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- Herausgeber: BookRix
- Kategorie: Wissenschaft und neue Technologien
- Sprache: Englisch
This is guainine effort to publish this book.
The term “phyto” means plant while “some” means cell like.
The Phytosome process produces is a little cell whereby the valuable components of the herbal extract are protected from destruction by digestive secretions and gut bacteria.
this book will be very helpful to botany,pharmacy and agriculture sciences students.
Das E-Book können Sie in Legimi-Apps oder einer beliebigen App lesen, die das folgende Format unterstützen:
Veröffentlichungsjahr: 2015
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Phytosome
overview
BookRix GmbH & Co. KG81371 MunichContent
Sr. No.
Content
1
Introduction to phytosome
2
Preparation of Phytosome
3
Properties of phytosomes
4
PHYTOSOME A Technical revolution in phytomedicine
5
The Flavonoids
6
Green Tea Phytosome
7
LEUCO PHYTOSOME
8
Hawthron Phytosome
9
Grape Seed Phytosome:
10
Conclusion
11
References
Introduction to phytosome
Introduction
A large number of herbal drugs possess the wide spectrum of therapeutic activity. But the potential use of these herbal drugs is limited due to their poor absorption and poor bioavailability after oral administration. The bioavailability can be improved by the use of delivery systems, which can enhance the rate and the extent of drug solubilizing into aqueous intestinal fluids as well as the capacity to cross the lipid rich biomembranes. Phospholipid based drug delivery systems have been found promising for the effective and efficacious herbal drug delivery. Complexing the polyphenolic phytoconstituents in molar ratio with phosphatidylcholine results into a new herbal drug delivery system- "Phytosome". Phytosomes show better pharmacokinetic and therapeutic profile than conventional herbal extracts. It having large application in hepatoprotective and antihepatotoxic activity.
The term “phyto” means plant while “some” means cell like.
The Phytosome process produces is a little cell whereby the valuable components of the herbal extract are protected from destruction by digestive secretions and gut bacteria.
Most of the bioactive constituents of herbal drugs are water soluble molecules However, water soluble phytoconstituents like many flavonoids are poorly absorbed(1) either due to their multiple-ring large size molecules which can not be absorbed by simple diffusion, or due to their poor miscibility with oils and other lipids, severely limiting their ability to pass across the lipid-rich outer membranes of the enterocytes of the small intestine.
Water-soluble phytoconstituent molecules (mainly polyphenoles) can be converted into lipid-compatible molecular complexes, which are called phytosomes.
Phytosomes are more bioavailable as compared to simple herbal extracts owing to their enhanced capacity to cross the lipid rich biomembranes and finally reaching the blood(2). The lipid-phase substances employed to make phytoconstituents, lipid-compatible are phospholipids from soy, mainly phosphatidylcholine (PC).
Phospholipids are complex molecules that are used in all known life forms to make cell membranes. They are cell membrane building blocks, making up the matrix into which fit a large variety of proteins that are enzymes, transport proteins, receptors, and other biological energy converters.
They are miscible both in water and in oil/ lipid environments, and are well absorbed orally. Phospholipids are small lipid molecules in which the glycerol is bonded only to two fatty acids, instead of three as in triglycerides, with the remaining site occupied by a phosphate group(3).
Most of the bioactive constituents of phytomedicines are flavonoids (e.g., anthocyanidins from bilberry, catechins from green tea, silymarin from milk thistle). However, many flavonoids are poorly absorbed. (1)
The poor absorption of flavonoid nutrients is likely due to two factors.
First, they are multiple-ring molecules too large to be absorbed by simple diffusion, while they are not absorbed actively, as occurs with some vitamins and minerals.
Second, flavonoid molecules typically have poor miscibility with oils and other lipids, severely limiting their ability to pass across the lipid-rich outer membranes of the enterocytes of the small intestine.The phytosome process has been applied to many popular herbal extract including Ginkgo biloba, grape seed, hawthorn, milk thistle (Silybum marianum), green tea (Thea sinensis) and ginseng (Panax ginseng). The flavonoid and terpenoid components of these herbal extracts lend themselves quite well for the direct binding to phosphatidylcholine.
