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Provides the comprehensive knowledge required to perform ERCP safely and effectively Authored by the very best in the field, this "how-to" guide to mastering the crucial yet complex gastrointestinal procedure called endoscopic retrograde cholangiopancreatography (ERCP) covers the entire range of both standard and advanced techniques, using a highly practical approach. It also places a strong emphasis on patient education, safety, and minimizing risks, offering "tips and tricks" and key points throughout to aid rapid understanding. The book is filled with over 250 illustrations Covering ERCP preparation, techniques, clinical applications, and quality and safety, ERCP: The Fundamentals, 3rd Edition begins with chapters on "getting prepared," including training and competence; facilities and equipment; risk assessment and reduction; sedation, anesthesia, and medications. It then covers "what can be done," describing standard devices and techniques; intraductal therapies; ampullectomy; and reporting and documentation. Next it has chapters on "what should be done," clinical applications of ERCP in acute cholangitis; peri-cholecystectomy; difficult bile duct stones; biliary pain; and numerous forms of pancreatitis. The book finishes with coverage of adverse events and how to ensure competent practice. * Teaches all of the standard and advanced ERCP techniques * Focuses on patient safety/comfort throughout * Brilliantly-illustrated with endoscopic, EUS and radiologic images, and anatomical drawings * Offers a step-by-step, practical approach to ERCP--highlighting potential technical and anatomical hazards * Packed with tips and tricks boxes and key points boxes to assist comprehension * 20 high-definition videos of ERCP performed by the experts, perfect to improve clinical technique * Full reference to the very latest ASGE, ACG, ASG and UEGW guidelines throughout Brought to you by world pioneers in endoscopy, ERCP: The Fundamentals, 3rd Edition is an essential purchase for gastroenterologists and endoscopists of all levels.

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Table of Contents

Cover

List of Contributors

Introduction: Developments in ERCP over 50 Years

Section 1: Preparation

1 Training and Assessment of Competence (Preparing the Endoscopist)

Background

Who Should Be Trained?

What Should Be Taught, and How?

Who Should Teach?

How Are Training and Competence Assessed?

What Level of Performance Is Acceptable?

Conclusion

Appendix

Cannulation

Guidewire Manipulation

Dilation (Rigid or Balloon)

Cytology

Stenting

Basket

Retrieval Balloons

Papillotomy

References

2 Preparing the Facilities and Equipment

Room Setup and Floor Plan

Modern Design of the ERCP Room

Electrosurgical Unit (Diathermy)

Additional Items

Personnel Protection

Conclusion

3 ERCP: The Team

Endoscopy Staff

The Team in the ERCP Room

The Team outside the Procedure Room

Clinical Support in the Unit

Education

Industry Partners

Motivation and Team Building

Pitfalls

Resources

Conclusion

Further Reading

4 Minimizing Duodenoscope Infections

Introduction

Patient Selection

Scope Reprocessing Steps

Staffing

What Progress Is Being Made?

Conclusion

References

5 Patient Education and Consent

Documenting the Process Is Important

Conclusion

Outstanding Issues

Further Reading

6 Risk Assessment and Reduction

Assessing and Reducing the Risks

Key Considerations in Preparing Patients for ERCP to Reduce Modifiable Risks

References

7 Sedation, Anesthesia, and Medications

Introduction

Preprocedural Preparation

Sedation Agents

Patient Monitoring

Cardiopulmonary Risk Assessment and Consequences

Are ERCP Outcomes Influenced by the Type of Sedation and Anesthesia Used?

The Patient’s Position

Propofol for Everyone? Endotracheal Intubation?

