Anatomy in Diagnostic Imaging E-Book

Peter Fleckenstein

• Herausgeber: John Wiley & Sons
• Kategorie: Fachliteratur
• Sprache: Englisch

Seitenzahl: 473

Veröffentlichungsjahr: 2014

Beschreibung

Now in its third edition, Anatomy in Diagnostic Imaging is an unrivalled atlas of anatomy applied to diagnostic imaging. The book covers the entire human body and employs all the imaging modalities used in clinical practice; x-ray, CT, MR, PET, ultrasound and scintigraphy. An introductory chapter explains succinctly the essentials of the imaging and examination techniques drawing on the latest technical developments.

In view of the great strides that have been made in this area recently, all chapters have been thoroughly revised in this third edition. The book’s original and didactically convincing presentation has been enhanced with over 250 new images. There are now more than 900 images, all carefully selected in order to be user-friendly and easy-to-read, due to their high quality and the comprehensive anatomical interpretation directly placed alongside every one.

Both for medical students and practising doctors, Anatomy in Diagnostic Imaging will serve as the go-to all-round reference collection linking anatomy and modern diagnostic imaging.

Winner of the Radiology category at the BMA Book Awards 2015

Leseprobe

Table of Contents

Dedication

Title page

Copyright page

Preface to the third edition

Acknowledgements

Principles and Techniques in Diagnostic Imaging

Techniques Based on X-Rays

The Generation and Nature of X-Rays

Interactions of X-Rays with Matter

Conventional Imaging with X-rays

Digital Radiography

Computed X-Ray Tomography

X-Ray Contrast Enhancing Media

Techniques Based on Nuclear Magnetic Resonance

Principles of MR Scanning

MR Imaging Modes and Pulse Sequences

Techniques Based on Ultrasound Reflection

The Generation and Nature of Ultrasound

Interactions of Ultrasound with Matter

Ultrasound Imaging Modes

The Doppler Shift and Doppler Imaging

Techniques Based on Radioisotope Emissions

Scintigraphy

Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET)

Principles of Nomenclature and Positioning

Upper Limb

Shoulder and Arm

Elbow

Forearm

Wrist and Hand

Arteries and Veins

Lower Limb

Pelvis

Hip and Thigh

Knee

Leg

Ankle and Foot

Arteries and Veins

Lymphatics

Spine

Cervical Spine

Thoracic Spine

Lumbar Spine

Head

Skull

Ear

Orbita

Paranasal Sinuses

Temporomandibular Joint

Teeth

Salivary Glands

Arteries

Brain

Axial CT Series

Axial MR Series

Coronal MR Series

Sagittal MR Series

Arteries and Veins

Newborn

Neck

Larynx

Pharynx

Axial CT Series

Thyroid Gland

Thorax

Thoracic Cage

Axial CT Series

Heart and Great Vessels

Esophagus

Breast

Thoracic Duct

Abdomen

Axial CT Series

Stomach

Small Intestine

Colon and Rectum

Liver and Pancreas

Spleen

Arteries and Veins

Lymphatics

Urogenital System

Kidney

Urinary Bladder and Urethra

Male Genital Organs

Female Genital Organs/Embryo

Fetus

Short Dictionary of Examination Procedures and Concepts in Diagnostic Imaging

Index

End User License Agreement

List of Tables

Table 1

List of Illustrations

Figure 1  The electromagnetic wave spectrum, given by wavelength, frequency and photon energy.

Figure 2  Diagrammatic presentation of the basic elements of a diagnostic X-ray tube.Details of circuitry are not given.

1: Cathode filament

2: Electron beam

3: Rotating anode

4: Anode motor drive

5: Vacuum tube

6: Lead shield

7: Window

8: Central ray

Figure 3  The effect of filtering on the distribution of photon energies in the X-ray beam from a 100 kVp tube.Even the unfiltered beam has been “filtered” by passage through the wall of the X-ray tube whereby the lowest energies have been rejected. Additional filtering lowers the overall intensity, but increases the mean photon energy.

