Evidence-Based Geriatric Medicine -  - E-Book

Evidence-Based Geriatric Medicine E-Book

0,0
55,99 €

oder
-100%
Sammeln Sie Punkte in unserem Gutscheinprogramm und kaufen Sie E-Books und Hörbücher mit bis zu 100% Rabatt.

Mehr erfahren.
Beschreibung

The latest addition to the Evidence-Based Book series, Evidence-Based Geriatric Medicine provides non-geriatrician clinicians an overview of key topics central to the care of the older patient. This guide focuses on the management of common problems in the elderly taking into account their life situations as well as treatment of specific conditions. Leading geriatricians with expertise in evidence-based medicine utilize the best available evidence and present this information in a concise, easy-to-use, question-based format. Evidence-Based Geriatric Medicine is a unique guide to the optimum management of older patients.

Sie lesen das E-Book in den Legimi-Apps auf:

Android
iOS
von Legimi
zertifizierten E-Readern

Seitenzahl: 536

Veröffentlichungsjahr: 2012

Bewertungen
0,0
0
0
0
0
0
Mehr Informationen
Mehr Informationen
Legimi prüft nicht, ob Rezensionen von Nutzern stammen, die den betreffenden Titel tatsächlich gekauft oder gelesen/gehört haben. Wir entfernen aber gefälschte Rezensionen.



Table of Contents

Cover

Series

Title

Copyright

List of Contributors

Foreword

CHAPTER 1: Function and frailty: the cornerstones of geriatric assessment

Introduction

Search strategy

What is frailty?

Is this person frail?

What are ADLs?

How do i assess ADLs?

How can i prevent this frail older adult from declining in ADLs?

Chapter summary

CHAPTER 2: Computer-based clinical decision support systems in the care of older patients

Introduction

Search strategy

Do cds tools improve healthcare providers’ performance of tasks or clinical outcomes related to appropriate medication prescribing for older patients?

Do cds tools improve healthcare providers’ performance of tasks or clinical outcomes in adult patients with hypertension, the most common ambulatory diagnosis among older patients?

Summary

Acknowledgment

Disclaimer

CHAPTER 3: Simplifying the pillbox: drugs and aging

Introduction

Search strategy

What is inappropriate prescribing and how can it be prevented?

What strategies can clinicians employ to optimize prescribing in individual older patients?

Once we identify optimal prescribing, how can we promote long-term adherence to these medications?

Acknowledgment

CHAPTER 4: Breathing easier: respiratory disease in the older adult

Introduction

Search strategy

How should i treat my older patient with asthma?

How should copd be managed in my older patient?

How should pneumonia be treated in the older patient?

Is my older patient at risk for tb?

How do i manage my older patients with obstructive sleep apnea?

How is lung cancer managed in the older patient?

Chapter summary

CHAPTER 5: Breathing easier: an approach to heart failure in a patient with an aging heart

Introduction

Search strategy

What role does exercise play in the management of heart failure?

Which pharmacological agents should be used in the management of heart failure?

What is the role for cardiac resynchronization and implantable cardioverter defibrillators?

How should heart failure patients be monitored?

Summary

CHAPTER 6: Clarifying confusion: preventing and managing delirium

Introduction

Search strategy

How can i screen for delirium?

How can i prevent this older hospitalized patient from becoming delirious?

How can i best manage this older hospitalized patient with delirium?

Summary

CHAPTER 7: Preserving memories: managing dementia

Introduction

Search strategy

What are the risk factors for alzheimer's dementia?

How can i screen for dementia?

What are other important areas to assess with caregivers and individuals diagnosed with dementia

Are medications effective in treating the cognitive symptoms of alzheimer's dementia?

What are the best interventions for challenging behaviors associated with dementia?

Chapter summary

Acknowledgments

CHAPTER 8: Enjoying the golden years: diagnosing and treating depression

Introduction

Search strategy

Is this older adult depressed?

What are the best options for the initial treatment of this depressed older adult?

Chapter summary

CHAPTER 9: A balancing act: preventing and treating falls

Introduction

Search strategy

What risk factors are associated with falls?

What interventions should be considered for fall prevention?

