Hepatology E-Book

• Herausgeber: John Wiley & Sons
• Kategorie: Fachliteratur
• Serie: Mount Sinai Expert Guides
• Sprache: Englisch

Seitenzahl: 899

Veröffentlichungsjahr: 2014

Beschreibung

Mount Sinai Expert Guides: Hepatology will provide gastroenterology and hepatology trainees with an extremely clinical and accessible handbook covering the major liver diseases and symptoms, their diagnosis and clinical management.  

Perfect as a point-of-care resource on the hospital wards and also as a refresher for board exam preparation, the focus throughout is on providing rapid reference, essential information on each disease to allow for quick, easy browsing and assimilation of the must-know information.  All chapters follow a consistent template including the following features:

- An opening bottom-line/key points section
- Classification, pathogenesis and prevention of disease
- Evidence-based diagnosis, including relevant algorithms, laboratory and imaging tests, and potential pitfalls when diagnosing a patient
- Disease management including commonly used medications with dosages, when to perform surgery, management algorithms and how to prevent complications
- How to manage special populations, ie, in pregnancy, children and the elderly
- The very latest evidence-based results, major society guidelines (AASLD/EASL) and key external sources to consult

In addition, the book comes with a companion website housing extra features such as case studies with related questions for self-assessment, key patient advice and ICD codes.  Each guide also has its own mobile app available for purchase, allowing you rapid access to the key features wherever you may be.

If you're specialising in hepatology and require a concise, practical guide to the clinical management of liver disease, bought to you by one of world's leading hospitals, then this is the perfect book for you.

This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand Store.

Leseprobe

Table of Contents

Title page

Copyright page

List of Contributors

Series Foreword

Preface

Abbreviation List

About the Companion Website

PART 1: HEPATOLOGY

CHAPTER 1: Approach to the Patient with Abnormal Liver Tests

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 2: Approach to the Patient with Jaundice

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 3: Drug-Induced Liver Injury

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 4: Hepatitis A and E

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 5: Hepatitis B and D

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 6: Hepatitis C: Diagnosis, Management and Treatment

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading list

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 7: HIV/HCV and HIV/HBV Co-infections

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 8: Hepatic Abscess

Amebic Liver Abscess

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

Pyogenic Liver Abscess

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 9: Biliary Infections

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 10: Alcoholic Hepatitis

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 11: Non-Alcoholic Fatty Liver Disease

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 12: Autoimmune Hepatitis and Overlap Syndromes

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 13: Primary Biliary Cirrhosis

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 14: Primary Sclerosing Cholangitis

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 15: Hereditary Hemochromatosis

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 16: Wilson Disease

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 17: Alpha-1 Antitrypsin Deficiency

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 18: Portal Hypertensive Bleeding

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 19: Ascites

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9 Evidence

Section 10: Images

CHAPTER 20: Spontaneous Bacterial Peritonitis

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 21: Hepatic Encephalopathy

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 22: Hepatorenal Syndrome

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8:Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 23: Hepatopulmonary Syndrome

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 24: Portopulmonary Hypertension

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 25: Pregnancy-Related Liver Disease

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 26: Acute Liver Failure

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 27: Budd–Chiari Syndrome

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 28: Portal Vein Thrombosis

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 29: Non-Cirrhotic Portal Hypertension

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 30: Liver Lesions

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 31: Cystic Lesions of the Liver

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 32: Surgery in Patients with Liver Disease

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 33: Nutrition in Liver Diseases

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

PART 2: PEDIATRICS

CHAPTER 34: Diagnosis and Management of Acute Liver Failure: A Pediatric Perspective

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 35: Liver Function Tests in Childhood

Section 1: Tests that Evaluate Liver Injury

Section 2: Tests that Evaluate Impaired Bile Flow or Cholestasis

Section 3: Tests that Evaluate Synthetic Capacity of the Liver

Section 4: Tests that Evaluate Excretory Function of the Liver

Section 5: Tests that Evaluate Metabolic Function

Section 6: Other Laboratory Tests

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 36: Approach to Jaundice in Infancy

