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Reference pocketbook containing common medications prescribed to patients to facilitate identification and revealing potential interactions, overdose symptoms, and common call outs
Easy to navigate and truly pocket-sized, the Paramedic Pocketbook of Prescription Medications covers common medications and their possible presentations, highlights risk of causing harm, and goes over mechanism of action, use, and potential risks for each.
Key features:
Paramedic Pocketbook of Prescription Medications is an essential guide for emergency services personnel and first responders to carry with them for easy reference and peace of mind.
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Seitenzahl: 263
Veröffentlichungsjahr: 2024
Cover
Table of Contents
Title Page
Copyright Page
Foreword
Acknowledgements
List of Abbreviations
Introduction
‘Have You Recently had a Change in Your Medications?’
References
Drug Legislation and Paramedic Practice
Schedule 19 of the Human Medicines Regulations 2012
Schedule 17 of the Human Medicines Act (Part 3.8)
Patient Group Directives
Associate of Ambulance Chief Executives Protocols
Prescribing
Controlled Drugs
References
Special Circumstances
Paediatrics
The Older Person
Kidney Injury and Disease
Hepatic Failure
Pregnancy and Breastfeeding
Palliative Care and Those at the End of Life
References
Medication Groups
An Example Table
A
References for A
B
References for B
C
References for C
D
References for D
E
References for E
F
References for F
G
References for G
H
References for H
I
References for I
K
References for K
L
References for L
M
References for M
N
References for N
O
Reference for O
P
References for P
Q
Reference for Q
R
References for R
S
References for S
T
References for T
V
Reference for V
W
Reference for W
Z
Brand Names Index
Glossary
End User License Agreement
Drug Legislation and Paramedic Practice
Table 1 Controlled Drug Schedules
Special Circumstances
Table 1 Classification of Paediatric Patient’s Based on Age [2]
Table 2 Estimated Glomerular Filtration Rates and Kidney Disease Classificat...
Table 3 Prehospital Medication and the Pregnant or Breastfeeding Person
Introduction
Figure 1 Ambulance call‐outs due to medicines can be grouped into different ...
Special Circumstances
Figure 1 The special circumstances surrounding medications and paediatric pa...
Figure 2 There are several considerations regarding medicines and the older ...
Figure 3 ‘Sick Day Rules’ are a useful piece of safety netting advice to giv...
Figure 4 Examples of Just in Case Medicines as per the Scottish Palliative C...
Drug Legislation and Paramedic Practice
Special Circumstances
Medication Groups
An Example Table
Cover Page
Table of Contents
Title Page
Copyright Page
Foreword
Acknowledgements
List of Abbreviations
Introduction
Begin Reading
Brand Names Index
Glossary
WILEY END USER LICENSE AGREEMENT
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Rose Matheson
Queen Margaret University
Edinburgh, UK
This edition first published 2024© 2024 by John Wiley & Sons Ltd
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Limit of Liability/Disclaimer of WarrantyThe contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or treatment by physicians for any particular patient. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.
Library of Congress Cataloging‐in‐Publication Data applied forPaperback ISBN: 9781394202492
Cover Design: WileyCover Image: © James Thew/Adobe Stock Photos
As paramedics, we are entrusted with the immense responsibility of caring for the health and well‐being of those in need. Every day, we face countless challenges, potentially making split‐second decisions that can have long‐lasting effects.
The world of paramedicine continues to evolve at pace, one area that has changed beyond recognition in the last couple of decades is the paramedic’s knowledge of pharmacology; no longer is a protocol approach sufficient. The modern paramedic is expected to understand and navigate the complexities presented by medications and drugs.
This remarkable book presents a treasure trove of easily accessible content offering a comprehensive guide to common prescription medications for paramedics working in a variety of environments. Within these pages you will find a wealth of information that will enhance your understanding of prescription medications and empower you to make informed decisions in this field. This book is a testament to the author in ensuring that paramedics have access to up to date and relevant information in this critical aspect of our practice.
