The Endocrine System - Ian Peate - E-Book

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Ian Peate

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PEATE'S BODY SYSTEMS
THE ENDOCRINE SYSTEM

A CONCISE, ILLUSTRATED, AND ACCESSIBLE GUIDE TO THE ENDOCRINE SYSTEM

Each of the twelve volumes in Peate’s Body Systems series is rooted in the belief that a deep and thorough understanding of the human body is essential for providing the highest standard of care. Offering clear, accessible and up-to-date information on different body systems, this series bridges the gap between complex scientific concepts and practical, everyday applications in health and care settings. This series makes for an invaluable resource for those committed to understanding the intricacies of human biology, physiology and the various systems that sustain life.

The Endocrine System is the perfect companion for students and newly registered practitioners across nursing and allied health fields with an interest in endocrinology, providing a comprehensive yet easy-to-digest guide for both academic and clinical application.

  • Equips healthcare students and practitioners with the necessary information to provide safe and competent care
  • Features colourful illustrations to aid comprehension, clarify complicated concepts, and render content more engaging and accessible
  • Empowers readers to adapt to a rapidly evolving healthcare landscape, preparing them for the future of healthcare delivery
  • Contains information necessary for effective patient care of those with hyper- and hypothyroidism, diabetes, and other diseases and conditions affecting the endocrine system

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Seitenzahl: 311

Veröffentlichungsjahr: 2025

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Table of Contents

Cover

Table of Contents

Title Page

Copyright

Preface

Acknowledgements

Chapter 1 Anatomy and Physiology: The Endocrine System

Homeostasis

The Endocrine Organs

Endocrine, Paracrine, Exocrine and Autocrine Signalling

Hormones

The Transportation of Hormones

Control of Hormone Release

The Physiology of the Endocrine Organs

The Hypothalamus and the Pituitary Gland

Growth Hormone

Prolactin

Follicle‐Stimulating Hormone and Luteinising Hormone (Gonadotrophins)

