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This book serves as a simple review of selected general surgery topics in outline format. The illustrations are exceptionally good, displaying sufficient detail to depict the important anatomy without unnecessary distractions. -- Kevin Helling, MD, University of Iowa Hospitals and Clinics
Covering all the main topics and latest operative techniques, General and Visceral Surgery Review is a compact, highly structured review book designed to maximize your study time for the medical residency board exams. It pinpoints only the information you need to master the exam—enhanced by highlighted key words, summary tables, outline lists, and sidebar notes that make understanding and retention fast and easy.
Features:
Optimally structured, clearly presented, and packed with helpful study aids, this book is the go-to companion for all students and residents specializing in general and visceral surgery and preparing for the medical residency board exams. It is also useful as a general study aid and a distillation of key points in conjunction with larger, more detailed texts.
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Seitenzahl: 636
Veröffentlichungsjahr: 2011
Nicolas T. Schwarz, MD
Associate ProfessorFriedrich Ebert HospitalSurgical ClinicNeumünsterGermany
Karl-Heinz Reutter, MD
StuttgartGermany
With contributions byHinrich Brunn, Ronald J. Elfeldt, Michael Fuchs,Jan M. Mayer, Ingo L. Schmalbach, Nicolas T. Schwarz,Alexander Selch, Burkhard Thiel, Michael Voelz
185 illustrations
Thieme Stuttgart · New York
Library of Congress Cataloging-in-Publication Data
Allgemein- und Viszeralchirurgie. English.
General and visceral surgery review/[edited by] Nicolas T. Schwarz, Karl-Heinz Reutter; with contributions by Hinrich Brunn … [et al.]; [translator, Geraldine O’Sullivan; illustrators, P. Gusta … et al.].
p.; cm.
Originally published in German as: Allgemein- und Viszeralchirurgie. 6th ed. 2009.
ISBN 978-3-13-154311-0 (pbk.: alk. paper) 1. Operations, Surgical–Handbooks, manuals, etc. 2. Viscera–Surgery–Handbooks, manuals, etc. I. Schwarz, Nicolas T. II. Reutter, Karl-Heinz. III. Brunn, Hinrich. IV. Title.
[DNLM: 1. Surgical Procedures, Operative–methods–Handbooks. 2. Viscera–surgery–Handbooks. WO 39]
RD32.A56513 2011
617'.9–dc23
2011015799
This book is an authorized translation of the 6th German edition published and copyrighted 2009 by Georg Thieme Verlag, Stuttgart. Title of the German edition: Allgemein-und Viszeralchirurgie.
Translator: Geraldine O’Sullivan, Dublin, Republic of Ireland
Illustrators: P. Gusta, Champigny sur Marne, France; J. and K. Hormann, Stuttgart, Germany; Christiane and Dr. Michael von Solodkoff, Neckargemünd, Germany
© 2012 Georg Thieme Verlag, Rüdigerstrasse 14, 70469 Stuttgart, Germanyhttp://www.thieme.de Thieme New York, 333 Seventh Avenue,http://www.thieme.com
Cover design: Thieme Publishing Group Typesetting by Druckhaus Götz, Ludwigsburg, Germany Printed in China by Everbest Printing Co. Ltd.
ISBN: 978-3-13-154311-0123456Important note: Medicine is an ever-changing science undergoing continual development. Research and clinical experience are continually expanding our knowledge, in particular our knowledge of proper treatment and drug therapy. Insofar as this book mentions any dosage or application, readers may rest assured that the authors, editors, and publishers have made every effort to ensure that such references are in accordance with the state of knowledge at the time of production of the book.
Nevertheless, this does not involve, imply, or express any guarantee or responsibility on the part of the publishers in respect to any dosage instructions and forms of applications stated in the book. Every user is requested to examine carefully the manufacturers’ leaflets accompanying each drug and to check, if necessary in consultation with a physician or specialist, whether the dosage schedules mentioned therein or the contraindications stated by the manufacturers differ from the statements made in the present book. Such examination is particularly important with drugs that are either rarely used or have been newly released on the market. Every dosage schedule or every form of application used is entirely at the user’s own risk and responsibility. The authors and publishers request every user to report to the publishers any discrepancies or inaccuracies noticed. If errors in this work are found after publication, errata will be posted at www.thieme.com on the product description page.
