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Unrelieved chronic pain is a worldwide epidemic Chronic pain has been subject to multiple international initiatives through the World Health Organization. Interventional Pain Medicine, the use of minimally invasive techniques to relieve pain, is the best approach when simpler measures such as physical therapy or medications fail. However, these procedures can be associated with significant risk and expense. Establishing uniformity in diagnostic criteria and procedural performance can reduce both morbidity and unnecessary procedures, and hence healthcare expenditures. While other texts explain how to perform these procedures, little focus has been given to diagnostic considerations: if and when these procedures should be performed. Evidence-Based Interventional Pain Medicine focuses on a balance between effectiveness and safety of interventional management for specific diagnoses, across all areas of chronic pain including: * Head, neck and shoulder pain * Lower back pain * Neuropathic pain syndromes * Complex Regional Pain Syndrome * Pain in patients with cancer * Vascular and visceral pain Evidence-Based Interventional Pain Medicine provides essential knowledge for anyone who uses, or intends to use, interventional pain techniques.
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Table of Contents
Cover
Title page
Copyright page
Contributor List
Foreword
Introduction
Guideline development
Guideline rationale
Future guidelines
Supporting information
Search strategy and evidence rating
1 Trigeminal Neuralgia
Introduction
Symptoms
Physical examination
Additional test
Differential diagnosis
Treatment options
Recommendations
Clinical practice algorithm
Summary
2 Cluster Headache
Introduction
Diagnosis
Treatment options
Recommendations
Summary
3 Persistent Idiopathic Facial Pain
Introduction
Diagnosis
Treatment options
Recommendations
Summary
4 Cervical Radicular Pain
Introduction
Diagnosis
Treatment options
Recommendations
Summary
5 Cervical Facet Pain
Introduction
Diagnosis
Treatment options
Recommendations
Summary
6 Cervicogenic Headache
Introduction
Diagnosis
Treatment options
Recommendations
Summary
7 Whiplash-Associated Disorders
Introduction
Diagnosis
Treatment options
Recommendations
Summary
8 Occipital Neuralgia
Introduction
Diagnosis
Treatment options
Recommendations
Summary
9 Painful Shoulder Complaints
Introduction
Diagnosis
Treatment options
Recommendations
Summary
10 Thoracic Pain
Introduction
Thoracic radicular pain symptoms
Thoracic facet pain
11 Lumbosacral Radicular Pain
Introduction
Diagnosis
Treatment options
Recommendations
Summary
12 Pain Originating from the Lumbar Facet Joints
Introduction
Diagnosis
Treatment options
Recommendations
Conclusions
Summary
13 Sacroiliac Joint Pain
Introduction
Diagnosis
Treatment options
Recommendations
Summary
14 Coccygodynia
Introduction
Diagnosis
Treatment options
Recommendations
Summary
15 Discogenic Low Back Pain
Introduction
Anatomy of the discus intervertebralis
Diagnosis
Treatment options
Recommendations
Summary
16 Complex Regional Pain Syndrome
Introduction
Pathophysiology
Diagnosis
Treatment options
Recommendations
Summary
17 Herpes Zoster and Post-Herpetic Neuralgia
Introduction
Pathophysiology
Diagnosis
Treatment options
Recommendations
Summary
18 Painful Diabetic Polyneuropathy
Introduction
Diagnosis
Treatment options
Recommendations
Summary
19 Carpal Tunnel Syndrome
Introduction
Diagnosis
Treatment options
Recommendations
Summary
20 Meralgia Paresthetica
Introduction
Diagnosis
Treatment options
Recommendations
Summary
21 Phantom Pain
Introduction
Mechanism
Diagnosis
Treatment options
Recommendations
Summary
22 Traumatic Plexus Lesion
Introduction
Diagnosis
Treatment options
Recommendations
Summary
23 Pain in Patients with Cancer
Introduction
Epidural and intrathecal administration of analgesics
Unilateral pain with limited life expectancy
Upper abdominal pain due to cancer of the pancreas/stomach