Figure 4  The photoelectric interaction.

Figure 5  The K-edge effect.X-ray absorption increases steeply at photon energies equal to the binding energy of the K-shell electrons of an element, a so-called K-edge.

Figure 6  Inelastic (Compton) scatter.

Figure 7  The relative contribution of the photoelectric effect and of Compton scatter to attenuation of X-rays in bone and muscle.

Figure 8  The effect of X-ray energy on image contrast between bone and soft tissues.Image (A) is recorded with a voltage setting at 50 kVp, (B) at 150 kVp. The lower beam energy in (A) yields higher contrast between bone and soft tissues, because of the contribution of photoelectric interactions in bone imaging at low kVp.

Figure 9  X-ray imaging geometry.

Linear magnification

Magnification as a function of the object-to-film distance (OFD) relative to the focus-to-film distance (FFD).

Figure 10  The influence of focal spot size on image sharpness.

Figure 11  Exclusion of scattered radiation by air-gap and grid.The depicted grid is of the “focussed” type with angledlamellae, designed to a certain film-to-focus distance.

Figure 12  Principle of conventional X-ray tomography.

Figure 13  Characteristic curve of two different films.Film A has a higher speed (is more sensitive) than film B. Film A also gives more contrast than B because a given narrow exposure range (ΔE) is differentiated over more gray tones by film A. Film B, on the other hand, will display a broader exposure range within the useful range of film densities (O.D. ∼ 0.25–2.0).The optical density (O.D.) of a transparent object, e.g. an X-ray film viewed on a light box, is defined bywhere I

i

and I

e

denote the intensity of incident and transmitted light, respectively. Thus, an O.D. of 2 means that only 1/100 of the incident light from the box is transmitted, which means nearly black.

Figure 14  The basic design of an image intensifier tube. For explanation, see text.

Figure 15  An imaging plate based on photo-stimulated luminescence.The latent X-ray image is stored in the luminescent layer of the plate. The plate is advanced on a table and scanned by a narrowly focused red laser beam which elicits release of blue-green light from the plate, proportionate to its X-ray exposure at each point along the scanned lines. The emitted (blue-green) light is picked up by a planar fiber-optic conductor and fed into a photomultiplier tube (PMT). A filter prevents red laser light from reaching the PMT. After reading of the plate the latent image is erased by exposure to strong bright light, and the plate can then be reused.

Figure 16  A direct flat panel detector.Each detector element consists of an electron capture area, a capacitor and a thin film transistor (TFT) switch. The aerial image hits a layer of amorphous selenium which releases free electrons when hit by X-ray photons. The free electrons are drawn in straight paths onto the detector elements by an electrical field. The accumulated electrical charge is stored in the capacitor. A net of leads operates the TFT switches during read-out of the charge stored by each element.

Figure 17  The characteristic curve of a digital imaging plate or a flat panel detector compared to a classical X-ray film.The sensitivity is strictly linear and covers a range 3–4 decades broader than classical X-ray films.r: useful exposure range of an X-ray film.

Figure 18  An image composed of pixels, each representing a volume element, a voxel.The yellow frame (lower left) contains 9 pixels, each representing a volume of tissue (a voxel) with a calculated CT number. According to these numbers, each pixel has been assigned a gray-tone. Together the collection of all the pixels make up the image (lower right). The depth (z) of the voxel equals the section thickness. For computation of images maintaining the same resolution at any angle through a stack of images, voxels must be cubic (x = y = z).

Figure 19  The basic design of a multislice CT scanner.The X-ray tube rotates in synchrony with the detector array which is composed of a large number of parallel rows of detectors recording the intensity of X-rays having passed through the patient in multiple directions during a turn of the tube and detector assembly. Each of the X-ray capturing detectors are shielded by a collimator that permits only X-rays coming in a straight line from the focal spot of the X-ray tube to reach the detector.