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 37: Management of End-Stage Liver Disease in Children

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 38: Liver Transplantation: A Pediatric Perspective

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

PART 3: TRANSPLANTATION

CHAPTER 39: Evaluation of Patients for Liver Transplantation

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 40: Live Donor Transplantation Evaluation

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 41: Surgical Evaluation for Liver Transplantation

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 42: Post-Operative Care of The Liver Transplantation Patient

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 43: Diagnostic Approach to Abnormal Liver Tests Following Liver Transplantation

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 44: Acute Rejection

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 45: Chronic Rejection

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 46: Primary Non-Function

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 47: Ischemia Reperfusion Injury after Liver Transplantation

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 48: Vascular Complications of Liver Transplantation

Hepatic Venous Occlusion

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5 Special Populations

Section 6 Prognosis

Portal Vein Thrombosis

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Hepatic Artery Thrombosis

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 49: Biliary Complications after Liver Transplantation

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 50: Approach to Prophylaxis and Management of Infections after Liver Transplantation

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 51: Malignancy after Liver Transplantation

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 52: Hepatitis C Post-Liver Transplantation

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 53: Recurrent Disease Post-Liver Transplantation: Autoimmune Diseases, Hepatitis B and NASH

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

CHAPTER 54: Health Maintenance after Liver Transplantation

Section 1: Background

Section 2: Prevention

Section 3: Diagnosis

Section 4: Treatment

Section 5: Special Populations

Section 6: Prognosis

Section 7: Reading List

Section 8: Guidelines

Section 9: Evidence

Section 10: Images

Supplemental Images

Index

This edition first published 2014 © 2014 by John Wiley & Sons, Ltd

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Library of Congress Cataloging-in-Publication Data

Mount Sinai expert guides. Hepatology / edited by Jawad Ahmad, Scott L. Friedman, Henryk Dancygier.

p. ; cm.

Hepatology

Includes bibliographical references and index.

ISBN 978-1-118-51734-5 (alk. paper) – ISBN 978-1-118-74251-8 (emobi) – ISBN 978-1-118-74252-5 (epub) – ISBN 978-1-118-74253-2 (epdf) – ISBN 978-1-118-74862-6

I. Ahmad, Jawad (Hepatologist), editor of compilation. II. Friedman, Scott L., editor of compilation. III. Dancygier, Henryk, editor of compilation. IV. Title: Hepatology.

[DNLM: 1. Liver Diseases. 2. Liver Transplantation. WI 700]

RC845

616.3’62–dc23

2013024785

A catalogue record for this book is available from the British Library.

Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic books.

Cover image: iStock file File #6124416 © David Marchal

Cover design by Ruth Bateson

List of Contributors

Jawad Ahmad MD

Associate Professor of Medicine

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Abdulelah Alhawsawi MD

Surgical Fellow

Recanati/Miller Transplantation Institute

Mount Sinai Hospital

New York, NY, USA

Costica Aloman MD

Associate Professor of Medicine

University of Illinois

Chicago, IL, USA

Ronen Arnon MD, MHA

Associate Professor of Pediatrics and Surgery

Department of Pediatrics

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Nancy Bach MD

Assistant Professor of Medicine

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Meena B. Bansal MD

Associate Professor of Medicine

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Charissa Y. Chang MD

Assistant Professor of Medicine

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Jaime Chu MD

Assistant Professor of Pediatrics

Division of Hepatology

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Alan G. Contreras Saldivar MD

Attending Transplant Surgeon

Instructor of Surgery

Mount Sinai Hospital

Icahn School of Medicine at Mount Sinai;

Recanati/Miller Transplantation Institute

Mount Sinai Hospital

New York, NY, USA

Henryk Dancygier MD, PhD

Professor of Medicine

Chair, Departments of Medicine II and IV

Sana Klinikum Offenbach, Goethe University

Frankfurt am Main, Germany;