Visceral pain due to pelvic tumors
Perineal pain due to pelvic tumors
Spinal pain related to vertebral compression fracture (with or without pathologic tumor invasion)
Summary
24 Chronic Refractory Angina Pectoris
Introduction
Diagnosis
Treatment options
Recommendations
Summary
25 Ischemic Pain in the Extremities and Raynaud’s Phenomenon
Introduction
Epidemiology
Etiology
Pathophysiology
Diagnosis
Treatment options
Summary
26 Pain in Chronic Pancreatitis
Introduction
Diagnosis
Treatment options
Recommendations
Other treatment options
Summary
Index
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Contributor List
Honorio T. Benzon MD, FIPP
Department of Anesthesiology
Northwestern University Feinberg School of Medicine
Chicago, IL, USA
Kees Besse MD, FIPP
Department of Anesthesiology Pain and Palliative Medicine
Radboud University
Nijmegen Medical Centre
Nijmegen, the Netherlands
Allen W. Burton MD, FIPP
Department of Pain Medicine
UT MD Anderson Cancer Center
Houston, TX, USA
Jianguo Cheng MD, PhD
Department of Pain Management
Cleveland Clinic, Cleveland
OH, USA
Steven P. Cohen MD
Department of Anesthesiology & Critical Care Medicine
John Hopkins School of Medicine, Baltimore
Walter Reed Army Medical Center
Washington, DC, USA
Paul Cornelissen MD
Department of Anesthesiology and Pain Management
Jeroen Bosch Ziekenhuis’s Hertogenbosch
the Netherlands
Miles Day MD, DABA FIPP, DABIPP
Professor
Medical Director
International Pain Centre Texas Tech University HSC
Lubbock, Texas, USA
Jan De Witte MD
Department of Anesthesiology
Intensive Care Medicine, and Pain Management
OLV-Ziekenhuis, Aalst, Belgium
Richard Derby, MD, FIPP
Medical Director
Spinal Diagnostics and Treatment Center
Daly City, CA, USA
Jacques Devulder MD, PhD
Department of Anesthesiology and Multidisciplinary Pain Centre
University Hospital Ghent
Ghent, Belgium
Sudhir Diwan, MD, DABIPP, FIPP
Executive Director
The Spine & Pain Institute of New York
Staten Island University Hospital
New York
Robert van Dongen MD, PhD, FIPP
Department of Anesthesiology, Pain and Palliative Medicine
Radboud University Nijmegen Medical Centre
Nijmegen, the Netherlands
Maarten van Eerd MD, FIPP
Department of Anesthesiology and Pain Management
Amphia Ziekenhuis, Breda
The Netherlands
Frank van Eijs MD
Department of Anesthesiology and Pain Management
St. Elisabeth Hospital
Tilburg, the Netherlands
Catharina G. Faber MD, PhD
Department of Neurology
Maastricht University Medical Centre
the Netherlands
Wilco E. van Genderen, MD
Department of Anesthesiology and Pain Management
Medical Centre Jan van Goyen
Amsterdam, the Netherlands
José W. Geurts, MSc
Department of Anesthesiology and Pain Management
Maastricht University Medical Centre
Maastricht, the Netherlands
Maurice J.M.M. Giezeman MD, PhD
Department of Anesthesiology and Pain Management
Diakonessenhuis, Utrecht
the Netherlands
Gerbrand J. Groen MD, PhD
Department of Anesthesiology & Pain Treatment,
University Medical Centre Groningen
University of Groningen, Groningen, the Netherlands
Craig T. Hartrick, MD, FIPP
Department of Anesthesiology, Biomedical Sciences, and Health Sciences
Oakland University William Beaumont School of Medicine
Rochester, MI, USA
Salim Hayek MD, PhD, FIPP
Division of Pain Medicine
University Hospitals
Cleveland, OH, USA
Marc Huntoon MD
Division of Pain Medicine
Chief
Professor of Anesthesiology Vanderbilt University, Nashville TN, USA
Frank Huygen MD, PhD, FIPP
Department of Anesthesiology and Pain Management
Erasmus University Medical Centre
Rotterdam
Markus Janssen MD, FIPP
Department of Anesthesiology and Pain Management
Maastricht University Medical Centre, Maastricht
The Netherlands
Jan Willem Kallewaard MD, FIPP
Department of Anesthesiology and Pain Management
Rijnstate Hospital
Arnhem, the Netherlands
Leonardo Kapural MD, PhD, FIPP
Department of Pain Management, Cleveland Clinic
Cleveland, OH, USA
Yolande Keulemans, MD, PhD
Department of Gastroenterology
Maastricht University Medical Centre