Thyroid‐Stimulating Hormone

Adrenocorticotrophic Hormone

The Thyroid Gland

Parathyroid Glands

The Adrenal Glands

The Pancreas

The Gonads

Other Endocrine Glands

Conclusion

Glossary of Terms

Multiple Choice Questions

References

Chapter 2 Assessment of the Endocrine System

Assessing Needs

The Patient History

Empathy

A Focused Endocrine Assessment

Assessing the Thyroid Gland

Conclusion

Glossary of Terms

Multiple Choice Questions

References

Chapter 3 Hyperthyroidism

The Thyroid Gland

Thyroxine and Triiodothyronine

Pathophysiological Changes Associated with Hyperthyroidism

Epidemiology

Risk Factors

Clinical Presentation

Clinical Investigations and Diagnosis

Management

Health Teaching

Understanding Hyperthyroidism

Treatment Options

Long-term Management and Follow-up

Conclusion

Glossary of Terms

Multiple Choice Questions

References

Chapter 4 Hypothyroidism

Total Thyroxine and Free Thyroxine

Pathophysiological Changes Associated with Hypothyroidism

Myxoedema

Primary and Secondary Hypothyroidism

Epidemiology

Risk Factors

Clinical Presentation

Clinical Investigations and Diagnosis

Management

Health Teaching

Conclusion

Glossary of Terms

Multiple Choice Questions

References

Chapter 5 Diabetes Mellitus

Type 1 Diabetes

Type 2 Diabetes

Gestational Diabetes

Diabetes Insipidus

Blood Glucose Regulation

Insulin

Glucagon

Other Factors Influencing Blood Glucose Regulation

Pathophysiological Changes Associated with Diabetes Mellitus

Epidemiology

Risk Factors

Clinical Presentation

Clinical Investigations and Diagnosis

Management

Dietary Therapy

Non-insulin Therapy

Insulin Therapy

Monitoring Response to Therapy

Physical Activity

Education and Self-management Skills

Regular Medical Follow-up

Psychosocial Support

Complications, Screening and Prevention

Health Teaching

Conclusion

Glossary of Terms

Multiple Choice Questions

References

Chapter 6 Cushing’s Syndrome

Pathophysiological Changes Associated with Cushing’s Syndrome

Epidemiology

Risk Factors

Clinical Presentation

Clinical Investigations and Diagnosis

Management

Health Teaching

Conclusion

Glossary of Terms

Multiple Choice Questions

References

Chapter 7 Polycystic Ovarian Syndrome

Pathophysiological Changes Associated with Polycystic Ovarian Syndrome

Epidemiology

Risk Factors

Clinical Presentation

Clinical Investigations and Diagnosis

Diagnostic Criteria

Management

Health Teaching

Conclusion

Glossary of Terms

Multiple Choice Questions

References

Chapter 8 Pituitary Tumours

The Pituitary Gland: An Overview

Pituitary Tumours

Pathophysiological Changes Associated with Pituitary Tumours

Hypopituitarism and Hyperpituitarism

Epidemiology

Risk Factors

Clinical Presentation

Clinical Investigations and Diagnosis

Management

Observation and Monitoring

Medication Therapy

Surgery

Radiation Therapy

Combination Therapy

Pituitary Carcinoma

Follow-up Care

Health Teaching

Conclusion

Glossary of Terms

Multiple Choice Questions

References

Index

End User License Agreement

List of Illustrations

Chapter 1

Figure 1.1 The endocrine organs and their location in the body

Figure 1.2 The transportation of hormones in the blood

Figure 1.3 Target cells and non-target cells

Figure 1.4 The negative feedback system

Figure 1.5 The hypothalamus and surrounding structures

Figure 1.6 Position of the adrenal glands

Figure 1.7 Transverse section of an adrenal gland

Figure 1.8 The thyroid and parathyroid glands

Figure 1.9 Control of thyroid hormone production and negative feedback mechanism

Figure 1.10 The pancreas

Figure 1.11 Insulin and glucagon effects on blood glucose

Chapter 2

Figure 2.1 Endocrine disorders across the lifespan.

Figure 2.2 The patient encounter

Figure 2.3 Clinical features of acromegaly and the face of a man with acromegaly

Chapter 3

Figure 3.1 The negative feedback control of thyroid hormone production. TSH, thyroid...

Figure 3.2 Hyperthyroidism

Chapter 4

Figure 4.1 Hypothyroidism

Chapter 5

Figure 5.1 Insulin and glucagon effects on blood glucose levels

Figure 5.2 Insufficient insulin leading to the development of type 1 diabetes

Figure 5.3 Insulin resistance

Figure 5.4 Metabolic syndrome

Figure 5.5 HbA1c measurement

Figure 5.6 Signs and symptoms of type 1 diabetes

Figure 5.7 Insulin pump.

Figure 5.8 Insulin pod

Figure 5.9 Correct performance of a skinfold

Figure 5.10 Taking a capillary blood glucose

Figure 5.11 Blood‐glucose monitoring procedure

Figure 5.12 Injection sites

Figure 5.13 Correct and incorrect depth of injection needles

Figure 5.14 Correct administration of an insulin injection using an injection pen

Figure 5.15 Layers of skin, fat and muscle (not to scale): the tip of a 4mm needle ...

Chapter 6

Figure 6.1 Cushing’s syndrome

Chapter 7

Figure 7.1 The pathophysiology associated with polycystic ovarian syndrome (PCOS)

Figure 7.2 Hirsutism in a patient with polycystic ovarian syndrome (PCOS)

Figure 7.3 Patient-centred approach can help achieve the key goals of PCOS management

Chapter 8

Figure 8.1 The pituitary gland and surrounding structures

Figure 8.2 Hypopituitarism

Figure 8.3 Transsphenoidal surgery

List of Tables

Chapter 1

Table 1.1 The differences between the nervous system and endocrine system

Table 1.2 Hormones released by the anterior pituitary gland

Table 1.3 Effects associated with abnormal secretion of thyroid hormones

Table 1.4 Other endocrine glands

Chapter 2

Table 2.1 Assessing needs

Table 2.2 Some common clinical features observed in endocrine disease

Table 2.3 The patient’s chief complaint of fatigue

Table 2.4 Certain features associated with some endocrine conditions

Table 2.5 Changes in facial features associated with some endocrine disorders

Table 2.6 Some aspects of thyroid gland assessment

Chapter 3

Table 3.1 Some risk factors associated with hyperthyroidism

Table 3.2 Some signs and symptoms associated with hyperthyroidism

Table 3.3 Treatment modalities for hyperthyroidism

Chapter 4

Table 4.1 Some risk factors associated with hypothyroidism

Table 4.2 Symptoms of hypothyroidism

Table 4.3 Examples of dynamic hormone testing

Chapter 5

Table 5.1 Pathophysiological changes associated with type 2 diabetes

Table 5.2 Type 2 and type 1 diabetes clinical presentation comparison

Chapter 6

Table 6.1 Cortisol

Table 6.2 Some of the risk factors associated with Cushing’s syndrome

Table 6.3 Potential imaging studies

Table 6.4 Issues associated with health teaching and Cushing’s syndrome

Chapter 7

Table 7.1 Metabolism associated with polycystic ovarian syndrome (PCOS)

Table 7.2 Inflammatory markers

Table 7.3 Some risk factors associated with polycystic ovarian syndrome (PCOS)

Table 7.4 Diagnosing polycystic ovarian syndrome (PCOS)

Chapter 8

Table 8.1 Hypopituitarism and Hyperpituitarism

Table 8.2 Signs and symptoms commonly associated with pituitary tumours related to cell ...

