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Manual for Long-Covid and Post-Vac: How do they work, which are the problems? How can they be detected and diagnosed? Which investigations and lab markers are crucial? What can we learn from them? Which tools do we have, to get back our health - may they be drugs, supplements, micronutrients, nutrition or instrument-based? The book provides comprehensive but comprehensible explanations, protocols and procedures.
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Long-Hauler
Manual for Long-Covid and Post-Vaccine Syndrome
Florian Schilling
Legal notice
Bibliographic information of the German National Library:
The German National Library lists this publication in the German National Bibliography; detailed bibliographic data are available on the Internet at http://dnb.dnb.de.
© 2022 Florian Schilling
Editing: Dietmar Böhmer
Graphics: Adnan Tignanj
Printing and distribution on behalf of the author:
tredition GmbH, Halenreie 40-44, 22359 Hamburg, Germany
The work, including its parts, is protected by copyright. The author is responsible for the contents. Any exploitation is not permitted without his consent. Publication and distribution are carried out on behalf of the author, who can be contacted at: tredition GmbH, "Imprint Service" Department, Halenreie 40-44, 22359 Hamburg, Germany.
ISBN Softcover: 978-3-347-68007-4
ISBN Hardcover: 978-3-347-68008-1
ISBN E-Book: 978-3-347-68013-5
We are co-creators of the Devine, all instrumental in changing and creating
our world and reality one step,
one person, and one day at a time.
With this awareness comes responsibility
and the need to be present and conscious of our actions at every moment.
Having consciousness means holding this responsibility with absolute respect
for all life and existence.
We hold the powerful and precious tool for transformation
in our own hands and hearts,
one loving thought and action at a time.
Each individual’s gift and contribution to the whole will vary,
but has equal importance.
Martina Hoffman
Table of contents
INTRODUCTION
PROLOGUE
INSTRUCTION MANUAL
PART I: MAIN PROBLEMS IN LONG-COVID & POST-VACCINE SYNDROME
INFECTION VS. VACCINATION: IMMUNOLOGICAL EFFECT
VACCINATION IMMUNOLOGICALLY RESEMBLES A SEVERE COURSE
VACCINATION AND INFECTION PRODUCE A DIFFERENT KIND OF IMMUNITY.
DIFFERENT „SPIKING” IN INFECTION AND VACCINATION
THE TOXIC EFFECT OF THE SPIKE
LONG-COVID VS. POST-VACCINE-SYNDROME: DIFFERENCES and SIMILARITIES
CLOT FORMATION, MYOCARDITIS, AND AMYLOID
BASICS
CLOT FORMATION DUE TO DESTRUCTION OF ENDOTHELIAL CELLS.
DIRECT ACTIVATION OF THE COAGULATION SYSTEM BY THE SPIKE
SPIKE CAN LEAD TO THE FORMATION OF AMYLOIDS AND PRIONS.
Fibrin-Amyloids
Spike-Amyloids
Amyloids, brain und prions
SUMMARY, DIAGNOSTICS & THERAPY
MYOCARDITIS
ENDOTHELIITIS & SILENT INFLAMMATION
ENDOTHELIITIS
SILENT INFLAMMATION
AUTOIMMUNITY
THE SPIKE PROTEIN INVITES AUTOREACTIONS
SPECIFIC AUTOANTIBODIES
GPCR-AK
THERAPY FOR AUTOIMMUNITY
Plasmapheresis
Immunosuppression
Combined Therapy
MITOCHONDRIOPATHY: THE UNDERESTIMATED PROBLEM
WHAT ARE MITOCHONDRIA?
SARS-COV2, THE SPIKE PROTEIN AND MITOCHONDRIA: AN UNFORTUNATE CLOSE RELATIONSHIP
HOW CAN WE MEASURE MITOCHONDRIAL DAMAGE?
Screening tests
The BHI (Bioenergetic Health Index)
THERAPY OF THE MITOCHONDRIOPATHY
Improvement of the mitochondrial structure
Improving mitochondrial function
Increasing the number of mitochondria
Increase oxygen supply to the mitochondria
NEUROINFLAMMATION: FIRE IN THE BRAIN
THE BLOOD-BRAIN BARRIER
The olfactory pathway
The intestinal tract
The spike and the blood-brain barrier
THE SPIKE IN THE CNS - A DISASTER TAKES ITS COURSE
ATTACK ON BRAIN METABOLISM
General anti-inflammation
THE TREATMENT OF A NEUROINFLAMMATION
Oral Therapy
The intranasal therapy (IN)
MAST CELL ACTIVATION SYNDROME
WHAT ARE MAST CELLS?