Maastricht, the Netherlands
Maarten van Kleef, MD, PhD, FIPP
Department of Anesthesiology and Pain Management
Maastricht University Pain Centre
Maastricht, the Netherlands
Arno Lataster MSc
Department of Anatomy and Embryology
Maastricht University
Maastricht, the Netherlands
Robert Levy MD, PhD
Professor and Chairman
Department of Neurological Surgery and Co-Director,
Shands Jacksonville Neuroscience Institute University of Florida College of Medicine
Jacksonville, Fl, USA
Timothy R. Lubenow MD, FIPP
Department of Anesthesiology
Rush University Medical Center
Chicago, IL, USA
Nagy Mekhail, MD, PhD, FIPP
Department of Pain Management
Cleveland Clinic
Cleveland, OH, USA
Samer Narouze MD, MSc, FIPP
Centre For Pain Medicine
Summa Western Reserve Hospital
Cuyahoga Falls, Oh, USA
Turo J. Nurmikko MD, PhD
Pain Research Institute and
Faculty of Health and Life Sciences
University of Liverpool
Liverpool, UK
Nileshkumar Patel MD, MBA
Clinical Professor, Anesthesiology
Advanced Pain Management
Green Bay, WI, USA
Jacob Patijn, MD, PhD
Department of Anesthesiology and Pain Management
Maastricht University Pain Centre
Maastricht, the Netherlands
Dirk Peek MD
Department of Anesthesiology and Pain Medicine
St. Jans Gasthuis, Weert
The Netherlands
Wouter Pluijms MD
Department of Anesthesiology and Pain Management
Maastricht University Medical
Centre, Maastricht
Jason E. Pope, MD
Director of the Headache Center
Napa Pain Institute
Napa, CA
Assistant Professor of Anesthesiology
Vanderbilt University Medical Center
Nashville, TN
Martine Puylaert MD, FIPP
Department of Anesthesiology and Multidisciplinary Pain Centre
Ziekenhuis Oost-Limburg
Genk, Belgium
Prithvi Raj, MD, FIPP
Department of Anesthesiology and Pain Medicine
Texas Tech University
Texas, TX, USA
Olav Rohof MD, PhD, FIPP
Orbis Medisch Centrum,
Pijnkliniek
Sittard Geleen
the Netherlands
Richard W. Rosenquist MD
Chairman of the Pain Management Department
Cleveland Clinic
Cleveland, OH, USA
Menno E. Sluijter MD, PhD, FIPP
Pain Unit, Swiss Paraplegic Centre
Nottwil, Switzerland
Peter Staats MD, FIPP
Department of Anesthesiology and Critical Care Medicine
John Hopkins University
Baltimore, MA, USA
Michael Stanton-Hicks MB; BS, Dr med, FIPP
Department of Pain Management
Cleveland Clinic, Cleveland
OH, USA
Robert Jan Stolker MD, PhD
Department of Anesthesiology and Pain Management
Erasmus University Medical Centre
Rotterdam the Netherlands
Hans van Suijlekom MD, PhD
Department of Anesthesiology and Pain Management
Catharina Ziekenhuis, Eindhoven
The Netherlands
Karolina Szadek MD
Department of Anesthesiology and Pain Management
Vrije Universiteit Amsterdam
Amsterdam, the Netherlands
Michel A. M. B. Terheggen MD
Department of Anesthesiology and Pain Management
Rijnstate Hospital
Arnhem, the Netherlands
Ricardo Vallejo MD, PhD, FIPP
Millennium Pain Center
Bloomington, IL, USA
Koen Van Boxem MD, FIPP
Department of Anesthesiology and Pain Management
Sint-Jozefkliniek, Bornem and Willebroek
Bornem, Belgium
Eric Vanduynhoven MD
Department of Anesthesiology and Pain Management
GZA, Campus Sint
Augustinus, Antwerp
Belgium
Pascal Vanelderen MD, FIPP
Department of Anesthesiology and Multidisciplinary Pain Centre
Ziekenhuis Oost-Limburg, Genk, Belgium
Jan Van Zundert, MD, PhD, FIPP
Department of Anesthesiology and Muitidisciplinary Pain Centre
Ziekenhuis Oost-Limburg, Genk, Belgium
Kris C. P. Vissers MD, PhD, FIPP
Department of Anesthesiology Pain and Palliative Medicine
Radboud University
Nijmegen Medical Centre
Nijmegen, the Netherlands
Michel Wagemans MD, PhD
Department of Anesthesiology and Pain Management
Renier de Graaf Groep
Delft, The Netherlands
Mark Wallace MD
Center for Pain Medicine
University of California
San Diego Medical Center
San Diego, CA, USA
Albert J. M. van Wijck
MD, PhD
Department of Anesthesiology and Pain Management
University Medical Centre, Utrecht
the Netherlands
Andre Wolff MD, PhD
Department of Anesthesiology Pain and Palliative Medicine
