Objective Pharmaceutics: A Comprehensive Compilation of Questions and Answers for Pharmaceutics Exam Prep E-Book

Beena Kumari

• Herausgeber: Bentham Science Publishers
• Kategorie: Lebensstil
• Sprache: Englisch
• Veröffentlichungsjahr: 2024

Seitenzahl: 296

Beschreibung

Unlock success in pharmaceutical exams with Objective Pharmaceutics: A Comprehensive Compilation of Questions and Answers for Pharmaceutics Exam Prep. This guide is meticulously crafted to tackle the challenges of pharmaceutics exams through a diverse range of questions. It covers multiple choice questions, concise one-liners, and true/false statements, mirroring the formats commonly found in drug inspector, pharmacist, GPAT, nursing exams, and more.
Key Features:
Exam-Ready Questions: Prepare for a variety of medical exams with more than 2000 carefully curated questions.
Diverse Testing Formats: Master multiple choice, one-liner, and true/false questions for a well-rounded exam readiness.
Broad Assessment: Tailored for drug inspectors, pharmacists, GPAT aspirants, and other medical professionals.
Build Thinking Capabilities: Progress from simple to challenging questions, enhancing critical thinking skills.
This thorough guide empowers you to learn the key topics in pharmaceutics and navigate the most challenging questions in your exam prep journey.
Readership
Pharma and GPAT exam students, inspectors and instructors

Leseprobe

Table of Contents

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General:

PREFACE

Multiple Choice Questions

One Liner Questions

True/False Statements

Bibliography

Objective Pharmaceutics: A Comprehensive Compilation of Questions and Answers for Pharmaceutics Exam Prep

Authored By

Beena Kumari

Department of Pharmaceutical Sciences

Indira Gandhi University

Rewari, Haryana, India

Sunil Kumar

Department of Pharmaceutical Sciences

Indira Gandhi University

Rewari, Haryana, India

Sandeep Kumar Kailey

National Institute of Pharmaceutical

Education and Research

Mohali, Punjab, India

&

Manish Kumar

College of Pharmacy

Maharishi Markandeshwar (Deemed to be University)

Mullana, Ambala, India

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PREFACE

The main objective of this book is to explain the trend of objective questions of Pharmaceutics including multiple choice questions, one liner, and true and false statements. This compilation provides the most probable questions of upcoming examinations like drug inspector, pharmacist, GPAT, nursing exams, and all the exams of medical lines. These questions range from the very simple to the fairly difficult ones in order to enhance thinking capabilities.

This book was written with a series of learning objectives in mind. After reading this book, the student should be able to clear many exams. Above all, we thank the Almighty for getting us towards the fulfillment of a long cherished dream.

Beena Kumari Department of Pharmaceutical Sciences Indira Gandhi University Rewari, Haryana, IndiaSunil Kumar Department of Pharmaceutical Sciences Indira Gandhi University Rewari, Haryana, IndiaSandeep Kumar Kailey National Institute of Pharmaceutical Education and Research Mohali, Punjab, India &Manish Kumar College of Pharmacy

Multiple Choice Questions

Beena Kumari1,Sunil Kumar1,Sandeep Kumar Kailey1,Manish Kumar1

1 Department of Pharmaceutical Sciences Indira Gandhi University Meerpur, Rewari (Haryana) India-123401

Identify the wrong statement for pyrogens: They are water-soluble components that are metabolic products of growing bacteria.Pyrogens are lipopolysaccharide compounds that are produced by gram-negative bacteria.LAL or BET (bacterial endotoxin test) represents the gelling property of pyrogens with RBCs and is a common test for pyrogen.They can be destroyed by autoclaving and gaseous sterilization.

Ans. d

2. The Brownian motion is due to: Impact of molecules of the dispersion medium on the colloidal particles.Convective currents.Temperature fluctuation within the liquid phase.Attraction and repulsion between charges on the colloidal particles.

Ans. a

3. Which of the following drug delivery systems comprises a hydrophobic core and a hydrophilic surface? LiposomesMicellesReverse micellesNone of the above.

