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In recent years, there has been a growing awareness of the multiple interrelationships between depression and various physical diseases. The WPA is providing an update of currently available evidence on these interrelationships by the publication of three books, dealing with the comorbidity of depression with diabetes, heart disease and cancer. Depression is a frequent and serious comorbid condition in diabetes, which adversely affects quality of life and the long-term prognosis. Co-occurrent depression presents peculiar clinical challenges, making both conditions harder to manage. Depression and Diabetes is the first book devoted to the interaction between these common disorders. World leaders in diabetes, depression and public health synthesize current evidence, including some previously unpublished data, in a concise, easy-to-read format. They provide an overview of the epidemiology, pathogenesis, medical costs, management, and public health and cultural implications of the comorbidity between depression and diabetes. The book describes how the negative consequences of depression in diabetes could be avoided, given that effective depression treatments for diabetic patients are available. Its practical approach makes the book ideal for all those involved in the management of these patients: psychiatrists, psychologists, diabetologists, general practitioners, diabetes specialist nurses and mental health nurses.
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Seitenzahl: 272
Veröffentlichungsjahr: 2011
Contents
Series Page
Copytright
List of Contributors
Preface
CHAPTER 1 The Epidemiology of Depression and Diabetes
RATES OF DEPRESSION IN PEOPLE WITH DIABETES
INTERNATIONAL VARIATIONS IN RATES OF DEPRESSION IN PEOPLE WITH DIABETES
RISK FACTORS FOR DEPRESSION IN PEOPLE WITH DIABETES
DEPRESSION AS A RISK FACTOR FOR DIABETES
DEPRESSIVE SYMPTOMATOLOGY AND GLYCAEMIC CONTROL
MILD DEPRESSION AND OTHER PSYCHOLOGICAL COMORBIDITIES IN PEOPLE WITH DIABETES
LONGER-TERM OUTCOMES AND THE IMPACT OF DEPRESSION IN DIABETES
CONCLUSIONS
ACKNOWLEDGEMENTS
REFERENCES
CHAPTER 2 Unraveling the Pathogenesis of the Depression–Diabetes Link
LIMITATIONS OF THE PSYCHOLOGICAL MODEL
DEPRESSION AND INSULIN RESISTANCE
DEPRESSION AND ACTIVITY OF THE HYPOTHALAMIC–PITUITARY–ADRENAL (HPA) AXIS
THE DIABETES-DEPRESSION LINK AND THE AUTONOMIC NERVOUS SYSTEM
THE DIABETES–DEPRESSION LINK AND THE INNATE INFLAMMATORY RESPONSE
GENETICS OF THE DIABETES–DEPRESSION LINK
THE DIABETES–DEPRESSION LINK AND BIRTH WEIGHT
THE DIABETES–DEPRESSION LINK AND EARLY CHILDHOOD ADVERSITY
THE ROLE OF ANTIDEPRESSANTS
CONCLUSIONS
REFERENCES
CHAPTER 3 Medical Costs of Depression and Diabetes
MEDICAL COSTS OF DIABETES AND OF DEPRESSION
IMPACT OF COEXISTING DEPRESSION AND DIABETES ON DISABILITY, PRODUCTIVITY AND QUALITY OF LIFE
MEDICAL COSTS OF COEXISTING DIABETES AND DEPRESSION
COSTS OF TREATMENT OF COEXISTING DIABETES AND DEPRESSION
AREAS FOR FUTURE RESEARCH
REFERENCES
CHAPTER 4 Treatment of Depression in Patients with Diabetes: Efficacy, Effectiveness and Maintenance Trials, and New Service Models
EFFICACY STUDIES
EFFECTIVENESS TRIALS: COLLABORATIVE DEPRESSION CARE
MAINTENANCE TRIALS
NEW TREATMENT MODELS
IMPROVING DEPRESSION CARE IN INDIVIDUAL PATIENTS WITH DIABETES
CHANGES IN PRIMARY CARE SYSTEMS NECESSARY TO IMPROVE OUTCOMES OF PATIENTS WITH DEPRESSION AND DIABETES
CONCLUSIONS
REFERENCES
CHAPTER 5 Diabetes and Depression: Management in Ordinary Clinical Conditions
THE IMPACT OF SETTINGS ON THERAPY
THE CLINICAL INTERPLAY BETWEEN DEPRESSION, COGNITIVE DYSFUNCTION, DIABETIC COMPLICATIONS AND GLYCAEMIC CONTROL
COORDINATION OF CARE AND USE OF TREATMENTS FOR DEPRESSION
OPTIMIZING THE PROVIDER-PATIENT RELATIONSHIP
HEALTH CARE USE
CONCLUSIONS
REFERENCES
CHAPTER 6 Depression and Diabetes: Sociodemographic and Cultural Aspects and Public Health Implications
WOMEN, DEPRESSION AND DIABETES
DEPRESSION AND DIABETES IN LATE LIFE
SOCIOECONOMIC STATUS, DEPRESSION AND DIABETES
MIGRATION, DIABETES AND DEPRESSION
IMPACT OF ETHNICITY-RELATED CULTURE
MEASURES TO REDUCE HEALTH DISPARITIES AMONG PEOPLE FROM DIFFERENT CULTURAL BACKGROUNDS
INTERVENTION STRATEGIES AND RESEARCH DIRECTIONS FORTRANSCULTURAL HEALTH NEEDS
CONCLUSIONS
REFERENCES
Acknowledgement
Index
World Psychiatric Association titles on Depression
In recent years, there has been a growing awareness of the multiple interrelationships between depression and various physical diseases. This series of volumes dealing with the comorbidity of depression with diabetes, heart disease and cancer provides an update of currently available evidence on these interrelationships.