Some of the product names, patents, and registered designs referred to in this book are in fact registered trademarks or proprietary names even though specific reference to this fact is not always made in the text. Therefore, the appearance of a name without designation as proprietary is not to be construed as a representation by the publisher that it is in the public domain.
This book, including all parts thereof, is legally protected by copyright. Any use, exploitation, or commercialization outside the narrow limits set by copyright legislation, without the publisher’s consent, is illegal and liable to prosecution. This applies in particular to photostat reproduction, copying, mimeographing, preparation of microfilms, and electronic data processing and storage.
Hinrich Brunn, MD Friedrich Ebert Hospital Surgical Clinic Department of Vascular Surgery Neumünster Germany
Ronald J. Elfeldt, MD Associate Professor Friedrich Ebert Hospital Surgical Clinic Department of Thoracic Surgery Neumünster Germany
Michael Fuchs, MD Associate Professor Friedrich Ebert Hospital Trauma and Orthopedic Clinic, Sports Trauma Clinic Neumünster Germany
Jan M. Mayer, MD Friedrich Ebert Hospital Surgical Clinic Neumünster Germany
Ingo L. Schmalbach, MD Friedrich Ebert Hospital Surgical Clinic Neumünster Germany
Nicolas T. Schwarz, MD Associate Professor Friedrich Ebert Hospital Surgical Clinic Neumünster Germany
Alexander Selch, MD Friedrich Ebert Hospital Surgical Clinic Department of Vascular Surgery Neumünster Germany
Burkhard Thiel, MD Friedrich Ebert Hospital Surgical Clinic Neumünster Germany
Michael Voelz, MD Friedrich Ebert Hospital Surgical Clinic Neumünster Germany
General and Visceral Surgery Review was originally published in German in 1996 as a revision aid for surgery in general. Since then, as the individual surgical subspecialties continue to develop, and today’s medical training is built around the “Common Trunk” (as it is called in Germany), with subsequent specialist training, it has been necessary to continually update and adapt the higher-training content according to the various surgical specialties. General and Visceral Surgery Review was published in its sixth German-language edition in 2009.
Karl-Heinz Reutter, MD, created General and Visceral Surgery Review and continued it through five successful editions in the German language. I am not only happy to take over the task of editor from him for further German language editions, I am also highly delighted to be able to present the first English-language edition.
The purpose of this textbook is higher training and examination preparation in general and visceral surgery. We have made every effort to include up-to-date information and to present this information in a concise and succinct format, thus enabling colleagues to acquire the necessary theoretical knowledge in the shortest possible time.
This book is designed to place emphasis on core statements, and includes suggestions for further reading to help consolidate what has been learned. Contributions were provided by surgeons actively working in this field. By calling on their own practical experiences they have produced an ideal learning tool suited to the current requirements of higher training and examination preparation.
Nicolas T. SchwarzNeumünster, GermanyI thank my colleague K.-H. Reutter, MD, for giving me the opportunity to take over the editorship of this book. My special thanks also go to my medical colleagues in the Departments of Surgery and Trauma Surgery in Neumünster. We owe the production of this new edition to their enthusiasm for general and visceral surgery and to their constant thirst for knowledge, coupled with the desire to pass on this interest and their love of the specialty to their many colleagues.