Ans. b

4. The simplest way to check whether a system is a colloid is by using: Brownian movementTyndall effectElectrodialysisFinding out particle size

Ans. b

5. Gold numbers of protective colloids A, B, C, and D are 0.50, 0.01, 0.10, and 0.005, respectively. Which of them has the highest protective powers? ABCD

Ans. d

6. The random movement of particles i.e., Brownian movement which is responsible for light scattering, resistant to sedimentation under gravity and rapid diffusion is exhibited by the particle less than 1 nm2 µm10 µm5 µm

Ans. b

7. The factors which are responsible for the stability of lyophilic sols are: Size of the colloidal particlesCharge of the colloidal particlesCharge and solvation of the colloidal particlesSolvation of the colloidal particles

Ans. c

8. Which of the following methods of distillation is also known as high vacuum distillation? Steam DistillationAzeotropic DistillationMolecular DistillationExtractive distillation

Ans. c

9. The graph between rate or shear and shear stress is called as RheogramViscogramDeltagramFluidgram

Ans. a

10. Which flow is also called Bingham’s Flow/bodies? PlasticPseudoplasticDilatantThixotropic

Ans. a

11. Which pair of the flow represents time-dependent non-Newtonian flow? Plastic: ThixotropyPseudoplastic: DilatantThixotropy: RheopexyAnti-thixotropic: Rheopexy

Ans. a

12. Yield value is a characteristic of which flow? Plastic fluidsDilatant fluidsNewtonian fluidsPseudoplastic fluids

Ans. a

13. Which flow is called the opposite of dilatant fluid? PlasticPseudoplasticThixotropicRheopexy

Ans. b

14. Which of the following values for contact angle with water corresponds to a hydrophobic drug particle? 45°120°0°None of the above.

Ans. b

15. Cone and plate viscometers are what types of viscometers? CapillaryDensity-dependent viscometerRotational viscometersNone

Ans. c

16. Brookfield viscometer works on the principle of Cup and bob viscometerCone & plate viscometerDensity-dependent viscometerRotational viscometers

Ans. d

17. Which one of the following is the test for clarity in parenteral preparations? LAL testLeak testWater Attack testParticulate matter test

Ans. d

18. Which of the following is not a method for the destruction of pyrogen? DistillationUltrafiltrationDesiccationAdsorbents

Ans. c

19.In vivo test for pyrogen is done on which animal? RatMiceRabbitGuinea pigs

Ans. c

20. Match the correct pair Leak test: to detect PyrogenClarity test: to detect incompletely sealed ampouleWater attack test: Particulate matterNone of the above

Ans. d

21. In freeze-drying, the moisture content in the finished content is less than 1%5%10%12%

Ans. a

22. Clarification/polishing of solution requires removal of particulate matter down to at least 3 µm0.3 µm10 µm5 µm

Ans. a

23. The particle size visible to the eye should be greater than 10 µm40 µm80 µm100µm

Ans. b

24. The LAL test results in Change in color of the reactionFormation of precipitateFormation of turbidityFormation of gel

Ans. d

25. Air velocity in HEPA filters is? 100± 20 ft/min90± 20 ft/min80± 20 ft/min50± 20 ft/min

Ans. a

26. A clean room for parenteral preparations means? Class 10 roomClass 100 roomClass 1000 roomClass 10000 room

Ans. b

27. For aseptic filling or areas, which work environment is desired? Class 10 roomClass 100 roomClass 1000 roomClass 10000 room

Ans. b

28. Various classrooms are defined by no. of particle limits in it and the particle size is 1 µm or greater0.3 µm and grater0.5 µm and greater0.22 µm and greater

Ans. c

29. Rinsing of equipment, new glass containers, and rubber closures is done by SFWIWFIDistilled waterPurified water

Ans. b

30. Removal of compounds by sorption and vapour transfer is commonly problem with Glass containerPlastic containerRubber closuresAll of above

Ans. c

31. Water attack test is done for which type of glass container? Type IType IIType IIIType IV

Ans. b

32. A water attack test is done for containers that are exposed to Silicone fluidSulphur dioxideSodaSodium hydroxide

Ans. b

33. Which glass is used for all types of parenteral preparations Type IType IIType IIIType IV

Ans. a

34. A powdered glass test is done for all excluded Type IType IIType IIIType IV

Ans. b

35. Sorption is maximum with the plastic container PolyethylenePolystyrenePolyamidePolypropylene

Ans. c

36. Permeability for gases or water vapours is least with which plastic container? PolyethylenePolystyrenePolyamidePolypropylene and polyethylene-polypropylene co-polymer

Ans. d

37. Plastic containers or disposable plastic syringes are sterilized by Moist heatEthylene oxideMoist heatFiltration

Ans. b

38. Toxicity test for which material is done by implanting small pieces of the material intramuscularly in rabbits? GlassPlasticRubberAll

Ans. b

39. Two solutions are separated by a semipermeable membrane and the movement of water between them is given by OsmolarityOsmolalityTonicityMolarity