Radboud University Nijmegen Medical Centre
Nijmegen, the Netherlands
Wouter Zuurmond MD, PhD
Department of Anesthesiology, Pain Therapy and Palliative Care
VU Medical Centre, Amsterdam
The Netherlands
Foreword
by Menno E. Sluijter MD, PhD, FIPP
Seeing this book makes me proud of my university city Maastricht, where I have left so many footsteps and where I still have many friends. It is a great honor for me to have been invited to write this foreword.
Besides accurately describing the various techniques in detail, this book has an accent on evidence-based medicine. This comes naturally for the Dutch since soberness and standing firmly on the ground belong to their prominent features. It makes the book into a solid and reliable guide for many pain practitioners.
My first footsteps in the world of invasive pain treatment date back to a very different period. My mentors and teachers were Jur Bouma in the Netherlands and legendary names, such as Sampson Lipton and Mark Mehta, who played such a pivotal role in their time. Those were the days when solitary observations easily sparked attention or even a trend. Epidural phenol at T12 has been recommended for anal pain for about a decade, one author copying it from another because it was so bizarre. Ondine’s syndrome, as a complication of a cordotomy, received undue attention probably because of its romantic name. Evidence-based medicine was still a far cry.
This book therefore symbolizes for me how invasive pain treatment has become mature within a relatively short period. This process of growth has taken place despite a head wind that is specific for the subject. Many of the procedures are intricate, and success or failure may depend on seemingly trivial details, causing differences in results between researchers. Also pain is a subjective experience and this has various consequences. It makes it particularly difficult to translate results into numbers that are suitable for meaningful statistical analysis. It may even influence results. I firmly believe that a procedure that is performed by a friendly, interested doctor in a friendly environment has a greater chance of success than a procedure under less favorable circumstances. If this is placebo, so be it. It makes pain treatment different from putting a stent into a coronary artery or from removing a tumor under general anesthesia.
Maturity is a sign of growth and it has to be encouraged. Evidence-based medicine will be an indispensible and welcome element of invasive pain treatment in the time to come. It will save patients from getting useless treatments and it will convince insurers to follow up on reasonable demands. It will hopefully discourage those who seek financial gain from a vulnerable group of patients. It will also provide interventional pain treatment with the respected place in the medical community that it deserves.
But, on the other hand, maturity may also be taken as a sign of immanent old age. When reading this book the reader should also realize that all these procedures have once been done for the first time. This reflects a mixture of prudence and courage, but also alertness to observations and the urge to make it a better world for patients who could not be helped before. This process of growth and renewal must not be lost. It should be seen as a complement of evidence-based medicine rather than as a contradiction. After all, without ideas and innovation the need for evidence would soon dry up, and what good is a new procedure without evidence?
The book underscores the need for proper training. The prevalence of chronic pain is such that, despite the laudable efforts of World Institute of Pain, there is still a shortage of well trained doctors who can provide this type of treatment. This is a problem because reading even this book is not enough and practical training is costly in terms of material and manpower. It is to be hoped that the increasing number of potential trainers will gradually resolve the problem.