THE MAST CELL ACTIVATION SYNDROME: MCAS
MAST CELLS AND THE SPIKE-PROTEIN
HISTAMINE-RECEPTORS AND HISTAMINE ANTAGONISTS
THE DIAGNOSIS MCAS: UNFORTUNATELY, NOT SO EASY
THERAPY OF MCAS: A BROAD APPROACH IS REQUIRED
The diary
Nutrition and Gut
PEG-Sensitivity
Histamine Liberators and DAO Inhibitors
Mast cell- stabilizers
Antihistamines
VITAMIN-D-BALANCE
BASICS OF THE VITAMIN D BALANCE
Vitamin-D-Sources
Vitamin-D- variants: storage form and active form
The Vitamin-D-Receptor
VDR-DEFICIENCY: CAUSES
VDR-DEFICIENCY: CONSEQUENCES
VITAMIN D AND VDR: MEASUREMENT AND NORMAL VALUES
VITAMIN-D-THERAPY: HOW TO DO.
HORMONE SYSTEM
Hypothalamus and pituitary gland
Epiphysis
Thyroid
Adrenal cortex
Adrenal medulla
Gonads
Pancreas
PART II: SPECIFIC PROBLEMS IN POST-VACCINE SYNDROME
THE VACCINES: WHAT ARE WE UP AGAINST?
HOW CLASSICAL VACCINES WORK
GEN-BASED VACCINES
DNA-vaccines: Vector viruses as Carrier
RNA-vaccines: Nanoparticles as carrier
INCORPORATION OF THE SPIKE PROTEIN INTO THE CELL MEMBRANE
PERSISTENCE: VACCINES REMAIN IN THE BODY LONGER THAN GENERALLY ASSUMED
PERSPECTIVE ON INACTIVATED VACCINES
V-AIDS
SYNCYTIA FORMATION: WHY DEATH STARS ARE A REAL PROBLEM
INTERFERON DEFICIENCY: EPIGENETIC BLOCKADE
NK-CELLS: EXHAUSTED KILLERS
T- HELPER CELLS: BURN-OUTIN THE GENERAL STAFF
TURBO CANCER
ADE, T-REG AND INTERFERENCE: INCREASED SUSCEPTIBILITY TO CORONA INFECTIONS
ADE: Infection-enhancing antibodies
Interference: Swap one virus for another
T-Reg: "habituation" to SARS-CoV2
BASICS: VDR, SILENT INFLAMMATION & MITOCHONDRIA
RECOGNIZING AND TREATING V-AIDS
Specific diagnostics and therapy
General support for weak defences
Cancer-Screening
PLATELET DISORDERS
PART III: SPECIFIC PROBLEMS IN LONG-COVID
ORGANIC CHANGES
CORONA, MICROBIOME AND CHRONIC INFECTIONS
CORONA AND THE MICROBIOME
Microbiome
Intestinal Barrier Disorder: Leaky Gut
PERSISTENCE OF THE VIRUS: CHRONIC INFECTIONS
PART IV: IMMEDIATE ACTION, PROTOCOLS & APPENDIX
PROTOCOLS
IMMEDIATE ACTIONS
First aid
How to find a suitable practice/clinic
Diagnostics: Mandatory program
Prevention before and after vaccination
THERAPY: CONSIDERATIONS AND TIPS
Endotheliitis, Microclots and Autoimmunity
Neuroinflammation
Vitamin-D-balance
MCAS
Mitochondria
Eliminate spike proteins
V-AIDS, turbo cancer and chronic corona infection.