Conclusion

References

Section 2: Techniques

8 Standard Devices and Techniques

Intubation and Examination of the Stomach

Cannulation Principles

Use of Guidewires

Cannulation of the Pancreatic Duct and Pancreatography

Techniques of Sphincterotomy: Biliary, Pancreatic, Minor

Dilation of the Papillary Orifice and Strictures

Dilation of Ductal Strictures

Bile Duct Stone Extraction

Pancreatic Stone Extraction

Tissue Sampling from the Bile Duct

Tissue Sampling from the Pancreatic Duct

Nasobiliary Catheter Drainage for Bile Duct Obstruction

Biliary Stenting

Plastic Stents in the Pancreas

Sphincter Manometry

Endoscopic Management of Bile Leaks

Conclusion

References

9 When Standard Cannulation Approaches Fail

Principles of Biliary Access

Placement of Double Guidewire or Pancreatic Stent to Facilitate Biliary Access

Precut or Access Sphincterotomy

Intradiverticular Papilla

Altered Surgical Anatomy

Combined Procedures

EUS‐Guided Pancreatic Duct Access

Conclusion

References

10 Intraductal Therapies

Equipment and Techniques

Application of Cholangioscopy and Pancreatoscopy in Pancreato‐Biliary Diseases

Diagnostic Applications: Pancreatic

Intraductal Therapeutic Applications

Intraductal Therapies: Tips and Tricks for the Beginners

Conclusion

References

11 Endoscopic Ampullectomy

Introduction

Lesion Assessment and Staging

Endoscopic Resection Technique

Complications and Management

Conclusion

References

12 The Radiology of ERCP

Emerging from the Gloom

Diagnostic Radiology and ERCP

The Radiology of ERCP

Tricky Imaging Situations

Radiation Risk and Protection

Conclusion

References

13 ERCP Reporting and Documentation

Structured Reporting

Report Content

Imaging

Postprocedural Data

Report Output

Endoscopy Reporting Software

References

Section 3: Clinical Applications

14 ERCP in Acute Cholangitis

Tips and Tricks

Background

Management for Acute Cholangitis

ERCP Techniques in Acute Cholangitis

Care after ERCP for Acute Cholangitis

Conclusion

Links to Society Guidelines

References

15 ERCP Peri‐Cholecystectomy

Preoperative ERCP for Treatment of Choledocholithiasis

ERCP during Cholecystectomy

Postoperative ERCP

Summary

Conclusions

References

16 Difficult Bile Duct Stones

Introduction

Techniques That Increase the Bile Duct Opening

Techniques to Decrease the Size of CBD Stones

Stones in Difficult Positions

Additional Interventions and Collaboration

Existing Guidelines and Consensus Recommendations

References

17 Patients with Obscure Biliary Pain; Sphincter of Oddi Dysfunction

SOD Type I

SOD Type III

SOD Type II

Alternative Treatments for SOD

Goodbye, Biliary Types I, II, and III

Medical Treatments

Conclusion

References

18 Benign Biliary Strictures

Introduction

Chronic Pancreatitis (CP)

Postoperative Strictures

Inflammatory Strictures: Primary Sclerosing Cholangitis (PSC) and IgG4‐Sclerosing Cholangitis (IgG4‐SC)

Conclusions

References

19 The Role of ERCP in Pancreaticobiliary Malignancies

ERCP in Diagnosis of Pancreaticobiliary Malignancies

Palliation of Obstructive Jaundice in Pancreatic Cancer

Endoscopic Stenting for Hilar Strictures

Other Techniques of Endoscopic Palliation

Ampullary Carcinoma

ERCP after Cancer Surgery

ERCP for Cholecystitis

ERCP in Duodenal Obstruction

Conclusion

References

20 ERCP in Acute and Recurrent Acute Pancreatitis

Introduction

Acute Biliary Pancreatitis

Recurrent Acute Pancreatitis

Pancreas Divisum

Summary

References

21 Chronic Pancreatitis

Introduction

When to Do ERCP in Chronic Pancreatitis

PD Strictures

PD Stones

Pancreatic Pseudocysts

Conclusion

References

22 Role of ERCP in Complicated Pancreatitis

Introduction

Acute Interstitial Pancreatitis

Severe Acute Pancreatitis

Local Complications of AP

Pancreatic Pseudocyst

Acute Necrotic Collection

Walled‐Off Pancreatic Necrosis (WOPN)

Timing and Indications for Endoscopic Intervention of Necrosis

Necrosectomy Methods

Pancreatic Ductal Disruptions

Outcomes

Conclusions

References

Guidelines

23 ERCP in Children

Introduction

Patient Preparation

Instruments

Technique

Indications

Success Rates for ERCP in Children

Adverse Events

Biliary Findings

Miscellaneous Genetic Cholestatic Diseases

Primary Sclerosing Cholangitis

Parasitic Infestation

Choledocholithiasis

Pancreatic Findings

Chronic Pancreatitis

Pancreatic Pseudocysts

Outstanding Issues and Future Trends

References

Section 4: Quality and Safety

24 Adverse Events: Definitions, Avoidance, and Management

Adverse Events

Overall Rates and Factors Affecting Them

Pancreatitis

Perforation

Infection

Bleeding

Basket Impaction

Cardiopulmonary Complications and Sedation Issues

Late Complications of Stents

Late Complications of Sphincterotomy

Rare Complications

Care after ERCP

Managing Adverse Events

Learning from Lawsuits

Risks for Endoscopists and Staff

Conclusion

References

25 Ensuring Really Competent Practice

What Is Quality Endoscopy?

How to Recognize and Measure Excellence in Endoscopists?

Report Cards and Benchmarking Performance

What Performance Level Is Good Enough? Who Decides?

Who Is Going to Do

Your

ERCP?

Credentialing and Privileges

How to Move Forward Now?

How to Recognize and Measure Excellence in Endoscopy Units?

