Rossi's Principles of Transfusion Medicine E-Book

• Herausgeber: John Wiley & Sons
• Kategorie: Fachliteratur
• Sprache: Englisch

Seitenzahl: 3238

Veröffentlichungsjahr: 2016

Beschreibung

Rossi's Principles of Transfusion Medicine is the most comprehensive and practical reference on transfusion science and medicine available

• Led by a world class Editor team, including two past-presidents of AABB, a past- President of the American Board of Pathology and members of the FDA Blood Products Advisory Committee , and international contributor team
• Comprehensive reference resource, considered the gold standard in transfusion 
• Covers current hot topics such as donor care – including the frequency of donation and management of iron deficiency/status), patient blood management, hemovigilance, cstem cell therapies, and global aspects of the organization of transfusion and transplant services
• New material on molecular immunohematology
• Companion website includes figures, full text and references 

Leseprobe

Contents

Cover

Title Page

Copyright

Contributors

Preface

List of Abbreviations

About the Companion Website

Chapter 1: Transfusion in the New Millennium

The First Animal Transfusion

The First Animal-to-Human Transfusion

The Beginnings of Modern Transfusion

The 20th Century

Anticoagulants, the Blood Bank, and Component Therapy

Transfusion in the Age of Technology

Concern for Blood Safety

Current Megatrends

Disclaimer

Key References

Section I: Contemporary Issues in Donation and Transfusion

Chapter 2: Patient Blood Management

Introduction

Implementing a PBM Program

Transfusion Guidelines

Physician Education and Monitoring

Preoperative Anemia Management

Cell Salvage

Acute Normovolemic Hemodilution (ANH)

Point-of-Care Testing

Use of Hemostatic Agents

Limiting Phlebotomy Blood Loss for Laboratory Testing

Summary

Acknowledgments

Key References

Chapter 3: Clinical and Technical Aspects of Blood Administration

Introduction

Pretransfusion Considerations

Component Issue, Release, Storage, and Transport

Component Modification and Preparation

At the Bedside: Transfusion Administration

Key References

Chapter 4: Recruitment and Screening of Donors and the Collection, Processing, and Testing of Blood

The Blood Donation and Transfusion Chain

Organization of Blood Services to Meet Global Needs

Recruitment of Blood Donors

Sociological and Psychological Theories of Blood Donation

The Collection Process for Blood Components for Transfusion: Screening, Phlebotomy, Choice of Product, Collection, Testing, and Distribution of Blood and Apheresis Components

Blood Collection

Testing

Component Modification and Distribution

Autologous and Directed Donation

The Collection Process for Source Plasma: Screening, Phlebotomy, Choice of Product, Collection, and Testing of Source Plasma Donors

The Blood Collection and Transfusion Chain is Heterogeneous

Key References

Chapter 5: Adverse Reactions and Iron Deficiency after Blood Donation

Adverse Reactions after Blood Donation

Acute Reactions after Blood Donation: Immediate Symptoms and Delayed Complications

Iron Deficiency after Blood Donation

Brief Review of Iron Physiology

Measurement of Iron Status

Prevalence and Risk Factors for Iron Deficiency in Blood Donors

Genetic Assessment of Iron Status in Blood Donors

Adverse Effects of Iron Depletion

Mitigation of Iron Deficiency

Conclusion

Key References

Chapter 6: Donor Vigilance and Hemovigilance

Introduction

Legal Framework

Donor Hemovigilance

Discussion

Conclusion

Key References

Chapter 7: Global Perspective on Ensuring Blood and Blood Product Safety and Availability

US Perspective on Ensuring Blood and Blood Product Safety and Availability

International Perspective on Ensuring Blood and Blood Product Safety and Availability

