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Today, nano- and microencapsulation are increasingly being utilized in the pharmaceutical, textile, agricultural and food industries. Microencapsulation is a process in which tiny particles or droplets of a food are surrounded by a coating to give small capsules. These capsules can be imagined as tiny uniform spheres, in which the particles at the core are protected from outside elements by the protective coating. For example, vitamins can be encapsulated to protect them from the deterioration they would undergo if they were exposed to oxygen.
This book highlights the principles, applications, toxicity and regulation of nano- and microencapsulated foods.
Section I describes the theories and concepts of nano- and microencapsulation for foods adapted from pharmaceutical areas, rationales and new strategies of encapsulation, and protection and controlled release of food ingredients.
Section II looks closely at the nano- and microencapsulation of food ingredients, such as vitamins, minerals, phytochemical, lipid, probiotics and flavors. This section provides a variety of references for functional food ingredients with various technologies of nano particles and microencapsulation. This section will be helpful to food processors and will deal with food ingredients for making newly developed functional food products.
Section III covers the application of encapsulated ingredients to various foods, such as milk and dairy products, beverages, bakery and confectionery products, and related food packaging materials.
Section IV touches on other related issues in nano- and microencapsulation, such as bioavailability, bioactivity, potential toxicity and regulation.
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Cover
Title Page
Copyright
List of Contributors
Preface
Chapter 1: Overview of Nano- and Microencapsulation for Foods
1.1 Introduction
1.2 Nano- or microencapsulation as a rich source of delivery of functional components
1.3 Wall materials used for encapsulation
1.4 Techniques used for the production of nano- or microencapsulation of foods
1.5 Characterization of nano- or microencapsulated functional particles
1.6 Fortification of foods through nano- or microcapsules
1.7 Nano- or microencapsulation technologies: industrial perspectives and applications in the food market
1.8 Overview of the book
Acknowledgments
References
Part I: Concepts and rationales of nano- and microencapsulation for foods
Chapter 2: Theories and Concepts of Nano Materials, Nano- and microencapsulation
2.1 Introduction
2.2 Materials used for nanoparticles, nano- and microencapsulation
2.3 Nano- and microencapsulation techniques
2.4 Pharmaceutical and nutraceutical applications
2.5 Food ingredients and nutraceutical applications
2.6 Conclusion
References
Chapter 3: Rationales of Nano- and Microencapsulation for Food Ingredients
3.1 Introduction
3.2 Factors affecting the quality loss of food ingredients
3.3 Case studies of food ingredient protection through nano- and microencapsulation
3.4 Conclusion
References
Chapter 4: Methodologies Used for the Characterization of Nano- and Microcapsules
4.1 Introduction
4.2 Methodologies used for the characterization of nano- and microcapsules
4.3 Conclusion
Acknowledgements
References
Chapter 5: Advanced Approaches of Nano- and Microencapsulation for Food Ingredients
5.1 Introduction
5.2 Nanoencapsulation based on the microencapsulation technology
5.3 Classification of the encapsulation system
5.4 Preparation methods for the encapsulation system
5.5 Application of the encapsulation system in food ingredients
5.6 Conclusion
References
Part II: Nano- and microencapsulations of food ingredients
Chapter 6: Nano- and Microencapsulation of Phytochemicals
6.1 Introduction
6.2 Classification of phytochemicals
6.3 Stability and solubility of phytochemicals
6.4 Microencapsulation of phytochemicals
6.5 Nanoencapsulation
6.6 Conclusion
References
Chapter 7: Microencapsulation for Gastrointestinal Delivery of Probiotic Bacteria
7.1 Introduction
7.2 The gastrointestinal (GI) tract
7.3 Encapsulation technologies for probiotics
7.4 Techniques for probiotic encapsulation
7.5 Controlled release of probiotic bacteria
7.6 Potential applications of encapsulated probiotics
7.7 Future trends and marketing perspectives
References