Ans. c

40. The osmolarity of blood is 260-280 mOsm280-300 mOsm300-350 mOsm200-250 mOsm

Ans. b

41. The tonicity adjuster used in parenteral preparation include GlycerinGlycinePolysorbatePEG

Ans. a

42. The non-electrolytes: electrolyte substances used as tonicity adjuster Lactose: GlycerinLactose: NaClGlycerin: MannitolSodium Sulfate: NaCl

Ans. b

43. Permeability for gases or water vapours is the maximum with which plastic container? PolyethylenePolystyrenePolyamidePolypropylene

Ans. b

44. The limit for conductance: Total solid content: endotoxin content for WFI is 1 ppm: 10 micromho: pyrogen free10 ppm: 1 micromho: pyrogen free10 ppm: 10 micromho: pyrogen free10 ppm: 0.1 micromho: pyrogen free

Ans. b

45. Which of the following is not used as a bulking agent in freeze-drying? NaClMannitolTrehalosePEG

Ans. d

46. The particle size of the droplet in parenteral emulsion is 1-5 µmLess than 1 µm10-20 µm5-10 µm

Ans. a

47. The rate of absorption of the drug will be fastest: slowest through which route? Intramuscular: SubcutaneousSubcutaneous: IntravenousIntravenous: IntramuscularIntravenous: Subcutaneous

Ans. d

48. The first dosage form that is employed in clinical trials for a new drug? TabletsSolutionsInjectionsCapsules

Ans. c

49. Only aqueous solutions are required for which route? IntramuscularIntravenousSubcutaneousAll

Ans. b

50. The best route for oleaginous suspensions and oleaginous solutions is IntramuscularIntravenousSubcutaneousAll

Ans. a

51. The requirement of isotonicity is a must in Intramuscular routeSubcutaneous routeIntravenous routeAll

Ans. c

52. In the Drug and Cosmetics Act and Rules, a list of substances that should be sold by retail only on prescription of a registered practitioner is given in Schedule HSchedule VSchedule XSchedule Q

Ans. a

53. Certain suspensions with a high percentage of dispersed solids exhibit an increase in resistance to flow with increasing rates of shear. Such systems actually increase in volume when sheared and are termed as ThixotropicDilatantPlasticNewtonian

Ans. b

54. The rancidity of fat is due to OxidationSaponificationHydrolysisNeutralization

Ans. a

55. The area under the serum concentration-time curve of the drug represents: The biological half-life of the drug.The amount of drug in the original dosage fromThe amount of drug absorbed.The amount of drug excreted in the urine.

Ans. c

56. One thousand nanograms are equal to one CentigramPicogramMilligramMicrogram

Ans. d

57. Osmolality measures the total number of particles dissolved in a _______ of water and depends on the electrolytic nature of the solute. KilogramKilolitreLitreSpecified quantity

Ans. a

58. The loading dose of a drug is based on the Time taken for complete eliminationPercentage of drug excreted unchanged in urinePercentage of drug bound to plasma proteinThe apparent volume of distribution and the desired drug concentration in plasma

Ans. d

59. Conformation of drugs is commonly determined by: NMRNMIMass spectrometrypH determination

Ans. a

60. Bubble point test is done to determine The surface tension of the liquid in capillary tubesThe viscosity of the liquid in ampoulesThe ph of a 1% solutionThe volume of the solution stored in a specified container

Ans. a

61. Benzoyl peroxide is A astringentA emollientA preservativeA keratolytic

Ans. d

62. Water for injection differs from sterile distilled water as it is free from: carbon dioxidePyrogensPreservativesAntioxidant

Ans. b

63. Sterility test for the materials meant for surgical suture requires incubation for 7 days14 days21 days28 days

Ans. b

64. According to pH partition theory, a weakly acidic drug will most likely be absorbed from the stomach because the drug which exists primarily in the un-ionised, more lipid soluble formionised, more water-soluble formform of weak acid and more soluble in acid mediaionic form of the drug which facilitates diffusion

Ans. a

65. The region of the electromagnetic spectrum below 200 nm is known as vacuum ultra violet regionfar UV regionlow UV regionmicrowave region

Ans. b

66. Rotosort is equipment used to separate unfilled capsulesto fix the cap and body of the capsules after fillingto separate the improper tabletsto adjust the required compression for the tablets

Ans. a

67. As per G.M.P. permitted limit of slid contents in water for injection is: 100 ppm1.0 ppm0.1 ppm10.0 ppm

Ans. d

68. Green bones are used for the preparation of a gelatin of the type ABCA and B

Ans. b

69. In capsules, ROTOFIL is used for filling: Powderspelletsliquidscorrosive liquids

Ans. b

70. Among the propellants used in aerosols, one of the following is used for topical pharmaceutical aerosols. Trichloro mono fluoro methaneDichloro difluoro methaneDichloro tetra fluoro ethanePropane