How should osteoporosis be addressed among fallers?

Chapter summary

Acknowledgment

CHAPTER 10: Keeping dry: managing urinary incontinence

Introduction

Search strategy

What is the best way to assess urinary incontinence in the office setting?

What are the best options for treating urinary incontinence?

What is the best treatment approach for ltc residents and people with dementia?

Summary

CHAPTER 11: Keeping things moving: preventing and managing constipation

Introduction

Search strategies

How do you define and diagnose chronic constipation?

What are the common causes of constipation in the older adult?

What is the suggested diagnostic workup of constipation?

What are the potential complications of constipation?

What are the methods of preventing constipation?

What are the nonpharmacological treatments of constipation?

What are the pharmacological treatments of constipation?

How should constipation be managed among patients on opioid analgesics?

Should my patient with severe constipation have colonic surgery?

Is there evidence to treat constipation with biofeedback?

Chapter summary

CHAPTER 12: Preventing and treating pressure ulcers

Introduction

Search strategy

What are the best ways to prevent pressure ulcers?

What are the best ways to treat pressure ulcers?

What are the best noninvasive ways to diagnose infection in chronic wounds?

Summary

CHAPTER 13: Elder abuse

Introduction

Search strategy

What are the types of elder abuse?

How do you identify a victim of elder abuse?

How can elder abuse be prevented or reduced?

Summary

Acknowledgment

CHAPTER 14: A good death: appropriate end-of-life care

Introduction

Search strategy

What is a good death?

How is pain management unique in the older adult?

What evidence exists for treatment of dyspnea at the end of life?

What role do advance directives play at the end of life for older adults?

Summary

Index

End User License Agreement

Guide

Cover

Table of Contents

Begin Reading

List of Tables

CHAPTER 1: Function and frailty: the cornerstones of geriatric assessment

Table 1.1 Contrasting the frailty phenotype and the frailty index

Table 1.2 Basic and instrumental activities of daily living

Table 1.3 Some commonly used, nondisease specific, disability assessment tools

CHAPTER 2: Computer-based clinical decision support systems in the care of older patients

Table 2.1 Summary of trials investigating computerized Clinical Decision Support (CDS) interventions to improve medication choice and decrease adverse events in older patients

Table 2.2 Summary of trials investigating computerized Clinical Decision Support (CDS) interventions to improve hypertension management and control in adult patients

CHAPTER 3: Simplifying the pillbox: drugs and aging

Table 3.1 2002 Criteria for potentially inappropriate medication use in older adults: independent of diagnoses or conditions

Table 3.2 2002 Criteria for potentially inappropriate medication use in older adults: considering diagnoses or conditions

Table 3.3 STOPP (Screening Tool of Older People's potentially inappropriate Prescriptions)

Table 3.4 START: Screening Tool to Alert doctors to Right i.e. appropriate, indicated Treatment

CHAPTER 4: Breathing easier: respiratory disease in the older adult

Table 4.1 Potentially modifiable risk factors for obstructive sleep apnea

Table 4.2 Symptoms and physical signs associated with obstructive sleep apnea

CHAPTER 5: Breathing easier: an approach to heart failure in a patient with an aging heart

Table 5.1 Evidence-based treatment options for heart failure

CHAPTER 6: Clarifying confusion: preventing and managing delirium

Table 6.1 Distinguishing delirium from dementia

Table 6.2 Multivariate predictors of postoperative delirium (a) Validated Clinical Prediction Rule developed among patients over 50 years of age scheduled for elective noncardiac surgery

Table 6.3 The Confusion Assessment Method (CAM)

Table 6.4 Examples of preventative strategies that target delirium risk factors

Table 6.5 Delirium management strategy

CHAPTER 7: Preserving memories: managing dementia

Table 7.1 Modifiable and nonmodifiable risk factors for dementia

Table 7.2 Commonly used dementia screening instruments

CHAPTER 8: Enjoying the golden years: diagnosing and treating depression

Table 8.1 The patient health questionnaire-9 (PHQ-9)