Hormonal system
SHEDDING
INITIAL SITUATION AND STATE OF THE SCIENCE
SYMPTOMS OF SHEDDING SENSITIVITY
POSSIBLE COUNTERMEASURES
SYMPTOMS IN LONG-COVID AND POST-VACCINE SYNDROME
THE REGISTRATION STUDIES: HOW TO AVOID MEANINGFUL STUDIES
THE PROBLEM OF TELESCOPING
THE PROBLEM OF STUDY SIZE
THE PLACEBO-PROBLEM
THE PROBLEM OF PARTICIPANT SELECTION
THE PROBLEM OF FALSE SURROGATE MARKERS
THE PROBLEM OF MISSING SURROGATE MARKERS
THE CONTROL GROUP PROBLEM
RELATIVE AND ABSOLUTE RISK REDUCTION
THE PFIZER CASE: THERE IS NO PIVOTAL STUDY AT ALL
THE VACCINATION FAILS AT THE POPULATION LEVEL
APPENDIX
TABLE OF FIGURES
INDEX
IMPORTANT PROTOCOLS AND SUMMARIES
BIBLIOGRAPHY AND REFERENCES
Introduction
Prologue
The most important message should be placed right at the beginning of this book:
Whether you are affected by long-covid (LC) or post-vaccine syndrome (PVS), you are not alone, and help is possible. With consistent application of the measures described in this book, over 85% of those affected experience rapid (a few weeks and months) and sustained improvement in their health. We have the tools to face these problems.
Thanks to dedicated scientists and physicians, it has been possible to achieve an extremely steep learning curve here. Many tools you can effectively use yourself - assuming you have understood what is happening in your body and why. After reading this book, you will absolutely be able to do so. Mainstream media and politicians act as if this whole complex of topics is terra incognita, unknown territory. This is not the case; we have a broad pool of scientific data and manifold practical experience from physicians around the globe at our disposal. But acknowledging the relevant findings would prove the official narrative wrong in many places - and, as should be avoided at all costs, undermine the authority of the proponents of this narrative. No one likes to admit mistakes, most of all physicians and politicians, especially when they are in the public spotlight. Not to mention unresolved legal issues. Some findings that endanger this narrative include.
• Covid-19 is a relatively treatable disease in the vast majority of cases - better than influenza, for example. Individual prevention, initial treatment and follow-up are very good and very successful. The established perspective of "vaccinate or risk your life" only applies in a few exceptional cases.
• In many cases, it is a matter of remarkably simple, very inexpensive tools (micronutrients, plant extracts, drugs that have been approved and proven to be safe for a long time) - from which neither the pharmaceutical companies nor the medical system profit greatly. Our health care systems are indeed an enormous industry, the main interest of most of those involved (with the regular exception of the patients) is all too often profit - not health.
• Vaccination offers no significant protection (especially in the longer term) - neither from infection nor from mild, severe, or fatal disease. Minimal protective effects are no longer detectable after a few weeks or months, but harmful effects are.
• Meanwhile, several studies have found that the health risks caused by vaccinations far exceed the potential benefits.
• The "vaccines" are by no means properly licensed and closely monitored medical agents. Approval, use, and monitoring of these experimental gene therapeutics undermine every previously accepted medical and ethical standard.
• Vaccine damage is neither "very rare" nor "usually mild and transient." In my experience, at least 1% of those vaccinated are affected by severe, persistent, and sometimes irreparable health disorders. For the majority of the population, this goes far beyond the risks of the actual disease. Official databases recording vaccine side effects show massive under-reporting, with a factor of at least 10 (very conservative estimate), more likely 20 (based on billing data) to 40 (comparing VAERS with manufacturers' registration studies).
• Long-covid is not a psychosomatic disorder. While antidepressants and pain medications may provide relief in individual cases, they miss the real heart of the problem. The psychological suffering that is actually frequently present is in many cases somatopsychic, i.e., caused by tangible, physical disorders.
• Long-Covid is more common than many want to admit. But instead of using it as a bogeyman to promote an agenda of vaccination campaigns, disenfranchisement, and surveillance, we should focus on solutions and offer speedy help to those affected.
No, corona is not an easy cold - especially when prevention, initial treatment and follow-up are not or sufficiently practiced. Then acute risks as well as medium- and long-term health problems are more probable and frequently imminent. The problem is: The vaccination is not the answer. Neither does it reliably prevent covid-19, nor the transmission of the virus, nor the potential long-term damage. Rather, it far too often precisely triggers these.
At the moment, affected people are predominantly left with one thing: abandoned. Whether LC (Long-Covid) or PVS (Post-Vaccine Syndrome), many physicians are overwhelmed by the situation. Even dedicated colleagues often do not know where to start, what to do - diagnostically as well as therapeutically. And since almost all established routine examinations do not reveal anything conclusive, a psychosomatic disorder is diagnosed in the end. In somewhat uglier terms, this means: The patient only imagines his complaints. This not being understood, not being taken seriously is an enormous additional burden for those affected.