Ans. d

71. Liposomes are: uni- or multilayered vesicles of phospholipidsType of enzymesfibrinopeptidesPolymeric vesicles

Ans. a

72. Disposable syringes are made up of: PolypropyleneTransparent polystyreneGlassPoly Tetra Chloro Ethylene

Ans. b

73. Which one of the following devices is used to increase the efficiency of drug delivery via aerosols? Tube spacerMetered valveActuatorPressure valve

Ans. b

74. Dose dumping is a problem in the formulation of: Compressed tabletsSuppositoriesSoft gelatin capsuleControlled-release drug products

Ans. d

75. The initial distribution of a drug into the tissue is determined chiefly by: Rate of blood flow to the tissuePlasma protein binding of the drugAffinity for the tissueStomach emptying time

Ans. a

76. One of the substances listed is muco-adhesive. AcaciaS.C.M.C.PEGSaccharin

Ans. b

77. Choose the correct pH of the lachrymal fluid: 8.06.27.49.0

Ans. c

78. The dip tube in the aerosol container is made from one of the following. Choose the correct one: PolypropyleneGlassStainless steelAluminium

Ans. a

79. The units of measurement for conductance is OhmsAmperesMhosMilli volts

Ans. c

80. The shells of soft gelatin capsules are made up of elastic or plastic-like, by the addition of SorbitolPovidonePEGHPMC

Ans. a

81. The rate of drug bioavailability is most rapid when the drug is formulated as: Controlled release productHard gelatin capsuleTabletSolution

Ans. d

82. The Schedule in Drugs and Cosmetics Act that deals with the requirements and guidelines for clinical trials, import, and manufacture of new drugs is Schedule ‘O’Schedule ‘M’Schedule ‘F’Schedule ‘Y’

Ans. d

83. The measure of cohesive strength of the cross-linking that occurs between gelatin Molecules and is proportional to the molecular weight of gelatin is so-called Bloom StrengthViscositySurface tensionPartition coefficient

Ans. a

84. If Carr’s index of a powder is 10% then the type of powder flow is: PoorExcellentvery poorgood

Ans. b

85. Mixing of semisolids is carried out using Double cone mixerRotating cube mixerPlanetary mixerFluidized bed mixer

Ans. c

86. A list of diseases and ailments that a drug may not purport to prevent or cure or make claims to prevent or cure under the Drugs and Cosmetics Rule 1945 is given under: Schedule JSchedule KSchedule MSchedule P

Ans. a

87. Cyclic oligomers of glucose form water-soluble inclusion complexes, which are biocompatible and improve the bioavailability of drugs LiposomeDendrimersNiosomesCyclodextrin

Ans. d

88. Draves test’ is associated with measuring the efficiency of: DetergentWetting agentsSuspending agentsAdsorbent

Ans. b

89. As per the Drugs and Cosmetics Act and Rules, the Good Manufacturing Practice for drugs is included under Schedule WPSM

Ans. d

90. In the IR spectrum, the functional group region is from 4000 cm-1to 900 cm-14000 cm-1 to 1400 cm-11400 cm-1 to 900 cm-140000 cm-1 to 660 cm-1

Ans. b

91. Thiomersal belongs to which category of preservative? AcidicNeutralMercurialQuaternary ammonium compound

Ans. c

92. Benzalkonium chloride is categorized as: Acidic preservativeNeutral preservativeMercurial preservativeQuaternary ammonium compounds

Ans. d

93. To increase the viscosity of the liquid, which of the following agents are used? PVPMethyl CelluloseSodium Carboxy Methyl CelluloseAll the above

Ans. c

94. In the formulation of suspensions, generally which types of drugs are selected? HydrophilicHydrophobicBothNone

Ans. c

95. Identity the false statement for cyclodextrins: The interior of the cavity has –CH2 groups while – OH groups are at the exterior.They are macrocyclic hosts composed of α 1,4 linkage of glucopyranose.Partial methylation of OH grp in CD decreases the aqueous solubility.Glucopyranose units form an intramolecular cavity of truncated cone which dissolves hydrophobic compounds.

