Transplant Immunology E-Book

• Herausgeber: John Wiley & Sons
• Kategorie: Fachliteratur
• Sprache: Englisch

Seitenzahl: 688

Veröffentlichungsjahr: 2015

Beschreibung

With all the complex issues of acceptance or rejection of a transplanted organ, immunology is a key subject for all transplantation clinicians. During recent years, there has been an explosion of research and knowledge in this area.

Produced in association with the American Society of Transplantation, and written by experts within the field, Transplant Immunology provides a comprehensive overview of the topic in relation to clinical transplantation.

Starting with the basic functionality of the immune system, it then moves on to cover the very latest developments in immunosuppressive drugs and protocols, as well as a look at all emerging technologies in the field.

Key chapters include:

• Transplant-related complications
• Immune responses to transplants
• Emerging issues in transplantation
• Biomarkers of Allograft rejection and tolerance
• T cells and the principles of immune responses

In full colour throughout, over 100 outstanding diagrams support the text, all figures being fully downloadable via the book's companion website. The result is an essential tool for all those responsible for managing patients awaiting and undergoing organ transplantation, including transplant surgeons and clinicians, immunologists and researchers.

Leseprobe

Table of Contents

Cover

Title page

Contributors

Foreword

Preface

About the companion website

CHAPTER 1: Tissues and organs of the immune system

Introduction

Primary lymphoid tissues

Secondary lymphoid tissues

Tertiary lymphoid tissues

Summary

References

Further reading

CHAPTER 2: Cells of the immune system

Introduction

Innate immune cells

Natural killer cells

Adaptive immune cells

Natural killer T (NKT) cells

Summary

Further reading

CHAPTER 3: Soluble mediators in the immune system

Introduction

Cytokines

Acute phase cytokines

The IL-1 family cytokines

The common γ

c

family of cytokines

The IL-12 family of cytokines

Adaptive immunity cytokines

Immunoregulatory cytokines

Further reading

CHAPTER 4: Costimulatory molecules

Introduction

Costimulatory molecules

Summary and relevance to clinical transplantation

References

CHAPTER 5: Major histocompatibility complex

Introduction

Structure and function of MHC

Anti-HLA antibodies in transplantation

Non-HLA antigens in organ transplantation

Summary

Further reading

CHAPTER 6: T cells and the principles of immune responses

Introduction

T cell activation

T cell differentiation to effector cells

Progression from naïve to memory T cells

Regulatory T cells

Summary

Further reading

CHAPTER 7: Ischemia and reperfusion injury

Introduction

Mechanism of organ injury

Toll-like receptors (TLRs) in innate immune activation during IRI

Non-TLRs in innate immune activation in IRI

IL-10 and innate immune activation

T cells, NK cells, and NKT cells in IRI

Conclusions

References

CHAPTER 8: Immune responses to transplants

Introduction

Tranpslant rejection

Transplant tolerance

Immune privilege and accommodation

Summary

References

Further reading

CHAPTER 9: Principles of hematopoietic cell transplantation

Introduction

Principles of HCT

GVHD: Principles

Acknowledgments

References

CHAPTER 10: Therapeutic approaches to organ transplantation

Introduction

General aspects of ISDs

Small-molecule drugs

Protein drugs and biologics

Immunosuppression protocols

Managing antibody-mediated rejection and the positive crossmatch patient

Tolerance induction strategies

References

Further reading

CHAPTER 11: Organ-specific features in clinical transplantation

Introduction

Kidney

Liver

Lung

Heart

Small bowel

Conclusion

Acknowledgment

References

CHAPTER 12: Transplant-related complications

Introduction

Infections

Post-transplant malignancy

Metabolic disorders

Hypertension

Hematologic disorders

Summary

References

Further reading

CHAPTER 13: Biomarkers of allograft rejection and tolerance

Introduction

Biomarkers

Summary

References

Further reading

CHAPTER 14: Emerging issues in transplantation

Introduction

Age and immune responses

Marginal donor organs

Organs from donors after cardiac or circulatory death (DCD)