I recommend this book as a standard manual in the library of every interventionalist. Happy reading!
Foreword
by P. Prithvi Raj MD, FIPP
Jan Van Zundert, Jaap Patijn, Craig Hartrick, Arno Lataster, Frank Huygen, Nagy Mekhail, and Maarten van Kleef, all internationally renowned pain physicians, have embarked on writing “Evidence-Based Interventional Pain Medicine According to Clinical Diagnosis”. They have devoted most of their lives to improving the pain management of patients globally. At their request, I am honored to write a Foreword for their new book.
To emphasize the importance of this book, I need to reiterate the statistics available to us on chronic pain today. Chronic pain prevails globally, the total number of persons living with this specific disease or condition with feeling of pain, ranges from 54% in Sweden to 13% in Japan. These studies show that in the rest of the developed countries, such as United States, United Kingdom and Australia, the incidence is somewhere in between. Studies also show that pain imposes a huge economic burden on all countries; for example, in the United States it was calculated that in 1991, the USA spent eighty-six billion dollars on chronic back pain management. Today, because the elderly are living longer, the prevalence of chronic pain is rising with age. Another problem one needs to recognize is that only one billion people in the developed countries have the luxury of utilizing the most advanced pain management techniques. The other five billion people, who have medium to low standards of living, are unable to receive the benefits of these new techniques of pain management.
The World Institute of Pain (WIP) and its members have been aware of this problem and the disparities between countries in terms of standard of care and practices of pain management. Since 1994, WIP’s mission has been to train pain physicians and certify their competency in interventional pain management. By all accounts, this mission has become very successful globally.
Pain practice today is fortunate to have many physicians taking this practice as a professional part of their career. They come from all specialties and the book now has to reflect the advances in Pain Practice of all those specialties, not just those in Anesthesiology. The debate is still raging whether a single pain specialist can deliver better pain management than a group of specialists together. The cost of managing such multidisciplinary clinics has been called into question especially by the reimbursement agencies. A program developed by a multidisciplinary clinic is nowadays rejected outright by the reimbursement agencies, and even if it is approved, the efficacy of such programs is questionable. More and more the patients are referring themselves to the Pain Clinics where their pain will be relieved over the short-term rather than addressing the long-term goal of improving the patient’s function and quality of life. That is why one finds a prolific growth of Interventional Pain Management Clinics and decrease in University-based Multidisciplinary Clinics. This is certainly the case in the USA and is also becoming common in other countries.
Pain Physicians have not tackled at all the discrepancy in pain practices between developed, developing and under developed countries. There is no factual account of the epidemiology of pain the world over; one cannot say for certain how many Pain Physicians are available per capita in any community. We certainly have made advances in understanding the new theories of pain, and in some pain syndromes, the longitudinal natural course, but we are far from having a reliable algorithm for any pain disorder. It is still hit and miss.
The challenge today is to train Pain Physicians in such a way that they have a standardized curriculum during their Residency and Pain Fellowship programs, followed by skilled practical training, either in Anesthesiology, Neurosurgery, Physical Medicine and Rehabilitation or Psychiatry. Once trained, they need to be examined and tested periodically for their competency. This will raise the standard of pain practice, not only in the USA, but all over the world.
Evidence-based medicine (EBM) or evidence-based practice (EBP) aims to apply the best available evidence gained from scientific methods to clinical decision making. It seeks to assess the strength of evidence of the risks and benefits of treatments (including lack of treatment) and diagnostic tests. Evidence quality can range from meta-analyses and systematic reviews of double-blind, placebo-controlled clinical trials at the top end, down to conventional wisdom at the bottom.