What truly sets this book apart is its commitment to accessibility. A talented artist, Rose has presented the information in a visually engaging manner, using graphics to enhance comprehension. This practical approach is suited fabulously to the pragmatic people that we paramedics tend to be; each medication is presented in a concise and easily understandable manner, making it accessible even to those with a limited pharmacological background.
I would like to express my deepest gratitude to Rose, for her dedication and expertise in compiling this essential resource. Her commitment to excellence is evident in every page, and her passion for advancing knowledge and understanding of pharmacology shines through.
To my fellow paramedics, I encourage you to embrace this text as a companion on your journey to providing the highest standard of care. May this book serve as a trusted ally in navigating the complex arena of medications.
Kirsty Lowery‐Richardson, Head ofEducation – College of Paramedics
Thanks to the team at Wiley for helping me write my first book! Specifically, I would like to thank Tom Marriott at Wiley for initially reaching out to me with his idea for this book and Christabel and Valli for their support during the writing stages. Equally I would like to thank my partner Harry and loyal wire‐haired pointer Marsco for their pastoral support! Thanks to my mum Fiona Matheson for reading through early drafts for spelling errors just as she used to do for my school essays and Maya Walker who also lent me sharp eye! Most importantly, thank you to my students who have helped me get rid of my imposter syndrome (a bit) and to the students who are reading this book to try and learn more to support the people they treat.
5HT – Serotonin
ACE – Angiotensin Converting Enzyme
AF – Atrial Fibrillation
AIDS – Acquired Immune Deficiency Syndrome
AKI – Acute Kidney Injury
BPH – Benign Prostate Hyperplasia
CCB – Calcium Channel Blocker
CK – Creatine Kinase
CKD – Chronic Kidney Disease
CKD‐EPI – Chronic Kidney Disease Epidemiology Collaboration
CNS – Central Nervous System
COPD – Chronic Obstructive Pulmonary Disease
COX – Cyclo‐oxygenase
D2 – Dopamine
DIC – Disseminated Intravascular Coagulation
DMARDs – Disease Modifying Anti‐Rheumatic Drugs
DOAC – Direct Oral Anti‐Coagulant
DPP‐4 – Dipeptidyl Peptidase 4
DRESS – Drug Reaction with Eosinophilia and Systemic Symptoms
DVLA – Driving and Vehicle Licensing Agency
DVT – Deep Vein Thrombosis
ECG – Electrocardiogram
FBC – Full Blood Count
GERD – Gastro‐oesophageal Reflux Disease
GSL – General Sales List
H@H – Hospital at Home
INR – International Normalised Ratio
JIC – Just In Case
LDL – Low Density Lipoproteins
LFT – Liver Function Tests
MHRA – Medicines and Healthcare Products Regulatory Agency
NG – Nasogastric (tube)
NJ – Nasojejunal (tube)
NSAID – Non‐steroidal Anti‐inflammatory Drug
OCD – Obsessive Compulsive Disorder
P – Pharmacy
PC – Palliative Care
PCOS – Polycystic Ovary Syndrome
PE – Pulmonary Embolism
PEG – Percutaneous Endoscopic Gastrostomy (tube)
PGD – Patient Group Directive
POM – Prescription Only Medicine
PPCI – Primary Percutaneous Coronary Intervention
PRN – ‘pro re nata’ (take as required)
QRS – QRS Complex of Electrocardiogram
RAAS – Renin Angiotensin Aldosterone System
RIG – Radiologically inserted gastrostomy (tube)
SCARs – Severe Cutaneous Adverse Reactions
SLE – Systemic Lupus Erythematosus
SNRI – Serotonin and Noradrenaline reuptake inhibitor
STEMI – ST‐Elevation Myocardial Infarction
T2DM – Type 2 Diabetes Mellitus
TIA – Transient Ischaemic Attack
URTI – Upper Respiratory Tract Infection
VT – Ventricular Tachycardia
This is one of my favourite questions to ask a patient. Mainly in the hope that I can use some pharmacological detective skills to find a medication that is causing their symptoms (Figure 1). Maybe their new blood pressure medication is the reason they are feeling dizzy when they stand up? Maybe their insulin dose is causing them to suffer regular hypoglycaemic events? Has their steroid inhaler caused their oral thrush? Has their lidocaine patch sent them into an arrhythmia?