Adjunct Professor of Medicine

Department of Medicine

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Eric G. Davis MD

Assistant Professor of Surgery

University of Louisville School of Medicine

Louisville, KY, USA

Douglas T. Dieterich MD

Professor of Medicine

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Deepti Dronamraju MD

Fellow

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Marcelo E. Facciuto MD, MPH

Associate Professor of Surgery

Recanati/Miller Transplantation Institute

Mount Sinai Hospital

New York, NY, USA

Donna J.C. Fanelli CRNP

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

M. Isabel Fiel MD

Professor of Pathology

Department of Pathology

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Sander S. Florman MD

The Charles Miller, MD Professor of Surgery

Director, Recanati/Miller Transplantation Institute

Mount Sinai Hospital

New York, NY, USA

Scott L. Friedman MD

Fishberg Professor of Medicine

Dean for Therapeutic Discovery

Chief, Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Priya Grewal MD

Associate Professor of Medicine

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Shirish Huprikar MD

Director, Transplant Infectious Diseases Program

Associate Professor

Division of Infectious Diseases

Department of Medicine

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Nanda Kerkar MD

Professor of Clinical Pediatrics

Medical Director Liver and Intestinal Program

Director Hepatology Program

Children's Hospital of Los Angeles

University of Southern California

Los Angeles, CA, USA

Vivek Kesar MD

Internal Medicine Resident

Lenox Hill Medical Center

New York, NY, USA

Leona Kim-Schluger MD

Professor of Medicine

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Elizabeth A. Kula CRNP

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Marie E. Le MD

Surgical Fellow

Recanati/Miller Transplantation Institute

Mount Sinai Hospital

New York, NY, USA

Lawrence U. Liu MD

Assistant Professor of Medicine

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Tamir Miloh MD

Director of Pediatric Liver and Liver Transplant Program

Department of Gastroenterology and Hepatology

Phoenix Children's Hospital;

Associate Professor of Pediatrics

University of Arizona, College of Medicine Phoenix, AZ;

Associate Professor in Pediatrics

Mayo Clinic

USA

Joseph A. Odin MD, PhD

Director, Autoimmune Liver Diseases Program

Associate Professor of Medicine

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

James S. Park MD, CNSC

Assistant Professor of Medicine

Division of Gastroenterology

NYU School of Medicine

New York, NY, USA

Gopi Patel MD, MS

Assistant Professor

Division of Infectious Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Ponni V. Perumalswami MD, MS

Assistant Professor of Medicine

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Juan P. Rocca MD

Assistant Professor of Surgery

Icahn School of Medicine at Mount Sinai;

Surgical Director, Live Donor Kidney Program

Associate Director, Transplant Surgery Fellowship

Recanati/Miller Transplantation Institute

Mount Sinai Hospital

New York, NY, USA

Thomas D. Schiano MD

Professor of Medicine

Medical Director, Liver Transplantation

Clinical Director, Hepatology

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Hiroshi Sogawa MD, FACS

Assistant Professor of Surgery

Director, Transplant Surgery Fellowship Program

Thomas E. Starzl Transplantation Institute

University of Pittsburgh Medical Center

Pittsburgh, PA, USA

Alicia C. Stivala NP

Nurse Practitioner

Division of Infectious Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Matthew Y. Suh MD

Surgical Fellow

Recanati/Miller Transplantation Institute

Mount Sinai Hospital

New York, NY, USA

Marie-Louise C. Vachon MD, MSc

Fellow

Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Series Foreword

Now more than ever, immediacy in obtaining accurate and practical information is the coin of the realm in providing high quality patient care. The Mount Sinai Expert Guides series addresses this vital need by providing accurate, up-to-date guidance, written by experts in formats that are accessible in the patient care setting: websites, smartphone apps and portable books. The Icahn School of Medicine, which was chartered in 1963, embodies a deep tradition of pre-eminence in clinical care and scholarship that was first shaped by the founding of the Mount Sinai Hospital in 1855. Today, the Mount Sinai Health System, comprised of seven hospitals anchored by the Icahn School of Medicine, is one of the largest health care systems in the United States, and is revolutionizing medicine through its embracing of transformative technologies for clinical diagnosis and treatment. The Mount Sinai Expert Guides series builds upon both this historical renown and contemporary excellence. Leading experts across a range of disciplines provide practical yet sage advice in a digestible format that is ideal for trainees, mid-level providers and practicing physicians. Few medical centers in the US could offer this type of breadth while relying exclusively on its own physicians, yet here no compromises were required in offering a truly unique series that is sure to become embedded within the key resources of busy providers. In producing this series, the editors and authors are fortunate to have an equally dynamic and forward-viewing partner in Wiley Blackwell, which together ensures that health care professionals will benefit from a unique, first-class effort that will advance the care of their patients.