Figure 20  Helical CT scanning.The patient is lying on the couch which moves at constant speed through a multislice scanner. If the couch during one 360° revolution of the X-ray tube moves the same distance as the width of the detector array (t), the pitch equals t; the pitch factor is one (upper figure). If the couch moves 25% faster, the pitch factor becomes 1.25, that is, the sections are spaced by a slice of tissue, one fourth of the section thickness, not being imaged (lower figure). A pitch factor of less than one means that the sections overlap.

Figure 21  The Hounsfield scale.Approximate CT numbers of some tissues and organs are indicated.

Figure 22  CT image of abdomen.R and L denote patient's right and left. A centimeter scale to the left in the image gives the linear calibration. The image is displayed with settings of level and window of 40 and 350, respectively. The X-ray tube has been operated at 140 kVp with a tube current of 170 mA. The tomographic slice thickness is 10 mm, and the data to construct the image have been collected over a period of 3 seconds. Three locations have been selected for display of numerical figures of X-ray attenuation. Location l is in the liver and has an area of 12.88 square centimeter, and an average CT number of 47.2 with a standard deviation (SD) of 7.0. Location 2 is in the gall bladder, location 3 is in the cancellous bone of a vertebral body. Note the high SD of the latter. Atherosclerotic calcifications are present in the aorta and right renal artery.

Figure 23  Effects of level and window setting in imaging of the brain by CT.The upper panel shows the tomogram displayed with a constant level (40) and increasing window from left to right. The lower panel shows the tomogram displayed with a constant window (80) and increasing level from left to right. Note calcifications in pineal body and choroid plexus.

Figure 24  Standard “tissue settings” in a CT slice of the thorax.Upper frame (A): “Lung settings” (L = −700/W = 1000).Middle frame (B): “Soft tissue settings” (L = 40/W = 500).Lower frame (C): “Bone settings” (L = 250/W = 500).

Figure 25  Example of maximum intensity projection, MIP (A) and volume rendering (B) of the heart.(A) is a MIP of an oblique slice of the heart imaged in (B), where the approximate slice location and thickness is indicated. (B) is a volume-rendered image, permitting only voxels with CT numbers characteristic of heart muscle and of contrast medium to contribute to the image.

Figure 26  Volume rendering of pelvis and hips.The image is computed only from voxels having CT numbers characteristic of bone.

Figure 27  Volume rendering of the lungs.(A) The lower panel shows a histogram of the CT numbers of all the voxels in the scanned body part, extending from −1000 (air) to dense bone (+1300). Only the voxels indicated by the rectangle to the left have been permitted to contribute to the image and are color coded as indicated on the color scale under the histogram. (B) The triangle to the left indicates the range of CT numbers (−800 to −225) selected to contribute to the image, however of increasing transparency towards the lower values as seen on the color scale below. The result is that the lung tissue appears transparent permitting imaging of the embedded bronchial tree.

Figure 28  Virtual colonoscopy.Frame (A) shows a surface-rendered image of an air inflated colon. The path of the virtual colonoscopy is indicated by the red line. The blue arrow indicates the direction of view into the stretch of transverse colon indicated by yellow and imaged in (B). The distance from anus is shown to the left. The image (C) is a so-called filet view of (B) where the colon has been cut open to allow “face-on” inspection of the mucosal surface.

Figure 29  The basic design of a MR scanner.

Figure 30  Proton spin and precession.

Figure 31  Illustration of proton spin levels.

Figure 32  Pictorial representation of the net magnetization vector.

Figure 33  Diagrammatic illustration of the gradual change of the net magnetization vector under the influence of an increasing input of energy, delivered by RF-waves at the Larmor frequency.

Figure 34

The exponential recovery of the longitudinal net magnetization vector (MZ) after termination of a 90° RF pulse at time 0. where M

0

is the magnitude of the net magnetization vector at equilibrium. T1 is the time constant of the recovery process.

The exponential decay of the transversal, rotating net magnetization vector (M

XY

) after termination of a 90° RF pulse at time 0.The magnitude of M

XY

as a function of time (t) is given by: where T2 is the time constant of the decay process.