Conclusion

References

Index

End User License Agreement

List of Tables

Chapter 1

Table 1.1 Complexity levels in ERCP.

Table 1.2 A comparison of different simulator models for advanced ERCP traini...

Table 1.3 Some suggested simulator practice score to evaluate trainees’ pract...

Table 1.4 Clinical assessment (to be filled in by trainer at completion of ER...

Table 1.5 Trainer assessment score of trainees’ performance (five‐point score...

Chapter 2

Table 2.1 Commonly used ERCP accessories.

Chapter 6

Table 6.1 Predictors of Adverse Events after ERCP.

Chapter 7

Table 7.1 Pharmacologic profile of drugs used for endoscopic sedation.

Table 7.2 ASA Physical Classification.

Table 7.3 Guidelines for anesthesiology assistance during ERCP.

Chapter 8

Table 8.1 A comparison of commonly used guidewires.

Table 8.2 A comparison of different short wire system for biliary stenting.

Table 8.3 Comparison of nasobiliary catheter versus plastic stent for biliary...

Chapter 9

Table 9.1 Precut sphincterotomy learning curve.

Chapter 10

Table 10.1 Endoscopic‐guided intraductal diagnostic and therapeutic procedure...

Table 10.2 Per‐oral cholangioscopy systems [1].

Table 10.3 Comparison of different cholangioscopy systems [21].

Chapter 11

Table 11.1 Incidence of ampullectomy complications.

Chapter 12

Table 12.1 Comparison of different imaging modalities for pancreaticobiliary ...

Chapter 15

Table 15.1 Potential indications for ERCP before cholecystectomy.

Table 15.2 Potential indications for ERCP during cholecystectomy.

Table 15.3 Potential indications for ERCP after cholecystectomy.

Table 15.4 Potential advantages and disadvantages according to timing of ERCP...

Chapter 16

Table 16.1 Possible approaches to treat large stones.

Chapter 21

Table 21.1 Selected studies of endotherapy in patients with chronic pancreati...

Table 21.2 Selected studies of endotherapy for pancreatic duct stones with or...

Table 21.3 Selected studies of endotherapy for pancreatic duct stones with pe...

Chapter 22

Table 22.1 Types of pancreatic fluid collections complicating acute pancreati...

Table 22.2 Endoscopic approaches to walled‐off pancreatic necrosis.

Chapter 23

Table 23.1 Biliary findings in ERCP in neonates and children.

Table 23.2 Pancreatic findings in ERCP in children.

Chapter 24

Table 24.1 Severity grading for adverse events.

Table 24.2 Risk factors for pancreatitis after ERCP.

List of Illustrations

Chapter 2

Figure 2.1 Room set‐up and floor plan. A, assistant; E, endoscopist; S, seda...

Figure 2.2 Space for endoscopists and trainee or assistant. Accessories orga...

Figure 2.3 Monitors for endoscopy, fluoroscopy, and vital signs are placed t...

Figure 2.4 (a) Layout of ERCP room with endoscopy tower and foot pedals, mon...

Figure 2.5 Organize accessories within easy reach for retrieval. Do not stac...

Figure 2.6 Personnel protection according to the Occupational Safety and Hea...

Chapter 3

Figure 3.1 Hands‐on educational practice between trainee and mentor. Discuss...

Figure 3.2 ERCP: The Team. Radiology tech, table nurse, ERCPist, certified r...

Chapter 5

Figure 5.1 The ERCP explanation document that I used in practice.

Chapter 8

Figure 8.1 Radiograph showing (a) short scope, (b) long scope, and (c) semi‐...

Figure 8.2 Location of papilla is where the longitudinal fold meets the vert...

Figure 8.3 (a) Displaced papilla on edge of a duodenal diverticulum and (b) ...

Figure 8.4 Keeping accessories relatively straight and looping a long guidew...

Figure 8.5 (a) V‐scope (Olympus, Tokyo, Japan) with a V‐notch on elevator ho...

Figure 8.6 (a) Fusion OSAIS stenting system with guidewire, inner catheter, ...

Figure 8.7 (a) Cutting a long guidewire; (b) inserting guidewire adaptor r i...

Figure 8.8 (a) Selective common bile duct cannulation. Stay close to papilla...

Figure 8.9 A combination of 12 different maneuvers (

arrows

), including air i...

Figure 8.10 (a) Shaping the sphincterotome allows the cutting wire to stay o...

Figure 8.11 (a) Straight guidewire protruding from sphincterotome, (b) a gen...

Figure 8.12 (a) Needle‐tip catheter with a straight tip, (b) gentle bend at ...

Figure 8.13 Perfect biliary axis along 11–12 o’clock direction (

blacked dott

...

Figure 8.14 (a) Intraduodenal papilla and distal bile duct determines the ex...