Ans. c

96. Which of the following is a solubilizing agent for gelatin? LecithinPEGHCHOFumaric acid

Ans. d

97. Perfect wetting of hydrophobic compound with solvent occurs if the contact angle is: 90045000180

Ans. c

98. The hardness of the gelatin shell is the ratio of the dry weight of the plasticizer/dry weight of gelatin is 0.8 then the gelatin shell will be: SoftModerateHardVery soft

Ans. a

99. Liposomes are: Nonionic surfactant meant for targeted drug delivery systems.Branched anionic polymers are meant for DNA transfer.Phospholipids bilayer vesicles are meant for targeted drug delivery systems.Biodegradable polymers are meant for the sustained release of drugs.

Ans. c

100. Which of the non-Newtonian fluid does not exhibit thixotrophy? PlasticPseudo plasticDilatants/rheopexyBoth a and b

Ans. a

101. The Isoelectric point of Type II gelatin is 94.78.57.5

Ans. b

102. Base absorption in SGC is mainly calculated for: EmulsionsSuspensionsAqueous solutionsPowders

Ans. b

103. Moisture content in the gelatin shell is < 2%5%10-15%15-20%

Ans. c

104. The wetting agent used for SGC is Sorbitol.Lecithin.HCHO.Fumaric acid.

Ans. b

105. Which of the following treatment can retard the solubility/dissolution of the gelatin shell? PEGSO2 treatmentHCHOFumaric acid

Ans. c

106. Antithixotropy is exhibited by: Deflocculated suspensionsFlocculated suspensionsPolymersClay suspension

Ans. b

107. Iron content in gelatin shell should not be more ………….. as it can cause color reaction 1 ppm5 ppm10 ppm15 ppm

Ans. d

108. The maximum volume in ml that can be filled in gelatin shell is 0.5 ml1 ml0.75 ml2 ml

Ans. c

109. Which of the following polymers can be used for enteric coating? GelatinMethyl celluloseSodium CMCShellac

Ans. d

110. Which of the polymer is water-soluble? Ethyl cellulosePolyamideMethyl celluloseCellulose nitrate

Ans. c

111. Viscosity of 6.66% gelatin solution in water at 600C ranges from 1-1.5 centipoises2.5-4.5 centipoises4.5-6.5 centipoises6.5-8.5 centipoises

Ans. b

112. The largest capsule for humans size is 000051

Ans. b

113. Bloom strength which measures cohesive strength/ internal cross-linking varies from 50-100 gm100-150 gm150-250 gm300-400 gm

Ans. c

114. Brookfield viscometer is Cup and bob type.Cone and plate type.Falling sphere type.Capillary type.

Ans. b

115. Ultrafilteraion have membrane filter size 0.1-1µm0.01 – 0.1µm0.001 – 0.01 µm0.0001 – 0.001 µm

Ans. c

116. Kraft point represents pHConcentrationTemperatureTime

Ans. b

117. Krafft point is related to Anionic surfactantCationic surfactantNonionic surfactantBoth a and b

Ans. c

118. Which of the following is called shear thinning system? PlasticPseudo plasticDilatantsNewtonian

Ans. b

119. Yield value is a characteristic of: Plastic flowPseudo plasticDilatantsNewtonian

Ans. d

120. Condensation and dispersion methods are employed for the preparation of Lyophilic colloidLyophobic colloidAssociation colloidBoth a and b

Ans. b

121. Hardy Schulze rule is for Lyophilic colloidLyophobic colloidAssociation colloidBoth band c

Ans. b

122. Which of the following acts as a co-solvent in parenteral’s preparations? Benzyl alcoholIsopropyl myristateDioxolanesEthyl oleate

Ans. c

123. β-cyclodextrins have how many glucopyranose units? 6789

Ans. b

124. Which of the cyclodextrins has the largest intramolecular cavity? αβγAll have the same cavity size

Ans. c

125. Different polymorphic forms can be obtained by: Varying storage temperatureVarying recrystallization solventVarying cooling ratesAll

Ans. d

126. Polymorphism can not be studied by: X-ray diffractionSolubility analysisDSC and SEMKarl Fischer titration

Ans. d

127. Solubility analysis can be done by: HPLCUV spectrometryGas chromatographyFluorescence spectroscopyAll

Ans. e

128. Which polymorphic form of Chloramphenicol is more soluble? ABCD

Ans. b

129. Moisture levels in drugs can be monitored by: Karl Fischer titrationGas chromatographyThermogravimetric analysisAll

Ans. c

130. Sequestration is Chelate and metal ions form lipid soluble complexChelate and metal ions form water-soluble complexChelate and metal ions form a partially water-soluble complexChelate and metal ions form a partially lipid-soluble complex

Ans. c

131. Which of the following antineoplastic agents exhibit their action by complex formation with DNA base pair? TopotecanActinomycin DHydroxy ureaProcarbazine