Figure 35  Recovery of longitudinal magnetization (M

Z

, full lines) and decay of transversal magnetization (M

XY

, broken lines) in two tissues, A and B. Tissue A has the shortest T1 and the longest T2.

Figure 36  The spin-echo phenomenon

In the equilibrium state all the transverse (M

XY

) components of the proton magnetization vectors are out of phase. The sum of the longitudinal components (M

Z

) is aligned with the main field (B

O

). Omega (ω) marks the angular velocity of precession.

A 90° RF pulse aligned with the X- or Y-axis flips the longitudinal vector into the transverse plane and forces the transverse components of the proton magnetization vectors to precess in phase. The single resultant M

XY

vector is large and emits a strong radiosignal at the Larmor frequency.

After termination of the 90° pulse the transverse component begins to fan out due to small differences in precessional frequency of the individual protons, i.e. T2* relaxation. At the same time the longitudinal vector begins to grow up due to T1 relaxation.

A 180° RF pulse applied at time TE/2 reverses the longitudinal vector and the direction of precession so that the faster precessing protons begin to catch up with the slower, i.e. the fan of vectors closes again.

At time TE (time of echo = 2 × TE/2) the transverse components of the proton magnetization vectors have regathered (‘refocussed’) and emit again a strong radiosignal, however reduced by the T1 relaxation which has taken place over the TE period.

Figure 37  Principle of spatial resolution.A thin slice (A) will be excited by an RF-pulse of e.g. 43.45 MHz. Changing the RF-pulse to 42.6 MHz moves the excited section to position B. If the RF-pulse has a bandwidth from 41.64 to 41.75 MHz, a thicker slice at position C becomes excited.

Figure 38  The standard spin-echo pulse sequence.This sequence begins with a 90° RF pulse, applied when the slice selecting (Z-) gradient has been switched on. The following period of Z-gradient reversal (1) compensates for the dephasing caused by the slice selecting gradient during the RF pulse period. The 90° pulse elicits a RF signal, produced by the M

XY

magnetization vector depicted in the lower panel (and in Fig. 36B). This signal decays exponentially, the so-called

free induction decay

(FID). At time TE/2 the slice selecting gradient is again switched on and a 180° RF pulse is sent in (conf. also Fig. 36D). This has the effect of refocussing the dephasing M

XY

vectors to produce an echo signal at time TE, rising and falling exponentially. The echo signal is normally sampled around its midpoint. This RF signal has been encoded along the X- and Y-axis by two additional gradients. The X-gradient (the ‘read out gradient’), which is active during signal sampling, has been preactivated (2) to compensate for the dephasing it produces. The preactivation is in this sequence positive because the phases have been reversed by the 180° pulse, otherwise it should have been negative. The multiple horizontal bars in the symbol for the phase encoding (Y-) gradient indicate that this gradient is given a new strength, each time the sequence is repeated at TR (time of repetition) until enough sequences have been run to compute the image, usually 256 times. The intentional phase changes produced by the Y-gradient are of course not compensated for by gradient reversal.

Figure 39  Diffusion weighted MR image of a transverse section of the brain.The tensors indicating the direction of spatially restricted diffusion are color coded so that voxels with free diffusional mobility in transverse direction are red, those with cranio-caudal mobility are blue, and those with dorso-ventral mobility are green. The collection of red voxels in the middle of the image represents the corpus callosum. Lateral to this is the corona radiate in blue, and lateral to this are bundles of association fibers in green.

Figure 40  Mapping of conduction tracts between cerebral cortex and spinal cord.For explanation see text.