Table 8.3 Components of the physical examination

Table 8.4 Microadenomas and macroadenomas

Table 8.5 Some key health teaching needs for those with pituitary tumours

Guide

Cover

Table of Contents

Title Page

Copyright

Preface

Acknowledgements

Begin Reading

Index

End User License Agreement

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Peate’s Body Systems

The Endocrine System

Ian Peate, OBE FRCN EN(G) RGN DipN(Lond) RNT BEd(Hons) MA(Lond) LLM

Editor in Chief, British Journal of Nursing;

Consultant Editor, Journal of Paramedic Practice;

Consultant Editor, International Journal for Advancing Practice;

Visiting Professor, Northumbria University;

Visiting Professor, Buckinghamshire New University;

Professorial Fellow, University of Roehampton;

Visiting Senior Clinical Fellow, University of Hertfordshire

This edition first published 2025.

©2025, John Wiley & Sons Ltd

All rights reserved, including rights for text and data mining and training of artificial intelligence technologies or similar technologies. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

The right of Ian Peate to be identified as the author of this work has been asserted in accordance with law.

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While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

Library of Congress Cataloging-in-Publication Data

Names: Peate, Ian, author.

Title: The endocrine system / Ian Peate, OBE FRCN EN(G) RGN DipN(Lond) RNT Bed BEd (Hons) MA(Lond) LLM Editor in Chief, British Journal of Nursing; Consultant Editor, Journal of Paramedic Practice; Consultant Editor, International Journal for Advancing Practice; Visiting Professor, Northumbria University; Visiting Professor, St Georges University of London and Kingston University London; Professorial Fellow, Roehampton University; Visiting Senior Clinical Fellow, University of Hertfordshire.

Description: Hoboken, NJ : Wiley-Blackwell, 2025. | Series: Peate’s body systems ; 6 | Includes bibliographical references and index.

Identifiers: LCCN 2024042311 (print) | LCCN 2024042312 (ebook) | ISBN 9781394252503 | ISBN 9781394252510 (epub)

Subjects: LCSH: Endocrine glands–Textbooks. | Endocrine glands–Diseases–Textbooks. | Endocrinology–Textbooks.

Classification: LCC QP187 .P393 2025 (print) | LCC QP187 (ebook) | DDC 612.4–dc23/eng/20250102

LC record available at https://lccn.loc.gov/2024042311

LC ebook record available at https://lccn.loc.gov/2024042312

Cover Images: © marinashevchenko/Adobe Stock, © phototechno/Getty Images, © 4luck/Adobe Stock, © Oleksandr Pokusai/Adobe Stock

Cover Design: Wiley

Preface

Welcome to Peate’s Body Systems; there are 12 books in the series. This is a comprehensive collection of textbooks designed to support and enrich the knowledge of health and care workers across various fields. This series is intended to be a valuable resource for those who are dedicated to understanding the intricacies of human biology, physiology and the various systems that sustain life.

Peate’s Body Systems series is rooted in the belief that a deep and thorough understanding of the human body is essential for providing the highest standard of care. Each book in this series is thoroughly crafted to offer clear, accurate and up-to-date information on different body systems. The aim is to bridge the gap between complex scientific concepts and practical, everyday applications in healthcare settings.

Purpose and Scope

The purpose of this series is to provide health and care workers with:

Foundational knowledge, with explanations of the anatomical structures and physiological functions of the body systems

Insights into how these systems interact with each other and how they are impacted by various diseases and conditions, highlighting clinical relevance and encouraging practical application

Structure of the Series

Each book in Peate’s Body Systems focuses on a specific body system:

The Cardiovascular System

The Respiratory System

The Digestive System

The Renal System

The Nervous System

The Endocrine System

The Female Reproductive System

The Male Reproductive System

The Musculoskeletal System

The Skin

The Ear, Nose and Throat

The Eyes

Every chapter is designed to be comprehensive yet accessible, making complex information easier to digest and apply. Figures, tables, boxes, illustrations and flowcharts have been extensively used to support visual learning and reinforce key concepts.

This series is tailored for:

Healthcare students: those in nursing and allied health programmes

Practicing professionals: nurses, therapists and other care workers seeking to deepen their understanding and stay current with the latest developments in health and care

Educators and trainers: educators who require reliable and comprehensive teaching materials to advise and instruct the next generation of healthcare providers

Commitment to Excellence.

The series is committed to providing quality educational resources that not only inform but also inspire and empower health and care workers. By equipping you with a robust understanding of the systems of life, you will be better prepared to make informed decisions, deliver compassionate care and ultimately improve patient outcomes.

Thank you for choosing Peate’s Body Systems as your trusted resource. I hope these textbooks serve as a valuable tool in your ongoing journey of learning and professional development.

Ian Peate

London

Acknowledgements

I would like to acknowledge the help and support of my partner Jussi Lahtinen. Acknowledgements also go to staff at the RCN Library in London. My thanks go to Tom Marriott, Christabel Daniel Raj, Bhavya Boopathi and all those at Wiley.