The poisoned social climate adds to this. Vaccination proponents and vaccination sceptics are irreconcilably opposed to each other, and those affected are all too often caught between the fronts. Vaccination sceptics partly deny the existence of Long-Covid and know only vaccination damage. For them, LC is an unproven disease, virtually non-existent and a pure propaganda tool of the vaccination proponents. The latter, in turn, not infrequently deny the existence of vaccine damage; for them, post-vaccine syndrome is an invention of conspiracy theorists. This division runs right through society, through businesses, associations, families, and marriages.
Our social and health care systems will be overburdened with the hundreds of thousands, even millions of people affected. The current, completely insufficient care of the sick will cost vast sums of money, will not reduce the drastically increasing sickness rate, but will leave permanent nursing cases behind. If we do not quickly succeed in making sensible and targeted use of the resources that are certainly available, the lack of knowledge will be compounded, in the worst case, by a lack of resources. Then, at the latest, we will be faced with a public health disaster.
Another problem for those affected: In the absence of sensible guidelines (and in modern medicine, nothing works without guidelines), health insurances will be extremely reluctant or even refuse to cover the costs of the measures described in this book. Ergo, at the moment, those affected have to cover the majority of the costs themselves. The financial burden can be heavy in individual cases; especially in severe cases, the total budget can be in the five-digit range. Here, too, a few words of encouragement: Not every therapy plan will be in such a range and there is almost always the possibility to switch to less elaborate tools. That may mean it takes longer to get from A to B, but you will still get there.
Nevertheless: We must get used to the idea that a significant budget is needed to bring this project to a successful conclusion. I would also like to point out the following circumstance here: While savings are certainly possible in some places, the same is not true for others. If you cut corners in the wrong places, you jeopardize the overall success. The protocols in this book take this into account. Wherever possible, a distinction is made between basics (these should absolutely be implemented) and add-ons or extensions (these are optional or useful in case the basics are not sufficient). In addition, it is advisable to use complex remedies with combinations of active ingredients whenever possible. This saves costs and simplifies the intake schedule.
A lot of china was smashed during the Corona pandemic, at all levels. The loss of trust is gigantic - between patients and doctors, citizens and government, neighbours, and friends. I am not an expert in politics and government, but I have known the medical system for decades. It needs to be extensively reorganized to make up for the breach of trust that has taken place. The miserable dependence on third-party funding in research must be ended; we need independent science again that is not oriented purely to profit opportunities. We also need neutral, financially independent publication platforms. Scientific journals are concentrated in the hands of a few global corporations - which in turn are closely intertwined with the pharmaceutical industry and politics. This prevents unpopular, non-mainstream publications from appearing, and leads to inconspicuous censorship. Regarding vaccination, for example, a kind of "underground literature" has developed. If authors wanted to publish a study like "Vaccination can lead to problem XY" - the relevant journals would probably reject it. Instead, these publications trade as "The spike protein may cause problem XY". Anyone with sense can now make the bridge between spike protein and spike protein-based vaccination. But it remains a shameful self-dislocation. All too radical findings, however, do not even become exposed this way. The studies then languish largely unnoticed on pre-print servers, leaving valuable knowledge unused. The highly praised peer review process has often degenerated into a modern form of self-censorship, since the "peers" are often subject to extensive constraints, dependencies and are by no means free to form their own scientific opinions.
Regulatory studies belong in the hands of independent research institutions, not manufacturers. The data from these studies must be fully disclosed and made available to the scientific community. It cannot be that billions of people are subjected to experimental treatment while the details of that treatment remain hidden with the label "trade secret." India, for example, required Pfizer to conduct a neutral pivotal study under the auspices of Indian authorities before the vaccine could be released to India. Pfizer refused, preferring to forgo several billion in revenue. Why, I wonder, if the vaccine is as safe and effective as officially promoted?
We also need more therapeutic freedom for doctors again. The constraining corset of guidelines must fall. Medicine is not only reproducible success based on statistics. Medicine is also an art, an empirical science. Creativity, research spirit and courage have made it possible to find effective protocols for covid-19, long-covid and post-vaccine syndrome in a brief time - not costly, pharma-funded, placebo-controlled double-blind studies. "He who cures is right" must apply again. Right now, "Whoever follows guidelines, no matter how bad the outcome, is right." Anyone who deviates from this is branded, prosecuted under professional law, and ostracized. Physicians who were primarily committed to their patients and not to the system were banned from their profession, had to endure house and practice searches, and in some cases lost their professional and material existence. Academics who were critical of pandemic policy or vaccination were removed from their chairs, lost research funding and posts.
