Homogeneous Catalysis for Unreactive Bond Activation E-Book

• Herausgeber: John Wiley & Sons
• Kategorie: Wissenschaft und neue Technologien
• Sprache: Englisch

Seitenzahl: 869

Veröffentlichungsjahr: 2014

Beschreibung

This book offers a comprehensive overview of different catalytic reactions applied to the activation of chemical bonds. Each of the seven chapters covers key C-X classes where carbon is combined with another element: chlorine, fluorine, nitrogen, sulfur, oxygen, hydrogen, and carbon. The first part of the book discusses homogeneous catalysis in the activation and transformation of C-Cl and C-F, highlighting their basic activation modes, cross-coupling, and intensive mechanisms. The second part of the book focuses on C-N, C-S, and C-O bonds, mentioning their catalytic pathways. Finally, C-H and C-C bonds, their activation, chemical transformations, and applicability are covered. Overall, the book presents methodologies that can be applied to the efficient synthesis of drug molecules and fine chemicals. Through their presentation, the authors show that synthetic chemistry can be done in greener ways that limit hazards and pollution.

Leseprobe

Table of Contents

Cover

Title Page

Copyright

Preface

Contributors

Chapter 1: Catalysis In C–Cl Activation

1.1 Introduction

1.2 Reductive Dechlorination

1.3 Formation of C–C Bonds

1.4 Formation of C–N Bonds

1.5 Formation of C–O Bonds

1.6 Formation of C–S Bonds

1.7 Formation of C–B Bonds

1.8 Conclusion and Outlook

References

Chapter 2: Homogeneous Transition-Metal-Catalyzed C–F Activation

2.1 Background

2.2 Transition-Metal-Mediated Cross-Coupling Reactions byC–F Bond Activation

2.4 Transition-Metal-Promoted Dehydrofluorination by C–F Bond Activation

2.5 The Applications of C–F Activation in Organic Synthesis

2.6 Summary and Outlook

References

Chapter 3: Homogeneous Transition-Metal Catalyzed C–N Activation

3.1 Background

3.2 Palladium-Catalyzed C–N Activation

3.3 Ruthenium-Catalyzed C–N Activation

3.4 Nickel-Catalyzed C–N Activation

3.5 Copper-Catalyzed C–N Activation

3.6 Iron-Catalyzed C–N Activation

3.7 Other-Transition–Metal-Catalyzed C–N Activation

3.8 Computationally and Experimentally Mechanistic Studies

3.9 Summary and Outlook

References

Chapter 4: Catalytic Carbon–Sulfur Bond Activation and Transformations

4.1 Background

4.2 C–S Bond Activation by Transition Metal Compounds

4.3 Catalytic C–S Cleavage in Thioesters

4.4 Catalytic C–S Cleavage in Dithioacetals

4.5 Diverse Catalytic C–S Cleavage

4.6 Summary and Outlook

References

Chapter 5: Homogeneous Transition-Metal-Catalyzed C–O Bond Activation

5.1 Introduction

5.2 Palladium-Catalyzed C–O Bond Activation

5.3 Nickel–Catalyzed C–O Bond Activation

5.4 Other-Transition-Metal-Catalyzed C–O Bond Activation

5.5 Summary and Outlook

References

Chapter 6: Homogeneous Transition-Metal-Catalyzed C–H Bond Functionalization

6.1 Overview

6.2 Mechanism of C–H Cleavage

6.3 Directed C–H Oxidation

6.4 Hydroarylation

6.5 Direct Arylation

6.6 Carbonylation

6.7 Hydroacylation

6.8 Alkane Dehydrogenation

6.9 Borylation and Silylation

6.10 Summary and Outlook

References

Chapter 7: Catalysis in C–C Activation

7.1 Introduction: Importance and Challenges in C–C Activation

7.2 C–C Activation of Strained Molecules

7.3 C–C Activation of Unstrained Molecules

7.4 Summary and Perspective

References

Index

End User License Agreement

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Guide

Cover

Table of Contents

Preface

Chapter 1: Catalysis In C–Cl Activation

List of Illustrations

Scheme 1.1

Figure 1.1

Figure 1.2

Figure 1.3

Scheme 1.2

Scheme 1.3

Figure 1.4

Figure 1.5

Scheme 1.4

Scheme 1.5

Scheme 1.6

Scheme 1.7

Scheme 1.8

Scheme 1.9

Scheme 1.10

Scheme 1.11

Scheme 1.12

Scheme 1.13

Scheme 1.14

Scheme 1.15

Scheme 1.16