Figure 8.15 (a) Bulging papilla from impacted stone, (b) standard sphinctero...

Figure 8.16 Balloon sphincteroplasty, (a) deep cannulation with catheter, (b...

Figure 8.17 Distal common bile duct stricture (see Figure 8.11d), (a) partia...

Figure 8.18 (a) Stricture in mid pancreatic duct (PD) from chronic pancreati...

Figure 8.19 (a) Tight pancreatic duct stricture in mid body, (b) dilation wi...

Figure 8.20 Balloon stone extraction. Extraction of small stones with balloo...

Figure 8.21 Dormia basket stone extraction, basket opened above stone and tr...

Figure 8.22 Mechanical lithotripsy (Soehendra lithotripter) or “life‐saver,”...

Figure 8.23 Through‐the‐scope mechanical lithotripter (BML, Olympus, Tokyo, ...

Figure 8.24 (a) Newly designed lithotripsy compatible basket, and (b) basket...

Figure 8.25 (a) Straight stent inserted to provide bile duct drainage bypass...

Figure 8.26 (a) Pancreatic duct (PD) stone (

dashed arrow

) causing obstructio...

Figure 8.27 Brush cytology of distal bile duct stricture. Double‐lumen cytol...

Figure 8.28 Nasobiliary catheter drainage. (a) 6.5 FG angled tip catheter wi...

Figure 8.29 (a) Biliary stenting system with large channel duodenoscope, 0.0...

Figure 8.30 Stent measurement by (a) pulling a catheter over an indwelling g...

Figure 8.31 (a) OASIS stenting system by combining inner catheter and pusher...

Figure 8.32 (a) Self‐expandable metallic stent (SEMS; Wallstent, Boston Scie...

Figure 8.33 Bilateral plastic stents for hilar obstruction (a) extensive tum...

Figure 8.34 Bilateral self‐expandable metallic stents (SEMS) for hilar obstr...

Figure 8.35 Pancreatic stent placement using a Fusion (short wire) catheter ...

Chapter 9

Figure 9.1 Fistulotomy is performed by creating a point of entry 3–5 mm supe...

Figure 9.2 Biliary access is gained by performing precut over a pancreatic d...

Figure 9.3 After cannulating the pancreatic duct, the sphincterotome is orie...

Figure 9.4 Intradiverticular papilla: The papilla was located within a deep ...

Figure 9.5 Billroth II ERCP fluoroscopy: The duodenoscope forms a “hockey st...

Figure 9.6 Roux en Y ERCP fluoroscopy: The double‐balloon enteroscope has a ...

Figure 9.7 A lumen‐apposing metal stent (

left panel

) is placed via the remna...

Figure 9.8 Endoscopic ultrasound (EUS)‐guided rendezvous: EUS‐guided rendezv...

Figure 9.9 Choledochoduodenostomy: A choledochoduodenostomy was performed in...

Chapter 10

Figure 10.1 Different cholangioscopy systems. (a) Ultra‐slim scope for direc...

Figure 10.2 Balloon‐assisted direct per‐oral cholangioscopy using an ultra‐s...

Figure 10.3 Single‐operator cholangioscopy system. (a) SpyScope attached to ...

Figure 10.4 Cholangioscopy in a case of indeterminate filling defect. (a) No...

Figure 10.5 Cholangioscopy‐assisted lithotripsy in difficult biliary calculi...

Figure 10.6 Radiofrequency ablation (RFA) in a case with cholangiocarcinoma....

Chapter 11

Figure 11.1 Significant intraductal extension suggested by magnetic resonanc...

Figure 11.2 (a) A granular or villiform exophytic ampullary adenoma. These a...

Figure 11.3 (a) The snare tip is anchored on the duodenal wall superior to t...

Figure 11.4 (a) A bulky lesion. (b) A submucosal injection is made beneath a...

Figure 11.5 (a) A 20‐mm papillary adenoma, in which there has been a small p...

Figure 11.6 (a) A 20‐mm smooth adenoma with extrapapillary extension has bee...

Chapter 12

Figure 12.1 A 70‐year‐old man with painless jaundice. (a) Axial image showin...

Figure 12.2 A 37‐year‐old woman with pain and jaundice. (a) A 20‐mm thick ra...

Figure 12.3 (a) A 40‐year‐old man who had recovered from an episode of mild ...

Figure 12.4 (a) Radiographically correct projection of ERCP image showing an...

Figure 12.5 (a) A correctly projected and collimated plain film before contr...

Figure 12.6 (a) Magnified image during sphincterotome and wire‐guided cannul...

Figure 12.7 Tight collimation of the magnified image allows clear definition...

Figure 12.8 (a) Normal confluence of sectoral and hepatic ducts. (b) A norma...