The actions of the regulatory authorities are an issue in themselves. Complete failure is still the mildest sentence that can be passed. Corruption, complicity within the pharmaceutical industry, cover-up and negligent homicide is probably closer to reality, according to all we know. Here, too, a break is needed. Financial contributions from the pharmaceutical industry to these agencies must be banned in all forms. There must be an incompatibility clause in employment contracts: A person can work for either one side (industry) or the other (government agencies) - but not both, in any order. The revolving door principle must be abolished. There must never again be an exemption from liability for manufacturers. There is a lot of work ahead of us, and the process has not even begun. If it fails, in the not-too-distant future we will live in a totalitarian, inhumane health care state, with no autonomy over our bodies, no decision-making authority over our mental and physical well-being.
An extremely important lesson from the pandemic is also to develop and perceive more self-responsibility for our own health again. Health begins in everyday life, with our habits. It is not the corona virus that determines the course of the disease, but the individual constitution. At first glance, factors such as age are out of our control - but at second glance, they are certainly within our control: healthy aging is possible, but it requires active intervention and dedication. We must learn again to practice prevention instead of relying on the idea that there is a pill or injection for every problem ("A pill for every ill"). We must also become more sensitive to the fact that every pill and every injection carries risks. We also need to question more again, to actively seek knowledge instead of blindly following the mainstream.
Instruction manual
This book is divided into four parts. The first deals with the most common and serious problems affecting both long-covid (LC) and post-vaccine syndrome (PVS). The second part covers issues that are specific to vaccinated individuals, while the third part looks at problems that (as of today) are unique to LC. In the fourth and concluding part, you will once again have compact access to the most valuable information - overview of initial diagnostics, immediate measures, and an extensive appendix with lists of illustrations, keywords, and literature. The following order is therefore recommended for those affected:
1. Even before working through the book, the implementation of first aid measures can be started in case of poor general condition (from page 191)
2. In parallel, the basic investigations should be initiated as quickly as possible (from page 192).
3. If you are about to be vaccinated or have just been vaccinated, initiate the appropriate prevention as soon as possible (page 196)
4. While these immediate measures are in progress, start reading Part I: This covers the most important and common problems; it is important for those affected to understand this background. Only in this way responsible decisions can be made.
5. Vaccine-injured patients subsequently work through Part II, and long-covid patients work through Part III.
6. As soon as the results of the initial examinations are available, the therapy regimen must be adapted and, as a rule, extended. The individual chapters offer more in-depth information on all aspects that were conspicuous in the initial diagnostics - therapeutically as well as with regard to further examinations.
7. Shedding-victims will find aid in the appendix (page 204)
8. those who are unsure whether their own symptoms are indicative of LC/PVS can consult the list of common symptoms (page 210). If the own complaints do not appear there, this by no means excludes LC/PVS! The disease mechanisms are too diverse and heterogeneous for this.
Finding a physician who is willing to (a) perform the required examinations and (b) implement the therapies based on the examinations can cost time and nerves. The vaccinator, for example, is regularly the wrong contact: clarifying problems that have arisen because of one's own actions does not enjoy a high priority - even more so because the liability issue for vaccination damage has not been conclusively clarified. Irrespective of this, most physicians are overburdened with the topics dealt with here. They neither know the relevant backgrounds, mechanisms, or laboratory values, nor are they familiar with most of the therapies in question. Alternative practitioners and naturopathic doctors are considerably more advanced in this regard, but often do not have the ability to use prescription drugs or imaging techniques. In quite a few cases, it may be useful to involve both parties. Tips on how to find the most suitable contacts are listed starting on p. 193.
Many of those affected, especially if the severity has led to extensive restrictions on everyday life and even incapacity to work, require medical assistance. Although the state of health can already be significantly improved by DIY measures, there are not infrequently limits to this. In addition, support from the closer social environment is valuable. Whether it is help in obtaining medication, driving services for clinic visits or even the incredibly valuable human assistance in this health and perhaps even existential crisis.