1 Perioperative Medicine N.T. Schwarz
Preoperative Phase
Intraoperative Phase
Postoperative Period
Fast-Track Surgery
2 Thyroid B. Thiel
Anatomy
Physiology
General Epidemiology
General Diagnostic Approach
General Treatment Approach
Diseases of the Thyroid
Euthyroid Goiter
Hyperthyroidism
Graves Disease, Immunogenic Hyperthyroidism
Thyrotoxic Crisis
Thyroiditis
Thyroid Carcinoma
3 Parathyroid B. Thiel
Anatomy
Physiology
Primary Hyperparathyroidism
Secondary Hyperparathyroidism
Tertiary Hyperparathyroidism
Parathyroid Carcinoma
Hypoparathyroidism
4 Thorax (Pleura, Lung) R.J. Elfeldt
Anatomy
Pleural Effusion
Pleural Empyema
Chest Trauma: Blunt Chest Injuries
Chest Contusion
Chest Compression
Rib Fractures
Fracture of the Sternum
Lung Contusion
Chest Trauma: Penetrating Chest Injuries
Traumatic Pneumothorax
Hemothorax
Chylothorax
Tracheal and Bronchial Injuries
5 Mediastinum R.J. Elfeldt
Anatomy
Mediastinoscopy
Subcutaneous Emphysema
Mediastinal Emphysema
Mediastinitis
6 Diaphragm I.L. Schmalbach
Anatomy
Diaphragmatic Hernias
Rare Disorders of the Diaphragm
7 Hernias J.M. Mayer
Inguinal Hernias
Femoral Hernias
Incisional Hernias
Umbilical Hernia
Epigastric Hernia
Internal Hernias
8 Esophagus M. Voelz
Anatomy
Histology
Physiology
Functional Disorders
Achalasia
Other Functional Disorders
Esophageal Diverticulum
Cervical Pulsion Diverticulum (Zenker Diverticulum)
Epiphrenic Pulsion Diverticulum
Traction Diverticulum
Gastroesophageal Reflux Disease (GERD)
Esophageal Carcinoma
Injuries of the Esophagus
Corrosive Injuries
Traumatic Perforation of the Esophagus
Spontaneous Esophageal Rupture (Boerhaave Syndrome)
9 Stomach and Duodenum N.T. Schwarz
Anatomy
Ulcer
Bleeding from the Stomach and Duodenum
Gastric Carcinoma
MALT Lymphoma
10 Small Intestine I.L. Schmalbach
Anatomy
Crohn Disease
Meckel Diverticulum
Jejunal Diverticulum
11 Vermiform Appendix I.L. Schmalbach
Anatomy
Acute Appendicitis
Rare Diseases of the Appendix
Endometriosis of the Appendix
Crohn Disease
Diverticulitis of the Appendix
Appendix Carcinoid
Mucinous Cystadenoma / Pseudomyxoma Peritonei
Appendix Carcinoma
12 Colon J.M. Mayer
Anatomy
Anastomosis Techniques
Minimally Invasive Colon Surgery
Diverticulosis and Diverticulitis
Ulcerative Colitis
Polyps of the Colon
Colon Cancer
13 Rectum J.M. Mayer
Anatomy
Rectal Cancer
Pelvic Floor Insufficiency
14 Anus J.M. Mayer
Anatomy
Hemorrhoids
Perianal Vein Thrombosis
Anal Fissure
Abscesses and Anal Fistulas
Fecal Incontinence
Anal Carcinoma
15 Intestinal Obstruction H. Brunn
16 Spleen H. Brunn
Anatomy
Physiology
Hypersplenism Syndrome
17 Liver M. Voelz
Anatomy
Benign Liver Tumors
Focal Nodular Hyperplasia (FNH)
Hepatocellular Adenoma
Hepatic Hemangioma
Hepatic Cysts
Malignant Liver Tumors
Primary Hepatic Carcinoma
Liver Metastases
Hydatid Disease of the Liver (Echinococcosis)
Portal Hypertension
Liver Trauma
18 Gallbladder and Biliary Tract M. Voelz
Anatomy
Cholecystolithiasis
Acute Cholecystitis
Gallbladder Carcinoma
Extrahepatic Bile Duct Carcinoma
19 Pancreas N.T. Schwarz
Anatomy
Physiology
Acute Pancreatitis
Chronic Pancreatitis
Pancreatic Pseudocysts
Carcinoma of the Pancreas
Endocrine Pancreatic Tumors
Pancreatic Trauma
20 Transplantation N.T. Schwarz
21 Peritonitis B. Thiel
22 Neuroendocrine Tumors and Gastrointestinal Stromal Tumors J.M. Mayer
Neuroendocrine Tumors
Stomach
Duodenum and Pancreas–Insulinoma
Duodenum and Pancreas–Gastrinoma
Ileum
Vermiform Appendix
Colon
Rectum
Gastrointestinal Stromal Tumors
23 Soft-Tissue Tumors H. Brunn
24 Vascular Surgery A. Selch
Arteries
Vascular Injuries
Aneurysms
Acute Limb Artery Occlusion
Acute Mesenteric Artery Occlusion
Chronic Arterial Disease of the Limbs
Subclavian Steal Syndrome
Veins
Varicose Veins
Phlebothrombosis
25 Emergency and Trauma Surgery M. Fuchs
Polytrauma
Head Injury
Fractures
Dislocations
Soft-Tissue Injuries
Bone Infection
Nerve Injury
Tendon Rupture
Illustration Credits
Index
N.T. Schwarz
• Perioperative course has multifactorial influences.