CHAPTER 9: A balancing act: preventing and treating falls

Table 9.1 Studies evaluating the tools used to assess falls

a

Table 9.2 Studies evaluating the risk factors for falls

Table 9.3 Studies evaluating the accuracy of elements of the history and physical exam for diagnosing falls

Table 9.4 Studies evaluating interventions for preventing falls

Table 9.5 Osteoporosis guidelines for Canada, United Kingdom, and United States

CHAPTER 10: Keeping dry: managing urinary incontinence

Table 10.1 Commonly used medications that can affect the lower urinary tract and the ability to toilet successfully

Table 10.2 Incontinence types and their underlying causes

Table 10.3 Evidence-based interventions for different UI types in women and men

Table 10.4 Characteristics of the different antimuscarinic agents used in the treatment of overactive bladder

CHAPTER 11: Keeping things moving: preventing and managing constipation

Table 11.1 Rome III Criteria for the diagnosis of functional constipation

Table 11.2 Drugs commonly associated with constipation

Table 11.3 Disease states associated with constipation

Table 11.4 Pharmacological treatment of constipation

CHAPTER 12: Preventing and treating pressure ulcers

Table 12.1 Prevention of pressure ulcers

Table 12.2 Medical management of pressure ulcers

CHAPTER 13: Elder abuse

Table 13.1 Types of elder abuse

Table 13.2 Historical and physical exam findings suggestive of elder mistreatment

CHAPTER 14: A good death: appropriate end-of-life care

Table 14.1 Treatments for pain

Table 14.2 Treatments for dyspnea

List of Illustrations

CHAPTER 7: Preserving memories: managing dementia

Figure 7.1 Timeline of symptom presentation and interventions for dementia. Solid line indicates strong evidence in support of a therapy, and dashed line indicates a potentially beneficial therapy.

Figure 7.2 Interventions for cognitive and behavioral symptoms of dementia. • indicates relevant chapter sections.

CHAPTER 8: Enjoying the golden years: diagnosing and treating depression

Figure 8.1 Flow chart for diagnosis and initial management of older adults with depressive symptoms.

CHAPTER 10: Keeping dry: managing urinary incontinence

Figure 10.1 Innervation of the lower urinary tract.

Figure 10.2 Seven-step-prompted voiding strategy.

CHAPTER 11: Keeping things moving: preventing and managing constipation

Figure 11.1 Management algorithm for constipation.

Pages

cover

contents

ii

iii

iv

vi

vii

viii

ix

x

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

21

22

23

24

25

26

27

28

29

30

31

32

33

34

35

36

37

38

39

40

41

42

43

44

45

46

47

48

49

50

51

52

53

54

55

56

57

58

59

60

61

62

63

64

65

66

67

68

69

70

71

72

73

74

75

76

77

78

79

80

81

82

83

84

85

86

87

88

89

90

91

92

93

94

95

96

97

98

99

100

101

102

103

104

105

106

107

108

109

110

111

112

113

114

115

116

117

118

119

120

121

122

123

124

125

126

127

128

129

130

131

132

133

134

135

136

137

138

139

140

141

142

143

144

145

146

147

148

149

150

151

152

153

154

155

156

157

158

159

160

161

162

163

164

165

166

167

168

169

170

171

172

173

174

175

176

177

178

179

180

181

182

183

184

185

186

187

188

189

190

191

192

Website: Evidence-Based Medicine Series

The Evidence-Based Medicine Series has a website at:www.evidencebasedseries.com

Where you can find:

Links to companion websites with additional resources and updates for books in the series

Details of all new and forthcoming titles

Links to more Evidence-Based products: including the Cochrane Library, Essential Evidence Plus, and EBM Guidelines.

How to access the companion sites with additional resources and updates:

Go to the Evidence-Based Series site:

www.evidencebasedseries.com

Select your book from the list of titles shown on the site

If your book has a website with supplementary material, it will show an icon next to the title

Click on the icon to access the website

Evidence-Based Geriatric Medicine

A Practical Clinical Guide

Jayna M. Holroyd-Leduc, MD FRCPC

Associate ProfessorDepartments of Medicine and Community Health SciencesDivision of GeriatricsUniversity of CalgaryCalgary, ABCanada

Madhuri Reddy, MD MSc

Hebrew Senior LifeBoston, MAUSA

This edition first published 2012, © 2012 by Blackwell Publishing Ltd.