Acknowledgement
I would like to take this opportunity to express my special thanks to some of them. In general, to all the medical professionals who kept calm and followed the basic rules of their guild: Primum nihil nocere, "First do no harm." They have also used their creativity, inquiring minds, and scientific thinking to find solutions for their patients. Without their work, we would not have the tools we fortunately now have to face these challenges. Of course, this gratitude must also be extended to the many patients who have been willing to take unconventional paths, to take risks, and to take personal responsibility. Without their willingness and courage, we would still be groping in the dark in many cases. Thanks also go to my editor, Dietmar Böhmer. He has once again and as always extremely competently taken on the task of revising a critical text about corona and vaccination. Believe me, it is anything but easy these days to find people who are willing to commit themselves in this sense. The same applies to my publishing house. In the meantime, it is anything but self-evident that a book like this can be published at all. Only very few publishers dare to publish content that is contrary to the mainstream. I would also like to thank all those who have supported my work directly or indirectly. Many contributions have been a valuable help - be it empirical data, insightful studies or collaboration with other experts and networks. Special thanks also go to my wife, who not only tolerated that many evenings and free weekends together fell victim to this book, but instead supported and encouraged me in my work. Especially since I am a repeat offender in this respect, this is now the fourth book on the complex of topics Corona, Long-Covid and Post-Vaccine Syndrome. This book is then also dedicated to her. May it be a valuable help to many affected persons, colleagues and contribute to mitigate and heal the damage that has been inflicted.
Florian Schilling,
28. June 2022
„The object in life is not to be on the side of the majority, but to escape finding oneself in the ranks of the insane.”
Marc Aurel
Part I:
Main Problems in Long-Covid & Post-Vaccine syndrome
" Problems can never be solved with the same mindset, which created them."
Albert Einstein
Clot formation, myocarditis, and amyloid
Basics
The perspective in this chapter is "Spike in the vessels and its effect on our coagulation system". It is important to know that our clotting system consists of three components: (1) clotting proteins (called clotting factors), (2) blood platelets (thrombocytes and (3) anti-clotting proteins, which suppress clot formation or dissolve formed clots. A clot consists of three components: (1) platelets stored together, (2) an adhesive protein that holds them together (fibrin) and (3) trapped red blood cells (erythrocytes). After its formation, a clot is initially called a thrombus . If it is mobilized, i.e., moves away from the site of its formation, enters the arterial bloodstream and clogs vessels there, it is called an embolism . Example: A clot forms in the leg veins: this is called a leg vein thrombosis. This thrombus now floats away, reaches the pulmonary arteries via the heart, and clogs a vessel there: This is called a pulmonary embolism. The "classic" phenomena that can occur because of acute embolisms are, for example:
• Heart attack (occlusion of a coronary vessel)
• Stroke (apoplexy, insult: occlusion of a cerebral vessel)
• pulmonary embolism
• renal infarction
• Intestinal infarction
• splenic infarction
In this context, blood clotting is by no means fundamentally pathological: In the event of a vascular injury, our clotting system minimizes blood loss and accelerates the repair processes on site. As soon as these are sufficiently advanced, our organism dissolves the clotted material again. This requires cutting the adhesive protein (fibrin) that holds the thrombus together. The "scissors" that are used are an enzyme - plasmin. It breaks down the fibrin into small individual parts called D-dimers. The detection of increased D-dimers in the blood is therefore very suitable for detecting thrombus formation. Where there are D-dimers, there was/is a thrombus (or several).
Back to the spike. Spike can appear in the vasculature under two conditions: Once if the virus manages to overcome the primary barrier in the respiratory tract and enter the bloodstream. Or in the context of vaccination: after injection into the muscle (usually upper arm), the vaccine spreads locally. Some will penetrate the local muscle cells; some will be carried away via blood and lymph. Either way, whether virus or vaccine, the first tissues now at risk are the vascular inner lining (endothelium) and the heart. The former carries risks in the direction of clot formation, the latter in the form of myocarditis. It is important to note different mechanisms by which the spike, the virus, or vaccine interacts with these tissues. When we speak of "spike" in the following, it is irrelevant whether it is the natural spike on the viral envelope in severe corona disease or free spike following vaccination. Possible are:
1. virus and vaccine penetrate vascular and cardiac muscle cells, leading to their subsequent destruction.