As paramedics, we have a unique knowledge of medications. We have the medications that we are privileged to provide people in an emergency through Schedule 17 and 19 of the Human Medicines Regulation 2012 and then some more that are mutually agreed to be beneficial and included in guidelines from the JRCALC or as a Patient Group Directive. As the role of the paramedic has developed from primarily a transport service to a mobile medical centre, we have developed into expert generalists in urgent and emergency medicine. The role of the paramedic has been less of an emerging profession but an exploding one with a dramatic change in the demands on the profession over the last few decades.
However, a lot of this learning is done post‐qualification. Education can still be focused on trauma and life‐threatening calls of which the latter is now well expected to make up only 10% of our workload [1]. The other 90% of calls we attend don’t always align to our training. This can leave both new and experienced clinicians to suffer from regular bouts of uncertainty which when repeated can contribute to burnout [2]. The role of the paramedic involves attending more and more people with urgent presentations and chronic disease which has resulted in paramedics needing a more rounded knowledge of prescription medicines despite this not classically being part of the curriculum for paramedics. That is where I am hoping this book comes in useful, as an easy‐to‐use resource to familiarise ambulance clinicians with commonly prescribed medications. The list of medications used includes the top prescribed medications in England [3] but with a greater focus on medications in a primary care setting as these are more commonly encountered by ambulance clinicians in the prehospital environment.
Figure 1 Ambulance call‐outs due to medicines can be grouped into different categories which can hide behind common presentations that we might not consider to be related to a person's medication.
Due to my location and training, this book focuses on UK‐based practice and legislation. However, in the main list, the drug names have been used rather than brand names and many of the uses, side effects and data will still be applicable elsewhere in the world. This pocketbook aims to provide an additional reference for ambulance staff and other non‐prescribers in order to familiarise themselves with commonly prescribed medications. It is not meant to be used as an alternative to the British National Formulary (BNF) or a discussion with a prescriber.
1
The Nuffield Trust. Ambulance Response Times [internet]. 2023. The Nuffield Trust: London. [cited 2023 08 29]. Available at:
https://www.nuffieldtrust.org.uk/resource/ambulance‐response‐times
2
Alzahrani, A., Keyworth, C., Wilson, C. and Johnson, J. Causes of stress and poor mental wellbieng among paramedic students in Saudi Arabia and the United Kingdom: a cross‐cultural qualitative study BMC Health Serv Res 2023 5 (23). [cited 2024 03 15]. Available at:
https://doi.org/10.1186/s12913‐023‐09374‐y
3
Audi, S., Burrage, DR., Lonsdale, DO., Pontefract, S. Coleman, JJ., Hitchings, AW. and Baker, EH. The ‘top 100’ drugs and classes in England: an updates ‘starter formulary’ for trainee prescribers Br J Clin Pharm 2018 84 (11) p2562–2571. [cited 2023 06 01]. Available at:
https://doi.org/10.1111/bcp.13709
Paramedics are able to administer several medications to patients autonomously, meaning without a discussion with a prescriber, but these medications do not all fall under the same legislation.