Chapter 8: Nano-Structured Minerals and Trace Elements for Food and Nutrition Applications
8.1 Introduction
8.2 Special characteristics of nanoparticles
8.3 Nano-structured entities in natural foods
8.4 Nano-structured minerals in nutritional applications
8.5 Uptake of nano-structured minerals
8.6 Conclusion
References
Chapter 9: Nano- and Microencapsulation of Vitamins
9.1 Introduction
9.2 Vitamins for food and nutraceutical applications
9.3 Colloidal encapsulation (nano and micro) in foods: principles of use
9.4 Conclusion and future trends
References
Chapter 10: Nano- and Microencapsulation of Flavor in Food Systems
10.1 Introduction
10.2 Flavor stabilization in food nano- and microstructures
10.3 Flavor retention and release in an encapsulated system
10.4 Nano- and microstructure processing
10.5 Conclusion
Acknowledgements
References
Chapter 11: Application of Nanomaterials, Nano- and Microencapsulation to Milk and Dairy Products
11.1 Introduction
11.2 Milk
11.3 Yogurt
11.4 Cheese
11.5 Others
11.6 Conclusion
References
Chapter 12: Application of Nano- and Microencapsulated Materials to Food Packaging
12.1 Introduction
12.2 Nanocomposite technologies
12.3 Intelligent and active packaging based on nano- and microencapsulation technologies
12.4 Conclusion
References
Part III: Bioactivity, toxicity, and regulation of nanomaterial, nano- and microencapsulated ingredients
Chapter 13: Controlled Release of Food Ingredients
13.1 Introduction
13.2 Fracturation
13.3 Diffusion
13.4 Dissolution
13.5 Biodegradation
13.6 External and internal triggering
13.7 Conclusion
References
Chapter 14: Bioavailability and Bioactivity of Nanomaterial, Nano- and Microencapsulated Ingredients in Foods
14.1 Introduction
14.2 Bioavailability of nano- and microencapsulated phytochemicals
14.3 Bioavailability of other nano- and microencapsulated nutraceuticals
14.4 Bioavailability of nano- and microencapsulated bioactive components
14.5 Conclusion
References
Chapter 15: Potential Toxicity of Food Ingredients Loaded in Nano- and Microparticles
15.1 Introduction
15.2 Factors influence the toxicity of nano- and microparticles
15.3 Behavior and health risk of nano- and microparticles in the gastrointestinal (GI) tract
15.4 Toxicity studies of nano- and microparticles
15.5 Risk assessment of micro- and nanomaterials in food applications
15.6 Conclusion
References
Chapter 16: Current Regulation of Nanomaterials Used as Food Ingredients
16.1 Introduction
16.2 The European Union (EU)
16.3 The United Kingdom (UK)
16.4 France
16.5 The United States of America (USA)
16.6 Canada
16.7 Korea
16.8 Australia and New Zealand
References
Index
End User License Agreement
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Cover
Table of Contents
Preface
Chapter 1: Overview of Nano- and Microencapsulation for Foods
Figure 1.1
Figure 1.2
Figure 1.3
Figure 1.4
Figure 2.1
Figure 2.2
Figure 2.3
Figure 2.4
Figure 2.5
Figure 2.6
Figure 2.7
Figure 2.8
Figure 4.1
Figure 4.2
Figure 4.3
Figure 4.4
Figure 4.5
Figure 4.6
Figure 4.7
Figure 4.8
Figure 5.1
Figure 5.2
Figure 5.3
Figure 5.4
Figure 5.5
Figure 5.6
Figure 5.7
Figure 6.1
Figure 6.2
Figure 6.3
Figure 6.4
Figure 6.5
Figure 6.6
Figure 6.7
Figure 6.8
Figure 6.9
Figure 6.10
Figure 7.1
Figure 7.2
Figure 7.3
Figure 7.4
Figure 7.5
Figure 7.6
Figure 8.1
Figure 8.2
Figure 8.3
Figure 9.1
Figure 9.2
Figure 9.3
Figure 9.4
Figure 9.5
Figure 10.1
Figure 10.2
Figure 10.3
Figure 10.4
Figure 10.5
Figure 10.6
Figure 10.7
Figure 10.8
Figure 10.9
Figure 10.10
Figure 11.1
Figure 11.2
Figure 11.3
Figure 11.4
Figure 11.5
Figure 11.6
Figure 11.7
Figure 12.1
Figure 12.2
Figure 12.3
Figure 12.4
Figure 12.5
Figure 12.6
Figure 12.7
Figure 12.8
Figure 12.9
Figure 13.1
Figure 14.1
Figure 14.2
Figure 14.3
Figure 14.4
Figure 14.5
Figure 14.6
Figure 14.7
Figure 14.8
Figure 15.1
Figure 15.2
Table 1.1
Table 2.1
Table 2.2
Table 3.1
Table 3.2
Table 4.1
Table 4.2
Table 6.1
Table 6.2
Table 7.1
Table 7.2
Table 7.3
Table 7.4
Table 8.1
Table 8.2
Table 9.1
Table 9.2
Table 9.3
Table 13.1
Table 13.2
Table 15.1
Table 15.2
Table 16.1
Table 16.2
Edited by
Hae-Soo Kwak
Sejong University, South Korea
This edition first published 2014 © 2014 by John Wiley & Sons, Ltd
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Library of Congress Cataloging-in-Publication Data
Nano- and microencapsulation for foods / edited by Hae-Soo Kwak.