2. this destruction leads to inflammation and activates the coagulation system; consequence: clot formation.
3. the spike directly activates clotting factors; consequence: clot formation.
4. the spike activates blood platelets (thrombocytes); consequence: clot formation.
5. the spike converts fibrinogen into amyloids, resulting in clot formation.
6. in addition, we must include different variants in the calculation, both in terms of time and type of clots:
7. thus, clot formation is (1) acute (during the disease, or immediately after vaccination), but also (2) chronic (over weeks and months), there are (3) typical clots and (4) atypical. The latter are characterized by the fact that they are not detectable in the conventional laboratory and are not degradable by the body's own mechanisms. We will now first address the mechanisms that can lead to clot formation in LC and PVS. It is important to understand these - firstly to understand what is happening in one's own body, and secondly as a prerequisite for taking and implementing the appropriate countermeasures. How clot formation can be diagnosed and treated therapeutically is the topic at the end of this chapter.
Some things we can do ourselves immediately, others will require therapeutic help. In general, cardiovascular complications (myocarditis, clots and consequent myocardial infarctions and other emboli) are significantly more common in vaccinated than in covid and LC patients. A large-scale study from Israel found that the incidence of cardiovascular emergencies correlated minimally with corona disease rates but strongly with the number of vaccinations administered. On average, the start of a vaccination campaign (basic immunization, booster, etc.) led to a 25% increase in cardiovascular emergencies - while the various Corona waves were unremarkable in this regard.12
Clot formation due to destruction of endothelial cells.
Let us start with the blood vessels. These consist of a multi-layered structure, from the inside out: (1) inner vessel skin (endothelium), (2) muscle layer, and (3) connective tissue. Endothelial cells that take up the virus or vaccine immediately begin to form spike proteins and incorporate them into their membrane. The latter is immediately noticed by patrolling immune cells, which now destroy the spike-bearing endothelial cells. As a result, inflammation develops locally, which now attracts blood platelets (thrombocytes). Their task is to cover the damaged area in the vessel wall and initiate repair processes. Depending on the extent of the defect, however, a large number of platelets stick together and a thrombus (clot), forms, which can then cause an embolism.
FIGURE 4: CLOT FORMATION DUE TO DISINTEGRATION OF THE INNER WALL OF THE BLOOD VESSEL (ENDOTHELIUM) IN THE CONTEXT OF A CORONA INFECTION; (1) VIRAL/INFECTANT ENTERS THE INNER LINING OF THE BLOOD VESSELS (ENDOTHELIUM); (2) THE ENDOTHELIAL CELLS DISPLAY THE SPIKE PROTEIN ON THEIR SURFACE; REPELLING CELLS ORDER THE ENDOTHELIUM AS INFUSED AND BIND TO IT, (4) AN IGNITION PROCESS OCCURS ON THE INNER WALL OF THE VESSEL, (5) THE IGNITION ACTIVATES BLOOD PLATELETS (THROMBOCYTES) THAT COME TOGETHER, (6) A THROMBUS FORMS, (7) THE THROMBUS DISSOLVES AND FLOATS IN THE BLOOD VESSEL, AN EMBOLISM MAY NOW OCCUR.
Most often affected by embolism are heart (occurrence of heart attack) ), lungs (pulmonary embolism ) and brain (stroke). The entire process does not take much time, we are not talking about weeks, but hours and days. That is why it is necessary to minimize this risk. This concerns the acute infection, the preparation for vaccination and in both cases the aftercare over weeks and months, because, as we have seen, the spike can remain in the body for a long time, or in the case of vaccinated people it is additionally replicated over months. Since this is a classic variant of clot formation, starting from a vascular injury (destruction of endothelial cells), the problem can be detected with conventional laboratory diagnostics (increase in D-dimer).
Direct activation of the coagulation system by the spike
We have already learned about the normal, physiological activation of the coagulation system: by vascular injury. And we have seen that virus and vaccination can induce one. But even without this detour, the spike (viral envelope or free, does not matter) can activate coagulation. And it does so in three ways:
• Activation of the coagulation cascade (hence: the coagulation proteins)13
• Activation of platelets via the complement system 14
• Elimination of the body's own anticoagulant (Heparan/Heparin)15
• The following applies: The activation of coagulation by the spike is significantly stronger than the usual endogenous coagulation.