These are medications that anyone can administer in an emergency [1]. This is why anyone can give an EpiPen® to someone suffering from suspected anaphylaxis and there is increasing training in ‘Take Home Naloxone’ for opiate overdoses. Medications under this legislation include:
Adrenaline 1:1000 up to 1 mg for intramuscular use in anaphylaxis
Atropine sulphate and obidoxime chloride injection
Atropine sulphate and pralidoxime chloride injection
Atropine sulphate injection
Atropine sulphate, pralidoxime mesylate and avizafone injection
Chlorphenamine injection
Dicobalt edetate injection
Glucagon injection
Glucose injection
Hydrocortisone injection
Naloxone hydrochloride
Pralidoxime chloride injection
Pralidoxime mesylate injection
Promethazine hydrochloride injection
Snake venom antiserum
Sodium nitrate injection
Sodium thiosulphate injection
Sterile pralidoxime
Note that the only indication here is for anaphylaxis and there is no clear guidance on when other medications should be indicated. Regulation 214 [2] may also be quoted in reference to paramedics which suggests prescription‐only medications can only be administered parenterally in the presence of an ‘appropriate practitioner’ of whom paramedics are not identified. However, Regulation 238 states that Regulation 214 should be disregarded in the instance of Schedule 19 medicines in order to save a life in an emergency. Therefore, these medications can still be given by anyone; however, the indication for giving them is not clear.
These prescription medications can be given by paramedics for the ‘necessary’ treatment of sick people [2]. This schedule covers different professions that have their own exemptions to allow them to provide certain prescription medications. These may be referred to as ‘exemption medications’. Not all medications we use are covered by this legislation and some of the medications here have fallen out of favour (e.g. streptokinase). Some medications are listed but not indicated for the use that they are now mainly given – for example, heparin is only stated to be used as a flush and not as part of cardiac thrombolysis. Again, there are no indications stated for all these medications.
These medications include:
Adrenaline acid tartrate
Adrenaline hydrochloride
Amiodarone
Anhydrous glucose
Benzylpenicillin
Compound sodium lactate (Hartmann’s Solution)
Diazepam 5 mg/ml
Ergometrine 500 mcg
Ergometrine maleate 500 mcg and oxytocin 5 units (Syntometrine
®
)
Furosemide
Glucose
Heparin sodium (only to flush a cannula)
Lidocaine hydrochloride
Metoclopramide
Morphine sulphate
Nalbuphine hydrochloride
Naloxone hydrochloride
Ondansetron
Paracetamol
Reteplase
Sodium chloride
Streptokinase
Succinylated modified fluid gelatin
Tenecteplase
Patient Group Directives (PGDs) are legislation that allows for a certain group of health care professionals to administer a specific medication to a specific patient group [3]. An example is heparin; ambulance services create a PGD to allow paramedics to administer heparin to people expecting Primary Percutaneous Coronary Intervention (PPCI) treatment or thrombolysis. Different ambulance services will have different medications available as PGDs and this can include a ‘new’ medication for paramedics such as codeine for moderate pain or a medication we use but in a different form or route, e.g. nebulised adrenaline for croup. What is important to understand is that these medications can only be given for the presentations mentioned on the PGD and if you change employment to another ambulance service or trust you cannot give this medication unless it is also a PGD in your new service.
The Joint Royal College Ambulance Liaison Committee (JRCALC) list medications that ambulance services and trusts have generally agreed will benefit people if paramedics are able to administer them. These medications are more colloquially known as ‘JRCALC medicines’. This includes medications such as clopidogrel. Individual ambulance trusts may have their own specific guidelines for these medications through PGD, or they will follow JRCALC guidance.
Some paramedics will choose to do additional training to gain their Non‐Medical Prescribing qualification at Bachelors or Masters level. This allows them to prescribe medications from the BNF and they will be listed as an independent or supplementary prescriber on the Health and Care Professions Council (HCPC). However, at the time of writing, paramedic prescribers are only able to prescribe a limited list of controlled drugs [4].
Since I’ve mentioned it, let’s talk about controlled drugs.
Paramedics can autonomously administer a selection of what are known as ‘controlled’ medications such as morphine sulphate and benzodiazepines through various forms of legislation. The Misuse of Drugs Act 1971 [5] places drugs in different ‘classes’ which are organised on a scale based on the potential harm when misused and includes both prescription drugs and illicit drugs.
Class A
– Includes cocaine, heroin, LSD, MDMA, morphine, methadone.
Class B
– Includes oral amphetamines, cannabis, codeine, dihydrocodeine, ketamine and barbiturates.