Figure 41  The influence of T1 in a spin-echo sequence.The graph shows the approximate time course of recovery of longitudinal magnetization (M

Z

) in cerebrospinal fluid (CSF), grey matter (GM) and white matter (WM) following a 90° RF pulse at time 0. The approximate relative proton density of these materials is indicated on the M

Z

-axis. A spin-echo with a short TE (20 msec) has been produced at 500, 1000, 1500 and 2240 msec after the 90° pulse. The short TE has the effect that T

2

relaxation does not significantly influence the signal strength which accordingly reflects the level of recovery of longitudinal magnetization, ruled by T1 of the materials. The resulting images are shown in the upper panel, all displayed with the same setting of imaging window and level, allowing assessment of relative signal strength between images.At 500 msec the overall signal strength is low, the signal from WM being a little higher than that from GM, while the signal from CSF in the ventricles is very low. This image reflects most clearly the differences in T1 and is accordingly a

T1 weighted image

. At 1000 msec the signal from WM and GM equals. At 1500 msec the signal from GM has risen above WM, and even more so at 2240 msec. At this time GM and WM are both approaching equilibrium, and the signal strengths reflect the proton spin density of WM relative to GM, but not to CSF which is still far from equilibrium and produce a relatively low signal due to its very long T1.At about 5000 msec the CSF would similarly have approached equilibrium. A spin-echo pulse sequence with a TR of 5000 msec and a TE of 20 msec, a so-called

saturation recovery pulse sequence

would therefore reflect the relative proton spin density of all the tissues/fluids. However, such long values of TR are not used in practice because the long data acquisition time required becomes impractical. The sequences with shorter TR used for the images in the upper panel are all

partial saturation recovery sequences

.

Figure 42  The influence of T2 in a spin-echo sequence.The graph shows (analogous to Fig. 41) the recovery of longitudinal magnetization in WM, GM and CSF up to 2500 msec following an initial 90° RF pulse. At 2500 msec (TR) another 90° pulse is applied. The curves to the right of this point in time show (on an extended time scale) the approximate time course of decay of the transverse magnetization vectors, ruled by the T2 of the tissues/CSF. At 10, 30, 55 or 120 msec (TE/2) after the 90° pulse, a 180° RF pulse is applied and the resulting echos (conf. Fig. 36) are sampled at 20, 60, 110 and 240 msec (TE). The 90° pulses are repeated every 2500 msec (TR) until sufficient data are collected to compute an image. The resulting images are shown in the upper panel.At a TE of 20 msec the signals from GM and WM are high, because the T2 relaxation is still only moderate. The signal from CSF is lower because the TR is short relative to the T1 of CSF.At a TE of 60 msec the fast T2 relaxation in WM and GM has markedly lowered the signal strength from these tissues, the WM signal has already fallen below that of CSF.At a TE of 110 msec the WM and GM signals have fallen well below CSF. This image which clearly display the differences in T2 between the tissues/CSF is a

T2 weighted image

.At TE of 240 msec signal remain only in CSF due to its long T2.

Figure 43  The inversion recovery pulse sequence.The graph shows the the approximate time course of recovery of longitudinal magnetization following a 180° RF pulse which has inverted the longitudinal net magnetization vector of the different tissues relative to the main field. During recovery of the inverted net longitudinal magnetization it becomes zero at one point in time. Because the rate of recovery is different: fat faster than WM – faster than GM – faster than CSF, the time at which the net longitudinal magnetization turns zero is different for the different tissues. This “null time” is for each tissue identified as the point where its graph of recovery crosses the abscissa. When a 90° pulse is applied at this time (the ‘inversion time,’ TI), and an echo signal is produced by a 180° pulse in rapid succession, the “nulled” tissue will produce no signal. The upper panel displays the images produced with inversion times (TI) of 250, 350, 550 and 2750 msec, and the same short TE of 20 msec. TR is chosen long, 3500 msec, to allow full recovery of the tissues between the inverting pulses (except for CSF). Note that the signals from the different tissues depend on the numerical value of the vectors, not their direction.At TI 250 msec the signal from subcutaneous fat is virtually zero, and the signal from WM is weak, while GM and CSF produce clear signals.At TI 350 msec WM is signal void while a weak signal has appeared in the subcutaneous fat and in fat between neck muscles (arrows). At the same time the GM signal has weakened while the CSF signal stay nearly constant.At TI 550 msec GM has become signal void while the signal from WM has reappeared and the signal from fat has grown stronger.At TI 2750 msec all the tissue signals have reached their maximum while the CSF signal is now around its point of “nulling”.