BMJ Books is an imprint of BMJ Publishing Group Limited, used under licence by Blackwell Publishing which was acquired by John Wiley & Sons in February 2007. Blackwell's publishing programme has been merged with Wiley's global Scientific, Technical and Medical business to form Wiley-Blackwell.

Registered office:John Wiley & Sons, Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK

Editorial offices:9600 Garsington Road, Oxford, OX4 2DQ, UKThe Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK111 River Street, Hoboken, NJ 07030-5774, USA

For details of our global editorial offices, for customer services and for information about how to apply for permission to reuse the copyright material in this book please see our website at www.wiley.com/wiley-blackwell

The right of the author to be identified as the author of this work has been asserted in accordance with the UK Copyright, Designs and Patents Act 1988.

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher.

Designations used by companies to distinguish their products are often claimed as trademarks. All brand names and product names used in this book are trade names, service marks, trademarks or registered trademarks of their respective owners. The publisher is not associated with any product or vendor mentioned in this book. This publication is designed to provide accurate and authoritative information in regard to the subject matter covered. It is sold on the understanding that the publisher is not engaged in rendering professional services. If professional advice or other expert assistance is required, the services of a competent professional should be sought.

The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting a specific method, diagnosis, or treatment by physicians for any particular patient. The publisher and the author make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of fitness for a particular purpose. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. Readers should consult with a specialist where appropriate. The fact that an organization or Website is referred to in this work as a citation and/or a potential source of further information does not mean that the author or the publisher endorses the information the organization or Website may provide or recommendations it may make. Further, readers should be aware that Internet Websites listed in this work may have changed or disappeared between when this work was written and when it is read. No warranty may be created or extended by any promotional statements for this work. Neither the publisher nor the author shall be liable for any damages arising herefrom.

Library of Congress Cataloging-in-Publication Data

Evidence-based geriatric medicine : a practical clinical guide / edited byJayna M. Holroyd-Leduc and Madhuri Reddy.p. ; cm.Includes bibliographical references and index.ISBN 978-1-4443-3718-1 (pbk. : alk. paper)I. Holroyd-Leduc, Jayna M., 1970– II. Reddy, Madhuri, 1972–DNLM: 1. Geriatrics–methods. 2. Aged. 3. Aging–physiology. 4. Evidence-Based Medicine. 5. Geriatric Assessment. WT 100]618.97–dc232011049726

1 2012

List of Contributors

Ranjani Aiyar

Fellow

General Internal Medicine

Division of General Internal Medicine

Department of Medicine

University of Calgary

Calgary, AB, Canada

 

Shabbir M.H. Alibhai

Associate Professor

Departments of Medicine and Health Policy, Management, and Evaluation

University of Toronto

Toronto, ON, Canada;

Consultant Geriatrician

Toronto Rehabilitation Institute

Toronto, ON, Canada;

Staff Physician

Internal Medicine and Geriatrics

University Health Network

Toronto, ON, Canada

 

Anita Asgar

Director

Transcatheter Valve Therapy Clinic

Institut de Cardiologie de Montréal

Montréal, Quebec, Canada;

Assistant Professor

Université de Montréal

Montréal, Quebec, Canada

 

Stuart Carney

Deputy National Director

UK Foundation Programme Office

Cardiff Bay, UK

 

Dov Gandell

Resident, Geriatric Medicine

Department of Medicine

Division of Geriatrics

University of Toronto

Toronto, ON, Canada

 

Sudeep S. Gill

Associate Professor

Department of Medicine

Division of Geriatric Medicine

Queen's University

Kingston, ON, Canada

 

Mary K. Goldstein

Director

Geriatrics Research Education and Clinical Center (GRECC)

VA Palo Alto Health Care System

Palo Alto, CA, USA;

Professor of Medicine (Center for Primary Care & Outcomes Research)

Stanford University School of Medicine

Stanford, CA, USA

 

Jayna M. Holroyd-Leduc

QI Lead

Department of Medicine

University of Calgary and Alberta Health Services

Calgary, AB, Canada;