Class C –
Includes buprenorphine, benzodiazepines, tramadol, zopiclone, androgenic and anabolic steroids, gabapentin, pregabalin and most recently nitrous oxide.
The Misuse of Drugs (Safe Custody) regulations 1973 is related to the safe storage of controlled drugs and the Misuse of Drugs Regulations 2001 discusses who can provide controlled drugs and the requirements for supply, prescribing and record keeping (Table 1). This is where the terminology of having different ‘schedules’ of controlled medications comes in. This is why morphine and midazolam need to be double locked in a safe whereas diazepam does not.
This legislation originates from attempts to prevent misuse of drugs to cause harm. The knowledge behind drug misuse is evolving and a greater understanding of life experiences that contributes to drug use is becoming clearer. There is greater appreciation that drug use and addiction is a coping mechanism for early childhood trauma which can be supported through appropriate rehabilitation. Legislation is yet to reflect this; however, there is growing acceptance within the medicine and psychology fields that to tackle drug misuse legislation needs to be supportive not punitive [6].
Table 1 Controlled Drug Schedules
SCHEDULE
EXAMPLES
REQUIREMENTS
PREHOSPITAL EXAMPLES
Schedule 1
Hallucinogenic drugs, ecstasy‐like drugs, opium, cannabis
Home office licence required for production, possession+supply. Controlled drugs register kept with pharmacy details.
NONE
Schedule 2
Opiates, stimulants, cocaine, ketamine, medicinal cannabis products
Controlled drugs register to be kept detailing administration of supply. Must be stored in a locked safe.
Morphine sulphate (IV preparation) Ketamine
Schedule 3
Most barbituates, gabapentin, pregabalin, midazolam, temazepam
Some groups must be stored in a locked safe. Retention of invoices for 2 years
Midazolam
Schedule 4
other benzodiazepines, Z‐drug, anabolic + androgenic steroids
Retention of invoices for 2 years
Diazepam
Schedule 5
Codeine phosphate, oral preparations of morphine
Retention of invoices for 2 years
Codeine, oramorph
®
1
United Kingdom. The Humans Medicines Regulation 2012 No 1916 Schedule 19
2
United Kingdom. The Human Medicines Regulation 2012 no 1916 Schedule 17 Part 3.8
3
Medicines and Healthcare Products Regulatory Authority. Patient Group Directions: who can use them [internet] 2017 [cited 2024 03 18]. Available at:
https://www.gov.uk/government/publications/patient‐group‐directions‐pgds/patient‐group‐directions‐who‐can‐use‐them
4
England, Wales and Scotland. The Misuse of Drugs Regulations 2023 No. 1345
5
United Kingdom, The Misuse of Drugs Act 1971 c.38
6
Maté, G. and Maté, D. The Myth of Normal. Vermillion: London, 2022, p213–234
Figure 1 The special circumstances surrounding medications and paediatric patients.
There are special circumstances surrounding medications and paediatric patients due to their unique stages of development (Figure 1). Dose and route considerations are important and several medications are unlicensed which leaves scope for adverse effects.
The phrase ‘children are not small adults’ is especially applicable to pharmacology. Paediatrics vary from adults not only in their size but also their organ maturity which can affect the pharmacokinetics and pharmacodynamics of a drug in the body.
Paediatrics is also not a single group, there are several stages of development that can alter aspects of pharmacology as we go through childhood. Anecdotally, defining different groups within paediatrics is a grey area in paramedic practice and we are not often sure of the boundaries. Often, we only consider there to be neonates and paediatrics in relation to resuscitation guidelines. However, when it comes to medication, these groups can be subdivided and furthermore there is still considerable overlap in rates of metabolism, physical and mental development (Table 1). For example, did you know that the dose of adrenaline in cardiac arrest is greater in a newborn than a one month old?1
Reporting of adverse reactions to medications in paediatric patients from practice is vital. Not only for duty of candour and authenticity as a professional but also because most clinical trials for developing medications and randomised controlled trials for testing effects do not routinely involve paediatric populations. Understandably, this would not be easy to gain ethical approval for. This means that many drugs are considered ‘off‐label’ or ‘unlicensed’ in paediatrics as they have not been fully tested on these patient groups. This means that many medications have not actually been tested for the same level of safety for paediatrics which can put both the prescriber and the child at risk. Many of the known side effects of medications on paediatric populations are because of people reporting adverse effects after using the medicine.