Ans. d

132. Which of the following agents can cause incompatibility due to complex formation with phenols and carboxylic acids grp in the ingredients? LecithinPolysorbatesPEGBoth b and c

Ans. b

133. In the formulation of suspensions for soft gelatin capsules encapsulation base adsorption of the solid to be suspended is expressed as: The number of grams of liquid base required to produce capsulatable mixture when mixed with 1 gm of solid.The number of ml of liquid base required to produce capsulatable mixture when mixed with 1 gm of solid.The number of grams of solid base required to produce capsulatable mixture when mixed with 1 gm of solid.The number of milligrams of liquid base required to produce capsulatable mixture when mixed with 10 gm of solid.

Ans. b

134. According to I.P sparingly soluble solute is soluble in how many parts of solvent means Less than 1 part1-10 part30-100 part100-1000 part

Ans. c

135. Which form of cocoa butter is more stable? αβγβ1

Ans. b

136. The ratio of the void volume to the bulk volume of the packing of the powder is called Porosity.True density.Granular density.Bulk density.

Ans. a

137. A co-solvent used in the preparation of parenteral products is: Benzyl alcoholMethyl alcoholDimethyl acetamidePhenol

Ans. c

138. Cohesive forces are the forces acting Between molecules of different materialsBetween molecules of the same materialBetween water and glass capillary tubeDue to gravity

Ans. b

139. Measuring zeta potential is useful in determining which property of a liquid formulation? ViscosityStabilitySolubilityParticle size

Ans. b

140. A surfactant with a very large Hydrophile-Lipophile Balance (HLB) value (e.g. 40 e.g. SLS/SDS) is expected to function as a: Anti-foaming agentWater in oil (w/o) emulsifierOil in water (o/w) emulsifierSolubility enhancer

Ans. d

141. An amphoteric surfactant used in pharmaceutical disperse systems is: Bile saltsLecithinSorbitan monolaurateSorbitan monostearate

Ans. b

142. In the preparation of suppositories, macrogols used are: Water soluble baseHydrocarbon baseAbsorption baseButylated hydroxytoluene

Ans. a

143. The antioxidant most commonly used in the formulation of non-aqueous parenteral preparation is Thioglycolic acidAscorbic acidSodium metabisulphiteBHT

Ans. d

144. With regards to the sterile water for injection, I.P, the residue on evaporation limit is Higher than water for injection.Lower than water for injection.Same as that of water for injection.No such standard in the monograph.

Ans. a

145. What is the best description of blood? SolFoamSolutionAerosol

Ans. a

146. Which of the following is not property of Colloids Scatter lightDoes not settleHigh diffusionEvolve heat

Ans. d

147. When colloids are subjected to an electrical field particles move towards an electrode and precipitate. Name the process. PeptizationElectrophoresisBrownian movementTyndal effect

Ans. b

148. Lyophilic colloids that show the property of protecting lyophobic colloids are also called: Protective colloids.Non-Protective colloids.Both protective and non-protective.Associated colloids.

Ans. a

149. Ferric hydroxide is a negative sol, which of the following electrolytes will coagulate it most? FeCl3CaCO3BaSO4NaCl

Ans. a

150. Which statement describes coagulation value? Maximum amount (in millimoles) of electrolyte required to cause complete coagulation in one-kilo gram of colloidal solution.Minimum amount (in kg) of electrolyte required to cause complete coagulation in one litre colloidal solution.Maximum amount (in millimoles) of electrolyte required to cause complete coagulation in one litre colloidal solution.Minimum amount (in millimoles) of electrolyte required to cause complete coagulation in one litre colloidal solution.

Ans. d

151. The process in which a colloid is placed inside a bag of semi-permeable membrane like cellophane or parchment paper which permits ions and not colloids to pass through, is called: Peptization.Emulsion.Coagulation.Dialysis.

Ans. d

152. The protecting power of lyophilic colloidal sol is expressed in terms of: CMCOxidation numberCoagulation valueGold number

Ans. d

153. Empty gelatin capsules are stored at temperature. 21-24°C25-30°C8-25°C2-8°C

Ans. a

154. Match the following examples with their respective flow: Newtonian flowPlastic flowPseudoplastic flowDilatent Flow Solution of proteins, blood, polymeric solutions of tragacanth or cellulose.Semisolids like gels, ointments, creams, ointment, Ketchup flow from bottles, conc. Flocculated suspension.Glycerine solution, alcohol solution or simple solution.Deflocculated Suspensions having high conc. Of solids.

