Hashimoto’s thyroiditis E-Book

PeGaz

• Herausgeber: Wydawnictwo Psychoskok
• Kategorie: Fachliteratur
• Sprache: Englisch
• Veröffentlichungsjahr: 2021

Beschreibung

I've decided to describe Hashimoto's disease with the essay. I'm afraid that I am not a clinician, but surely I am able to give some essential information about that illness. As a doctor I've been working on that since 1986. Day by day, step by step I discovered Hashimoto's Thyroiditis. By the way, I've realised that it's the global problem. I do believe that it will be sightful trip to the inside of the human essence.

Leseprobe

PeGaz

Hashimoto's thyroiditis

Psychoskok

PeGaz „Hashimoto’s thyroiditis”

Copyright © by PeGaz, 2021

Copyright © by Psychoskok Sp. z o.o. 2021

Leading editor: Renata Grześkowiak

Cover Design: PeGaz

Composition: Kamil Skitek

ISBN: 978-83-959247-0-5

Psychoskok Sp. z o.o.

Spoldzielcow 3/325, 62-510 Konin

Poland

http://www.psychoskok.pl/http://wydawnictwo.psychoskok.pl/ e-mail:[email protected]

August 21, 2011 Hashimoto’s thyroiditis

Yes, I have for sure discovered something very important – I thought a few years ago and this thought kept bothering me.

In this book, which I finally decided to write, I’ll try to tell about one of the most astonishing diseases I’ve ever came across in my life as a doctor. This book is a result of 25 years of pursuing my interest in thyroid, encouraged by the events of April 1986, related to the Chernobyl reactor explosion.

Step by step, I reached surprising observations, which I’ll try to describe. I examined about 12 thousand people, mainly in Poland, but there were also people from different countries and continents – Asia, America, Africa, Australia, Europe – who visited Poland.

On the basis of those examinations I noticed that the Hashimoto’s thyroiditis has global reach, but also that, though discovered in 1912 by Dr Hashimoto from Japan, occurred already much earlier. Many famous people from the history suffered from it – leaders of countries, emperors, presidents, actors, teachers, journalists, painters, writers, poets, doctors, soldiers, clergymen. In a word, the whole humankind was affected by this disease. Chasing similarities like in a game of chess, which I believe is the most suitable of the mind sharpening games, I reached unexpected conclusions, asking myself where and when all of it started. Who was first? Today I know it was a Neanderthal, although the first one could have been even earlier. Was the beginning of life on earth related to the Hashimoto gene? Sounds improbable, but not impossible and not inacceptable. Each face is a mosaic of genes. It reflects all of our ancestors’ features. Thanks to thorough observation of faces one can precisely assess person’s susceptibility to various diseases. I’ve learned to do it. The Hashimoto’s thyroiditis is an autoimmune disease related to a disorder of function of T lymphocytes, which are responsible for destruction of thyrocytes and in consequence for development of hypothyroidism.

The Hashimoto’s thyroiditis and its opposite, Graves-Basedow disease, are nothing else than apoptosis disorders. Both those diseases start with activation of CD 4 lymphocytes, which stimulate the B lymphocytes to produce antithyroid antibodies. In Gaves-Basedow disease the activation of B lymphocytes leads to the synthesis of antibodies, stimulating the TSH receptor, which causes overproduction of hormones and development of hyperthyroidism. Chronic diseases such as, for example, hypertension, diabetes, asthma, allergies, rheumatoid arthritis (RA), coronary artery disease (CAD), depression, depressive syndromes, e.g. obsessive-compulsive disorder, are in fact autoimmune diseases related to pathological response of T lymphocytes to an inflammation in the body. On the verge of this there lays the autoimmune thyroiditis, the Hashimoto’s disease with the Hashimoto’s gene, which we all have when we come to this world. In Hashimoto’s thyroiditis the proinflammatory cytokines affect the immune system and the target cells (thyrocytes). During the autoimmune inflammation, macrophages and Th1 lymphocytes induce mass regulation of increase of CD95 molecules expression on the surface of thyroid follicular cells, which subsequently causes activation of programmed death of those cells. It happens similarly in the mechanisms of diabetes, hypertension, coronary artery disease, rheumatoid arthritis, asthma, allergy, depression. Those are autoimmune diseases. The Hashimoto’s thyroiditis reveals itself in various stages of life, although it prognosticates the worst if it happens in childhood or youth. The later, the better. The ‘masks’ of this disease are the abovementioned: hypertension, diabetes, coronary artery disease, rheumatoid arthritis, allergy, asthma, arteriosclerosis, Addison’s disease, myasthenia gravis, ADHD, irritable bowel syndrome. Those diseases should be treated as its equivalents. Each autoimmune disease should be treated as an equivalent of other autoimmune disease, as it is assumed that diabetes is an equivalent of coronary artery disease and for example rheumatoid arthritis should be the equivalent of coronary artery disease. They all lead to pathological response of T lymphocytes. The nature in the autoimmune process creates apoptosis. It is a form programmed cell death. It is also referred to as physiological death or suicidal cell death. This mechanism is a regulatory process, allowing to remove the cells produced in excess and therefore unnecessary at that time. In case of Hashimoto’s thyroiditis the production of TPO antibodies is excessive, although we all – all the people in the world – have the TPO antibodies, sooner or later. Not everybody gets sick at once. The level increases with age and the subsequently emerging diseases – ‘masks’ – such as hypertension, coronary artery disease, rheumatoid arthritis etc., indicate the beginning of pathological process. It is inevitable due to the apoptosis process, accompanying us our whole lives. Examples of chromosome regions related to the autoimmune diseases: HT-1 at chromosome 13q33 and HT-2 at chromosome 12q22 susceptibility genes at chromosome 6, responsible for expansion of the human leukocyte antigens (HLA). At chromosome 2H antigen-4 gene, related to cytotoxic T lymphocytes, at chromosome 20 the gene for CD-40, at chromosome 8 the gene encoding the expression for thyroglobulin and the autoimmune regulator gene (chromosome 21). In autoimmune diseases there are disorders of functions of HLA-Dq dimers. In Graves-Basedow and Hashimoto’s diseases there occurs a genetic slowdown from locus 2q33. Currently, the medicine officially distinguishes a few types of syndromes in autoimmune diseases.

TYPE 1

• chronic mucous membranes candidiasis

• primary hypoparathyroidism

• Addison’s disease

To diagnose this syndrome there must occur 2 of 3 disorders.

TYPE 2

• Addison’s disease

• Graves-Basedow or Hashimoto’s type of autoimmune inflammation

• type 1 diabetes

Accompanying symptoms: atrophic gastritis, pernicious anaemia, leukoderma (vitiligo), alopecia areata (spot baldness), hypogonadotropic hypogonadism (HH). To diagnose this syndrome there must occur 2 of 3 disorders.