Figure 12.9 The right posterior sectoral duct. (a) ERCP in a patient after c...

Chapter 13

Figure 13.1 Standardized terminology of the pancreato‐biliary ductal anatomy...

Chapter 14

Figure 14.1 (a) Stone impaction at papilla. (b) Exposure of the impacted sto...

Figure 14.2 Endoscopic sphincterotomy.

Figure 14.3 (a) Endoscopic papillary balloon dilation using a 10‐mm diameter...

Figure 14.4 Endoscopic papillary large balloon dilation using a 12‐13.5‐15–m...

Chapter 15

Figure 15.1 A 79‐year‐oldfemale was referred for repeat ERCP. Intraoperative...

Figure 15.2 A 23‐year‐old female presented with upper abdominal pain and jau...

Figure 15.3 A 75‐year‐old female was transferred from another institution fo...

Figure 15.4 A 28‐year‐old female with a history of biliary colic presented f...

Figure 15.5 A 53‐year‐old female presented with upper abdominal pain and inc...

Figure 15.6 Suggested algorithm for utilization and timing of ERCP related t...

Chapter 16

Figure 16.1 Large common bile duct stone demonstrated on occlusion cholangio...

Figure 16.2 Partial sphincterotomy.

Figure 16.3 Insertion of the controlled radial expansion balloon.

Figure 16.4 Inflation of the controlled radial expansion balloon.

Figure 16.5 Appearance of the papilla after partial sphincterotomy and endos...

Figure 16.6 Stones being extracted from the common bile duct.

Figure 16.7 Stones in the duodenum after extraction from the common bile duc...

Figure 16.8 Insertion of a 10 Fr, 7‐cm biliary plastic stent into the common...

Figure 16.9 Fluoroscopic image of an inserted single operator cholangioscope...

Figure 16.10 (a) A cholangiogram demonstrating a large common bile duct ston...

Figure 16.11 (a) The Spyglass single operator cholangioscope (courtesy of Bo...

Figure 16.12 Electrohydraulic lithotripsy probe in proximity to the stone an...

Figure 16.13 Mirizzi syndrome: the thin arrow shows stones in cystic duct, a...

Chapter 18

Figure 18.1 (a) Patient 1 month after liver transplant with high bilirubin, ...

Figure 18.2 (a) End of multiple stent trial, endoscopic view four stents. (b...

Figure 18.3 Magnetic resonance cholangiogram with dominant stricture of left...

Figure 18.4 (a) Magnetic resonance cholangiogram showing a tight common bile...

Figure 18.5 (a) ERCP with main duct biliary stricture (

arrow

) and (b) strict...

Figure 18.6 (a) ERCP in Type I IgG4‐associated sclerosing cholangitis (IgG4‐...

Figure 18.7 (a) ERCP with common bile duct stricture (

curved arrow

) and obst...

Chapter 19

Figure 19.1 A 70‐year‐old woman underwent cholangioscopy for evaluation of h...

Figure 19.2 A 50‐year‐old woman with metastatic breast cancer was referred f...

Figure 19.3 A 73‐year‐old woman presented with metastatic cholangiocarcinoma...

Figure 19.4 A 64‐year‐old woman with cholangiocarcinoma presented with worse...

Figure 19.5 A 79‐year‐old man presented with obstructive jaundice from suspe...

Figure 19.6 A 63‐year‐old woman was referred for evaluation of jaundice, abd...

Figure 19.7 A 70‐year‐old woman was referred for evaluation of jaundice, pai...

Chapter 20

Figure 20.1 ERCP in acute biliary pancreatitis. Algorithm for the management...

Figure 20.2 The major papilla in the setting of acute pancreatitis. Normally...

Figure 20.3 Suggested second‐tier diagnostic tests for patients with unexpla...

Figure 20.4 Autoimmune pancreatitis. A 58‐year‐old man presented with painle...

Figure 20.5 Anomalous pancreatobiliary union. A 3‐year‐old girl presented wi...

Figure 20.6 Minor papilla. Endoscopic inspection of the minor papilla can tr...

Figure 20.7 Pancreas divisum: Ventral pancreatic duct terminal arborization....

Chapter 21

Figure 21.1 (a) Main pancreatic duct stricture in the head and body of pancr...

Figure 21.2 (a) Main pancreatic duct stricture in the head and body of pancr...

Figure 21.3 (a) Initial pancreatogram showed a filling defect in the pancrea...

Figure 21.4 (a) Initial pancreatogram demonstrates a large stone obstructing...

Figure 21.5 (a) Visualization of a pancreatic duct stone during single‐opera...

Figure 21.6 (a) Computed tomography scan demonstrating pancreatic pseudocyst...

Chapter 22

Figure 22.1 Computed tomography findings of walled‐off necrosis obtained 8 w...