Ans. 1c, 2b, 3a, 4d

155. Match the following type of flow: Anti-thixotropyThixotropyPseudoplastic flowDilatant Flow Shear thinning systemShear thickening systemGel to sol transformationReversible time-dependent increase in viscosity at a particular rate of shear

Ans. 1d, 2c, 3a, 4b

156. Match the following type of flow: ThixotropyPseudoplastic flowDilatent FlowNewtonian flowPlastic flow Viscosity is independent of the rate of shearAn increase in the rate of shear the material becomes more viscous and attains paste-like consistencyAn increase in shear rate results decrease in viscosityRequires yield value before any rheological flowReversible time-dependent increase or decrease in viscosity.

Ans. 1e, 2c, 3b, 4a, 5d

157. Match the following types of viscometers with their examples: Capillarity viscometersDensity-dependent viscometersRotational viscometers Cup and bob viscometersFalling sphere viscometerOstwald viscometer

Ans. 1c, 2b, 3a

158. Match the following NDDS with their composition part: LiposomesNiosomesDendrimersLipoproteins Endogenous monolayer vesicle of lipid with apoprotein moietyBranched tree-like polymeric structureSelf-Assembled Non-ionic surfactant vesiclesD. Self-assembled Phospholipid bilayer vesicles

Ans. 1d, 2c, 3b, 4a

159. Match the following non-ionic surfactants with their chemical composition: Pluronics or PoloxamersCarbowaxesTweensSpansPromulgens Co-polymer of Polyoxyethylene and polyoxypropyleneHigh molecular weight. polyethylenegylycolsPolyoxyethylene ethers of Sorbitan estersFatty acid ester of sorbitolA mixture of Fatty alcohols and their ethoxylates

Ans. a.i, b. ii, c. iii, d. iv, e v

160. Which of the following Propellant is Hydrochlorofluorocarbon (HCFC)? 1142271211

Ans. b

161. Which of the following are compressed gases? NitrogenNitrous oxidePropaneAll of the above

Ans. d

162. Which of the compressed gases are soluble in water-insoluble? Nitrogen: ArgonCarbon dioxide: Nitrous oxidePropane: IsobutaneCFC: n-Butane

Ans. a

163. Which of the compressed gases are soluble in water? Nitrogen: ArgonCarbon dioxide: Nitrous oxidePropane: IsobutaneCFC: n-Butane

Ans. b

164. In number based three-digit system, CFC or fluoro hydrocarbons the first, second and third digit represents: No. of C atoms minus one: No. of H atoms plus one: No. of F atomsNo. of C atoms minus one: No. of F atoms: No. of H atoms plusNo. of F atoms: No. of C atoms minus: one No. of H atoms plus oneNo. of F atoms: one: No. of C atoms minus one: No. of H atoms plus

Ans. a

165. In propellant 12, the total no. of C: H: F: Cl atoms present respectively in the order as mentioned above: 1:0:2:22:0:1:22:1:0:21:1:2:2

Ans. a

166. As per three-digit numeric system, the propellant 114 is: DichlorodifluoromethaneTetrafluorodichloroethaneTetrafluoromonochloroethaneTetrafluoroethane

Ans. b

167. Aerosol formulations are tested on the temperature. 37˚C21˚C25˚C40˚C

Ans. b

168. The particle size in suspension aerosols should be less than …. to prevent clogging of the value and efficient delivery to lungs Less than 10 µmLess than 20 µmLess than 50 µmLess than 100 µm

Ans. a

169. The spray pattern is determined by: Internal pressureProduct-Propellant ratioViscosity of the productAll

Ans. d

170. What is the temperature used in cold filling of aerosols? -10°C to – 20° C0°C to – 20° C-30°C to – 40° CNone

Ans. c

171. The product dispensed by aerosol is foam, then propellant conc.: type of propellant used are: Less than 5%: HydrocarbonsLess than 50%: HydrocarbonsLess than 90%: CFCLess than 50%: CFC

Ans. a

172. Which pair of the following CFC or CFHC-based propellant has the highest vapour pressure (so dispense the product in a fine spray of smaller particle size) and lowest vapour pressure (dispense the product in coarse particle size in a stream)? 12:1112:11411:15212:152

Ans. a

173. The hydrocarbon-based propellant uses the numerical designation A-17: A-31: A-108, to identify which of the following propellants respectively? N-Butane: Isobutane: PropaneIsobutane: Propane N-ButaneN-Butane: Propane IsobutaneIsobutane: Propane: N-Butane