Regulation of and Guidance on Blood Products in Europe

Authorization in Europe of Plasma Derivative and Analogous Recombinant Products

Activities to Promote Blood Component Safety in Europe

Notes

Key References

Section II: Blood Components and Derivatives

Part I: Red Blood Cells

Chapter 8: Red Blood Cell Production and Kinetics

Introduction

Erythropoiesis

Erythropoietin

Nutritional Requirements for Erythropoiesis

Summary and Outlook

Key References

Chapter 9: Red Blood Cell Metabolism, Preservation, and Oxygen Delivery

Metabolism

Red Cell Preservation in Transfusion Medicine

Oxygen Delivery

Validation of RBC Quality and in Vivo Recovery

Summary

Key References

Chapter 10: Anemia and Red Blood Cell Transfusion

Introduction

Adaptive Mechanisms in Anemia

Microcirculatory Effects of Anemia and Red Cell Transfusion

Interaction between Pathophysiologic Processes and Anemia

Clinical Outcomes of Anemia and Red Cell Transfusion

Future

Summary

Disclaimer

Key References

Chapter 11: Sickle Cell Anemia, Thalassemia, and Congenital Hemolytic Anemias

Malaria, Blood Groups, and Hemoglobinopathy

Blood Groups

Enzymopathy

Thalassemia

Membrane Mutation

Structural Hemoglobin Mutations

Clinical Review of Sickle Cell Disease/Transfusion Indications

Thalassemia

Transfusion Methods

Transfusion Monitoring

Key References

Chapter 12: Autoimmune Hemolytic Anemias and Paroxysmal Nocturnal Hemoglobinuria

Autoimmune Hemolytic Anemias

Classification

Warm Autoimmune Hemolytic Anemia

Cold Autoimmune Hemolytic Anemia

Paroxysmal Nocturnal Hemoglobinuria

Epidemiology and Risk Factors

Pathophysiology

Clinical Features

Diagnosis

Differential Diagnosis

Treatment

Special Clinical Situations

Children

Transfusion Management

Prognosis

Key References

Chapter 13: Carbohydrate Blood Groups

ABO System

Lewis Blood Group

I Blood Group

P Blood Group System

Key References

Chapter 14: Rh and LW Blood Group Antigens

Summary

Rh Blood Group System

LW Blood Group System

Summary

Key References

Chapter 15: Other Protein Blood Groups

MNS Blood Group System (ISBT 002)

Lutheran Blood Group System (ISBT 005)

Kell and Kx Blood Group Systems (ISBT 006 and 019)

Duffy Blood Group System (ISBT 008)

Kidd Blood Group System (ISBT 009)

Diego Blood Group System (ISBT 010)

Xg Blood Group System (ISBT 012)

Scianna Blood Group System (ISBT 013)

Colton and GIL Blood Group Systems (ISBT 015 and 029)

Chido/Rodgers Blood Group System (ISBT 017)

Gerbich Blood Group System (ISBT 020)

Knops Blood Group System (ISBT 022)

Indian Blood Group System (ISBT 023)

Blood Group Antigens on Glycosylphosphatidylinositol-Linked Proteins: Cartwright (ISBT 011), Dombrock (ISBT 014), Cromer (ISBT 021), JMH (ISBT 026), and CD59 (ISBT 035)

Other Minor Blood Group Systems: OK (ISBT 024), RAPH (ISBT 025), JR (ISBT 032), LAN (ISBT 033), and VEL (ISBT 034)

Summary

Disclaimer

Key References

Chapter 16: Red Cell Immunology and Compatibility Testing

Introduction

Red Cell Immunology

Compatibility Testing

Conclusion

Disclaimer

Key References

Part II: Platelets

Chapter 17: Platelet Production and Kinetics

Platelet Production

Platelet Kinetics

Summary

Key References

Chapter 18: Platelet Immunology and Alloimmunization

Antigens on the Platelet Surface

Alloimmunization to Platelet Antigens

Transfusion Refractoriness

Platelet Selection

Overcoming Established Alloimmunization

Summary

Disclaimer

Key References

Chapter 19: Preparation, Preservation, and Storage of Platelet Concentrates

Preparation of Platelets from Whole Blood: The Platelet-Rich Plasma Method

Preparation of Platelets from Whole Blood: The Buffy Coat Method

Preparation of Platelets by Plateletpheresis

Alternative Sources of Platelets

Storage Conditions

Disclaimer

Key References

Chapter 20: Thrombocytopenia and Platelet Transfusion

Thrombocytopenia

Platelet Transfusion

Summary

Disclaimer

Key References

Chapter 21: Management of Immune-Mediated Thrombocytopenia

Introduction

Laboratory Tests for the Investigation of Thrombocytopenia

Immune-Mediated Thrombocytopenic Syndromes

Summary

Acknowledgment

Key References

Part III: White Blood Cells

Chapter 22: Neutrophil Production and Kinetics: Neutropenia and Neutrophilia

Introduction

Normal Neutrophil Kinetics

Neutrophilia

Neutropenia

Key References

Chapter 23: Neutrophil Collection and Transfusion

Collection of Neutrophils for Transfusion

Neutrophil Transfusion in Clinical Medicine

Summary and Recommendations for Clinical Practice

Disclaimer

Key References

Chapter 24: Leukocyte-Reduced Blood Components: Laboratory and Clinical Aspects

How do Leukocytes Affect Red Cell and Platelet Storage?

Techniques for Leukocyte Removal from Cellular Blood Components

Process Control of Leukocyte-Reduced Components

Clinical Indications for Leukocyte Reduction

Nonhemolytic Febrile Transfusion Reactions

Immunomodulation

Cost-Effectiveness of Leukocyte Reduction

Summary

Acknowledgments

Key References

Part IV: Plasma

Chapter 25: Composition of Plasma

Plasma Composition

Factors Influencing Individual Plasma Composition

Regulation of Blood Coagulation and Fibrinolysis

Fibrinolysis and its Inhibition

Summary

Disclaimer

Key References

Chapter 26: Plasma and Cryoprecipitate for Transfusion

Plasma for Transfusion

Clinical Effectiveness of Cryoprecipitate

Use of Guidelines for Plasma Transfusion

Key References

Chapter 27: The Purification of Plasma Proteins for Therapeutic Use

Introduction

Key Components of the Manufacture of Plasma Protein Therapeutics

Manufacturing Processes for Plasma Protein Therapeutics

Conclusion

Key References

Chapter 28: Recombinant Products for the Treatment of Hemophilia: Recent Advances

Recombinant FVIII

Recombinant FIX

Recombinant Factor VIIa

Conclusions