Let me explain the history of evidence-based medicine’s origin. Traces of evidence-based medicine’s origin can be found in ancient Greece. Although testing medical interventions for efficacy has existed since the time of Avicenna’s The Canon of Medicine in the 11th century, it was only in the 20th century that this effort evolved to impact almost all fields of health care and policy. Professor Archie Cochrane, a Scottish Epidemiologist, through his book Effectiveness and Efficiency: Random Reflections on Health Services (1972) and subsequent advocacy caused increasing acceptance of the concepts behind evidence-based practice. Cochrane’s work was honored through the naming of centers of evidence-based medical research—Cochrane Centers—and an international organization, the Cochrane Collaboration. The explicit methodologies used to determine “best evidence” were largely established by the McMaster University research group led by David Sackett and Gordon Guyatt. Guyatt later coined the term “evidence-based” in 1990. The term “evidence-based medicine” first appeared in the medical literature in 1992 in a paper by Guyatt et al. Relevant journals include the British Medical Journal’s Clinical Evidence, the Journal of Evidence-Based Healthcare and Evidence-Based Health Policy. All of these were co-founded by Anna Donald, an Australian pioneer in the discipline.
There has been discussion of applying what has been learned from EBM to public policy. In his 1996 inaugural speech as President of the Royal Statistical Society, Adrian Smith held out evidence-based medicine as an exemplar for all public policy. He proposed that “evidence-based policy” should be established for education, prisons and policing policy, and all areas of government
This book “Evidence-Based Interventional Pain Medicine According to Clinical Diagnoses” fits the void where literature should conform to local necessities for information to be useful in that society. The format of the book is excellent; each chapter is consistent in describing an interventional technique in simple terms from history to complications and efficacy, stressing at all times the technique.
The reader who is interested in learning, training and practicing interventional pain medicine will find this book extremely useful and informative. It illustrates not only the usual common techniques but also the emerging techniques; this makes it unique and different from the usual text books on pain. I wholeheartedly recommend the interventional pain physician to have this book in their library.
Introduction
The use of interventional pain management techniques has gradually become integrated into the treatment plan of patients suffering from chronic pain. After a long period of empirical use, it is time to move on to the professionalization and standardization of this practice. Interventional pain management techniques are target specific. There is evidence that better patient selection increases the success ratio.1 Therefore, a standard patient evaluation to “fine-tune” the clinical pain diagnosis is mandatory. A detailed description of the technical performance provides a guideline for the standardized interventional pain procedure.
The efficacy of these techniques has been described in randomized controlled trials, observational studies, retrospective studies, and case reports. Evidence-based practice guidelines provide a good review of the literature in a context that makes it accessible and useful to both the clinician and researcher.2,3
The available evidence is summarized by treatment option or technique. There are, however, several studies indicating that the chances for treatment success increase with better patient selection.1,4–7 A wellformed management strategy starts with an accurate evaluation process to identify the pain diagnosis. It is of utmost importance to first check for the so-called red flags that may be indicative of an underlying primary pathology, which needs adequate treatment prior to symptomatic pain management techniques. The treatment relies on accurate use of conservative interventions, potentially in association with interventional pain management techniques. Consequently, evidence-based practice guidelines are of greater practical value when they are specific for each different pain diagnosis.
Guideline Development
In daily practice the important goal of pain medicine is to use a specific treatment, conservative and/or interventional, for the right patient at the right moment. Therefore, treatment selection should be according to clinical diagnoses. To improve recognition and information retrieval, the articles have been organized according to a strict structure:
Introduction
Diagnosis
History
Physical examination
Additional tests
Differential diagnosis
Treatment
Conservative management
Interventional management
Complications of interventional treatment
Evidence for interventional management
Recommendations
Treatment algorithm
Techniques
Summary
Although the scientific literature is predominantly Anglo-Saxon and most doctors use the English denominations of anatomical structures, in this series, anatomical structures were indicated with the Latin denomination (Terminologia Anatomica) and the English denomination was, where appropriate, added between brackets.8 This option was specifically chosen to help people around the world to use the correct denomination when expressing themselves in a language other than English.
This series has focused on interventional pain management techniques, because they have undergone a rapid evolution in recent decades with additional well-conducted research being published regularly. The use of these techniques for the right indication may improve the quality of life of carefully selected patients. Moreover, for correct application of interventional pain management techniques, both good theoretical knowledge and practical experience are mandatory. These skills can only be acquired through training and continuing education.
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
Lesen Sie weiter in der vollständigen Ausgabe!