Figure 22.2 Endoscopic view of 20‐mm lumen‐apposing metal stent immediately ...

Figure 22.3 Endoscopic view within walled‐off pancreatic necrosis (WOPN) sho...

Figure 22.4 Necrotic material after removal with direct endoscopic necrosect...

Chapter 23

Figure 23.1 Variants of biliary atresia.

Figure 23.2 Biliary atresia Type 1. No visualization of biliary tree. Opacif...

Figure 23.3 Biliary atresia Type 2. Visualization of a narrow and irregular ...

Figure 23.4 Biliary atresia Type 3a in a 25‐day‐old neonate. Visualization o...

Figure 23.5 Congenital hepatic fibrosis in a 38‐day‐old infant. Normal extra...

Figure 23.6 The normal pancreaticobiliary union is located within the duoden...

Figure 23.7 There are three types of anomalous pancreaticobiliary union. Typ...

Figure 23.8 Anatomical classification by Todani et al. [38] of choledochal c...

Figure 23.9 Choledochal cyst Type I‐C in a 3‐year‐old female. Note an anomal...

Figure 23.10 Choledochal cyst Type I‐C with cystolithiasis (

arrow

).

Figure 23.11 Choledochal cyst Type IV‐A in a 12‐year‐old female. Note an ano...

Figure 23.12 Primary sclerosing cholangitis in a 16‐year‐old male. Severe na...

Figure 23.13 Choledochal cyst Type I‐A and pancreas divisum in a 5‐year‐old ...

Figure 23.14 Choledochal cyst Type IV‐A in a 6‐year‐old female with recurren...

Figure 23.15 Pancreas divisum and chronic pancreatitis in a 12‐year‐old male...

Figure 23.16 Endoscopic view of the major and minor papilla. (a) A tapered b...

Figure 23.17 Recurrent acute pancreatitis in an 8‐year‐old girl. (a) Magneti...

Figure 23.18 A 12‐year‐old girl was kicked by a horse in the abdomen with su...

Figure 23.19 Chronic pancreatitis in a 14‐year‐old female with hereditary pa...

Figure 23.20 Pancreatic pseudocyst with ductal communication treated by tran...

Chapter 24

Figure 24.1 Computed tomography scan of severe pancreatitis, taken 1 week af...

Figure 24.2 Abdominal radiograph at ERCP showing retroperitoneal air.

Figure 24.3 Computed tomography scan showing retroperitoneal air after perfo...

Figure 24.4 Bleeding immediately after starting sphincterotomy.

Guide

Cover

Table of Contents

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ERCP

The Fundamentals

 

Third Edition

 

Edited by

Peter B. Cotton, MD, FRCP, FRCS

Digestive Disease CenterMedical University of South CarolinaCharleston, SC, USA

Joseph W. Leung, MD, FRCP, FACP, MACG, FASGE

Department of Gastroenterology and HepatologyUniversity of California Davis School of MedicineSacramento, CA, USA;Section of GastroenterologyVA Northern California Health Care SystemGI Unit, Sacramento VAMCMather, CA, USA

 

 

 

 

 

 

 

This edition first published 2020© 2020 John Wiley & Sons Ltd

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Library of Congress Cataloging‐in‐Publication Data

Names: Cotton, Peter B., editor. | Leung, J. W. C., editor.Title: ERCP : the fundamentals / [edited by] Peter B. Cotton, MD FRCP FRCS, Professor of Medicine, Digestive Disease Center, Medical University of South Carolina, Charleston, South Carolina, Joseph W. Leung, MD FRCP FACP MACG FASGE, Mr. & Mrs. C.W. Law Professor of Medicine, Department of Gastroenterology and Hepatology, University of California, Davis School of Medicine, Chief, Section of Gastroenterology, VA Northern California Health Care System, GI Unit, Sacramento VAMC Mather, California.Description: Third edition. | Hoboken, NJ : Wiley‐Blackwell, 2020. | Includes index.Identifiers: LCCN 2020010927 (print) | LCCN 2020010928 (ebook) | ISBN 9781119601098 (hardback) | ISBN 9781119601067 (adobe pdf) | ISBN 9781119601081 (epub)Subjects: LCSH: Endoscopic retrograde cholangiopancreatography. | Gastroscopy.Classification: LCC RC847.5.E53 A38 2020 (print) | LCC RC847.5.E53 (ebook) | DDC 616.36/07572–dc23LC record available at https://lccn.loc.gov/2020010927LC ebook record available at https://lccn.loc.gov/2020010928

Cover Design: WileyCover Image: Courtesy of Joseph W. Leung

List of Contributors

Lars Aabakken, MD, PhD, BCProfessor of MedicineChief of Gastrointestinal EndoscopyOslo University Hospital, RikshospitaletOslo, Norway