Figure 44  The basic design of an ultrasound transducer.

Figure 45  The shape of ultrasound “beams” produced by an unfocussed and a focussed transducer.

Figure 46

Specular reflection.

The angle of incidence equals the angle of reflection. If the angle deviates more than little from perpendicular, the reflected sound waves will miss the transducer.

Reflection from a ruffled surface.

The reflected waves spread over an angle so that only a smaller fraction reaches the transducer.

Diffuse scatter.

Small corpuscles or a finely rippled surface will spread the sound waves in all directions so that only a very small fraction returns to the transducer.

Figure 47  Ultrasound imaging modes.Ultrasound beam passing various reflecting surfaces.

A

-mode display, “amplitude mode”.The echoes are displayed on an oscilloscope screen as deflections with amplitudes and positions corresponding to the reflecting surfaces.

B

-mode display, “brightness mode”.The echoes are displayed as dots with brightness and positions corresponding to the reflecting surfaces.

M

-mode display, “motion mode”.The echoes are recorded in the B-mode on a strip chart. If the reflecting surfaces move, their movements are recorded as waving curves. Periodicity and amplitude of movements are clearly visualized.

Sector

scanning, real-time tomographic mode.The echoes are displayed in the B-mode on a videoscreen as the transducer scans back and forth through an angle (a “sector”).

Figure 48  Ultrasound scanning principles.

Simple mechanical device to produce sector scanning.

Linear transducer array.

Phased array transducer.

Figure 49  Duplex scanning of fetal heart.The site for measurement of blood flow is selected on the ultrasonogram and indicated by two parallel lines on the track from the transducer element selected for the Doppler measurement. The lower panel displays the spectrum of Doppler shifts as a function of time (in cm/s) recorded from which the magnitude and direction of blood flow recorded over five cardiac cycles can be read. The downward-directed flow stems from the inflow of blood from the atrium, initially passive, then forced by atrial contraction (sharp downward peak). The broad upward peak represents aortic outflow. The distance marked “1” represents the atrio-ventricular conduction time.

Figure 50  Color flow Doppler imaging of the umbilical cord.The direction of blood flow in the umbilical vein and the arteries is opposite and has accordingly been color coded opposite in blue and red.

Figure 51  Whole body

99m

Tc-diphosphonate bone scintigrams of a six year old boy.(A) is recorded with the boy's front in contact with the gamma camera; (B) with the back and buttock in contact. Note the high signal intensity from growth plates and other sites of growth. By comparing the two images it is clearly seen that the recorded signal intensity is dependent on the distance from the camera.

Figure 52  The basic design of a gamma camera with parallel hole collimator.

Figure 53  CT-SPECT scanning of neck and thorax.The patient has received a dose of

99m

Tc-sestamibi which (among others) is taken up by the parathyroid glands. The upper left image is one image in the series of axial CT images. The lower left image is a coronal section reconstructed from the series of axial SPECT images recording the distribution of the isotope. The image at upper right is the SPECT image superimposed on the corresponding CT image and the two images at lower right are similarly superimposed sagittal and coronal images. The examination has revealed a parathyroid gland (arrows) with an aberrant location in the superior mediastinum.

Figure 54  Tomographic planes.

Figure 55  Denotations of directions in conventional X-ray imaging.Arrows mark the beam direction.

Guide

Cover

Table of Contents

Start Reading

Preface

CHAPTER 1

Index

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Dedicated to our inquiring students

This third edition first published 2014, © Peter Fleckenstein, Jørgen Tranum-Jensen and Peter Sand Myschetzky. First edition 1993 © Munksgaard/Blackwell/Saunders, second edition 2001 © Munksgaard/Blackwell

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Library of Congress Cataloging-in-Publication Data

Fleckenstein, Peter, author.