Depression and Diabetes
Edited by Wayne Katon, Mario Maj and Norman Sartorius
ISBN: 9780470688380
Depression and Heart Disease
Edited by Alexander Glassman, Mario Maj and Norman Sartorius
ISBN: 9780470710579
Depression and Cancer
Edited by David W. Kissane, Mario Maj and Norman Sartorius
ISBN: 9780470689660
Related WPA title on depression:
Depressive Disorders, 3e
Edited by Helen Herrman, Mario Maj and Norman Sartorius
ISBN: 9780470987209
For all other WPA titles published by John Wiley & Sons Ltd, please visit the following website pages:
http://eu.wiley.com/WileyCDA/Section/id-305609.html
http://eu.wiley.com/WileyCDA/Section/id-303180.html
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Library of Congress Cataloguing-in-Publication Data
Depression and diabetes/editors, Wayne Katon, Mario Maj, Norman Sartorius.
p.; cm.
Includes bibliographical references and index.
Summary: ‘‘Depression and Diabetes is the first book devoted to the interaction between these common disorders. World leaders in diabetes, depression, and public health synthesize current evidence, including some previously unpublished data, in a concise, easy-to-read format. They provide an overview of the epidemiology, pathogenesis, medical costs, management, and public health and cultural implications of the comorbidity between depression and diabetes. The book describes how the negative consequences of depression in diabetes could be avoided, given that effective depression treatments for diabetic patients are available.’’–Provided by publisher.
ISBN 978-0-470-68838-0 (paper)
1. Diabetes–Treatment. 2. Diabetes–Psychological aspects. 3. Depression, Mental–Treatment. I. Katon, Wayne. II. Maj, Mario, 1953- III. Sartorius, N.
[DNLM: 1. Depressive Disorder. 2. Diabetes Complications. WM 171 D42238 2010]
RC660.D43 2010
616.4’6206-dc22
2010016178
ISBN: 9780470688380
A catalogue record for this book is available from the British Library.
List of Contributors
Juliana Chan Hong Kong Institute of Diabetes and Obesity; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
Paul Ciechanowski Department of Psychiatric and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
Leonard E. Egede Department of Medicine, Center for Health Disparities Research, Medical University of South Carolina; and Center for Disease Prevention and Health Interventions for Diverse Populations, Ralph H. Johnson VA Medical Center, Charleston, SC, USA
Christina van der Feltz-Cornelis Department of Clinical and Developmental Psychology, University of Tilburg; Centre of Top Clinical Care for Somatoform Disorder, GGZ Breburg, Breda; Trimbos Institute, Utrecht, The Netherlands
Richard Hellman Department of Medicine, University of Missouri, Kansas City, MO, USA
Norbert Hermanns Research Institute, Mergentheim, Germany
Khalida Ismail Department of Psychological Medicine, Institute of Psychiatry, King’s College London, London, UK
Wayne Katon Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
Cathy E. Lloyd Faculty of Health and Social Care, The Open University, Milton Keynes, UK
Hairong Nan Hong Kong Institute of Diabetes and Obesity, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
Arie Nouwen School of Psychology, University of Birmingham, Birmingham, UK
Frans Pouwer Centre for Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Tilburg, The Netherlands
Rose Ting Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China
Leigh Underwood Greater Western Area Health Service/Centre for Rural and Remote Mental Health, New South Wales, Australia
Kirsty Winkley Diabetes and Mental Health Unit, King’s College London, and Institute of Psychiatry, London, UK
Preface
The association between depression and diabetes was first described in the seventeenth century by Thomas Willis, an English physician and anatomist, who stated, ‘Diabetes is caused by sadness or long sorrow’. Indeed, in modern times, a systematic review found that depression earlier in life increased the risk of development of type 2 diabetes by up to 37%.