pages cm
Includes bibliographical references and index.
ISBN 978-1-118-29233-4 (cloth)
1. Food addititives. 2. Microencapsulation. 3. Functional foods. 4. Controlled release preparations. I. Kwak, Hae-Soo, editor of compilation.
TX553.A3N254 2014
641.3′08—dc23
2013045013
A catalogue record for this book is available from the British Library.
Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic books.
Cover image: Food Background © iStock/ fcafotodigital
Healthy Oils © iStock/Rinelle
Cover design by www.hisandhersdesign.co.uk
1 2014
Raid G. Alany
Department of Pharmaceutical Science, The School of Pharmacy, University of Auckland, Auckland, New Zealand
Nurul Fadhilah Kamalul Aripin
Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea
Bhesh Bhandari
Food Processing Technology and Engineering, School of Agriculture and Food Sciences, The University of Queensland, Brisbane, Australia
Guanyu Chen
The School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Xi G. Chen
College of Marine Life Science, Ocean University of China, Qingdao, People's Republic of China
Mi-Jung Choi
Department of Bioresources and Food Science, College of Life and Environmental Science, Konkuk University, Seoul, South Korea
Soo-Jin Choi
Department of Food Science and Technology, Sejong Women's University, Seoul, South Korea
Palanivel Ganesan
Department of Food Technology, Universiti putra Malaysia, Serdang, Malaysia
Sundaram Gunasekaran
Department of Biological Systems Engineering and Food Science, University of Wisconsin-Madison, Madison, WI, USA
Florentine M. Hilty
Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
Kasipathy Kailasapathy
School of Science and Health, University of Western Sydney, NSW, Australia and School of Biosciences, Taylor's University, Subang Jaya, Malaysia
Hyun-Kyung Kim
Korea Ministry of Food and Drug Administration, Chungcheongbuk-do, South Korea
Sanghoon Ko
Department of Food Science and Technology, Sejong University, Seoul, South Korea
Hae-Soo Kwak
Department of Food Science and Technology, Sejong University, Seoul, South Korea
Jong-Gu Lee
Korea Ministry of Food and Drug Administration, Chungcheongbuk-do, South Korea
Si-Young Lee
Korea Ministry of Food and Drug Administration, Chungcheongbuk-do, South Korea
Sung Je Lee
Institute of Food, Nutrition and Human Health, Massey University, Auckland, New Zealand
Loong-Tak Lim
Department of Food Science, University of Guelph, Ontario, Canada
Mohammad Al Mijan
Department of Food Science and Technology, Sejong University, Seoul, South Korea
Kyuya Nakagawa
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
Minh-Hiep Nguyen
Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea
Hyun-Jin Park
Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea
Ashok R. Patel
Vandemoortele Centre, Laboratory of Food Technology and Engineering, Faculty of Bioscience Engineering, Gent University Gent, Belgium
Soon-Mi Shim
Department of Food Science and Technology, Sejong University, Seoul, South Korea
Jingyuan Wen
The School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Marie Wong
Institute of Food, Nutrition and Human Health, Massey University, Auckland, New Zealand
Michael B. Zimmermann
Laboratory for Human Nutrition, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
Nano- or microencapsulation technology is a very innovative and emerging technology which will have a great impact on bioactive food product development in the coming years. The technologies are already well known in the fields of medicinal, pharmaceutical, and cosmetic product development. For the last 30 years, food science text books have been written about chemistry or microbiology of food. Now nano and medical science are joining with food science to increase the nano food market value and open up a new focus on the delivery of functional ingredients with high activity. These functional ingredients provide additional benefit to the consumers, aged from infants to senior citizens, by providing healthy enhancement of bodily functions.