    Anatomy in diagnostic imaging / Peter Fleckenstein, Jørgen Tranum-Jensen; co-author, Peter Sand Myschetzky. – Third edition.

            p. ; cm.

    Includes index.

    ISBN 978-1-4051-3991-5 (pbk.)

    I.  Tranum-Jensen, Jørgen, author.    II.  Myschetzky, Peter Sand, author.    III.  Title.

    [DNLM:    1.  Anatomy–Atlases.    2.  Diagnostic Imaging–Atlases. QS 17]

    RC78.7.D53

    616.07'54022–dc23

                                                            2013049538

A catalogue record for this book is available from the British Library.

Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic books.

Cover image: courtesy of Peter Fleckenstein and Jørgen Tranum-Jensen

Cover design by Sarah Dickinson

Preface to the third edition

Almost 20 years have passed since the first edition of Anatomy in Diagnostic Imaging was published, and encouraged by the receipt of the second edition we felt it was time to prepare this third edition, maintaining the scope of the previous editions, as an all-round reference collection of fully interpreted normal images, addressing students as well as professional medical personnel working with diagnostic imaging.

We have made a special effort to elaborate on MR imaging of the major joints, shoulder, elbow, hip, knee and ankle imaged in two or three planes. A CT series of the skull has been added and the CT series of the brain has been replaced by a new series. The section on obstetric ultrasonography has been considerably expanded to cover all standard examinations performed during a normal pregnancy. Further, we have added an MR series of the orbit and a new series of the lumbar spine, and other images have been supplemented or replaced.

The introductory chapter has been revised and updated, still with the scope that it should be nothing more than an understandable introduction to the imaging techniques and principles presented in the book.

Acknowledgements

During the preparation of the third edition we have again profited from the generous help of many colleagues: Connie Jørgensen, Rigshospitalet, Copenhagen; Anne-Mette Leffers, Hamlet Private Hospital, Copenhagen; Peter Oturai, Rigshospitalet, Copenhagen; Henrik Lundell, Hvidovre Hospital, Copenhagen and Martin Vinten, Glostrup Hospital, Copenhagen, together with colleagues and staff at the X-ray Department of Gentofte Hospital, and our thanks also go to photographer Keld Ottosen, Department of Cellular and Molecular Medicine, University of Copenhagen for skillful help with the photographic plates.

We also wish to thank Wiley Blackwell for their excellent collaboration and patience during the preparation of this third edition.

Finally, we cannot sink deeper into the bottomless debt of gratitude to our families for allowing us again to spend countless, but exciting hours preparing this third edition.

Peter Fleckenstein

Jørgen Tranum-Jensen

Peter Sand Myschetzky

Principles and Techniques in Diagnostic Imaging

Several physical principles are utilized in diagnostic imaging to visualize the structure, composition and functions of the living body. An elementary understanding of the imaging techniques and the basic physical principles is a prerequisite for full recognition of the diagnostic possibilities and for thorough and critical image interpretation.

This chapter is an introduction to the basic physical principles, the techniques and the concepts used in diagnostic imaging, avoiding undue technical details and strenuous mathematical formalisms.

Techniques

X-ray

CT

MR

Ultrasound

Scintigraphy

Techniques Based on X-Rays

The Generation and Nature of X-Rays

X-rays occupy a range within the electromagnetic wave spectrum. For purposes of diagnostic imaging, useful wavelengths are between 0.06 and 0.006 nm. Unlike visible light, X-rays cannot be deflected by lenses or analogous devices. Diffraction and wave optics can therefore largely be ignored in diagnostic imaging with X-rays. It is useful to picture X-rays as linearly propagating streams of indivisible quanta of energy, photons. Accordingly, X-rays are commonly characterized by their photon energies rather than by their wavelengths or their wave frequency. Because X-rays are generated by conversion of the energy acquired by electrons accelerated through an electric field in the kilo-volt (kV) range, the convenient unit for X-ray photon energies is the kilo-electron-volt (keV); the diagnostic relevant range being 20–200 keV (Figure 1).