• A patient’s postoperative recovery has multifactorial influences (Fig. 1.1). The perfect surgical technique on its own does not suffice. The patient’s progress is influenced particularly by physiological and psychological factors. “Evidence-based medicine” casts new light on traditional perioperative measures to produce new treatment concepts, the aim of which is to preserve or restore patient autonomy and homeostasis.
Fig. 1.1 Multifactorial influences on homeostasis.
• The perioperative risk increases as the number of individual risk factors increases. Patients are classified prior to anesthesia according to the ASA (American Society of Anesthesiologists) classification (Table 1.1).
• In addition, a distinction can be made between patient-specific (Table 1.2) and operation-specific (Table 1.3) risks. Accordingly, preoperative investigations are necessary to assess the operative risk. In general, they are ordered when the results are likely to affect the management of the patient.
• Postoperative nausea and vomiting (PONV syndrome) are observed more
in females,
in nonsmokers,
with travel sickness,
with intraoperative opioid administration, and
with addition of nitrous oxide.
• PONV syndrome can be prevented effectively by various drugs (serotonin antagonists, dexamethasone, droperidol, propofol).
Table 1.1 ASA classificationGroupDescriptionIHealthy, not taking any medicationIIMild disease without functional limitation and need for medicationIIIDisease requiring medication, mild limitation of activityIVSevere disease, permanent severe limitation of capacityVMoribund, life expectancy < 24 hVIEmergency surgery regardless of I-V
Source: ACC/AHA guideline update for perioperative cardiovascular evaluation for non-cardiac surgery. Circulation 2002:103:1257–1267.
Table 1.2 Patient risk factorsLow riskMedium riskHigh risk
• Advanced age
• ECG abnormalities
• Rhythms other than sinus rhythm
• Low functional capacity
• History of stroke
• Poorly controlled hypertension
• Mild angina pectoris
• Previous myocardial infarction
• Compensated or early heart failure
• Diabetes mellitus
• Unstable coronary syndrome
• Decompensated heart failure
• Severe arrhythmias
Source: ACC/AHA guideline update for perioperative cardiovascular evaluation for non-cardiac surgery. Circulation 2002:103:1257–1267.
Table 1.3 Operation risk factorsLow riskMedium riskHigh risk
• Endoscopic and superficial procedures
• Cataract surgery
• Breast surgery
• Carotid endarterectomy
• Head and neck surgery
• Intraperitoneal, intrathoracic and orthopedic procedures and prostate surgery
• Surgery on the aorta, other major vascular surgery and operations on peripheral vessels
• Prolonged operations with major “volume shift” and/or blood loss
Source: ACC/AHA guideline update for perioperative cardiovascular evaluation for non-cardiac surgery. Circulation 2002:103:1257–1267.
• Patients may generally drink low-fat liquids up to 2 hours preoperatively
• Patients fast preoperatively to protect against aspiration. Aspiration of solid food can lead to vagal reactions, bradycardia, and asystole, and aspiration of liquids can also lead to pneumonia, respiratory insufficiency and, in extreme cases, to ARDS (adult respiratory distress syndrome). Adequate preoperative hydration is an important requirement for maintaining perioperative homeostasis.
•Less than 6 hours preoperatively: no high-fat liquids or solid foods
•Up to 2 hours preoperatively: clear fluids
• Deviations in the case of:
emergency surgery,
massive obesity,
gastric emptying disorder,
pyloric stenosis,
gastric atony,
esophageal stenosis and diverticula,
certain neurological diseases, and
apparent hypothyroidism
• Prevention of stress-induced postoperative insulin resistance has been investigated in numerous studies. There is evidence that preoperative high-carbohydrate liquids, which are consumed up to 2 hours before the procedure, have a positive effect.
• Apart from the legal requirement for patients to give informed consent, preoperative discussion of how patients can take an active part in their postoperative recovery is often positively motivating. Patients and relatives are given comprehensive information so that they are prepared as well as possible and can provide mutual support.
• Orthograde bowel irrigation is virtually obsolete, and laxatives, enemas, or osmotically active solutions are used instead.
• Orthograde bowel irrigation for bowel preparation before major abdominal surgery is obsolete. Like osmotically active irrigation fluids, they can lead to measurable electrolyte shifts and thus to fluid losses into the bowel lumen, which can be hazardous for patients with cardiovascular risks.
• In elective colorectal procedures using fast-track surgery, preparation with a laxative and an enema on the previous evening has proved to be sufficient.