This book contributes important information to world food science by detailing what nano- or microencapsulation of foods is, the bioactive ingredients of which contribute significantly to human health. There has not been such a comprehensive book published on nano- or microencapsulation previously, and this text covers the whole principle of encapsulation, the technologies involved in encapsulation, the characterization of encapsulation, the functional products containing vitamins, minerals, probiotics, and its regulations for its development in the world.
This book will be of interest to students, academics, and scientists who are involved in the development of functional food using encapsulation technologies. Nano- or microencapsulation of functional compounds provides an alternative technology in the protection of these compounds and offers efficient delivery to the target site. Uniquely this book covers the encapsulated products from nano- to microsize with significant bioactive functions. Thus, this work will be an important reference book on microencapsulation and is intended to present up-to-date information on the state of the art as the contributors are world authorities in this field.
Only a few books discuss nano- or microencapsulation and deal with the production, characterization, and toxicity of capsules. However, most books deal with the fragment information of encapsulation and none of them cover the micro- or nanoencapsulation for foods. I hope that this book will be unique in offering in-depth knowledge of nano- or microencapsulation, particularly with a focus on foods.
It has been quite challenging to produce a book with the broad scope covering the scientists all over the world. A special thanks to the publisher for giving me the chance to publish the work. My special thanks goes to Dr. Palanivel Ganesan, as well as the lab students involved in editing of this publication. Finally, I am deeply indebted to my wife and sons for their strong support in the completion of this work.
Hae-Soo KwakEditor
Hae-Soo Kwak
Department of Food Science and Technology, Sejong University, Seoul, South Korea
Nano- or microencapsulation technology is a rapidly expanding technology offering numerous beneficial applications in the food industries. Nano- or microencapsulation technology is the process by which core materials enriched with bioactive compounds are packed within wall materials to form capsules. This method helps to protect many functional core compounds, such as antioxidants, enzyme, polyphenol, and micronutrients, to deliver them to the controlled target site and to protect them from an adverse environment (Gouin, 2004; Lee et al., 2013). Based on the capsule size, the name and the technology of the encapsulation are different: the capsules which range from 3 to 800 µm in size are called microcapsules and the technology is called microencapsulation technology (Ahn et al., 2010). If the particle size ranges from 10 to 1,000 nm, these are called nanospheres and the technology involved to encapsulate the bioactive compounds within the nano size range is termed nanoencapsulation technology (Lopez et al., 2006). Nanocapsules differ from nanospheres when the bioactive systems are dispersed uniformly (Couvreur et al., 1995). The development of the nanotechnology on the nanometer scale has led to the development of many technological, commercial, and scientific opportunities for the industry (Huang et al., 2010).
Application of nanotechnology in the food industry involves many characteristic changes on the macroscale, such as texture, taste, and color, which have led to the development of many new products. This also improves many functions, such as oral bioavailability, water solubility, and the thermal stability of functional compounds (McClements et al., 2009). It is claimed that the functional compounds provide many health benefits in the prevention and treatment of many diseases, and these compounds can easily be seen on the market in various forms. However, the sustainability of the delivery of functional bioactive compounds to the target site is very low, particularly lipophilic compounds. Improving the availability of the functional compounds enhances the absorption of the functional compounds in the gastrointestinal tract, which is a critical requirement. The development of nano- or microencapsulation technologies offers possible solutions to improve the bioavailability of many functional compounds (Chau ., 2007). The methods used to develop the encapsulation technologies, to enclose the functional compound encapsulated along with its applications in food, and its regulatory framework are described in various chapters in this volume.
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