Majid A. Almadi, MB, BS, MSc, FRCDivision of GastroenterologyKing Khalid University HospitalKing Saud UniversityRiyadh, Saudi Arabia

Alan Barkun, MD, CM, MSc, FRCPCDivision of GastroenterologyMontreal General Hospital, McGill UniversityMontreal, Quebec, Canada

Todd H. Baron, MD, FASGEDirector of Advanced Therapeutic EndoscopyProfessor of MedicineDivision of Gastroenterology & HepatologyUniversity of North CarolinaChapel Hill, NC, USA

Catherine Bauer, RNBS, MSN, MBA, CGRN, CFERDirector of Digestive HealthUniversity of Virginia Medical CenterCharlottesville, VA, USA;Society of Gastroenterology Nurses and Associate President 2018–2019

Benjamin L. Bick, MDIndiana University School of MedicineIndianapolis, IN, USA

Michael Bourke, MD, PhDClinical Professor of MedicineUniversity of SydneySydney;Director of Gastrointestinal EndoscopyWestmead HospitalWestmead, Australia

Gregory A. Coté, MD, MSProfessor of MedicineMedical University of South CarolinaCharleston, SC, USA

Peter B. Cotton, MD, FRCP, FRCSProfessor of MedicineDigestive Disease CenterMedical University of South CarolinaCharleston, SC, USA

John T. Cunningham, MDProfessor Emeritus of MedicineSection of Gastroenterology and HepatologyUniversity of Arizona School of MedicineTucson, AZ, USA

B. Joseph Elmunzer, MD, MScThe Peter B. Cotton Endowed Chair in Endoscopic InnovationProfessor of Medicine and Endoscopic InnovationDivision or Gastroenterology and HepatologyMedical University of South CarolinaCharleston, SC, USA

Evan L. Fogel, MDIndiana University School of MedicineIndianapolis, IN, USA

Erin Forster, MD, MPHDepartment of MedicineDivision of Gastroenterology and HepatologyMedical University of South CarolinaCharleston, SC, USA

Andres Gelrud, MD, MMScGastro Health and Miami Cancer InstituteMiami, FL, USA

Moises Guelrud, MDGastro Health and Miami Cancer InstituteMiami, FL, USA

Sundeep Lakhtakia, MD, DMAsian Institute of GastroenterologyHyderabad, India

John G. Lee, MDH. H. Chao Comprehensive Digestive Disease CenterUniversity of California at Irvine Medical Center, Irvine, CA, USA

Joseph W. Leung, MD, FRCP, FACP, MACG, FASGEEmeritus Professor of MedicineDepartment of Gastroenterology and HepatologyUniversity of California Davis School of MedicineSacramento, CA;Chief of GastroenterologySection of GastroenterologyVA Northern California Health Care SystemGI Unit, Sacramento VAMCMather, CA, USA

Wei‐Chih Liao, MD, PhDAssociate ProfessorDepartment of Internal MedicineNational Taiwan University HospitalNational Taiwan University College of MedicineTaipei, Taiwan

Phyllis Malpas, MA, RN, CGRNDigestive Disease CenterMedical University of South Carolina Charleston, SC, USA

Derrick Martin, FRCR, FRCP, Mb, CHbRadiology DepartmentWythenshawe HospitalManchester, UK

Robert A. Moran, MDMedical University of South CarolinaCharleston, SC, USA

Zaheer Nabi, MD, DNB GastroenterologyConsultant GastroenterologistAsian Institute of GastroenterologyHyderabad, India

D. Nageshwar Reddy, MD, DM, DSc, FRCPChairman and Chief of GastroenterologyAsian Institute of GastroenterologyHyderabad, India

Stuart Ashley Roberts, MDRadiology DepartmentUniversity Hospital of WalesCardiff, UK

Joseph Romagnuolo, MD, MSc, FRCPCDepartment of MedicineDivision of Gastroenterology and HepatologyMedical University of South CarolinaCharleston, SC, USA

Stuart Sherman, MDIndiana University School of MedicineIndianapolis, IN, USA

Paul R. Tarnasky, MDDigestive Health Associates of TexasProgram Director GastroenterologyMethodist Dallas Medical CenterDallas, TX, USA

Shyam Varadarajulu, MDCenter for Interventional EndoscopyFlorida HospitalOrlando, FL, USA

John J. Vargo, II, MD, MPHCleveland ClinicCleveland, OH, USA

Hsiu‐Po Wang, MDDepartment of Internal MedicineNational Taiwan University HospitalNational Taiwan University College of MedicineTaipei, Taiwan

Andrew Yen, MD, FACG, FASGEChief of Endoscopy and Associate Chief of GastroenterologySection of GastroenterologyVA Northern California Health Care SystemGI Unit, Sacramento VAMCMather, CA, USA