• Apart from the anesthetic risk work-up and legal obligations, premedication serves to establish the perioperative anesthesiological treatment plan, particularly analgesia. The patient is given drug premedication for anxiolysis and sedation.
• The incidence of perioperative thrombosis in abdominal surgery averages 25% in studies. There are predisposing risk factors, which, together with the exposure factors (Table 1.4), define the individual’s thrombosis risk (Table 1.5).
Table 1.4 Exposure factorsLow riskMedium riskHigh risk
• Minor or medium surgery with low trauma
• Injuries without or with minor soft tissue damage
• No additional or slight predisposing risk
• More prolonged surgery
• Lower limb immobilization in a cast including a joint
• Low thromboembolism risk due to operation or injury and additional predisposing thromboembolism risk
• Major surgery in the abdomen and pelvis for malignant or inflammatory disease
• Polytrauma, severe injuries of the spine, pelvis and/or lower limb
• Major surgery on the spine, pelvis, hip and knee
• Major surgery in the chest, abdominal and/or pelvic body cavities
• Medium risk due to operation or injury and additional predisposing risk
• Patients with a history of thrombosis or pulmonary embolism
Source: AWMF (Working Group of German Specialist Scientific Medical Societies) guidelines: Inpatient and Outpatient Thromboembolism Prophylaxis in Surgery and Perioperative Medicine (April 24, 2003).On the Internet: http://www.awmf-leitlinien.de/003-001.htm; revised February 28, 2009 [in German].
• Thrombophilia:
History of venous thromboembolism
Congenital or acquired thrombophilic defects of hemostasis (e.g., anti-phospholipid syndrome, antithrombin, protein C or protein S deficiency, activated protein C resistance / factor V Leiden mutation, thrombophilic prothrombin polymorphism, etc.)
• Malignant disease
• Pregnancy and the postpartum period
• Advanced age (> 50 years; risk increases with age)
• Therapy with or block of sex hormones (including contraceptives and hormone replacement therapy)
• Chronic venous insufficiency
• Severe systemic infection
• Severe overweight (body mass index >30)
• Heart failure: NYHA (New York Heart Association) grade III or IV
• Nephrotic syndrome
• Thrombosis prophylaxis consists of physical measures and, if necessary, medical thromboembolism prophylaxis.
• In patients with a low thrombosis risk, physical measures and early mobilization suffice, but in patients with a medium and higher thrombosis risk, medical thrombosis prophylaxis is usually indicated in addition.
• Perioperative thrombosis prophylaxis usually begins preoperatively.
• In contrast to the common practice in North America, thrombosis prophylaxis in Europe is started on the evening before surgery, using unfractionated heparin (UFH) or low molecular weight heparin (LMWH).
• The duration of the medical thrombosis prophylaxis depends on predisposing risk factors, the degree of operative trauma, and postoperative immobilization. After major surgery for malignant disease in the abdomen, it lasts for an average of 4–5 weeks, but so far there are no binding recommendations.
• Current medications for thrombosis prophylaxis:
Heparins
– UFH
– LMWH
Danaparoid
Fondaparinux
Thrombin inhibitors
Hirudin
Vitamin K antagonists (coumarin)
• Most of the changes in recent years have been made in this phase.
• Minimally invasive operation techniques have functional postoperative benefits compared with laparotomy, such as
less pain,
less postoperative intestinal atony,
altered postoperative immune response and inflammatory reaction, and
less postoperative pulmonary dysfunction.
• When laparotomy is performed, transverse incisions have proved to be superior compared with midline and paramedian laparotomy in respect of postoperative pain and pulmonary function. In general, they result in fewer incisional hernias.
• Perioperative nasogastric tubes should remain in place for as short a time as possible.
• Experience has shown that anastomotic leaks and secondary hemorrhage are not identified despite intraperitoneal drains. This has also been confirmed in randomized controlled studies.
• The benefit of routine placement of a nasogastric tube has not been confirmed either. It does not prevent, but rather promotes, postoperative intestinal atony and may enable silent aspiration to occur.
• Anesthesia and analgesia have an important influence on the postoperative course following general and visceral surgical procedures. The following are beneficial for these procedures:
Rapidly controllable anesthetics
Increase in the inspiratory oxygen concentration
Normothermia
Regional anesthesia methods (epidural anesthesia → analgesia and sympathetic block)
Calculated intraoperative fluid replacement
• Preoperative normovolemia is important for perioperative hemostasis.