FIGURE 5: FLUORESCENCE MICROSCOPY OF BLOOD PLATELETS (VIOLET) BEFORE (A) AND AFTER CONTACT WITH SPIKE (B): PLATELET AGGREGATION AND THUS THROMBUS FORMATION CAN BE CLEARLY SEEN; SOURCE: GROBBELAAR, 2021.13
FIGURE 6: FLUORESCENCE MICROSCOPY; ACTIVATED FIBRIN (GREEN) DURING NORMAL ACTIVATION (A) AND AFTER ACTIVATION BY SPIKE (B) SOURCE: GROBBELAAR, 2021.13
These phenomena are best known in the acute time window (whether during infection or shortly after vaccination). In severe covid courses, uncontrolled massive clot formation is one of the most common causes of death. The clot issue has also received some media attention as an acute vaccine complication - primarily AstraZeneca's vaccine. Quite unfairly, it is the only one with a reputation for being "risky" here - not because it is not, but because the RNA preparations are no less dangerous.
Spike in the bloodstream is highly dangerous - at any time. Any corona infection with viremia (SC2 in the bloodstream) and any injected vaccination based on the spike are critical.
However, we now know that these processes also take place chronically (persistence of the spike in the body), and we also know, above all, that not only classical, macroscopic thromboses and embolisms develop. These at least have the "advantage" of often (but not always) producing acute symptoms, so that one becomes aware of them. Much more problematic here are so-called microthrombi. They are orders of magnitude smaller, so cannot occlude larger vessels, and are too small to be detected by imaging (ultrasound, CT, MRI). But they do block end-stream pathways. These are the last, smallest branches of the vessels (arterioles, capillaries), where the actual exchange of substances with the tissue takes place: (micro)nutrients and oxygen leave the capillaries, waste and CO2 are taken up from the tissue. With their few micrometres (millionths of a meter) in diameter, the capillaries form a gigantic surface area - the capillaries of the lungs alone add up to 300 m2 of surface area to ensure the exchange of substances.
FIGURE 7: CAPILLARIES CONNECT THE ARTERIAL AND VENOUS PATHWAYS AND EXCHANGE SUBSTANCES WITH THE TISSUE; SCHEMATIC (LEFT) AND CAPILLARY NETWORK IN THE BRAIN (RIGHT).
Microcirculatory disturbances caused by microthrombi can add up in the medium and long term, lead to persistent tissue damage, and thus cause just as big or even bigger problems than classic, large clots. Some tissues recover from persistent under perfusion (e.g., muscle or bone tissue, liver tissue, mucous membranes) - but others do not, especially nerve tissue. The organs most affected are those with dense capillary networks: brain, lungs, and kidneys. Neurological symptoms (brain fog, dizziness , tinnitus), but also persistent respiratory problems (especially shortness of breath ) are not without reason among the most common complaints in LC and PVS. Further, frequently affected tissues are:
• Musculature: muscle weakness, muscle pain, stiffness
• Peripheral nerves: sensitivity disorders (reduced sensation, false sensations such as tingling and formication), pain in the nerve course (neuralgia), signs of paralysis
FIGURE 8: BLOOD FLOW IN NORMAL CONDITION (A) AND AFTER ADDITION OF SPIKE PROTEIN (B); SOURCE: ZHENG ET AL.,2021.15
Diagnostically, it is fortunately easy to detect this variant of clot formation: An elevation of the D-dimer is sufficient to provide evidence.
Spike can lead to the formation of amyloids and prions.
Unfortunately, there is more to the topic of clot formation. So far, we have dealt with typical clots - typical in the sense that the formation and type of clots correspond to those otherwise known. However, the spike can also cause atypical clots via amyloids which cannot be detected by conventional laboratory tests and are difficult for the body to break down. This brings us to the first question: what are amyloids - and what can they do?
Amyloids are misfolded proteins or protein fragments. They are difficult for the body to break down and tend to be deposited in various organs and tissues (for example, in the heart muscle). This is known as amyloidosis. Perhaps the best-known disease involving amyloid deposits is Alzheimer's disease (deposition of amyloid beta, Aβ).
FIGURE 9: HEALTHY TISSUE (A), AMYLOID DEPOSITS (B) AND THE RESULTING PROGRESSIVE DESTRUCTION OF THE BRAIN IN THE FORM OF ALZHEIMER'S DISEASE (C); SOURCE: LOOF (2019).16
