type 1 and 2 diabetes, evidence of bidirectional links between these two disorders, and associations of depression with adverse health habits (i.e. smoking and obesity), poor disease control, medical complications and mortality. Khalida Ismail reviews the putative biologic links between depression and diabetes, which may explain why depression in early life is a risk factor for development of type 2 diabetes as well as an important factor in risk of complications and mortality in those with type 2 diabetes.

Leonard Egede reviews the extensive data on the increased medical and personal, familial and employment-related costs of comorbid depression and diabetes. These data are extremely important to health policy planners in emphasizing the potential benefit of screening patients with diabetes for depression. The epidemiologic data have shown that depression is a risk factor for poor disease control, diabetes macrovascular and microvascular complications and mortality, and Egede’s data add tothese findings by showing the high direct medical and indirect costs, such as days off work and decreased productivity.

Wayne Katon and Christina van der Felz-Cornelis describe the clinical trials that have been completed in patients with depression and diabetes, including pharmacologic, psychotherapy and collaborative care trials. This extensive research demonstrates that depression can be effectively treated by both evidence-based depression-focused psychotherapy and antidepressant medications, and that collaborative care is an effective health service model to deliver these treatments to large, primary carebased populations. Collaborative care is associated not only with improved quality of depression care and depressive outcomes, but also with a high likelihood of savings in total medical costs.

Richard Hellman and Paul Ciechanowski review the important patient-physician factors that need to be emphasized to provide guideline level diabetes care. Their chapter focuses on the interaction of depression, cognitive dysfunction, glycemic control and diabetes complications and provides state-of-the-art recommendations about how to improve quality of biopsychosocial care for patients with diabetes.

In the final chapter, Juliana Chan and colleagues describe the important cultural issues in patients with depression and diabetes in both high and low income countries. Public health campaigns aimed at decreasing the incidence of obesity and type 2 diabetes and improving screening and treatment of depression will clearly need to understand the sociocultural causes and meanings of these illnesses in diverse populations.

This volume is part of a WPA series focusing on the comorbidity of depression with various physical diseases. Forthcoming volumes will deal with depression and heart disease and depression and cancer.

Wayne Katon

Mario Maj

Norman Sartorius

CHAPTER 1

The Epidemiology of Depression and Diabetes

Cathy E. Lloyd

Faculty of Health and Social Care, The Open University, Milton Keynes, UK

Norbert Hermanns

Research Institute, Mergentheim, Germany

Arie Nouwen

School of Psychology, University of Birmingham, Birmingham, UK

Frans Pouwer

Centre for Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Tilburg, The Netherlands

Leigh Underwood

Greater Western Area Health Service/Centre for Rural and Remote Mental Health, New South Wales, Australia

Kirsty Winkley

Diabetes and Mental Health Unit, King’s College London, and Institute of Psychiatry, London, UK

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