• Maintenance of normovolemia and electrolyte balance is the most important goal High infusion volumes were usual in the past to compensate assumed “third space” fluid losses. Avoidance of preoperative hypovolemia allows a restrictive fluid infusion regimen with complete electrolyte solution and colloid solution in a ratio of 2:1.
• Excessive infusion volumes can
cause edema of the bowel wall;
produce protracted postoperative intestinal motility dysfunction;
have effects on cardiac function;
cause pulmonary side effects; and
lead to prolonged convalescence and hospitalization.
• Postoperative care is multidisciplinary.
• Postoperative care of patients is multidisciplinary. The postoperative period is characterized by analgesia, diet, mobilization, and discharge planning. The aim is freedom from pain while avoiding the use of systemic opioids. Where possible, mobilization should begin on the day of surgery.
• In meta-analyses of randomized studies, no advantage was found for postoperative fasting compared with early enteral feeding. In particular, anastomosis leak rates are not increased with early enteral feeding and there are fewer general infectious complications.
• Fast-track surgery is evidence-based and is intended to reduce complications.
• “Fast-track” implies an interdisciplinary and multimodal approach to improve and speed up convalescence and reduce postoperative complications, thus shortening hospitalization.
• Fast-track surgery comprises:
Preoperative patient informed consent
Atraumatic surgical technique
Reduction of stress
Elimination of pain, usually by regional anesthesia techniques (especially in the form of thoracic epidural anesthesia)
Optimized fluid and temperature management
Early enteral diet
Prevention of gastrointestinal atony and PONV
Rapid postoperative mobilization
• Informed consent: discussion with the patient and relatives, planned discharge from the third postoperative day
• No bowel lavage, laxative if necessary
• Fasting: 6 hours for solids, 2 hours for liquids
• Thoracic combined epidural anesthesia (EDA) and local anesthesia (LA)/opioids; coxibs IV, if necessary
• Laparoscopic surgery as far as possible, otherwise transverse or curved laparotomy
• Avoid drains as far as possible
• Remove gastric tube on extubation
• Transfer from recovery room to normal ward
• Limit postoperative infusion to 500 mL electrolyte solution
• Continuous thoracic EDA (LA/opioid), coxibs IV if necessary, avoid systemic opiates, morphine sulfate, 5 mg SC only if necessary
• Magnesium oxide or sodium picosulfate daily until first defecation
• Tea (maximum 100 mL), 2 portions of yogurt
• Early mobilization
• Continuous EDA (LA/opioid), oral coxibs, avoidance of systemic opiates; morphine sulfate 10 mg orally, only if necessary
• Magnesium oxide or sodium picosulfate daily until first defecation
• Basic hospital diet, drinking volume > 1500 mL, mobilization out of bed for at least 8 hours or at least twice daily
• Removal of any drains and bladder catheter
• Removal of epidural and central venous catheters, oral coxibs, avoidance of systemic opiates; morphine sulfate 10 mg orally only if necessary
• Magnesium oxide or sodium picosulfate daily until first defecation, basic hospital diet, drinking volume > 1500 mL
• Full mobilization (retiring to bed only for an afternoon nap and at night)
• As second postoperative day
• Discuss discharge with patient and relatives, information sheet for post-hospital course (to return immediately if any problems)
• Dietary advice
• As second postoperative day
• Final discussion with patient and relatives
• Discharge by agreement
• Removal of sutures
• Discussion of histological results; if necessary schedule adjuvant therapy
ACC/AHA guideline update for perioperative cardiovascular evaluation for non-cardiac surgery. Circulation 2002; 105: 1257–1267
Fearon KC et al. Enhanced recovery after surgery : a consensus review of clinical care for patients undergoing colonic resections. Clin Nutr 2005; 24: 466–477
Kehlet H et al. Care after colonic operation – is it evidence based? Results from a multinational survey in Europe and the Unites States. J Am Coll Surg 2006; 202: 45–54
National Collaborating Centre for Acute and Chronic Conditions. Venous thromboembolism: reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in patients admitted to hospital. National Institute for Health and Clinical Excellence (NICE); 2010 Jan. 50 p. (Clinical guideline; no. 92). http://www.guideline.gov/content.aspx?id=24106&search=thrombosis (accessed May 2011)
Schwenk W et al. Wandel der perioperativen Therapie bei elektiven kolorektalen Resektionen in Deutschland 1991 und 2000/2001. Zentralbl Chir 2003; 128: 1086–1092