Medical Coordinator of Clinical Informatics

Department of Medicine

Alberta Health Services

Calgary, AB, Canada;

Associate Professor

Departments of Medicine and Community Health Sciences

Director, Geriatric Medicine Training Program

Division of Geriatrics

University of Calgary

Calgary, AB, Canada

 

Landon D. Hough

Resident Physician

Department of Family and Community Medicine

University of Missouri

Columbia, MO, USA

 

Sunila R. Kalkar

Research Coordinator

Women's College Research Institute

Women's College Hospital

Toronto, ON, Canada

 

Jean S. Kutner

Professor of Medicine

University of Colorado

Denver School of Medicine

Aurora, CO, USA

 

Emily Kwan

Resident, Geriatric Medicine

Department of Medicine

Division of Geriatrics

University of Toronto

Toronto, ON, Canada

 

Philip E. Lee

Assistant Professor

Division of Geriatric Medicine

University of British Columbia

Vancouver, BC, Canada

 

Cari Levy

Associate Professor of Medicine

University of Colorado Denver School of Medicine

Denver, CO, USA;

Denver VA Medical Center

Denver, CO, USA

 

Erik J. Lindbloom

Associate Professor

Department of Family and Community Medicine

University of Missouri

Columbia, MO, USA

 

Salahaddin Mahmudi-Azer

Clinical Fellow

Department of Critical Care Medicine

Foothills Hospital

University of Calgary

Calgary, AB, Canada

 

Marina Martin

Clinical Instructor of Medicine (General Internal Medicine)

Stanford University

Stanford, CA, USA

 

Paige K. Moorhouse

Assistant Professor

Geriatric Medicine

Dalhousie University

Halifax, NS, Canada

 

Jane Pearce

Consultant Old Age Psychiatrist and Honorary Senior Clinical Lecturer in Psychiatry

University of Oxford

Oxford, UK;

Fulbrook Centre

Churchill Hospital

Oxford, UK

 

Madhuri Reddy

Hebrew Senior Life

Boston, MA, USA

 

Paula A. Rochon

Vice President, Research

Women's College Research Institute

Women's College Hospital

Toronto, ON, Canada;

Senior Scientist

Institute for Clinical Evaluative Sciences

Toronto, ON, Canada;

Professor

Department of Medicine

University of Toronto

Toronto, ON, Canada

 

Kenneth Rockwood

Professor

Geriatric Medicine

Dalhousie University

Halifax, NS, Canada;

Kathryn Allen Weldon Professor of Alzheimer Research

Dalhousie University

Halifax, NS, Canada;

Consultant Physician

Queen Elizabeth II Health Sciences Centre

Halifax, NS, Canada

 

Dallas P. Seitz

Assistant Professor

Department of Psychiatry

Division of Geriatric Psychiatry

Queen's University

Kingston, ON, Canada;

Fellow

Women's College Research Institute

Toronto, ON, Canada

 

Sharon Straus

Professor

Department of Medicine

Director, Division of Geriatrics

University of Toronto

Toronto, ON, Canada;

Director, Knowledge Translation Program

Li Ka Shing Knowledge Institute of St. Michael's

Toronto, ON, Canada

 

Cara Tannenbaum

Associate Professor

Faculties of Medicine and Pharmacy

Université de Montréal

Montréal, QC, Canada;

Director

Geriatric Incontinence Clinic

Institut Universitaire de Gériatrie

Université de Montréal

Montréal, QC, Canada

 

Karli R.E. Urban

Resident Physician

Department of Family and Community Medicine

University of Missouri

Columbia, MO, USA

 

Wei Wu

Statistical Analyst

Women's College Research Institute

Women's College Hospital

Toronto, ON, Canada

Foreword

Worldwide a major change in the population demographic is posing challenges to health care systems. In many countries the baby boom, that followed World War II and extended to the 1960s, will soon result in a substantial increase in the number of people over 65 years of age. Moreover, most countries including Canada, the United States and the United Kingdom have experienced a continuing increase in life expectancy, with an increase of approximately 1 year occurring every 5 years. These factors translate into a growing proportion of people aged 65 and older and these people will have many more years of life after attaining age 65. This situation is not unique to western countries; many developing countries will grow old before they get rich. For example, in 2000, 7% of China's population was ≥ 65 years old; by 2030 this will increase to 16%. As the proportion of older people increases, there is an increasing need for services targeted to care for older people, in particular to optimize the independence and vitality of those living in the community. There is an urgent need for health care professionals from all disciplines (aside from paediatrics!) to become comfortable with caring for this population. This book will address this demand and provide a resource for health care professionals to provide evidence-based care for older patients.