Ans. a

174. In hydrocarbon-based propellant, the no. A-17, 31, 108 denotes which of the parameters at 21˚C? Boling point liquidVapour pressure liquidDensity of the liquidViscosity of the liquid

Ans. b

175. The propellant that does not produce any chilling effect and is therefore applicable to topical preparation: HydrocarbonsCFCCompressed gasesBoth a and c

Ans. c

176. Which of the following containers undergoes corrosion in the presence of anhydrous alcohol by chemically producing H2 gas which ruptures the container? GlassTinAluminumEpoxy/ vinyl-coated metals

Ans. c

177. Which of the following containers can be used to prevent corrosion in low-pH preparations: GlassTinAluminumEpoxy/vinyl-coated metals

Ans. d

178. Mention the following techniques or methods used in the quality control of aerosols with their application: Gas Chromatography and Infra-red spectroscopyKarl Fischer MethodDixon-MethodCascade Impactor and Dynamic Light Scattering (DLS)Tag open cup testDOP specification

Ans. a. Identification of Propellant b. Moisture content determination, c. Analysis of spray patterns d. Particle size determination e. Flash point determination f. Transportation or shipment specification regulations

179. What type of colloid is an aerosol? Solid in gasGas in solid or fluidFluid in gasFluid or solid in gas

Ans. c

180. What is the size of the particles categorised as aerosols? Greater than 1 micronLess than 1 micronBetween 0.01-1 micronLess than 0.01 micron

Ans. c

181. For pressurised metered dose inhalers (pMDI), which of the following is NOT true? pMDI emits aerosols at high velocitypMDI uses liquefied gases as propellantspMDI may be formulated as solutions or suspensionspMDI cannot be used with spacers

Ans. d

182. Which of the following is NOT true of a typical dry powder inhaler (DPI)? DPI is difficult for patients to coordinate.DPI requires high-velocity airflow through the device to aerosolise the powder.DPI liberates fine powder particles from carrier particles upon inhalation.DPI may contain the powder in a unit dose or reservoir.

Ans. a

183. Which of the following is NOT true of jet nebulisers? Jet nebulisers produce mists.Jet nebulisers use high-velocity gas flows to generate the Venturi effect to draw solution into the airflow.Jet nebulisers induce a decrease in the temperature of the nebuliser solution during the operation.Jet nebulisers use ultrasonic forces to produce the aerosol.

Ans. d

184. Match the correct pair regarding the weight of the suppositories used for adults in the case of Rectum: Vaginal: Urethral respectively? 4g:3g: 2g2g:3g: 4g3g:2g: 4g4g:2g: 2g

Ans. b

185. Match the correct pair regarding the shape of the suppositories used for adults in the case of Rectum: Vaginal: Urethral respectively? Pencil: Globular: TorpedoTorpedo: Globular: PencilGlobular: Torpedo: PencilPencil: torpedo: Oval

Ans. b

186. Which of the following suppositories is the highest in length? RectumVaginalUrethralNasal

Ans. c

187. The mass of potassium hydroxide in milligrams that is required to neutralize the free acid in one gram of chemical substance is called: Acid valueSaponification valueHydroxyl valueIodine value

Ans. a

188. The number of milligrams of potassium hydroxide required to neutralize the acetic acid taken up on acetylation of one gram of a chemical substance is called: Acid valueSaponification valueHydroxyl valueIodine value

Ans. c

189. Which value measures the average molecular weight of all the fatty acids present? Acid valueSaponification valueHydroxyl valueIodine value

Ans. b

190. Which value measure of the average molecular weight of all the fatty acids present: Degree of unsaturation? Acid valueSaponification valueHydroxyl valueIodine value

Ans. d

191. Which value should be zero or near to zero in the suppository base to prevent irritation with mucous membranes? Acid valueSaponification valueHydroxyl valueIodine value

Ans. a

192. Rancidity is a common problem in which suppository base? Water dispersible basesWater soluble basesLipophilic basesAll

Ans. c

193. Match the correct pair of non-ionic surfactants with their chemical composition of Spans: Tweens: Myrj respectively. Polyoxyethylene stearates: Polyoxyethylene sorbitan fatty acids esters: Sorbitan fatty acid estersSorbitan fatty acid esters: Polyoxyethylene stearates: Polyoxyethylene sorbitan fatty acids estersPolyoxyethylene sorbitan fatty acids esters: Sorbitan fatty acid esters: Polyoxyethylene stearatesSorbitan fatty acid esters: Polyoxyethylene sorbitan fatty acids esters ; Polyoxyethylene stearates

Ans. d

194. Which of the following suppository bases are also called carbowaxes or macrogols?