Scott Friedman MD

Series Editor

Dean for Therapeutic Discovery

Fishberg Professor and Chief, Division of Liver Diseases

Icahn School of Medicine at Mount Sinai

New York, NY, USA

Preface

The last 20 years has seen hepatology emerge as a distinct discipline, separate from gastroenterology, reflecting the profound advances in our understanding of the pathophysiology, diagnosis and management of liver diseases. Concurrently, academic centers throughout the world now have faculty who function exclusively as hepatologists, and even in these institutions there is often further distinction between non-transplant and transplant hepatologists, with a similar trend emerging in pediatrics.

In recognition of these trends, international liver societies in the US (American Society for the Study of Liver Diseases), Europe (European Association for the Study of the Liver) and Asia (Asian Pacific Association for the Study of the Liver), seek evidence-based guidelines to standardize management of the most common liver diseases. This expert guide is intended to address this need for a concise and practical guide to patient management. While many textbooks provide detailed descriptions of pathophysiology, they may not be well suited to provide practical, accessible treatment options in the clinical setting where information is urgently needed and time is short. For students and trainees, a basic understanding of epidemiology and pathogenesis of disease entities is important, but guidance for the management of a specific clinical condition is the real world need.

This book is separated into three sections: hepatology, pediatrics and transplantation, with each chapter organized in a standardized format. The first section of each chapter provides the reader a bottom-line of ‘take home’ points that emphasizes the most important aspects of the chapter. This is followed by sections on background, prevention and diagnosis. Key features across the chapters are: easily accessible evidence-based management algorithms, with appropriate laboratory and imaging tests and commonly used medications with dosages. Short reading lists with society guidelines complete the text. Also accompanying the book is a companion website which provides the reader with case histories and multiple choice questions for those preparing for specialty exams. An additional multimedia resource available for purchase is an app with highlights of each chapter for smartphone users.

We have sought to provide a comprehensive list of diseases and situations that clinicians will confront in general hepatology and transplant hepatology practices. The pediatric and surgical chapters have been included to ensure that adult hepatologists understand problems they are likely to encounter in these related specialities in practice, but not as a guide specifically for pediatricians and surgeons.

We thank the staff at Wiley Blackwell, particularly Oliver Walter and Jennifer Seward, for ensuring such a smooth publication process. We also gratefully acknowledge the many Mount Sinai residents and hepatology fellows for their enthusiasm, dedication to their patients and candid feedback throughout the preparation of this text.

Finally, we are indebted to our Mount Sinai colleagues in the Divisions of Liver Diseases and Infectious Diseases, the Departments of Pediatrics and Pathology, and in the Recanati/Miller Transplantation Institute. The editors are fortunate to work with such superb physicians, but what truly distinguishes our colleagues is their selfless dedication to mentoring the next generation of trainees in caring for patients with liver disease. This book reflects their exceptional generosity as clinicians, teachers and role models.

Jawad Ahmad

Scott L. Friedman

Henryk Dancygier

Abbreviation List

AAPAmerican Academy of PediatricsAASLDAmerican Association for the Study of Liver DiseasesAATalpha-1 antitrypsinABGArterial blood gasABWAdjusted body weightACEAngiotensin-converting enzymeACRAcute cellular rejectionADHAlcohol dehydrogenaseAD-PCLDAdult polycystic liver diseaseADVAdefovirAFLPAcute fatty liver of pregnancyAFPAlpha-fetoproteinAHAlcoholic hepatitisAIDsAcquired immunodeficiency syndromeAIHAutoimmune hepatitisALAAmebic liver abscess