Evidence of a bidirectional relationship between depression and diabetes has also been recently documented in large prospective studies. Comorbid depression is associated with an increased risk of poor glycemic control, diabetes complications and mortality. Incident diabetes complications have also been found to be risk factors for subsequent development of depressive episodes.
In this book, authors on the cutting edge of research in patients with comorbid depression and diabetes describe the most up-to-date findings. The importance of the research on depression and diabetes has been emphasized in recent years because of the modern-day epidemic of obesity and diabetes that is emerging in both high and low income countries. The direct medical and indirect personal and familial costs of this epidemic are starting to get international attention. In the United States, the cost of diabetes already is estimated to represent about 10% of all medical costs and is expected to increase by 50-100% over the next decade. The public health importance and the scientific issues related to the comorbidity of depression and diabetes have led to an international scientific collaboration, the Diabetes and Depression Initiative, which is bringing together a number of organizations and experts, several of whom have participated in the production of this volume.
In this exciting new text, Cathy Lloyd and colleagues describe the epidemiology of depression and diabetes, including the prevalence and course of depression in patients with type 1 and 2 diabetes, evidence of bidirectional links between these two disorders, and associations of depression with adverse health habits (i.e. smoking and obesity), poor disease control, medical complications and mortality. Khalida Ismail reviews the putative biologic links between depression and diabetes, which may explain why depression in early life is a risk factor for development of type 2 diabetes as well as an important factor in risk of complications and mortality in those with type 2 diabetes.
Leonard Egede reviews the extensive data on the increased medical and personal, familial and employment-related costs of comorbid depression and diabetes. These data are extremely important to health policy planners in emphasizing the potential benefit of screening patients with diabetes for depression. The epidemiologic data have shown that depression is a risk factor for poor disease control, diabetes macrovascular and microvascular complications and mortality, and Egede’s data add tothese findings by showing the high direct medical and indirect costs, such as days off work and decreased productivity.
Wayne Katon and Christina van der Felz-Cornelis describe the clinical trials that have been completed in patients with depression and diabetes, including pharmacologic, psychotherapy and collaborative care trials. This extensive research demonstrates that depression can be effectively treated by both evidence-based depression-focused psychotherapy and antidepressant medications, and that collaborative care is an effective health service model to deliver these treatments to large, primary carebased populations. Collaborative care is associated not only with improved quality of depression care and depressive outcomes, but also with a high likelihood of savings in total medical costs.
Richard Hellman and Paul Ciechanowski review the important patient-physician factors that need to be emphasized to provide guideline level diabetes care. Their chapter focuses on the interaction of depression, cognitive dysfunction, glycemic control and diabetes complications and provides state-of-the-art recommendations about how to improve quality of biopsychosocial care for patients with diabetes.
In the final chapter, Juliana Chan and colleagues describe the important cultural issues in patients with depression and diabetes in both high and low income countries. Public health campaigns aimed at decreasing the incidence of obesity and type 2 diabetes and improving screening and treatment of depression will clearly need to understand the sociocultural causes and meanings of these illnesses in diverse populations.
This volume is part of a WPA series focusing on the comorbidity of depression with various physical diseases. Forthcoming volumes will deal with depression and heart disease and depression and cancer.
Wayne Katon
Mario Maj
Norman Sartorius
CHAPTER 1
The Epidemiology of Depression and Diabetes
Cathy E. Lloyd
Faculty of Health and Social Care, The Open University, Milton Keynes, UK
Norbert Hermanns
Research Institute, Mergentheim, Germany
Arie Nouwen
School of Psychology, University of Birmingham, Birmingham, UK
Frans Pouwer
Centre for Research on Psychology in Somatic Diseases (CoRPS), Tilburg University, Tilburg, The Netherlands
Leigh Underwood
Greater Western Area Health Service/Centre for Rural and Remote Mental Health, New South Wales, Australia
Kirsty Winkley
Diabetes and Mental Health Unit, King’s College London, and Institute of Psychiatry, London, UK
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