Introduction: Developments in ERCP over 50 Years

The History

Attempts at endoscopic cannulation of the papilla of Vater were first reported in 1968. However, the method was put on the map shortly afterward by Japanese gastroenterologists working with instrument manufacturers to develop appropriate long side‐viewing instruments. The name “ERCP” (endoscopic retrograde cholangiopancreatography) was agreed at a symposium at the World Congress in Mexico City in 1974. The technique gradually became established worldwide as a valuable diagnostic technique, although some were skeptical about its feasibility and role, and the potential for serious complications soon became clear. It was given a tremendous boost by the development of the therapeutic applications, notably biliary sphincterotomy in 1974 and biliary stenting 5 years later.

It is difficult for most gastroenterologists today to imagine the diagnostic and therapeutic challenges of pancreatic and biliary medicine 50 years ago. There were no scans. The pancreas was a black box and its diseases diagnosed only at a late stage. Biliary obstruction was diagnosed and treated surgically with substantial operative mortality.

The period of 20 or so years from the mid‐1970s was a “golden age” for ERCP. Despite significant risks, it was quite obvious to everyone that ERCP management of bile duct stones, strictures, and leaks was easier, cheaper, and safer than available surgical alternatives. Percutaneous transhepatic cholangiography (PTC) and its drainage applications were also developed during this time but were used (with the exception of a few units) only when ERCP failed or was not available.

The situation has evolved progressively in many ways during recent decades. There are some new techniques (such as expandable and biodegradable stents, simpler cholangioscopy, balloon sphincteroplasty, pseudocyst debridement, and laparoscopic‐ and endoscopic ultrasound [EUS]‐guided cannulation) and improvements in safety (e.g. pancreatic stents, nonsteroidal anti‐inflammatory drugs [NSAIDs], anesthesia, and carbon dioxide [CO2]).

Other important changes in ERCP practice have been driven by improvements in radiology and surgery and the increasing focus on quality.

Radiology

Imaging modalities for the biliary tree and pancreas have proliferated. High‐quality ultrasound, computed tomography (CT), EUS, and magnetic resonance scanning (with magnetic resonance cholangiopancreatography [MRCP]) have greatly facilitated the noninvasive evaluation of patients with known and suspected biliary and pancreatic disease. As a result, ERCP is now almost exclusively used for treatment of conditions already documented by less‐invasive techniques. There have also been some improvements in interventional radiology techniques in the biliary tree, which are useful adjuncts when ERCP is unsuccessful or impractical.

Surgery

There has been substantial and progressive reduction in the risks associated with surgery as a result of minimally invasive techniques and better perioperative and anesthesia care. It is no longer correct to assume that ERCP is always safer than surgery. Surgery should be considered as a legitimate alternative to ERCP and not only when ERCP is unsuccessful.

Patient Empowerment

Another relevant development in this field is the increased participation of patients in decisions about their care. Patients are right in demanding information about their potential interventionists and the likely benefits, risks, and limitations of all of the possible approaches to their problems.

The Quality Imperative

The term ERCP is now inaccurate. It was invented to describe a method for obtaining radiographs of the biliary and pancreatic trees. It is now a broad therapeutic platform, like laparoscopy. It may be better remodeled as “Ensuring Really Competent Practice,” because quality is now the main challenge. We have to make sure that the right things are done and in the right way. There is increasing attention on who should be trained and to what level of expertise. How many ERCPists are really needed? Previously, most gastroenterology trainees did some ERCP and continued to dabble in practice. Now the focus is on ensuring that there is a smaller cadre of properly trained ERCPists with sufficient numbers to maintain and enhance their skills and to be able to address the more complex cases. These issues come into clearest focus where the role of ERCP is still not firmly established (e.g. in the management of recurrent acute and chronic pancreatitis and of possible sphincter of Oddi dysfunction). Such issues are being addressed by increasingly stringent research.

This Book

This is the third edition of this book devoted to ERCP. The first, Advanced Digestive Endoscopy: ERCP was published on gastrohep.com in 2002 and printed by Blackwell in 2006 and again in 2015. This edition owes much to its predecessors, but the title ERCP: The Fundamentals emphasizes our attempt to provide core information for trainees and practitioners, rather than a scholarly review of the (now) massive literature. Note that we have largely separated the technical aspects (how it can be done) from the clinical aspects, to allow the authors of the latter chapters to review the complex questions of when they might be done (and when best not).

We greatly appreciate the efforts of all the contributors and look forward to constructive feedback.

Peter B. Cotton, MD, FRCS, FRCP

Joseph W. Leung, MD, FRCP, FACP, MACG, FASGE

April 2020

Section 1Preparation