Evidence-Based Geriatric Medicine, a Practical Guide focuses on bringing together 2 critically important issues in health care – evidence-based practice (EBP) and care of the older patient. Interest in EBP has grown exponentially since the coining of the term in 1992, from 1 MEDLINE citation in that year to more than 75000 hits in January 2012. Training in EBP has become a component of educational curricula for health care disciplines, patients and policy makers amongst others[1]. This growing interest arose from a number of realisations including: our inability to afford more than a few seconds per patient for finding and assimilating evidence[2] or to set aside more than half an hour per week for general reading and study[3]; and the finding that the gaps between evidence and practice (including underuse and overuse of evidence) lead to variations in practice and quality of care[4, 5].

To meet these challenges, this book focuses on providing an approach to care for older patients that is based on the best available evidence. An ideal evidence-based resource should use rigorous and transparent methods for seeking and appraising the evidence, and provide the evidence in a clinically useful format. The format of each chapter in this book includes questions that have been generated by clinicians while the content focuses on a systematic review of the evidence and provides the reader with the bottom line for their clinical practice. Finally, the book highlights the gaps in the evidence, which are targets for future research (we hope!).

Topics addressed in the book include assessing and managing the geriatric giants such as delirium, dementia, urinary incontinence and falls. The authors also tackle issues, such as elder abuse, that are often underappreciated in clinical care. And, the book includes discussion of the management of chronic diseases in the complex older patient which is useful information for any generalist clinician.

This book will be a resource for trainees and clinicians from various disciplines, worldwide. It addresses issues of global importance – promoting healthy aging and building capacity to care for older persons.

References

1.Straus SE, Richardson WS, Glasziou P, Haynes RB (2011) Evidence-based Medicine: How to practice and teach it. Fourth Edition. Elsevier; Edinburgh.

2. Sackett DL, Straus SE (1998) Finding and applying evidence during clinical rounds: the ‘evidence cart’. JAMA 280: 1336–8.

3. Sackett DL (1997) Using evidence-based medicine to help physicians keep up-to-date. Serials 9: 178–81.

4. Shah BR, Mamdani M, Jaakkimainen L, Hux JE (2004) Risk modification for diabetic patients. Can J Clin Pharmacol 11: 239–44.

5. Pimlott NJ, Hux JE, Wilson LM, et al. (2003) Educating physicians to reduce benzodiazepine use by elderly patients. CMAJ 168: 835–9.

Sharon StrausFebruary 2012

CHAPTER 1Function and frailty: the cornerstones of geriatric assessment

Paige K. Moorhouse1,2 & Kenneth Rockwood1,2

Lesen Sie weiter in der vollständigen Ausgabe!

Lesen Sie weiter in der vollständigen Ausgabe!

Lesen Sie weiter in der vollständigen Ausgabe!

Lesen Sie weiter in der vollständigen Ausgabe!

Lesen Sie weiter in der vollständigen Ausgabe!

Lesen Sie weiter in der vollständigen Ausgabe!

Lesen Sie weiter in der vollständigen Ausgabe!

Lesen Sie weiter in der vollständigen Ausgabe!

Lesen Sie weiter in der vollständigen Ausgabe!

Lesen Sie weiter in der vollständigen Ausgabe!

Lesen Sie weiter in der vollständigen Ausgabe!

Lesen Sie weiter in der vollständigen Ausgabe!

Lesen Sie weiter in der vollständigen Ausgabe!

Lesen Sie weiter in der vollständigen Ausgabe!

Lesen Sie weiter in der vollständigen Ausgabe!