Scheme 1.17

Scheme 1.18

Figure 1.6

Scheme 1.19

Scheme 1.20

Figure 1.7

Scheme 1.21

Scheme 1.22

Scheme 1.23

Figure 1.8

Scheme 1.24

Scheme 1.25

Scheme 1.26

Scheme 1.27

Scheme 1.28

Figure 1.9

Scheme 1.29

Figure 1.10

Scheme 1.30

Scheme 1.31

Scheme 1.32

Scheme 1.33

Scheme 1.34

Scheme 1.35

Scheme 1.36

Scheme 1.37

Scheme 1.38

Scheme 1.39

Scheme 1.40

Scheme 1.41

Scheme 1.42

Scheme 1.43

Scheme 1.44

Figure 1.11

Scheme 1.45

Scheme 1.46

Scheme 1.47

Scheme 1.48

Scheme 1.49

Figure 1.12

Figure 1.13

Figure 1.14

Scheme 1.50

Scheme 1.51

Scheme 1.52

Scheme 1.53

Scheme 1.54

Scheme 1.55

Scheme 1.56

Figure 1.15

Scheme 1.57

Scheme 1.58

Scheme 1.59

Figure 2.1

Figure 2.2

Figure 2.3

Scheme 2.1

Scheme 2.2

Scheme 2.3

Scheme 2.4

Scheme 2.5

Scheme 2.6

Scheme 2.7

Scheme 2.8

Scheme 2.9

Scheme 2.10

Scheme 2.11

Scheme 2.12

Scheme 2.13

Scheme 2.14

Scheme 2.15

Schemes 2.16

Scheme 2.17

Scheme 2.18

Scheme 2.19

Scheme 2.20

Scheme 2.21

Scheme 2.22

Scheme 2.23

Scheme 2.24

Scheme 2.25

Scheme 2.26

Scheme 2.27

Schemes 2.28

Scheme 2.29

Scheme 2.30

Scheme 2.31

Scheme 2.32

Scheme 2.33

Scheme 2.34

Scheme 2.35

Scheme 2.36

Figure 2.4

Scheme 2.37

Scheme 2.38

Figure 2.5

Scheme 2.39

Scheme 2.40

Scheme 2.41

Scheme 2.42

Scheme 2.43

Scheme 2.44

Scheme 2.45

Scheme 2.46

Scheme 2.47

Scheme 2.48

Scheme 2.49

Scheme 2.50

Scheme 2.51

Scheme 2.52

Scheme 2.53

Scheme 2.54

Scheme 2.55

Scheme 2.56

Scheme 2.57

Scheme 2.58

Scheme 2.59

Scheme 2.60

Scheme 2.61

Scheme 2.62

Scheme 2.63

Scheme 2.64

Scheme 2.65

Scheme 3.1

Scheme 3.3

Scheme 3.4

Scheme 3.5

Scheme 3.6

Scheme 3.7

Scheme 3.8

Scheme 3.9

Scheme 3.10

Scheme 3.11

Scheme 3.12

Scheme 3.14

Scheme 3.15

Scheme 3.16

Scheme 3.17

Figure 3.1

Scheme 3.18

Scheme 3.19

Scheme 3.20

Scheme 3.21

Scheme 3.22

Scheme 3.23

Scheme 3.24

Scheme 3.25

Scheme 3.26

Scheme 3.27

Scheme 3.28

Scheme 3.29

Scheme 3.30

Scheme 3.31

Scheme 5.1

Scheme 5.2

Scheme 5.3

Scheme 5.4

Scheme 5.5

Scheme 5.6

Scheme 5.7

Scheme 5.8

Scheme 5.9

Scheme 5.10

Scheme 5.11

Scheme 5.12

Scheme 5.13

Scheme 5.14

Scheme 5.15

Scheme 5.16

Scheme 5.17

Scheme 5.18

Scheme 5.19

Scheme 5.20

Scheme 5.21

Scheme 5.22

Scheme 5.23

Scheme 5.24

Scheme 5.25

Scheme 5.26

Scheme 5.27

Scheme 5.28

Scheme 5.29

Scheme 5.30

Scheme 5.31

Scheme 5.32

Scheme 5.33

Scheme 5.34

Scheme 5.35

Scheme 5.36

Scheme 5.37

Scheme 5.38

Scheme 5.39

Scheme 5.40

Scheme 5.41

Scheme 5.42

Scheme 5.43

Scheme 5.44

Scheme 5.45

Scheme 5.46

Scheme 5.47

Scheme 5.48

Scheme 5.49

Scheme 5.50

Scheme 5.51

Scheme 5.52

Scheme 5.53

Scheme 5.54

Scheme 5.55

Scheme 5.56

Scheme 5.57

Scheme 5.58

Scheme 5.59

Scheme 5.60

Scheme 5.61

Scheme 5.62

Scheme 5.63

Scheme 5.64

Scheme 5.65

Scheme 5.66

Scheme 5.67

Scheme 5.68

Scheme 5.69

Scheme 5.70

Scheme 5.71

Scheme 5.72

Scheme 5.73

Scheme 5.74

Scheme 5.75

Scheme 5.76

Scheme 5.77

Scheme 5.78

Scheme 5.79

Scheme 5.80

Scheme 5.81

Scheme 5.82

Scheme 5.83

Scheme 5.84

Scheme 5.85

Scheme 5.86

Scheme 5.87

Scheme 5.88

Scheme 5.89

Scheme 5.90

Scheme 5.91

Scheme 5.92

Scheme 5.93

Scheme 5.94

Scheme 5.95

Scheme 5.96

Scheme 5.97

Scheme 5.98

Scheme 5.99

Scheme 5.100

Scheme 5.101

Scheme 5.102

Scheme 5.103

Scheme 5.104

Scheme 5.105

Scheme 5.106

Scheme 5.107

Scheme 5.108

Scheme 5.109

Scheme 5.110

Scheme 5.111

Scheme 5.112

Scheme 5.113

Scheme 5.114

Scheme 5.115

Scheme 5.116

Scheme 5.117

Schemes 5.118

Figure 5.119

Scheme 5.120

Scheme 5.121

Scheme 5.122

Scheme 5.123

Scheme 5.124

Scheme 5.125

Scheme 5.126

Scheme 5.127

Scheme 5.128

Scheme 5.129

Scheme 5.130

Scheme 5.131

Scheme 5.132

Scheme 5.133

Scheme 5.134

Scheme 5.135

Scheme 5.136

Scheme 5.137

Scheme 5.138

Scheme 5.139

Scheme 5.140

Scheme 5.141

Scheme 5.142

Scheme 5.143