Table 1 Classification of Paediatric Patient’s Based on Age [2]
TERM
AGE RANGE
CONSIDERATIONS
Pre‐term Newborn
Delivery < 37 weeks
There is still considerable variation in this category as a baby delivered at 25 weeks can differ in development from a baby delivered at 30 weeks. Expected birth weight is also a factor as low birth weight may align to a more prematurely developed infant.
Term Newborn
Delivery > 37 weeks
Infant
0 – 28 days
There is high body surface area to weight ratio at this stage. Small volumes can account for a large portion of the overall blood volume. The blood‐brain barrier is not fully formed. Hepatic and renal clearance is immature leading to an increased suspectability to toxic effects.
Infant ‐ Toddler
28 days – 25 months
Hepatic + renal clearance continue to develop. Clearance of drugs can be quicker than in adults so doses may be higher than adult doses. The blood‐brain barrier is fully formed at 4 months.
Children
2 – 11 years
Again drug clearance can exceed adult values so doses may still be high. There are several growth and cognitive milestones during this phase which may be affected by medications. Consider that onset of puberty can vary and may occur in the later stages of this age group.
Addescents
12 – 18 years
Consideration is required for medications or conditions that interfere with sex hormones at these ages. Pregnancy, alcohol and drug use can be genuine considerations. Individuals start to take ownership of their own health decisions. Variable degrees of emotional maturity.
We have already seen that children are not just small adults and can have different levels of organ maturity which may mean that the action of a drug or metabolite may differ to that of an adult. Aspirin is a well‐known example where, given to a person under 16 can cause Reye’s Syndrome2 where the components of aspirin damage mitochondria in children but not adults. Clinical presentations of disease can also differ between adults and children – croup is an example where a viral upper respiratory infection can be fatal in children but a mere annoyance in an adult.
Due to the important growth milestones throughout childhood, it is not certain how some medications might affect different stages of development.
Medications may not be available in formulations that allow for specific dosing for paediatrics. Continuing with croup, consider the use of dispersible tablet formulations of dexamethasone compared to the solution. It is much easier to give the exact dosing using the solution, but this is not always made available by ambulance trusts.
Children should be involved in discussions regarding their medications where possible to improve agency over their own health. Paediatric dosing can be complex when trying to balance an increased metabolic rate with a small blood volume which can result in increased daily dosing. It is important to consider the regime for drug dosing and to avoid midday doses in younger children who might be at school and away from a caregiver to provide or supervise administration.
Generally, the oral route is preferred by most children with solutions being the easiest and most palatable. It can be common practice to disguise the taste of medicines using food – this is known as covert administration and if a person has capacity, they still must provide consent to being given the medication even if it is disguised. Caregivers must check that the medication absorption will not be hindered by being given with food. In children, this can also result in developing an aversion to certain foodstuffs as they are associated with medication.
Invasive parenteral routes such as intramuscular and intravenous administration should be avoided where possible. However, some drugs and clinical scenarios will necessitate the use of these routes especially in the prehospital environment. It is worth remembering that these procedures can be traumatic for both child and caregiver (as well as the clinician!) and there are some things we can try to help improve the overall experience:
Try to avoid doing the procedure in a child’s ‘safe space’ so as to not tarnish an area of sanctuary.
If a topical anaesthetic is available for pre‐cannulation, then this should be utilised.
Explain what you are doing in appropriate terms for the child and caregiver. Where possible explain each piece of equipment and perhaps practice on a cuddly toy or trusted adult (where appropriate!).
Do not always assume a child will have a fear of needles. Some children may be accustomed or even interested in injections. Judge your response based on the child and react accordingly – assuming fear may just encourage a fear response.